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DOT1L Gene Record

  • Summary
  • Interactions
  • Claims
  • DOT1L 84444 Druggable GenomeClinically Actionable

    Alternate Names:

    84444
    DOT1 LIKE HISTONE LYSINE METHYLTRANSFERASE
    DOT1L
    DOT1
    KMT4
    607375
    24948
    ENSG00000104885
    OTTHUMG00000150431
    PA134993717
    KIAA1814

    Gene Info:

    Initial Gene Query DOT1L
    Counted Citations from 1950-2000 67
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DNA REPAIR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    METHYL TRANSFERASE

    Publications:

    Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
    Duarte JD et al., 2012, Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide., J Transl Med
  • CANDESARTAN   DOT1L

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31327267


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   DOT1L

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22440088


    Sources:
    PharmGKB

  • Ensembl: ENSG00000104885

    • Version: 101_38

    Alternate Names:
    DOT1L Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: DOT1L

    • Version: February-2014

    Alternate Names:
    84444 Entrez Gene ID

    Gene Info:
    Initial Gene Query DOT1L
    Counted Citations from 1950-2000 67

    Gene Categories:
    METHYL TRANSFERASE

    Publications:

  • PharmGKB: DOT1L

    • Version: 18-August-2020

    Alternate Names:
    PA134993717 PharmGKB ID

    Gene Info:

    Publications:
    Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
    Duarte JD et al., 2012, Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide., J Transl Med

  • HingoraniCasas: ENSG00000104885

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000104885 Gene Symbol
    DOT1L Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: DOT1L

    • Version: 01-February-2022

    Alternate Names:
    KIAA1814 GO Gene Synonym
    KMT4 GO Gene Synonym

    Gene Info:

    Gene Categories:
    DNA REPAIR

    Publications:

  • Tempus: DOT1L

    • Version: 11-November-2018

    Alternate Names:
    DOT1L Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • MskImpact: DOT1L

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: DOT1L

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: DOT1L

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21