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ELANE Gene Record

  • Summary
  • Interactions
  • Claims
  • ELANE 1991 Druggable Genome

    Alternate Names:

    1991
    ELASTASE, NEUTROPHIL EXPRESSED
    ELANE
    ELA2
    GE
    HLE
    HNE
    NE
    PMN-E
    SCN1
    130130
    3309
    ENSG00000197561
    OTTHUMG00000181839
    P08246
    NEUTROPHIL ELASTASE
    ELNE_HUMAN
    LEUKOCYTE ELASTASE PRECURSOR (EC 3.4.21.37) (NEUTROPHIL ELASTASE) (PMN ELASTASE) (BONE MARROW SERINE PROTEASE) (MEDULLASIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08246]
    T40332

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.4.21.37
    Human Readable Name PROTEASE
    Target Subclass 3.4.21.37
    Target Main Class Enzymes
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Interpro Short Name Peptidase_S1_S6
    Interpro Acc IPR001254
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Salvador LA et al., 2013, Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells., J Med Chem
    Ozaki et al., 1998, Role of medullasin in nifedipine-induced gingival overgrowth in rats., Arch. Oral Biol.
    Kunimatsu et al., 1996, Possible roles of medullasin in nifedipine-induced human gingival overgrowth., Arch. Oral Biol.
    Méthot N et al., 2007, Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing., J Biol Chem
    Armstrong et al., 1996, Nicotine enhances expression of the neutrophil elastase gene and protein in a human myeloblast/promyelocyte cell line., Am. J. Respir. Crit. Care Med.
  • SYMPLOSTATIN 5   ELANE

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23350733


    Sources:
    DTC

  • CHEMBL310871   ELANE

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17535802


    Sources:
    DTC

  • SIVELESTAT   ELANE

    Interaction Score: 15.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name sivelestat sodium hydrate,Elaspol
    Novel drug target Established target

    PMIDs:
    23350733


    Sources:
    DTC TdgClinicalTrial TTD

  • DEPELESTAT   ELANE

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ERDOSTEINE   ELANE

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name erdosteine
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TIPRELESTAT   ELANE

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NIFEDIPINE   ELANE

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9796781 8833599


    Sources:
    NCI

  • NICOTINE   ELANE

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8912774


    Sources:
    NCI

  • Ensembl: ENSG00000197561

    • Version: 101_38

    Alternate Names:
    ELANE Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P08246

    • Version: 01-August-2011

    Alternate Names:
    ELA2 Gene Symbol
    P08246 Uniprot Accession
    ENSG00000197561 Ensembl Gene Id

    Gene Info:
    Target Subclass 3.4.21.37
    Target Main Class Enzymes

    Publications:

  • TdgClinicalTrial: P08246

    • Version: January-2014

    Alternate Names:
    ELANE Gene Symbol
    ELA2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.37

    Publications:

  • RussLampel: ENSG00000197561

    • Version: 26-July-2011

    Alternate Names:
    ELA2 Display Id
    LEUKOCYTE ELASTASE PRECURSOR (EC 3.4.21.37) (NEUTROPHIL ELASTASE) (PMN ELASTASE) (BONE MARROW SERINE PROTEASE) (MEDULLASIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08246] Description
    ENSG00000197561 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P08246

    • Version: 11-September-2012

    Alternate Names:
    NEUTROPHIL ELASTASE Uniprot Protein Name
    ENSG00000197561 Ensembl Gene Id
    ELNE_HUMAN Uniprot Id

    Gene Info:
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Interpro Short Name Peptidase_S1_S6
    Interpro Acc IPR001254

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • NCI: ELA2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Armstrong et al., 1996, Nicotine enhances expression of the neutrophil elastase gene and protein in a human myeloblast/promyelocyte cell line., Am. J. Respir. Crit. Care Med.
    Ozaki et al., 1998, Role of medullasin in nifedipine-induced gingival overgrowth in rats., Arch. Oral Biol.
    Kunimatsu et al., 1996, Possible roles of medullasin in nifedipine-induced human gingival overgrowth., Arch. Oral Biol.

  • DTC: ELANE

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Salvador LA et al., 2013, Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells., J Med Chem
    Méthot N et al., 2007, Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing., J Biol Chem

  • HingoraniCasas: ENSG00000197561

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000197561 Gene Symbol
    ELANE Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ELANE

    • Version: 01-February-2022

    Alternate Names:
    ELA2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, PROTEASE

    Publications:

  • dGene: ELANE

    • Version: 27-Jun-2013

    Alternate Names:
    1991 Gene ID
    ELA2 dGene Synonym
    GE dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Neutrophil elastase

    • Version: 2020.06.01

    Alternate Names:
    NE TTD Gene Abbreviation
    T40332 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ELANE

    • Version: 01-February-2022

    Alternate Names:
    Neutrophil elastase Gene Name
    P08246 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21