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ESR2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ESR2 2100 Druggable Genome

    Alternate Names:

    ESR2
    2100
    ESTROGEN RECEPTOR 2
    ER-BETA
    ESR-BETA
    ESRB
    ESTRB
    Erb
    NR3A2
    601663
    3468
    ENSG00000140009
    OTTHUMG00000141306
    Q92731
    ESTROGEN RECEPTOR BETA (ER-BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92731]
    BE0000792
    ESTROGEN RECEPTOR BETA
    ESR2_HUMAN
    PA27886
    621
    NP_001428
    NM_001040276
    Estrogen receptor-β
    Nuclear receptor subfamily 3 group A member 2
    T80896

    Gene Info:

    Target Class Receptors
    Target Subclass Nuclear receptor
    Human Readable Name DRUGGABLE GENOME
    Initial Gene Query NR3A2
    Counted Citations from 1950-2000 3987
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000536
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Uniprot Evidence 1: Evidence at protein level
    GuideToPharmacology Gene Category Name 3A. Estrogen receptors
    GuideToPharmacology Gene Category ID 96
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (13 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Mc Ilroy et al., 2006, Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence., Endocr. Relat. Cancer
    Hayes et al., 2010, Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results., Clin. Pharmacol. Ther.
    Jain D et al., 2010, A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements., Bioorg Med Chem Lett
    Chen et al., 2005, Potential of endogenous estrogen receptor beta to influence the selective ER modulator ERbeta complex., Int. J. Oncol.
    Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
    Horner-Glister et al., 2005, Influence of oestradiol and tamoxifen on oestrogen receptors-alpha and -beta protein degradation and non-genomic signalling pathways in uterine and breast carcinoma cells., J. Mol. Endocrinol.
    Gruvberger-Saal et al., 2007, Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma., Clin. Cancer Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Girault et al., 2006, Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer., Maturitas
    Ntukidem NI et al., 2008, Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen., Clin Pharmacol Ther
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Min J et al., 2013, Thiophene-core estrogen receptor ligands having superagonist activity., J Med Chem
    Komm BS et al., 2005, Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity., Endocrinology
    Bryant et al., An estrogen receptor basis for raloxifene action in bone., J. Steroid Biochem. Mol. Biol.
    Zhou et al., 2002, Selective estrogen receptor modulator effects in the rat brain., Neuroendocrinology
    Kim et al., 2002, Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line LNCaP through an androgen-independent pathway., Cancer Res.
    Iannone et al., 2001, Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres., Cytometry
    Sun et al., 2002, Antagonists selective for estrogen receptor alpha., Endocrinology
    Jiang Y et al., 2013, Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens., FASEB J
    Vijayanathan et al., 2007, Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta., Biochem. Cell Biol.
    Bologa et al., 2006, Virtual and biomolecular screening converge on a selective agonist for GPR30., Nat. Chem. Biol.
    Paterni I et al., 2014, Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential., Steroids
    Renner S et al., 2009, Bioactivity-guided mapping and navigation of chemical space., Nat Chem Biol
    Mishra et al., 2006, Metabolite ligands of estrogen receptor-beta reduce primate coronary hyperreactivity., Am. J. Physiol. Heart Circ. Physiol.
    Calogeropoulou T et al., 2009, Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity., J Med Chem
    Peng J et al., 2009, Potential of selective estrogen receptor modulators as treatments and preventives of breast cancer., Anticancer Agents Med Chem
    Barker et al., 2006, Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta., J. Steroid Biochem. Mol. Biol.
    Puddefoot et al., 2006, Trilostane in advanced breast cancer., Expert Opin Pharmacother
    Puddefoot et al., 2002, Non-competitive steroid inhibition of oestrogen receptor functions., Int. J. Cancer
    Woo HI et al., 2012, Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine., Pharmacogenomics
    Setchell KD et al., 2005, S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora., Am J Clin Nutr
    Mueller SO et al., 2004, Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells., Toxicol Sci
    Ho, 2004, Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates., J. Cell. Biochem.
    Oesterreich S et al., 2015, Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover., Breast Cancer Res Treat
    2008, Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products., Int. J. Toxicol.
    Geistlinger et al., 2004, Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms., Chem. Biol.
    Kuiper GG et al., 1998, Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta., Endocrinology
    Chen et al., 2005, Direct agonist/antagonist functions of dehydroepiandrosterone., Endocrinology
    Gutendorf B et al., 2001, Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens., Toxicology
    Dang Z, 2010, Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications., Toxicol Lett
    Reed et al., 2005, Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus., Anticancer Drugs
    van der Woude H et al., 2005, The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor., Mol Nutr Food Res
    Leung LK et al., 2004, Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction., Br J Nutr
    Maggiolini M et al., 2001, Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells., Mol Pharmacol
    Howes MJ et al., 2002, Assessment of estrogenic activity in some common essential oil constituents., J Pharm Pharmacol
    Jayaraman A et al., 2009, Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones., J Neuroendocrinol
    Aguirre C et al., 2010, Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-β., J Neurochem
    Montero Girard et al., 2007, Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment., Breast Cancer Res.
    Tessier C et al., 2000, Estrogen receptors alpha and beta in rat decidua cells: cell-specific expression and differential regulation by steroid hormones and prolactin., Endocrinology
    Matsumoto H et al., 2005, [Estrogenic activity of ultraviolet absorbers and the related compounds]., Yakugaku Zasshi
    Naoum F et al., 2007, Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands., Molecules
    Norata et al., 2010, The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta., Atherosclerosis
    Takeuchi S et al., 2005, Differential effects of phthalate esters on transcriptional activities via human estrogen receptors alpha and beta, and androgen receptor., Toxicology
  • MF101   ESR2

