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ESR2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ESR2 2100 Druggable Genome

    Alternate Names:

    ESR2
    2100
    ESTROGEN RECEPTOR 2
    ER-BETA
    ESR-BETA
    ESRB
    ESTRB
    Erb
    NR3A2
    601663
    3468
    ENSG00000140009
    OTTHUMG00000141306
    Q92731
    ESTROGEN RECEPTOR BETA (ER-BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92731]
    ESTROGEN RECEPTOR BETA
    ESR2_HUMAN
    PA27886
    Nuclear receptor subfamily 3 group A member 2
    T80896
    ODG8

    Gene Info:

    Target Class Receptors
    Target Subclass Nuclear receptor
    Human Readable Name DRUGGABLE GENOME
    Initial Gene Query NR3A2
    Counted Citations from 1950-2000 3987
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000536
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Uniprot Evidence 1: Evidence at protein level
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Mc Ilroy et al., 2006, Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence., Endocr. Relat. Cancer
    Girault et al., 2006, Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer., Maturitas
    Hayes et al., 2010, Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results., Clin. Pharmacol. Ther.
    Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
    Chen et al., 2005, Potential of endogenous estrogen receptor beta to influence the selective ER modulator ERbeta complex., Int. J. Oncol.
    Gruvberger-Saal et al., 2007, Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma., Clin. Cancer Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Horner-Glister et al., 2005, Influence of oestradiol and tamoxifen on oestrogen receptors-alpha and -beta protein degradation and non-genomic signalling pathways in uterine and breast carcinoma cells., J. Mol. Endocrinol.
    Ntukidem NI et al., 2008, Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen., Clin Pharmacol Ther
    Jain D et al., 2010, A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements., Bioorg Med Chem Lett
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Min J et al., 2013, Thiophene-core estrogen receptor ligands having superagonist activity., J Med Chem
    Komm BS et al., 2005, Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity., Endocrinology
    Zhou et al., 2002, Selective estrogen receptor modulator effects in the rat brain., Neuroendocrinology
    Bryant et al., An estrogen receptor basis for raloxifene action in bone., J. Steroid Biochem. Mol. Biol.
    Sun et al., 2002, Antagonists selective for estrogen receptor alpha., Endocrinology
    Kim et al., 2002, Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line LNCaP through an androgen-independent pathway., Cancer Res.
    Iannone et al., 2001, Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres., Cytometry
    Bologa et al., 2006, Virtual and biomolecular screening converge on a selective agonist for GPR30., Nat. Chem. Biol.
    Renner S et al., 2009, Bioactivity-guided mapping and navigation of chemical space., Nat Chem Biol
    Vijayanathan et al., 2007, Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta., Biochem. Cell Biol.
    Jiang Y et al., 2013, Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens., FASEB J
    Paterni I et al., 2014, Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential., Steroids
    Calogeropoulou T et al., 2009, Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity., J Med Chem
    Puddefoot et al., 2006, Trilostane in advanced breast cancer., Expert Opin Pharmacother
    Barker et al., 2006, Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta., J. Steroid Biochem. Mol. Biol.
    Puddefoot et al., 2002, Non-competitive steroid inhibition of oestrogen receptor functions., Int. J. Cancer
    Woo HI et al., 2012, Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine., Pharmacogenomics
    Setchell KD et al., 2005, S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora., Am J Clin Nutr
    Mueller SO et al., 2004, Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells., Toxicol Sci
    Oesterreich S et al., 2015, Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover., Breast Cancer Res Treat
    Kuiper GG et al., 1998, Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta., Endocrinology
    Reed et al., 2005, Dose-dependent effects of 4-hydroxytamoxifen, the active metabolite of tamoxifen, on estrogen receptor-alpha expression in the rat uterus., Anticancer Drugs
  • AUS-131   ESR2

    Interaction Score: 5.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor beta agonist
    Trial Name AUS-131

