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E2F1 Gene Record

  • Summary
  • Interactions
  • Claims
  • E2F1 1869

    Alternate Names:

    1869
    E2F TRANSCRIPTION FACTOR 1
    E2F1
    E2F-1
    RBAP1
    RBBP3
    RBP3
    189971
    3113
    ENSG00000101412
    OTTHUMG00000032265
    T57059
    Transcription factor E2F1
    Q01094

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR

    Publications:

    Salleh et al., 2004, Gene expression profiling of p53(+/-) knockout and wild-type mice following diethylstilbestrol administration., IUBMB Life
    Gomez-Manzano et al., 2001, Adenovirally-mediated transfer of E2F-1 potentiates chemosensitivity of human glioma cells to temozolomide and BCNU., Int. J. Oncol.
    Lee et al., 2006, Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells., Cancer Lett.
    Fujita et al., 2002, Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells., Am. J. Physiol. Heart Circ. Physiol.
    Meng et al., 1999, p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin., Int. J. Oncol.
    Rieber et al., 2003, N-Acetylcysteine enhances UV-mediated caspase-3 activation, fragmentation of E2F-4, and apoptosis in human C8161 melanoma: inhibition by ectopic Bcl-2 expression., Biochem. Pharmacol.
    Banerjee et al., 1998, Role of E2F-1 in chemosensitivity., Cancer Res.
    Russo et al., 2006, E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents., Cancer Res.
    Martirosyan et al., 2004, Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model., Biochem. Pharmacol.
    Dasgupta et al., 2006, Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin., Proc. Natl. Acad. Sci. U.S.A.
    Tahara et al., 2004, Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil., Oncol. Rep.
    Jung et al., 2001, Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit., Clin. Cancer Res.
  • PRIMAQUINE   E2F1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15450938


    Sources:
    NCI

  • CARMUSTINE   E2F1

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11445852


    Sources:
    NCI

  • ACETYLCYSTEINE   E2F1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12754095


    Sources:
    NCI

  • VASOPRESSIN   E2F1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12063292


    Sources:
    NCI

  • ADRIAMYCIN   E2F1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9863003


    Sources:
    NCI

  • DIETHYLSTILBESTROL   E2F1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15545218


    Sources:
    NCI

  • ETOPOSIDE   E2F1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9766655 16849574


    Sources:
    NCI

  • NICOTINE   E2F1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16601104


    Sources:
    NCI

  • IRINOTECAN   E2F1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9766655


    Sources:
    NCI

  • LARGAZOLE   E2F1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • QUERCETIN   E2F1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16274926


    Sources:
    NCI

  • BORTEZOMIB   E2F1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11489836


    Sources:
    NCI

  • PACLITAXEL   E2F1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16849574


    Sources:
    NCI

  • FLUOROURACIL   E2F1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9766655


    Sources:
    NCI

  • METHOTREXATE   E2F1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14654896


    Sources:
    NCI

  • CISPLATIN   E2F1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16849574


    Sources:
    NCI

  • Ensembl: ENSG00000101412

    • Version: 101_38

    Alternate Names:
    E2F1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: E2F1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Salleh et al., 2004, Gene expression profiling of p53(+/-) knockout and wild-type mice following diethylstilbestrol administration., IUBMB Life
    Meng et al., 1999, p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin., Int. J. Oncol.
    Banerjee et al., 1998, Role of E2F-1 in chemosensitivity., Cancer Res.

  • TTD: E2F transcription factor 1

    • Version: 2020.06.01

    Alternate Names:
    E2F1 TTD Gene Abbreviation
    T57059 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: E2F1

    • Version: 01-February-2022

    Alternate Names:
    Transcription factor E2F1 Gene Name
    Q01094 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • DTC: E2F1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21