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DRD4 Gene Record

  • Summary
  • Interactions
  • Claims
  • DRD4 1815 Druggable Genome

    Alternate Names:

    1815
    DOPAMINE RECEPTOR D4
    DRD4
    D4DR
    126452
    3025
    ENSG00000069696
    OTTHUMG00000133312
    DOPAMINE RECEPTOR D4 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_000788]
    NP_000788.2
    BE0000389
    P21917
    217
    NM_000797
    D<sub>4</sub> receptor
    NP_000788
    D(4) dopamine receptor
    D(2C) dopamine receptor
    Dopamine D4 receptor
    DRD4_HUMAN
    D4R
    T24983

    Gene Info:

    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name Dopamine receptors
    GuideToPharmacology Gene Category ID 20
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Interpro Type Family
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000276
    Uniprot Evidence 1: Evidence at protein level
    Transmembrane Helix Count 7
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Kuballa et al., Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine., Pharmacol Rep
    Glatt et al., 2003, Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis., Biol. Psychiatry
    Nakane et al., 2005, 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist., Neuropharmacology
    Zhao et al., 2005, Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine., Int. J. Neurosci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Patel et al., 2003, Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina., Neuropharmacology
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Roth et al., 1995, D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs., Psychopharmacology (Berl.)
    Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Li P et al., 2016, Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future., Curr Top Med Chem
    Piercey MF, 1998, Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease., Clin Neuropharmacol
    Mierau et al., 1995, Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors., Eur. J. Pharmacol.
    Dooley M et al., 1998, Pramipexole. A review of its use in the management of early and advanced Parkinson's disease., Drugs Aging
    Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
    Burstein et al., 2005, Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist., J. Pharmacol. Exp. Ther.
    Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
    Hutchison et al., 2006, The effect of olanzapine on craving and alcohol consumption., Neuropsychopharmacology
    de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
    Shill HA et al., 2009, Update on ropinirole in the treatment of Parkinson's disease., Neuropsychiatr Dis Treat
    Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol
    Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry
    Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)
    LeWitt PA, 2004, Subcutaneously administered apomorphine: pharmacokinetics and metabolism., Neurology
    Melis et al., 2006, PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain., Eur. J. Neurosci.
    Succu et al., 2007, Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin., Neuropharmacology
    Boeckler et al., 2004, FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia., Psychopharmacology (Berl.)
    Sanner et al., 1998, Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist., Bioorg. Med. Chem. Lett.
    Mansbach et al., 1998, Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition., Psychopharmacology (Berl.)
    Newman-Tancredi et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor., J. Pharmacol. Exp. Ther.
    Ostadali et al., 2004, The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR., Iran J Allergy Asthma Immunol
    Deleu et al., 2002, Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease., Clin Pharmacokinet
    Onofrj et al., 2008, An expert opinion on safinamide in Parkinson's disease., Expert Opin Investig Drugs
    Koller et al., 1998, Mechanism of action of dopaminergic agents in Parkinson's disease., Neurology
    Seeman et al., 1997, Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors., Neuropsychopharmacology
    Kishi T et al., 2013, Efficacy and tolerability of perospirone in schizophrenia: a systematic review and meta-analysis of randomized controlled trials., CNS Drugs
    Gilliland SL et al., 2000, Characterization of dopaminergic compounds at hD2short, hD4.2 and hD4.7 receptors in agonist-stimulated [35S]GTPgammaS binding assays., Naunyn Schmiedebergs Arch Pharmacol
    Deeks, 2015, Flibanserin: First Global Approval., Drugs
    Invernizzi et al., 2003, Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors., Br. J. Pharmacol.
    Borsini et al., 2002, Pharmacology of flibanserin., CNS Drug Rev
    Schotte et al., 1996, Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding., Psychopharmacology (Berl.)
    Howland RH, 2015, Buspirone: Back to the Future., J Psychosoc Nurs Ment Health Serv
  • PRAMIPEXOLE   DRD4

    Interaction Score: 1.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Mirapex
    Novel drug target Established target

    PMIDs:
    9617505 18691132 7664822 9638397 11752352


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SONEPIPRAZOLE   DRD4

    Interaction Score: 0.78

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL219182   DRD4

    Interaction Score: 0.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ROPINIROLE   DRD4

