2099 |
ESTROGEN RECEPTOR 1 |
ESR1 |
ER |
ESR |
ESRA |
ESTRR |
Era |
NR3A1 |
133430 |
3467 |
ENSG00000091831 |
OTTHUMG00000016103 |
ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) (ER-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P03372] |
P03372 |
ESR1_HUMAN |
21 |
Nuclear receptor subfamily 3 group A member 1 |
Estradiol receptor |
ER-alpha |
Estrogen receptor |
PA156 |
T89534 |
Human Readable Name | NUCLEAR HORMONE RECEPTOR |
Human Readable Name | DRUGGABLE GENOME |
Target Main Class | Receptors |
Target Subclass | Nuclear receptor |
Initial Gene Query | NR3A1 |
Counted Citations from 1950-2000 | 29833 |
Target Class | Receptors |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Nucl_hrmn_rcpt_lig-bd_core |
Interpro Type | Domain |
Interpro Name | Nuclear hormone receptor, ligand-binding, core |
Interpro Acc | IPR000536 |
Uniprot Status | Swiss-Prot |
Gene Biotype | PROTEIN_CODING |
TRANSCRIPTION FACTOR COMPLEX |
KINASE |
DRUG RESISTANCE |
NUCLEAR HORMONE RECEPTOR |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
TRANSCRIPTION FACTOR |
n/a |
other/unknown |
Trial Name | ethinyl estradiol + levonorgestrel,Seasonale, Lo Seasonale, Seasonique |
Novel drug target | Established target |
Trial Name | AG-200-15 |
negative modulator (inhibitory) |
agonist (activating) |
antagonist (inhibitory) |
Trial Name | lasofoxifene,Fablyn, Oporia |
Novel drug target | Established target |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
modulator |
Trial Name | Acapodene |
Novel drug target | Established target |
Trial Name | atamestane-plus-toremifene |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | fulvestrant,Faslodex |
Mechanism of Interaction | Estrogen receptor antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor alpha antagonist |
n/a |
Trial Name | RAD1901 |
Novel drug target | Established target |
Mechanism of Interaction | Estrogen receptor alpha degrader |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor alpha agonist |
Direct Interaction | yes |
Novel drug target | Established target |
agonist (activating) |
modulator |
Novel drug target | Established target |
Trial Name | - |
Direct Interaction | yes |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
antagonist (inhibitory) |
modulator |
Mechanism of Interaction | Estrogen receptor modulator |
Direct Interaction | yes |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor alpha agonist |
Direct Interaction | yes |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | molecular iodine,IoGen |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor agonist |
Direct Interaction | yes |
modulator |
Mechanism of Interaction | Estrogen receptor alpha modulator |
Direct Interaction | yes |
modulator |
Trial Name | fispemifene, HM-101 |
Novel drug target | Established target |
Mechanism of Interaction | Estrogen receptor modulator |
n/a |
Novel drug target | Established target |
Trial Name | Arzoxifene, LY353381 |
agonist (activating) |
Trial Name | etonogestrel implant,Implanon |
Novel drug target | Established target |
Trial Name | etonogestrel/ethinyl estradiol vaginal ring,Nuvaring |
modulator |
Mechanism of Interaction | Estrogen receptor modulator |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Estrogen receptor alpha antagonist |
Direct Interaction | yes |
Trial Name | TAS-108 |
n/a |
Trial Name | conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase |
Novel drug target | Established target |
Trial Name | oral contraceptive,Pill-Plus |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor agonist |
Direct Interaction | yes |
Trial Name | MK-6913 |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor alpha agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor alpha agonist |
Direct Interaction | yes |
Trial Name | - |
modulator |
Mechanism of Interaction | Estrogen receptor modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor alpha agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor alpha agonist |
Trial Name | - |
agonist (activating) |
antagonist (inhibitory) |
Trial Name | bazedoxifene, bazedoxifene/conjugated estrogens, TSE-424,Viviant, Aprela, Conbriza |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor alpha agonist |
Trial Name | transdermal estradiol,Divigel |
agonist (activating) |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
antagonist (inhibitory) |
modulator |
Mechanism of Interaction | Estrogen receptor modulator |
Direct Interaction | yes |
n/a |
Trial Name | estradiol valerate + dienogest,Natazia, Qlaira |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor agonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor agonist |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor agonist |
Direct Interaction | yes |
n/a |
Trial Name | Evista |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Estrogen receptor alpha agonist |
Direct Interaction | yes |
n/a |
Trial Name | A-007 |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor agonist |
n/a |
agonist (activating) |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor alpha agonist |
modulator |
Mechanism of Interaction | Estrogen receptor modulator |
Direct Interaction | yes |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | norelgestromin/ethinyl estradiol,Ortho Evra |
Novel drug target | Established target |
modulator |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor modulator |
n/a |
modulator |
Mechanism of Interaction | Estrogen receptor modulator |
Direct Interaction | yes |
negative modulator (inhibitory) |
agonist (activating) |
inhibitor (inhibitory) |
Trial Name | conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase |
Novel drug target | Established target |
Trial Name | BHR-100 |
modulator |
Direct Interaction | yes |
Mechanism of Interaction | Estrogen receptor modulator |
modulator |
Mechanism of Interaction | Estrogen receptor alpha modulator |
Direct Interaction | yes |
agonist (activating) |
ESR1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000091831 | Ensembl Gene Id |
ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR) (ER-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P03372] | Description |
ESR1 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
2099 | Entrez Gene ID |
Initial Gene Query | NR3A1 |
Counted Citations from 1950-2000 | 29833 |
NUCLEAR HORMONE RECEPTOR |
P03372 | Uniprot Accession |
ENSG00000091831 | Ensembl Gene Id |
ESR1 | Uniprot Gene Name |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Nucl_hrmn_rcpt_lig-bd_core |
NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME |
2099 | Entrez Gene Id |
ENSG00000091831 | Ensembl Gene Id |
ESR1_HUMAN | Uniprot Id |
Target Subclass | Nuclear receptor |
Target Main Class | Receptors |
ESR1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | Nuclear receptor |
PA156 | PharmGKB ID |
2099 | Entrez Gene ID |
21 | CIViC Gene ID |
DRUG RESISTANCE |
ESR | TTD Gene Abbreviation |
T89534 | TTD Target ID |
ESR1 | Gene Symbol |
ENSG00000091831 | Gene Symbol |
ESR1 | Ensembl Id |
DRUGGABLE GENOME |
NR3A1 | GENE_SYMBOL |
ESR1 | GENE_SYMBOL |
Estrogen receptor | UNIPROT |
2099 | OncoKB Entrez Id |
ESR | OncoKB Gene Synonym |
ESTRR | OncoKB Gene Synonym |
ESR | GO Gene Synonym |
NR3A1 | GO Gene Synonym |
TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR |
ESR1 | Gene Symbol |
CLINICALLY ACTIONABLE |
2099 | Gene ID |
ER | dGene Synonym |
ESR | dGene Synonym |
NUCLEAR HORMONE RECEPTOR |
Estrogen receptor | Gene Name |
P03372 | UniProt ID |
KINASE, TRANSCRIPTION FACTOR |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
DRUG RESISTANCE |