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EDN1 Gene Record

  • Summary
  • Interactions
  • Claims
  • EDN1 1906 Druggable Genome

    Alternate Names:

    1906
    ENDOTHELIN 1
    EDN1
    ARCND3
    ET1
    HDLCQ7
    PPET1
    QME
    131240
    3176
    ENSG00000078401
    OTTHUMG00000014266
    PA27614

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    HORMONE ACTIVITY
    DRUGGABLE GENOME

    Publications:

    Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics
    Yamashita et al., 1993, Interleukin 6 stimulates the production of immunoreactive endothelin 1 in human breast cancer cells., Cancer Res.
    Diamanti-Kandarakis et al., 2001, Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy., J. Clin. Endocrinol. Metab.
    Aliev et al., 2000, Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of donryu rats on a cholesterol-enriched diet., Anat. Rec.
    Fabricio et al., 2005, The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Sayed-Ahmed et al., 2001, Increased plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy., Pharmacol. Toxicol.
    Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration
    Huang et al., 2006, Lanreotide on collateral response to endothelin-1 and vasopressin in cirrhotic rats., J Chin Med Assoc
    Sarioğlu et al., 1997, Effects of deferoxamine and sympathectomy on endothelin-1-induced contraction and acetylcholine-induced relaxation following subarachnoid hemorrhage in carotid artery., Gen. Pharmacol.
    Gampenrieder SP et al., 2017, Endothelin-1 genetic polymorphism as predictive marker for bevacizumab in metastatic breast cancer., Pharmacogenomics J
    Hallberg P et al., 2004, Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)., Clin Cardiol
  • THIOURACIL   EDN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10967532


    Sources:
    NCI

  • LANREOTIDE   EDN1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17051749


    Sources:
    NCI

  • MURAGLITAZAR   EDN1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18794727


    Sources:
    PharmGKB

  • IRBESARTAN   EDN1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15188945


    Sources:
    PharmGKB

  • BUDESONIDE   EDN1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7716352


    Sources:
    NCI

  • DEFEROXAMINE   EDN1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9112092


    Sources:
    NCI

  • BEVACIZUMAB   EDN1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27139155


    Sources:
    PharmGKB

  • ATENOLOL   EDN1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15188945


    Sources:
    PharmGKB

  • INSULIN   EDN1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11600523


    Sources:
    NCI

  • TAMOXIFEN   EDN1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8425178


    Sources:
    NCI

  • CELECOXIB   EDN1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15539607


    Sources:
    NCI

  • DOXORUBICIN   EDN1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11589785


    Sources:
    NCI

  • Ensembl: ENSG00000078401

    • Version: 101_38

    Alternate Names:
    EDN1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: EDN1

    • Version: 18-August-2020

    Alternate Names:
    PA27614 PharmGKB ID

    Gene Info:

    Publications:
    Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics
    Gampenrieder SP et al., 2017, Endothelin-1 genetic polymorphism as predictive marker for bevacizumab in metastatic breast cancer., Pharmacogenomics J
    Hallberg P et al., 2004, Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)., Clin Cardiol

  • NCI: EDN1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Fabricio et al., 2005, The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration
    Shakunaga et al., 1998, Ketamine suppresses the production and release of endothelin 1 from cultured bovine endothelial cells., Anesth. Analg.

  • HingoraniCasas: ENSG00000078401

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000078401 Gene Symbol
    EDN1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: EDN1

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    HORMONE ACTIVITY

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21