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EPHX2 Gene Record

  • Summary
  • Interactions
  • Claims
  • EPHX2 2053 Druggable Genome

    Alternate Names:

    2053
    EPOXIDE HYDROLASE 2
    EPHX2
    CEH
    SEH
    132811
    3402
    ENSG00000120915
    OTTHUMG00000102115
    P34913
    PA27830
    Soluble epoxide hydrolase
    T35734
    ABHD20
    Bifunctional epoxide hydrolase 2

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.3.2.10
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    International Consortium on Lithium Genetics (ConLi+Gen). et al., 2018, Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study., JAMA Psychiatry
    Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
    Morisseau C et al., 2013, Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides., Bioorg Med Chem Lett
    Sun YN et al., 2015, Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe., Bioorg Med Chem
  • ALOIN   EPHX2

    Interaction Score: 20.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26372074


    Sources:
    DTC

  • AR9281   EPHX2

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name AR9281

    PMIDs:
    10592235


    Sources:
    TdgClinicalTrial TTD

  • 6BIO   EPHX2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24697244


    Sources:
    DTC

  • ALOE-EMODIN   EPHX2

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26372074


    Sources:
    DTC

  • FULVESTRANT   EPHX2

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23684894


    Sources:
    DTC

  • LITHIUM   EPHX2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29121268


    Sources:
    PharmGKB

  • Ensembl: ENSG00000120915

    • Version: 101_38

    Alternate Names:
    EPHX2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P34913

    • Version: January-2014

    Alternate Names:
    EPHX2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.3.2.10

    Publications:

  • PharmGKB: EPHX2

    • Version: 18-August-2020

    Alternate Names:
    PA27830 PharmGKB ID

    Gene Info:

    Publications:
    International Consortium on Lithium Genetics (ConLi+Gen). et al., 2018, Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study., JAMA Psychiatry

  • DTC: EPHX2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Sun YN et al., 2015, Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe., Bioorg Med Chem
    Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
    Morisseau C et al., 2013, Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000120915

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000120915 Gene Symbol
    EPHX2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Soluble epoxide hydrolase

    • Version: 2020.06.01

    Alternate Names:
    EPHX2 TTD Gene Abbreviation
    T35734 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: EPHX2

    • Version: 01-February-2022

    Alternate Names:
    Bifunctional epoxide hydrolase 2 Gene Name
    P34913 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21