• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

EPOR Gene Record

  • Summary
  • Interactions
  • Claims
  • EPOR 2057 Druggable GenomeClinically Actionable

    Alternate Names:

    2057
    ERYTHROPOIETIN RECEPTOR
    EPOR
    EPO-R
    133171
    3416
    ENSG00000187266
    OTTHUMG00000182027
    P19235
    1718
    Eythropoietin receptor
    EPOR_HUMAN
    BE0000654
    T65197
    1728

    Gene Info:

    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor
    Target Subclass IG
    Transmembrane Helix Count 1
    Target Main Class Receptors
    Target Subclass CytokineR
    Target Subclass Type1
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Prolactin receptor family
    GuideToPharmacology Gene Category ID 309
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Kokhaei et al., 2007, Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies., Clin. Cancer Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    LaMontagne et al., 2006, Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor-positive breast carcinoma models., Mol. Cancer Ther.
    Woodburn et al., 2013, Peginesatide clearance, distribution, metabolism, and excretion in monkeys following intravenous administration., Drug Metab. Dispos.
    Lee et al., 2007, Capsaicin promotes the development of burst-forming units--erythroid (BFU-E) from mouse bone marrow cells., Exp. Mol. Med.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
  • PEGINESATIDE   EPOR

    Interaction Score: 42.6

    Interaction Types & Directionality:
    agonist (activating)
    stimulator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name Hematide
    Mechanism of Interaction Erythropoietin receptor agonist

    PMIDs:
    23318685


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • CIBINETIDE   EPOR

    Interaction Score: 14.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Agonist

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • PEGINESATIDE ACETATE   EPOR

    Interaction Score: 7.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Erythropoietin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DARBEPOETIN ALFA   EPOR

    Interaction Score: 7.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Erythropoietin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIBROMOTYROSINE   EPOR

    Interaction Score: 3.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • EPOETIN BETA   EPOR

    Interaction Score: 3.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Assay performed using recombinant human EPO
    Specific Action of the Ligand Agonist
    Endogenous Drug? True

    PMIDs:
    17575216 11752352 16505108


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • CAPSAICIN   EPOR

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17603282


    Sources:
    NCI

  • EPOETIN ALFA   EPOR

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Erythropoietin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000187266

    • Version: 101_38

    Alternate Names:
    EPOR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P19235

    • Version: 01-August-2011

    Alternate Names:
    EPOR_HUMAN Uniprot Id
    ENSG00000187266 Ensembl Gene Id
    P19235 Uniprot Accession

    Gene Info:
    Target Subclass IG
    Transmembrane Helix Count 1
    Target Main Class Receptors

    Publications:

  • TdgClinicalTrial: P19235

    • Version: January-2014

    Alternate Names:
    EPOR Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor

    Publications:

  • GuideToPharmacology: 2057

    • Version: 29-September-2020

    Alternate Names:
    3416 HUGO Gene ID
    3416 HUGO Gene Symbol
    erythropoietin receptor HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Prolactin receptor family
    GuideToPharmacology Gene Category ID 309

    Publications:

  • CIViC: EPOR

    • Version: 14-September-2020

    Alternate Names:
    2057 Entrez Gene ID
    1728 CIViC Gene ID

    Gene Info:

    Publications:
    Iacobucci I et al., 2016, Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia., Cancer Cell

  • DrugBank: BE0000654

    • Version: 5.1.7

    Alternate Names:
    EPOR DrugBank Gene Name
    P19235 UniProt Accession
    2057 Entrez Gene Id

    Gene Info:

    Publications:
    Kokhaei et al., 2007, Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies., Clin. Cancer Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    LaMontagne et al., 2006, Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor-positive breast carcinoma models., Mol. Cancer Ther.

  • NCI: EPOR

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lee et al., 2007, Capsaicin promotes the development of burst-forming units--erythroid (BFU-E) from mouse bone marrow cells., Exp. Mol. Med.

  • ChemblInteractions: EPOR

    • Version: chembl_23

    Alternate Names:
    EPOR GENE_SYMBOL
    Erythropoietin receptor UNIPROT
    EPO-R UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000187266

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000187266 Gene Symbol
    EPOR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: EPOR

    • Version: 03-September-2020

    Alternate Names:
    Erythropoietin receptor Gene Name
    P19235 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • Tempus: EPOR

    • Version: 11-November-2018

    Alternate Names:
    EPOR Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Erythropoietin Receptor

    • Version: 2020.06.01

    Alternate Names:
    EPOR TTD Gene Abbreviation
    T65197 TTD Target ID

    Gene Info:

    Publications:

  • FoundationOneGenes: EPOR

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21