DGIdb - EPHX1 Gene Record

EPHX1 2052 Druggable Genome

Alternate Names:

2052
EPOXIDE HYDROLASE 1
EPHX1
EPHX
EPOX
HYL1
MEH
132810
3401
ENSG00000143819
OTTHUMG00000037743
PA27829
P07099

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.3.2.9
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Edvardsen H et al., 2010, SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance., Pharmacogenomics J
Azzato EM et al., 2010, Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations., Pharmacogenet Genomics
Khrunin AV et al., 2014, Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer., Pharmacogenomics
Luxembourg B et al., 2011, Impact of pharmacokinetic (CYP2C9) and pharmacodynamic (VKORC1, F7, GGCX, CALU, EPHX1) gene variants on the initiation and maintenance phases of phenprocoumon therapy., Thromb Haemost
Ma CL et al., 2015, Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy., Pharmacogenomics
Zhu X et al., 2014, Effects of major transporter and metabolizing enzyme gene polymorphisms on carbamazepine metabolism in Chinese patients with epilepsy., Pharmacogenomics
Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics
Makmor-Bakry M et al., 2009, Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing., Clin Neuropharmacol
Nakajima Y et al., 2005, Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients., Eur J Clin Pharmacol

AR9281 EPHX1

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name AR9281

PMIDs:
None found

Sources:
TdgClinicalTrial
PHENPROCOUMON EPHX1

Interaction Score: 2.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21057703

Sources:
PharmGKB
CARBAMAZEPINE EPHX1

Interaction Score: 1.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26314341 25495409 22188362 19620853 15692831

Sources:
PharmGKB
PHENYTOIN EPHX1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19952982

Sources:
PharmGKB
DOCETAXEL EPHX1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20157331

Sources:
PharmGKB
CYCLOPHOSPHAMIDE EPHX1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24533712

Sources:
PharmGKB
CISPLATIN EPHX1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24533712

Sources:
PharmGKB

Ensembl: ENSG00000143819
- Version: 101_38
Alternate Names:

EPHX1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P07099
- Version: January-2014
Alternate Names:

EPHX1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.3.2.9

Publications:

PharmGKB: EPHX1

Version: 18-August-2020

Alternate Names:

PA27829 PharmGKB ID

Gene Info:

Publications:

Edvardsen H et al., 2010, SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance., Pharmacogenomics J

Nakajima Y et al., 2005, Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients., Eur J Clin Pharmacol

Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics

NCI: EPHX1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Spiegelstein et al., 1999, Stereoselective pharmacokinetics and pharmacodynamics of propylisopropyl acetamide, a CNS-active chiral amide analog of valproic acid., Pharm. Res.
HingoraniCasas: ENSG00000143819
- Version: 31-May-2017
Alternate Names:

ENSG00000143819 Gene Symbol

EPHX1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: EPHX1
- Version: 19.3
Alternate Names:

ENSG00000143819 Ensembl Gene ID

EPHX Human Protein Atlas Gene Synonym

Epoxide hydrolase 1 Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: EPHX1
- Version: 01-February-2022
Alternate Names:

Epoxide hydrolase 1 Gene Name

P07099 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ENSG00000143819	Ensembl Gene ID
EPHX	Human Protein Atlas Gene Synonym
Epoxide hydrolase 1	Human Protein Atlas Gene Description

Novel drug target	Novel Target
Trial Name	AR9281

EPHX1 Gene Record

EPHX1 2052 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

AR9281 EPHX1

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name AR9281

PMIDs: None found

Sources: TdgClinicalTrial

PHENPROCOUMON EPHX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21057703

Sources: PharmGKB

CARBAMAZEPINE EPHX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26314341 25495409 22188362 19620853 15692831

Sources: PharmGKB

PHENYTOIN EPHX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19952982

Sources: PharmGKB

DOCETAXEL EPHX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20157331

Sources: PharmGKB

CYCLOPHOSPHAMIDE EPHX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24533712

Sources: PharmGKB

CISPLATIN EPHX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24533712

Sources: PharmGKB

Ensembl: ENSG00000143819

Alternate Names: EPHX1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P07099

Alternate Names: EPHX1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.3.2.9

Publications:

PharmGKB: EPHX1

Alternate Names: PA27829 PharmGKB ID

Gene Info:

NCI: EPHX1

Alternate Names:

Gene Info:

Publications: Spiegelstein et al., 1999, Stereoselective pharmacokinetics and pharmacodynamics of propylisopropyl acetamide, a CNS-active chiral amide analog of valproic acid., Pharm. Res.

HingoraniCasas: ENSG00000143819

Alternate Names: ENSG00000143819 Gene Symbol EPHX1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: EPHX1

Alternate Names: ENSG00000143819 Ensembl Gene ID EPHX Human Protein Atlas Gene Synonym Epoxide hydrolase 1 Human Protein Atlas Gene Description

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: EPHX1

Alternate Names: Epoxide hydrolase 1 Gene Name P07099 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name AR9281

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
21057703

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26314341 25495409 22188362 19620853 15692831

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19952982

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20157331

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24533712

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24533712

Sources:
PharmGKB

Alternate Names:

EPHX1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

EPHX1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.3.2.9

Alternate Names:

PA27829 PharmGKB ID

Publications:

Spiegelstein et al., 1999, Stereoselective pharmacokinetics and pharmacodynamics of propylisopropyl acetamide, a CNS-active chiral amide analog of valproic acid., Pharm. Res.

Alternate Names:

ENSG00000143819 Gene Symbol

EPHX1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000143819 Ensembl Gene ID

EPHX Human Protein Atlas Gene Synonym

Epoxide hydrolase 1 Human Protein Atlas Gene Description

Gene Categories:

ENZYME

Alternate Names:

Epoxide hydrolase 1 Gene Name

P07099 UniProt ID

Gene Categories:

ENZYME