    Interaction Score: 2.27

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MF101 ,Menerba
    Novel drug target Established target
    Mechanism of Interaction Estrogen receptor beta agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank ChemblInteractions

  • CHEMBL346455   ESR2

    Interaction Score: 1.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • AUS-131   ESR2

    Interaction Score: 1.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor beta agonist
    Trial Name AUS-131

    PMIDs:
    15883431 15084758


    Sources:
    TdgClinicalTrial TTD DrugBank ChemblInteractions

  • CHEMBL1222035   ESR2

    Interaction Score: 1.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20659801 10592235 17139284 17016423


    Sources:
    DTC DrugBank

  • CHEMBL211614   ESR2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL360410   ESR2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL367588   ESR2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL236720   ESR2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • ANDROSTANEDIOL   ESR2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    20557886


    Sources:
    DrugBank

  • ERTEBEREL   ESR2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor beta agonist
    Direct Interaction yes

    PMIDs:
    10592235


    Sources:
    TTD DrugBank ChemblInteractions

  • CHEMBL2332580   ESR2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23586645


    Sources:
    DTC

  • PRINABEREL   ESR2

    Interaction Score: 0.95

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor beta agonist
    Specific Action of the Ligand Agonist

    PMIDs:
    10592235


    Sources:
    TTD DrugBank GuideToPharmacology ChemblInteractions

  • CHEMBL185918   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL395308   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL187105   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL236718   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL364092   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1232445   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL192154   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL190467   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL236086   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL363498   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • MK-6913   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes
    Trial Name MK-6913

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ARZOXIFENE   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD DrugBank

  • SR16234   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name TAS-108
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial DrugBank

  • ESTROGEN   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase
    Novel drug target Established target
    Trial Name oral contraceptive,Pill-Plus

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • LASOFOXIFENE   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    19519291


    Sources:
    DrugBank GuideToPharmacology

  • FISPEMIFENE   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Trial Name fispemifene, HM-101
    Novel drug target Established target
    Mechanism of Interaction Estrogen receptor modulator

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • BAZEDOXIFENE   ESR2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name bazedoxifene, bazedoxifene/conjugated estrogens, TSE-424,Viviant, Aprela, Conbriza
    Specific Action of the Ligand Antagonist

    PMIDs:
    15961563


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • ESTROPIPATE   ESR2

    Interaction Score: 0.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    2011412 17464340


    Sources:
    DrugBank

  • ESTRIOL   ESR2

    Interaction Score: 0.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Agonist

    PMIDs:
    16199482


    Sources:
    DrugBank GuideToPharmacology

  • TRILOSTANE   ESR2

    Interaction Score: 0.41

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:

