DGIdb - EDN1 Gene Record

EDN1 1906 Druggable Genome

Alternate Names:

1906
ENDOTHELIN 1
EDN1
ARCND3
ET1
HDLCQ7
PPET1
QME
131240
3176
ENSG00000078401
OTTHUMG00000014266
PA27614

Gene Info:

Gene Biotype	PROTEIN_CODING

(1 More Sources)

Gene Categories: Category Details

HORMONE ACTIVITY
DRUGGABLE GENOME

Publications:

Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics
Yamashita et al., 1993, Interleukin 6 stimulates the production of immunoreactive endothelin 1 in human breast cancer cells., Cancer Res.
Diamanti-Kandarakis et al., 2001, Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy., J. Clin. Endocrinol. Metab.
Aliev et al., 2000, Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of donryu rats on a cholesterol-enriched diet., Anat. Rec.
Fabricio et al., 2005, The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Sayed-Ahmed et al., 2001, Increased plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy., Pharmacol. Toxicol.
Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration
Huang et al., 2006, Lanreotide on collateral response to endothelin-1 and vasopressin in cirrhotic rats., J Chin Med Assoc
Sarioğlu et al., 1997, Effects of deferoxamine and sympathectomy on endothelin-1-induced contraction and acetylcholine-induced relaxation following subarachnoid hemorrhage in carotid artery., Gen. Pharmacol.
Gampenrieder SP et al., 2017, Endothelin-1 genetic polymorphism as predictive marker for bevacizumab in metastatic breast cancer., Pharmacogenomics J
Hallberg P et al., 2004, Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)., Clin Cardiol

THIOURACIL EDN1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10967532

Sources:
NCI
LANREOTIDE EDN1

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17051749

Sources:
NCI
MURAGLITAZAR EDN1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18794727

Sources:
PharmGKB
IRBESARTAN EDN1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15188945

Sources:
PharmGKB
BUDESONIDE EDN1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7716352

Sources:
NCI
DEFEROXAMINE EDN1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9112092

Sources:
NCI
BEVACIZUMAB EDN1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27139155

Sources:
PharmGKB
ATENOLOL EDN1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15188945

Sources:
PharmGKB
INSULIN EDN1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11600523

Sources:
NCI
TAMOXIFEN EDN1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8425178

Sources:
NCI
CELECOXIB EDN1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15539607

Sources:
NCI
DOXORUBICIN EDN1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11589785

Sources:
NCI

Ensembl: ENSG00000078401
- Version: 101_38
Alternate Names:

EDN1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: EDN1

Version: 18-August-2020

Alternate Names:

PA27614 PharmGKB ID

Gene Info:

Publications:

Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics

Gampenrieder SP et al., 2017, Endothelin-1 genetic polymorphism as predictive marker for bevacizumab in metastatic breast cancer., Pharmacogenomics J

Hallberg P et al., 2004, Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)., Clin Cardiol

NCI: EDN1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Fabricio et al., 2005, The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.

Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration

Shakunaga et al., 1998, Ketamine suppresses the production and release of endothelin 1 from cultured bovine endothelial cells., Anesth. Analg.

HingoraniCasas: ENSG00000078401
- Version: 31-May-2017
Alternate Names:

ENSG00000078401 Gene Symbol

EDN1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: EDN1
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

HORMONE ACTIVITY

Publications:

EDN1 Gene Record

EDN1 1906 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10967532

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17051749

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18794727

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15188945

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7716352

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9112092

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27139155

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15188945

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11600523

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8425178

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15539607

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11589785

Sources: NCI

Ensembl: ENSG00000078401

Alternate Names: EDN1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: EDN1

Alternate Names: PA27614 PharmGKB ID

Gene Info:

NCI: EDN1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000078401

Alternate Names: ENSG00000078401 Gene Symbol EDN1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: EDN1

Alternate Names:

Gene Info:

Gene Categories: HORMONE ACTIVITY

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10967532

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17051749

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18794727

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15188945

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7716352

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9112092

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
27139155

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15188945

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11600523

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8425178

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15539607

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11589785

Sources:
NCI

Alternate Names:

EDN1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA27614 PharmGKB ID

Alternate Names:

ENSG00000078401 Gene Symbol

EDN1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Gene Categories:

HORMONE ACTIVITY