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EGF Gene Record

  • Summary
  • Interactions
  • Claims
  • EGF 1950 Druggable GenomeDrug Resistance

    Alternate Names:

    1950
    EPIDERMAL GROWTH FACTOR
    EGF
    HOMG4
    URG
    131530
    3229
    ENSG00000138798
    OTTHUMG00000132044
    BE0000953
    P01133
    PA27664
    1634
    T33425

    Gene Info:

    Target Class Receptors
    Target Subclass Receptor
    Target Subclass LDLR
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUG RESISTANCE
    DRUGGABLE GENOME

    Publications:

    Ansell et al., 2016, Epidermal growth factor is a potential biomarker for poor cetuximab response in tongue cancer cells., J. Oral Pathol. Med.
    Sebio A et al., 2014, Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan., Pharmacogenomics J
    Zhang W et al., 2006, Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab., Pharmacogenet Genomics
    Morgen EK et al., 2017, Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis., Pharmacogenomics J
    Graziano F et al., 2008, Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer., J Clin Oncol
    Tarnawski et al., 1995, Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment?, Scand. J. Gastroenterol. Suppl.
    Szabo, 1991, The mode of action of sucralfate: the 1 x 1 x 1 mechanism of action., Scand. J. Gastroenterol. Suppl.
    Konturek, 1990, Role of growth factors in gastroduodenal protection and healing of peptic ulcers., Gastroenterol. Clin. North Am.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • CHEMBL553426   EGF

    Interaction Score: 16.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • SUCRALFATE   EGF

    Interaction Score: 6.49

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:

    PMIDs:
    8578218 1957124 1970337


    Sources:
    DrugBank

  • NIMOTUZUMAB   EGF

    Interaction Score: 4.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name vaccine, EGF cancer
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • SINCALIDE   EGF

    Interaction Score: 1.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CETUXIMAB   EGF

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25677871 23959273 16788380 27897268 18349392


    Sources:
    PharmGKB CIViC

  • TESEVATINIB   EGF

    Interaction Score: 1.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • PANITUMUMAB   EGF

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000138798

    • Version: 101_38

    Alternate Names:
    EGF Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P01133

    • Version: January-2014

    Alternate Names:
    EGF Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass LDLR

    Publications:

  • PharmGKB: EGF

    • Version: 18-August-2020

    Alternate Names:
    PA27664 PharmGKB ID

    Gene Info:

    Publications:
    Sebio A et al., 2014, Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan., Pharmacogenomics J
    Zhang W et al., 2006, Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab., Pharmacogenet Genomics
    Morgen EK et al., 2017, Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis., Pharmacogenomics J

  • CIViC: EGF

    • Version: 14-September-2020

    Alternate Names:
    1950 Entrez Gene ID
    1634 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Ansell et al., 2016, Epidermal growth factor is a potential biomarker for poor cetuximab response in tongue cancer cells., J. Oral Pathol. Med.

  • DrugBank: BE0000953

    • Version: 5.1.7

    Alternate Names:
    EGF DrugBank Gene Name
    P01133 UniProt Accession
    1950 Entrez Gene Id

    Gene Info:

    Publications:
    Tarnawski et al., 1995, Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment?, Scand. J. Gastroenterol. Suppl.
    Szabo, 1991, The mode of action of sucralfate: the 1 x 1 x 1 mechanism of action., Scand. J. Gastroenterol. Suppl.
    Konturek, 1990, Role of growth factors in gastroduodenal protection and healing of peptic ulcers., Gastroenterol. Clin. North Am.

  • HingoraniCasas: ENSG00000138798

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000138798 Gene Symbol
    EGF Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: EGF

    • Version: 12-May-2016

    Alternate Names:
    EGF Gene Symbol

    Gene Info:

    Publications:

  • Tempus: EGF

    • Version: 11-November-2018

    Alternate Names:
    EGF Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Epidermal growth factor

    • Version: 2020.06.01

    Alternate Names:
    EGF TTD Gene Abbreviation
    T33425 TTD Target ID

    Gene Info:

    Publications:

  • GO: EGF

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21