    PMIDs:
    16806905 17109615 12209583


    Sources:
    TTD DrugBank

  • CHEMBL184151   ESR2

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL3559901   ESR2

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16199482


    Sources:
    DrugBank

  • OCTOCRYLENE   ESR2

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16079615


    Sources:
    DrugBank

  • BENZOPHENONE   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16079615


    Sources:
    DrugBank

  • ENZACAMENE   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16079615


    Sources:
    DrugBank

  • RALOXIFEN   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Evista
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ACOLBIFENE   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHF4227   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTROGENS, CONJUGATED SYNTHETIC A   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIETHYLSTILBESTROL DIPHOSPHATE   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SYNTHETIC CONJUGATED ESTROGENS, B   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LY2245461   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTROGENS, CONJUGATED   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SIVIFENE   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name A-007

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LIQUIRTIGENIN   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Measuring activation of the ERE tk-Luc reporter by ER&bets; in transfected U2OS cells.
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ESTRAMUSTINE PHOSPHATE SODIUM   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor beta

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTROGENS, ESTERIFIED   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIARYLPROPIONITRILE   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Direct Interaction? True
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CR 1447   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor beta agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OSPEMIFENE   ESR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Trial Name ospemifene,Ophena
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FULVESTRANT   ESR2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Estrogen receptor antagonist
    Direct Interaction yes

    PMIDs:
    19845386


    Sources:
    DTC PharmGKB TALC GuideToPharmacology ChemblInteractions

  • RALOXIFENE   ESR2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Specific Action of the Ligand Antagonist

    PMIDs:
    20659801 10418979 11810032 12097269 11752352 11500849 11861516


    Sources:
    TEND DTC PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • ESTRONE   ESR2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? True

    PMIDs:
    11518614 19913605


    Sources:
    DrugBank GuideToPharmacology

  • EUGENOL   ESR2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12495555


    Sources:
    DrugBank

  • BAZEDOXIFENE ACETATE   ESR2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTRADIOL   ESR2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Bio-E-Gel, estradiol,Elestrin
    Novel drug target Established target
    Trial Name drospirenone plus estradiol,Angeliq

    PMIDs:
    20659801 23882126 2011412 17464340 16520733 24971815 19561619


    Sources:
    TEND DTC TdgClinicalTrial DrugBank

  • PYRAZOLE   ESR2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17909483


    Sources:
    DrugBank

  • OXYBENZONE   ESR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16079615


    Sources:
    DrugBank

  • AFIMOXIFENE   ESR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NARINGENIN   ESR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    9751507


    Sources:
    TTD DrugBank

  • TOREMIFENE   ESR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name atamestane-plus-toremifene

    PMIDs:
    None found


    Sources:
    PharmGKB TdgClinicalTrial

  • IDOXIFENE   ESR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TAMOXIFEN   ESR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Specific Action of the Ligand Agonist

    PMIDs:
    17158759 20827267 20659801 16010412 2011412 16326830 17404078 11752352 16822624 17713466


    Sources:
    TEND DTC PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • ESTRADIOL BENZOATE   ESR2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    2011412 17464340


    Sources:
    DrugBank

  • PHTHALIC ACID   ESR2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15840436


    Sources:
    DrugBank

  • QUINESTROL   ESR2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHLOROTRIANISENE   ESR2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor beta modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AFIMOXIFENE   ESR2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    15846122


    Sources:
    DrugBank ChemblInteractions

  • DROLOXIFENE   ESR2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOREMIFENE CITRATE   ESR2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GOSERELIN   ESR2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LETROZOLE   ESR2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26536870


    Sources:
    PharmGKB

  • ESTRAMUSTINE   ESR2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    14755680


    Sources:
    DrugBank

  • PERTUZUMAB   ESR2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIETHYLSTILBESTROL   ESR2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    19101832 15123288


    Sources:
    DrugBank GuideToPharmacology

  • ERIBULIN   ESR2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • GENISTEIN   ESR2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    10592235 17139284 17016423


    Sources:
    TTD DrugBank GuideToPharmacology

  • NERATINIB   ESR2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHEMBL600336   ESR2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PRASTERONE   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    15994348


    Sources:
    DrugBank

  • ETHINYL ESTRADIOL   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ANASTROZOLE   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • EXEMESTANE   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ABEMACICLIB   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROGESTERONE   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    negative modulator (inhibitory)
    agonist (activating)

    Interaction Info:

    PMIDs:
    19094096 20977477 17341305 11014241


    Sources:
    DrugBank

  • RIBOCICLIB   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • QUERCETIN   ESR2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15937998 15182386 11502892 9751507