    Interaction Score: 0.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name JZP-7
    Novel drug target Established target

    PMIDs:
    19557097 18691132 11752352


    Sources:
    TdgClinicalTrial DrugBank

  • ROTIGOTINE   DRD4

    Interaction Score: 0.56

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction D2-like dopamine receptor agonist
    Trial Name Neupro

    PMIDs:
    18691132


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • APOMORPHINE   DRD4

    Interaction Score: 0.39

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name intranasal apomorphine
    Trial Name inhaled apomorphine hydrochloride, VR004, VR-040, VR-400
    Trial Name apomorphine hydrochloride,Apokyn, APO-go

    PMIDs:
    15037665 17067298 18691132 17164075 15007532 9871530 11752352 9497025


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • PEROSPIRONE   DRD4

    Interaction Score: 0.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    23812802


    Sources:
    DrugBank GuideToPharmacology

  • FLIBANSERIN   DRD4

    Interaction Score: 0.31

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    26412054 12890707 12177684


    Sources:
    DrugBank

  • THIETHYLPERAZINE   DRD4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 17016423


    Sources:
    TEND TdgClinicalTrial

  • SUMANIROLE   DRD4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • BENPERIDOL   DRD4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • APOMORPHINE HYDROCHLORIDE   DRD4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction D2-like dopamine receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DEXPRAMIPEXOLE   DRD4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name dexpramipexole, KNS-760704
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PRAMIPEXOLE DIHYDROCHLORIDE   DRD4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • WAY-100,635   DRD4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PARDOPRUNOX   DRD4

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name pardoprunox, SLV 308
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial DrugBank

  • PROPIOMAZINE   DRD4

    Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17139284 17016423


    Sources:
    TEND TdgClinicalTrial

  • PHENYLTOLOXAMINE   DRD4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NEMONAPRIDE   DRD4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • HALOPERIDOL DECANOATE   DRD4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor inverse agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ROPINIROLE HYDROCHLORIDE   DRD4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SARIZOTAN HYDROCHLORIDE   DRD4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Dopamine D4 receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZICRONAPINE   DRD4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name LU-31130

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • HALOPERIDOL LACTATE   DRD4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction D2-like dopamine receptor inverse agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ASENAPINE   DRD4

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 21655346 10592235


    Sources:
    TdgClinicalTrial DrugBank

  • PERGOLIDE   DRD4

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    10832603 18691132


    Sources:
    DrugBank GuideToPharmacology

  • PROMAZINE   DRD4

    Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17139284 17016423


    Sources:
    TEND TdgClinicalTrial

  • BUSPIRONE   DRD4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    26535760


    Sources:
    DrugBank

  • OLANZAPINE PAMOATE   DRD4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • REMOXIPRIDE   DRD4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    9015795


    Sources:
    DrugBank

  • CABERGOLINE   DRD4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    12388667 18691132


    Sources:
    DrugBank GuideToPharmacology

  • LOXAPINE HYDROCHLORIDE   DRD4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETILEVODOPA   DRD4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name etilevodopa, TV-1203

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LISURIDE   DRD4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • PIPAMPERONE   DRD4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8935801


    Sources:
    DrugBank

  • ETICLOPRIDE   DRD4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LOXAPINE SUCCINATE   DRD4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PERGOLIDE MESYLATE   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MELEVODOPA   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name V-1512, CHF-1512,Levomet Complex, Sirio
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DROPERIDOL   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PALIPERIDONE   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7520908 7531353


    Sources:
    DrugBank

  • BROMOCRIPTINE MESYLATE   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZIPRASIDONE   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 17139284 17016423


    Sources:
    TEND DrugBank

  • LEVOMEPROMAZINE   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    15701205


    Sources:
    DrugBank ChemblInteractions

  • CLOZAPINE   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist
    Novel drug target Established target

    PMIDs:
    15886414 13129658 15992586 16223700 11752352 12763097


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • LEVODOPA   DRD4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name entacapone/levodopa/carbidopa,Stalevo
    Novel drug target Established target
    Trial Name levodopa + carbidopa,Duodopa