    PMIDs:
    15883431 15084758


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • ERTEBEREL   ESR2

    Interaction Score: 3.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor beta agonist
    Direct Interaction yes

    PMIDs:
    10592235


    Sources:
    ChemblInteractions TTD

  • PRINABEREL   ESR2

    Interaction Score: 3.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor beta agonist

    PMIDs:
    10592235


    Sources:
    ChemblInteractions TTD

  • MF101   ESR2

    Interaction Score: 3.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MF101 ,Menerba
    Novel drug target Established target
    Mechanism of Interaction Estrogen receptor beta agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • CHEMBL1222035   ESR2

    Interaction Score: 2.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20659801 17139284 17016423 10592235


    Sources:
    DTC

  • CHEMBL2332580   ESR2

    Interaction Score: 2.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23586645


    Sources:
    DTC

  • MK-6913   ESR2

    Interaction Score: 1.01

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes
    Trial Name MK-6913

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ESTROGEN   ESR2

    Interaction Score: 1.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase
    Novel drug target Established target
    Trial Name oral contraceptive,Pill-Plus

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • FISPEMIFENE   ESR2

    Interaction Score: 1.01

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Trial Name fispemifene, HM-101
    Novel drug target Established target
    Mechanism of Interaction Estrogen receptor modulator

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • TRILOSTANE   ESR2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:

    PMIDs:
    17109615 16806905 12209583


    Sources:
    TTD

  • RALOXIFEN   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Evista
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ACOLBIFENE   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHF4227   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTROGENS, CONJUGATED SYNTHETIC A   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIETHYLSTILBESTROL DIPHOSPHATE   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SYNTHETIC CONJUGATED ESTROGENS, B   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ARZOXIFENE   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LY2245461   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTROGENS, CONJUGATED   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SR16234   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name TAS-108
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • SIVIFENE   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name A-007

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ESTRAMUSTINE PHOSPHATE SODIUM   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor beta

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTROGENS, ESTERIFIED   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BAZEDOXIFENE   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name bazedoxifene, bazedoxifene/conjugated estrogens, TSE-424,Viviant, Aprela, Conbriza

    PMIDs:
    15961563


    Sources:
    TdgClinicalTrial

  • CR 1447   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Estrogen receptor beta agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OSPEMIFENE   ESR2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Trial Name ospemifene,Ophena
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FULVESTRANT   ESR2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Estrogen receptor antagonist
    Direct Interaction yes

    PMIDs:
    19845386


    Sources:
    TALC DTC ChemblInteractions PharmGKB

  • RALOXIFENE   ESR2

    Interaction Score: 0.38

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    20659801 11810032 10418979 11861516 11752352 12097269 11500849


    Sources:
    DTC TdgClinicalTrial TEND PharmGKB

  • BAZEDOXIFENE ACETATE   ESR2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESTRADIOL   ESR2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Bio-E-Gel, estradiol,Elestrin
    Novel drug target Established target
    Trial Name drospirenone plus estradiol,Angeliq

    PMIDs:
    16520733 19561619 20659801 17464340 2011412 23882126 24971815


    Sources:
    DTC TdgClinicalTrial TEND

  • NARINGENIN   ESR2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    9751507


    Sources:
    TTD

  • TOREMIFENE   ESR2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name atamestane-plus-toremifene

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial PharmGKB

  • IDOXIFENE   ESR2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TAMOXIFEN   ESR2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17158759 16822624 20827267 2011412 16010412 17404078 11752352 16326830 17713466 20659801


    Sources:
    DTC TdgClinicalTrial TEND PharmGKB

  • QUINESTROL   ESR2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHLOROTRIANISENE   ESR2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor beta modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DROLOXIFENE   ESR2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERIBULIN   ESR2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • GOSERELIN   ESR2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AFIMOXIFENE   ESR2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    15846122


