DGIdb - EPOR Gene Record

EPOR 2057 Druggable GenomeClinically Actionable

Alternate Names:

2057
ERYTHROPOIETIN RECEPTOR
EPOR
EPO-R
133171
3416
ENSG00000187266
OTTHUMG00000182027
P19235
EPOR_HUMAN
T65197
1728

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Target Subclass	IG
Transmembrane Helix Count	1
Target Main Class	Receptors
Target Subclass	CytokineR
Target Subclass	Type1
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

KINASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

LaMontagne et al., 2006, Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor-positive breast carcinoma models., Mol. Cancer Ther.
Kokhaei et al., 2007, Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies., Clin. Cancer Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Woodburn et al., 2013, Peginesatide clearance, distribution, metabolism, and excretion in monkeys following intravenous administration., Drug Metab. Dispos.
Lee et al., 2007, Capsaicin promotes the development of burst-forming units--erythroid (BFU-E) from mouse bone marrow cells., Exp. Mol. Med.

PEGINESATIDE EPOR

Interaction Score: 35.33

Interaction Types & Directionality:

agonist (activating)

stimulator (activating)

Interaction Info:

Novel drug target Established target

Trial Name Hematide

Mechanism of Interaction Erythropoietin receptor agonist

PMIDs:
23318685

Sources:
TdgClinicalTrial ChemblInteractions TTD
PEGINESATIDE ACETATE EPOR

Interaction Score: 8.83

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Erythropoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CIBINETIDE EPOR

Interaction Score: 8.83

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
TTD
DARBEPOETIN ALFA EPOR

Interaction Score: 8.83

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Erythropoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPOETIN BETA EPOR

Interaction Score: 2.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name epoetin alpha

Novel drug target Established target

Trial Name epoetin delta, gene-activated erythropoietin,Dynepo

PMIDs:
16505108 17575216 11752352

Sources:
TdgClinicalTrial
CAPSAICIN EPOR

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17603282

Sources:
NCI
EPOETIN ALFA EPOR

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Erythropoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000187266
- Version: 101_38
Alternate Names:

EPOR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P19235
- Version: 01-August-2011
Alternate Names:

EPOR_HUMAN Uniprot Id

ENSG00000187266 Ensembl Gene Id

P19235 Uniprot Accession

Gene Info:

Target Subclass IG

Transmembrane Helix Count 1

Target Main Class Receptors

Publications:
TdgClinicalTrial: P19235
- Version: January-2014
Alternate Names:

EPOR Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:
CIViC: EPOR
- Version: 14-September-2020
Alternate Names:

2057 Entrez Gene ID

1728 CIViC Gene ID

Gene Info:

Publications:

Iacobucci I et al., 2016, Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia., Cancer Cell
NCI: EPOR
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Lee et al., 2007, Capsaicin promotes the development of burst-forming units--erythroid (BFU-E) from mouse bone marrow cells., Exp. Mol. Med.
ChemblInteractions: EPOR
- Version: chembl_23
Alternate Names:

EPOR GENE_SYMBOL

Erythropoietin receptor UNIPROT

EPO-R UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000187266
- Version: 31-May-2017
Alternate Names:

ENSG00000187266 Gene Symbol

EPOR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: EPOR
- Version: 11-November-2018
Alternate Names:

EPOR Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Erythropoietin Receptor
- Version: 2020.06.01
Alternate Names:

EPOR TTD Gene Abbreviation

T65197 TTD Target ID

Gene Info:

Publications:
Pharos: EPOR
- Version: 01-February-2022
Alternate Names:

Erythropoietin receptor Gene Name

P19235 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
FoundationOneGenes: EPOR
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: EPOR
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Novel drug target	Established target
Trial Name	Hematide
Mechanism of Interaction	Erythropoietin receptor agonist

Mechanism of Interaction	Erythropoietin receptor agonist
Direct Interaction	yes

Trial Name	epoetin alpha
Novel drug target	Established target
Trial Name	epoetin delta, gene-activated erythropoietin,Dynepo