    PMIDs:
    11978145 18549347 9633680


    Sources:
    TdgClinicalTrial DrugBank

  • PROMAZINE HYDROCHLORIDE   DRD4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ILOPERIDONE   DRD4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    23272794


    Sources:
    DrugBank

  • AMOXAPINE   DRD4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Dopamine receptor antagonist

    PMIDs:
    16135699


    Sources:
    DrugBank ChemblInteractions

  • CHLORPROMAZINE   DRD4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Specific Action of the Ligand Antagonist

    PMIDs:
    8524985


    Sources:
    DrugBank GuideToPharmacology ChemblInteractions

  • QUINPIROLE   DRD4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • OLANZAPINE   DRD4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes
    Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

    PMIDs:
    11752352 25032030 16237394


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • BROMOCRIPTINE   DRD4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • DOPAMINE   DRD4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True
    Direct Interaction? True

    PMIDs:
    17301410


    Sources:
    DrugBank GuideToPharmacology

  • LOXAPINE   DRD4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    DrugBank GuideToPharmacology ChemblInteractions

  • TRIFLUOPERAZINE HYDROCHLORIDE   DRD4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FENOLDOPAM   DRD4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ERGOLOID MESYLATES   DRD4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PIRIBEDIL   DRD4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TERGURIDE   DRD4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ROXINDOLE   DRD4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIORIDAZINE HYDROCHLORIDE   DRD4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUETIAPINE   DRD4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    ligand
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 27291902


    Sources:
    DrugBank

  • ARIPIPRAZOLE   DRD4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    partial agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 26346901


    Sources:
    DrugBank

  • ZOTEPINE   DRD4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHLORPROMAZINE HYDROCHLORIDE   DRD4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SPIPERONE   DRD4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SERTINDOLE   DRD4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIORIDAZINE   DRD4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction D2-like dopamine receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCHLORPERAZINE   DRD4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TRIFLUOPERAZINE   DRD4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PIMOZIDE   DRD4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HALOPERIDOL   DRD4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inverse agonist (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor inverse agonist
    Direct Interaction yes
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • Ensembl: ENSG00000069696

    • Version: 101_38

    Alternate Names:
    DRD4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P21917

    • Version: 01-August-2011

    Alternate Names:
    1815 Entrez Gene Id
    P21917 Uniprot Accession
    DRD4 Gene Symbol

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass GPCR
    Target Main Class Receptors

    Publications:

  • TdgClinicalTrial: P21917

    • Version: January-2014

    Alternate Names:
    DRD4 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P21917

    • Version: 11-September-2012

    Alternate Names:
    1815 Entrez Gene Id
    DRD4 Uniprot Gene Name
    ENSG00000069696 Ensembl Gene Id

    Gene Info:
    Interpro Type Family
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000069696

    • Version: 26-July-2011

    Alternate Names:
    NP_000788.2 Display Id
    ENSG00000069696 Ensembl Gene Id
    DOPAMINE RECEPTOR D4 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_000788] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 1815

    • Version: 29-September-2020

    Alternate Names:
    3025 HUGO Gene ID
    3025 HUGO Gene Symbol
    dopamine receptor D4 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Dopamine receptors
    GuideToPharmacology Gene Category ID 20

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • DrugBank: BE0000389

    • Version: 5.1.7

    Alternate Names:
    DRD4 DrugBank Gene Name
    P21917 UniProt Accession
    1815 Entrez Gene Id

    Gene Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • ChemblInteractions: DRD4

    • Version: chembl_23

    Alternate Names:
    DRD4 GENE_SYMBOL
    D(4) dopamine receptor UNIPROT
    D(2C) dopamine receptor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000069696

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000069696 Gene Symbol
    DRD4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: DRD4

    • Version: 27-Jun-2013

    Alternate Names:
    1815 Gene ID
    D4DR dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Dopamine D4 receptor

    • Version: 2020.06.01

    Alternate Names:
    D4R TTD Gene Abbreviation
    T24983 TTD Target ID

    Gene Info:

    Publications:

  • GO: DRD4

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21