DGIdb - EPHX2 Gene Record

EPHX2 2053 Druggable Genome

Alternate Names:

2053
EPOXIDE HYDROLASE 2
EPHX2
CEH
SEH
132811
3402
ENSG00000120915
OTTHUMG00000102115
P34913
PA27830
Soluble epoxide hydrolase
T35734
2970
NM_001979
NP_001970
ABHD20
Bifunctional epoxide hydrolase 2

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.3.2.10
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Hydrolases
GuideToPharmacology Gene Category ID	799

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
International Consortium on Lithium Genetics (ConLi+Gen). et al., 2018, Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study., JAMA Psychiatry
Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
Morisseau C et al., 2013, Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides., Bioorg Med Chem Lett
Sun YN et al., 2015, Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe., Bioorg Med Chem

ALOIN EPHX2

Interaction Score: 15.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26372074

Sources:
DTC
AR9281 EPHX2

Interaction Score: 11.96

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name AR9281

PMIDs:
10592235

Sources:
TdgClinicalTrial TTD
6BIO EPHX2

Interaction Score: 5.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24697244

Sources:
DTC
ALOE-EMODIN EPHX2

Interaction Score: 3.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26372074

Sources:
DTC

OXAPROZIN EPHX2

Interaction Score: 2.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of sEH's phosphatase activity <i>in vitro</i> using bacterially-expressed recombinant N-terminal domain of sEH.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

FULVESTRANT EPHX2

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23684894

Sources:
DTC
ZAFIRLUKAST EPHX2

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
LITHIUM EPHX2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29121268

Sources:
PharmGKB

Ensembl: ENSG00000120915
- Version: 101_38
Alternate Names:

EPHX2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P34913
- Version: January-2014
Alternate Names:

EPHX2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.3.2.10

Publications:
GuideToPharmacology: 2053
- Version: 29-September-2020
Alternate Names:

3402 HUGO Gene ID

3402 HUGO Gene Symbol

epoxide hydrolase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Hydrolases

GuideToPharmacology Gene Category ID 799

Gene Categories:

ENZYME

Publications:

PharmGKB: EPHX2

Version: 18-August-2020

Alternate Names:

PA27830 PharmGKB ID

Gene Info:

Publications:

International Consortium on Lithium Genetics (ConLi+Gen). et al., 2018, Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study., JAMA Psychiatry

DTC: EPHX2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Sun YN et al., 2015, Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe., Bioorg Med Chem

Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem

Morisseau C et al., 2013, Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000120915
- Version: 31-May-2017
Alternate Names:

ENSG00000120915 Gene Symbol

EPHX2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Soluble epoxide hydrolase
- Version: 2020.06.01
Alternate Names:

EPHX2 TTD Gene Abbreviation

T35734 TTD Target ID

Gene Info:

Publications:
Pharos: EPHX2
- Version: 01-May-2021
Alternate Names:

Bifunctional epoxide hydrolase 2 Gene Name

P34913 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Details of the Assay for Interaction	Inhibition of sEH's phosphatase activity <i>in vitro</i> using bacterially-expressed recombinant N-terminal domain of sEH.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

3402	HUGO Gene ID
3402	HUGO Gene Symbol
epoxide hydrolase 2	HUGO Gene Name

Novel drug target	Novel Target
Trial Name	AR9281

EPHX2 Gene Record

EPHX2 2053 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26372074

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name AR9281

PMIDs: 10592235

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24697244

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26372074

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of sEH's phosphatase activity <i>in vitro</i> using bacterially-expressed recombinant N-terminal domain of sEH. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23684894

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29121268

Sources: PharmGKB

Ensembl: ENSG00000120915

Alternate Names: EPHX2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P34913

Alternate Names: EPHX2 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.3.2.10

Publications:

GuideToPharmacology: 2053

Alternate Names: 3402 HUGO Gene ID 3402 HUGO Gene Symbol epoxide hydrolase 2 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Hydrolases GuideToPharmacology Gene Category ID 799

Gene Categories: ENZYME

Publications:

PharmGKB: EPHX2

Alternate Names: PA27830 PharmGKB ID

Gene Info:

Publications: International Consortium on Lithium Genetics (ConLi+Gen). et al., 2018, Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study., JAMA Psychiatry

DTC: EPHX2

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000120915

Alternate Names: ENSG00000120915 Gene Symbol EPHX2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Soluble epoxide hydrolase

Alternate Names: EPHX2 TTD Gene Abbreviation T35734 TTD Target ID

Gene Info:

Publications:

Pharos: EPHX2

Alternate Names: Bifunctional epoxide hydrolase 2 Gene Name P34913 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
26372074

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name AR9281

PMIDs:
10592235

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
24697244

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26372074

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of sEH's phosphatase activity <i>in vitro</i> using bacterially-expressed recombinant N-terminal domain of sEH.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23684894

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
29121268

Sources:
PharmGKB

Alternate Names:

EPHX2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

EPHX2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.3.2.10

Alternate Names:

3402 HUGO Gene ID

3402 HUGO Gene Symbol

epoxide hydrolase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Hydrolases

GuideToPharmacology Gene Category ID 799

Gene Categories:

ENZYME

Alternate Names:

PA27830 PharmGKB ID

Publications:

International Consortium on Lithium Genetics (ConLi+Gen). et al., 2018, Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study., JAMA Psychiatry

Alternate Names:

ENSG00000120915 Gene Symbol

EPHX2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

EPHX2 TTD Gene Abbreviation

T35734 TTD Target ID

Alternate Names:

Bifunctional epoxide hydrolase 2 Gene Name

P34913 UniProt ID

Gene Categories:

ENZYME