EPOR_HUMAN	Uniprot Id
ENSG00000187266	Ensembl Gene Id
P19235	Uniprot Accession

agonist (activating)
stimulator (activating)

EPOR Gene Record

EPOR 2057 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PEGINESATIDE EPOR

Interaction Types & Directionality: agonist (activating) stimulator (activating)

Interaction Info: Novel drug target Established target Trial Name Hematide Mechanism of Interaction Erythropoietin receptor agonist

PMIDs: 23318685

Sources: TdgClinicalTrial ChemblInteractions TTD

PEGINESATIDE ACETATE EPOR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Erythropoietin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

CIBINETIDE EPOR

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: None found

Sources: TTD

DARBEPOETIN ALFA EPOR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Erythropoietin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

EPOETIN BETA EPOR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name epoetin alpha Novel drug target Established target Trial Name epoetin delta, gene-activated erythropoietin,Dynepo

PMIDs: 16505108 17575216 11752352

Sources: TdgClinicalTrial

CAPSAICIN EPOR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17603282

Sources: NCI

EPOETIN ALFA EPOR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Erythropoietin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000187266

Alternate Names: EPOR Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P19235

Alternate Names: EPOR_HUMAN Uniprot Id ENSG00000187266 Ensembl Gene Id P19235 Uniprot Accession

Gene Info: Target Subclass IG Transmembrane Helix Count 1 Target Main Class Receptors

Publications:

TdgClinicalTrial: P19235

Alternate Names: EPOR Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

CIViC: EPOR

Alternate Names: 2057 Entrez Gene ID 1728 CIViC Gene ID

Gene Info:

Publications: Iacobucci I et al., 2016, Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia., Cancer Cell

NCI: EPOR

Alternate Names:

Gene Info:

Publications: Lee et al., 2007, Capsaicin promotes the development of burst-forming units--erythroid (BFU-E) from mouse bone marrow cells., Exp. Mol. Med.

ChemblInteractions: EPOR

Alternate Names: EPOR GENE_SYMBOL Erythropoietin receptor UNIPROT EPO-R UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000187266

Alternate Names: ENSG00000187266 Gene Symbol EPOR Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Tempus: EPOR

Alternate Names: EPOR Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

TTD: Erythropoietin Receptor

Alternate Names: EPOR TTD Gene Abbreviation T65197 TTD Target ID

Gene Info:

Publications:

Pharos: EPOR

Interaction Types & Directionality:

agonist (activating)

stimulator (activating)

Interaction Info:

Novel drug target Established target

Trial Name Hematide

Mechanism of Interaction Erythropoietin receptor agonist

PMIDs:
23318685

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Erythropoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Erythropoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name epoetin alpha

Novel drug target Established target

Trial Name epoetin delta, gene-activated erythropoietin,Dynepo

PMIDs:
16505108 17575216 11752352

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
17603282

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Erythropoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

EPOR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

EPOR_HUMAN Uniprot Id

ENSG00000187266 Ensembl Gene Id

P19235 Uniprot Accession

Gene Info:

Target Subclass IG

Transmembrane Helix Count 1

Target Main Class Receptors

Alternate Names:

EPOR Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

2057 Entrez Gene ID

1728 CIViC Gene ID

Publications:

Iacobucci I et al., 2016, Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia., Cancer Cell

Publications:

Lee et al., 2007, Capsaicin promotes the development of burst-forming units--erythroid (BFU-E) from mouse bone marrow cells., Exp. Mol. Med.

Alternate Names:

EPOR GENE_SYMBOL

Erythropoietin receptor UNIPROT

EPO-R UNIPROT

Alternate Names:

ENSG00000187266 Gene Symbol

EPOR Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

EPOR Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

EPOR TTD Gene Abbreviation

T65197 TTD Target ID

Alternate Names:

Erythropoietin receptor Gene Name

P19235 UniProt ID

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE