DGIdb - EPRS Gene Record

EPRS 2058 Druggable Genome

Alternate Names:

2058
GLUTAMYL-PROLYL-TRNA SYNTHETASE
EPRS
EARS
GLUPRORS
PARS
PIG32
QARS
QPRS
138295
3418
ENSG00000136628
OTTHUMG00000037433
P07814
SYEP_HUMAN
GLUTAMATE--TRNA LIGASE
BE0000188
Bifunctional aminoacyl-tRNA synthetase
T67416
Bifunctional glutamate/proline--tRNA ligase
EPRS1

Gene Info:

Interpro Name	Aminoacyl-tRNA synthetase, class I, conserved site
Interpro Acc	IPR001412
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Type	Conserved_site
Interpro Short Name	aa-tRNA-synth_I_CS
Target Class	Enzymes
Target Subclass	EC:6.1.1
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Cerini et al., 1997, Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex., Eur. J. Biochem.
Ting et al., 1994, Post-transcriptional regulation of glutamyl-prolyl-tRNA synthetase in rat salivary gland., J. Biol. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

CHEMBL1163074 EPRS

Interaction Score: 37.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 10592235

Sources:
DrugBank
ALASA EPRS

Interaction Score: 37.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 10592235

Sources:
DrugBank
CHEMBL1163086 EPRS

Interaction Score: 37.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 10592235

Sources:
DrugBank
HALOFUGINONE EPRS

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name halofuginone ,Tempostatin

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
PROLINE EPRS

Interaction Score: 1.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17016423 17139284

Sources:
DrugBank
GLUTAMIC ACID EPRS

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9063462 8132637 17016423 17139284

Sources:
DrugBank

Ensembl: ENSG00000136628
- Version: 101_38
Alternate Names:

EPRS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P07814
- Version: 11-September-2012
Alternate Names:

GLUTAMATE--TRNA LIGASE Uniprot Protein Name

2058 Entrez Gene Id

EPRS Uniprot Gene Name

Gene Info:

Interpro Name Aminoacyl-tRNA synthetase, class I, conserved site

Interpro Acc IPR001412

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P07814
- Version: January-2014
Alternate Names:

EPRS Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:6.1.1

Publications:

DrugBank: BE0000188

Version: 5.1.7

Alternate Names:

EPRS DrugBank Gene Name

P07814 UniProt Accession

2058 Entrez Gene Id

Gene Info:

Publications:

Cerini et al., 1997, Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex., Eur. J. Biochem.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Pharos: EPRS
- Version: 03-September-2020
Alternate Names:

Bifunctional glutamate/proline--tRNA ligase Gene Name

P07814 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Bifunctional aminoacyl-tRNA synthetase
- Version: 2020.06.01
Alternate Names:

EPRS TTD Gene Abbreviation

T67416 TTD Target ID

Gene Info:

Publications:

Novel drug target	Novel Target
Trial Name	halofuginone ,Tempostatin

GLUTAMATE--TRNA LIGASE	Uniprot Protein Name
2058	Entrez Gene Id
EPRS	Uniprot Gene Name

EPRS	DrugBank Gene Name
P07814	UniProt Accession
2058	Entrez Gene Id

Bifunctional glutamate/proline--tRNA ligase	Gene Name
P07814	UniProt ID

EPRS Gene Record

EPRS 2058 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL1163074 EPRS

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 10592235

Sources: DrugBank

ALASA EPRS

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 10592235

Sources: DrugBank

CHEMBL1163086 EPRS

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 10592235

Sources: DrugBank

HALOFUGINONE EPRS

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name halofuginone ,Tempostatin

PMIDs: None found

Sources: TdgClinicalTrial TTD

PROLINE EPRS

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17016423 17139284

Sources: DrugBank

GLUTAMIC ACID EPRS

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9063462 8132637 17016423 17139284

Sources: DrugBank

Ensembl: ENSG00000136628

Alternate Names: EPRS1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P07814

Alternate Names: GLUTAMATE--TRNA LIGASE Uniprot Protein Name 2058 Entrez Gene Id EPRS Uniprot Gene Name

Gene Info: Interpro Name Aminoacyl-tRNA synthetase, class I, conserved site Interpro Acc IPR001412 Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P07814

Alternate Names: EPRS Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:6.1.1

Publications:

DrugBank: BE0000188

Alternate Names: EPRS DrugBank Gene Name P07814 UniProt Accession 2058 Entrez Gene Id

Gene Info:

Pharos: EPRS

Alternate Names: Bifunctional glutamate/proline--tRNA ligase Gene Name P07814 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

TTD: Bifunctional aminoacyl-tRNA synthetase

Alternate Names: EPRS TTD Gene Abbreviation T67416 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name halofuginone ,Tempostatin

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
17016423 17139284

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9063462 8132637 17016423 17139284

Sources:
DrugBank

Alternate Names:

EPRS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

GLUTAMATE--TRNA LIGASE Uniprot Protein Name

2058 Entrez Gene Id

EPRS Uniprot Gene Name

Gene Info:

Interpro Name Aminoacyl-tRNA synthetase, class I, conserved site

Interpro Acc IPR001412

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

EPRS Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:6.1.1

Alternate Names:

EPRS DrugBank Gene Name

P07814 UniProt Accession

2058 Entrez Gene Id

Alternate Names:

Bifunctional glutamate/proline--tRNA ligase Gene Name

P07814 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

EPRS TTD Gene Abbreviation

T67416 TTD Target ID