    Sources:
    DrugBank

  • IXABEPILONE   ESR2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RALOXIFENE HYDROCHLORIDE   ESR2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor beta modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BITHIONOL   ESR2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRASTUZUMAB   ESR2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LAPATINIB   ESR2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • OLAPARIB   ESR2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALPELISIB   ESR2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • GEMCITABINE   ESR2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22838950


    Sources:
    PharmGKB

  • EVEROLIMUS   ESR2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PALBOCICLIB   ESR2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOCETAXEL   ESR2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000140009

    • Version: 101_38

    Alternate Names:
    ESR2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: ESR2

    • Version: February-2014

    Alternate Names:
    2100 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR3A2
    Counted Citations from 1950-2000 3987

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • RussLampel: ENSG00000140009

    • Version: 26-July-2011

    Alternate Names:
    ESR2 Display Id
    ESTROGEN RECEPTOR BETA (ER-BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92731] Description
    ENSG00000140009 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q92731

    • Version: 11-September-2012

    Alternate Names:
    ESR2 Uniprot Gene Name
    ENSG00000140009 Ensembl Gene Id
    2100 Entrez Gene Id

    Gene Info:
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name NUCLEAR HORMONE RECEPTOR

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: Q92731

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000140009 Ensembl Gene Id
    Q92731 Uniprot Accession
    2100 Entrez Gene Id

    Gene Info:
    Target Subclass Nuclear receptor
    Target Main Class Receptors

    Publications:

  • TdgClinicalTrial: Q92731

    • Version: January-2014

    Alternate Names:
    ESR2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • GuideToPharmacology: 2100

    • Version: 29-September-2020

    Alternate Names:
    3468 HUGO Gene ID
    3468 HUGO Gene Symbol
    estrogen receptor 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 3A. Estrogen receptors
    GuideToPharmacology Gene Category ID 96

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • PharmGKB: ESR2

    • Version: 18-August-2020

    Alternate Names:
    PA27886 PharmGKB ID

    Gene Info:

    Publications:
    Ntukidem NI et al., 2008, Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen., Clin Pharmacol Ther
    Woo HI et al., 2012, Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine., Pharmacogenomics
    Oesterreich S et al., 2015, Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover., Breast Cancer Res Treat

  • DrugBank: BE0000792

    • Version: 5.1.7

    Alternate Names:
    ESR2 DrugBank Gene Name
    Q92731 UniProt Accession
    2100 Entrez Gene Id

    Gene Info:

    Publications:
    Cada DJ et al., 2014, Conjugated estrogens and bazedoxifene., Hosp Pharm
    Ropero et al., 2006, Heart estrogen receptor alpha: distinct membrane and nuclear distribution patterns and regulation by estrogen., J. Mol. Cell. Cardiol.
    Stroud et al., 2006, Concentrations of isoflavones in macaques consuming standard laboratory monkey diet., J. Am. Assoc. Lab. Anim. Sci.

  • TTD: Estrogen receptor beta

    • Version: 2020.06.01

    Alternate Names:
    ESR2 TTD Gene Abbreviation
    T80896 TTD Target ID

    Gene Info:

    Publications:
    Chollet JA, 2011, Update on alternative therapies for vulvovaginal atrophy., Patient Prefer Adherence

  • DTC: ESR2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Calogeropoulou T et al., 2009, Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity., J Med Chem
    Jain D et al., 2010, A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements., Bioorg Med Chem Lett
    Bologa et al., 2006, Virtual and biomolecular screening converge on a selective agonist for GPR30., Nat. Chem. Biol.

  • HingoraniCasas: ENSG00000140009

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000140009 Gene Symbol
    ESR2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: ESR2

    • Version: 12-May-2016

    Alternate Names:
    ESR2 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: ESTRB

    • Version: chembl_23

    Alternate Names:
    NR3A2 GENE_SYMBOL
    ESR2 GENE_SYMBOL
    Estrogen receptor beta UNIPROT

    Gene Info:

    Publications:

  • Pharos: ESR2

    • Version: 03-September-2020

    Alternate Names:
    Estrogen receptor beta Gene Name
    Q92731 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

    Publications:

  • GO: ESR2

    • Version: 05-September-2020

    Alternate Names:
    ESTRB GO Gene Synonym
    NR3A2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: ESR2

    • Version: 27-Jun-2013

    Alternate Names:
    2100 Gene ID
    ER-BETA dGene Synonym
    ESR-BETA dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21