    Sources:
    ChemblInteractions

  • LETROZOLE   ESR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26536870


    Sources:
    PharmGKB

  • TOREMIFENE CITRATE   ESR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PERTUZUMAB   ESR2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NERATINIB   ESR2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHEMBL600336   ESR2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   ESR2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    10592235 17016423 17139284


    Sources:
    TTD

  • ANASTROZOLE   ESR2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • EXEMESTANE   ESR2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ABEMACICLIB   ESR2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RIBOCICLIB   ESR2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TRASTUZUMAB   ESR2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • IXABEPILONE   ESR2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RALOXIFENE HYDROCHLORIDE   ESR2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Estrogen receptor beta modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BITHIONOL   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OLAPARIB   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LAPATINIB   ESR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALPELISIB   ESR2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • EVEROLIMUS   ESR2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • GEMCITABINE   ESR2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22838950


    Sources:
    PharmGKB

  • PALBOCICLIB   ESR2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOCETAXEL   ESR2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000140009

    • Version: 101_38

    Alternate Names:
    ESR2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: ESR2

    • Version: February-2014

    Alternate Names:
    2100 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR3A2
    Counted Citations from 1950-2000 3987

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • RussLampel: ENSG00000140009

    • Version: 26-July-2011

    Alternate Names:
    ESR2 Display Id
    ESTROGEN RECEPTOR BETA (ER-BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92731] Description
    ENSG00000140009 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q92731

    • Version: 11-September-2012

    Alternate Names:
    ESR2 Uniprot Gene Name
    ENSG00000140009 Ensembl Gene Id
    2100 Entrez Gene Id

    Gene Info:
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name NUCLEAR HORMONE RECEPTOR

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: Q92731

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000140009 Ensembl Gene Id
    Q92731 Uniprot Accession
    2100 Entrez Gene Id

    Gene Info:
    Target Subclass Nuclear receptor
    Target Main Class Receptors

    Publications:

  • TdgClinicalTrial: Q92731

    • Version: January-2014

    Alternate Names:
    ESR2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • PharmGKB: ESR2

    • Version: 18-August-2020

    Alternate Names:
    PA27886 PharmGKB ID

    Gene Info:

    Publications:
    Ntukidem NI et al., 2008, Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen., Clin Pharmacol Ther
    Woo HI et al., 2012, Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine., Pharmacogenomics
    Oesterreich S et al., 2015, Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover., Breast Cancer Res Treat

  • TTD: Estrogen receptor beta

    • Version: 2020.06.01

    Alternate Names:
    ESR2 TTD Gene Abbreviation
    T80896 TTD Target ID

    Gene Info:

    Publications:
    Chollet JA, 2011, Update on alternative therapies for vulvovaginal atrophy., Patient Prefer Adherence

  • DTC: ESR2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Calogeropoulou T et al., 2009, Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity., J Med Chem
    Jain D et al., 2010, A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements., Bioorg Med Chem Lett
    Bologa et al., 2006, Virtual and biomolecular screening converge on a selective agonist for GPR30., Nat. Chem. Biol.

  • HingoraniCasas: ENSG00000140009

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000140009 Gene Symbol
    ESR2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: ESR2

    • Version: 12-May-2016

    Alternate Names:
    ESR2 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: ESTRB

    • Version: chembl_23

    Alternate Names:
    NR3A2 GENE_SYMBOL
    ESR2 GENE_SYMBOL
    Estrogen receptor beta UNIPROT

    Gene Info:

    Publications:

  • GO: ESR2

    • Version: 01-February-2022

    Alternate Names:
    ESTRB GO Gene Synonym
    NR3A2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: ESR2

    • Version: 27-Jun-2013

    Alternate Names:
    2100 Gene ID
    ER-BETA dGene Synonym
    ESR-BETA dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • Pharos: ESR2

    • Version: 01-February-2022

    Alternate Names:
    Estrogen receptor beta Gene Name
    Q92731 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21