DGIdb - DNTT Gene Record

DNTT 1791

Alternate Names:

1791
DNA NUCLEOTIDYLEXOTRANSFERASE
DNTT
TDT
187410
2983
ENSG00000107447
OTTHUMG00000018832
BE0004486
P04053

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.7.31
Gene Biotype	PROTEIN_CODING

(1 More Sources)

Gene Categories: Category Details

ENZYME

Publications:

Ross et al., 1979, Loss of terminal deoxynucleotidyl transferase (TdT) activity as a predictor of emergence of resistance to chemotherapy in a case of chronic myelogenous leukemia in blast crisis., Cancer
Takano et al., 1984, Disappearance of terminal deoxynucleotidyltransferase in human malignant T-lymphoblasts treated with a human alpha interferon preparation., Microbiol. Immunol.
Kukhanova et al., 2005, Structural-functional relationships between terminal deoxynucleotidyltransferase and 5'-triphosphates of nucleoside analogs., Biochemistry Mosc.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

2',3'-DIDEOXYADENOSINE TRIPHOSPHATE DNTT

Interaction Score: 45.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
ACYCLOVIR DNTT

Interaction Score: 4.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16212545

Sources:
NCI
CORDYCEPIN DNTT

Interaction Score: 3.79

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name cordycepin

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
HYDROXYUREA DNTT

Interaction Score: 1.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
291471

Sources:
NCI
CETUXIMAB DNTT

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6335218

Sources:
NCI

Ensembl: ENSG00000107447
- Version: 101_38
Alternate Names:

DNTT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P04053
- Version: January-2014
Alternate Names:

DNTT Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.7.31

Publications:

DrugBank: BE0004486

Version: 5.1.7

Alternate Names:

DNTT DrugBank Gene Name

P04053 UniProt Accession

1791 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

NCI: DNTT

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ho et al., 1982, Therapeutic and prognostic implications of glucocorticoid receptors and terminal deoxynucleotidyl transferase in acute leukemia., Leuk. Res.

Ono, 1990, Inhibitory effects of various 2',3'-dideoxynucleoside 5'-triphosphates on the utilization of 2'-deoxynucleoside 5'-triphosphates by terminal deoxynucleotidyltransferase from calf thymus., Biochim. Biophys. Acta

Ross et al., 1979, Loss of terminal deoxynucleotidyl transferase (TdT) activity as a predictor of emergence of resistance to chemotherapy in a case of chronic myelogenous leukemia in blast crisis., Cancer

Pharos: DNTT
- Version: 03-September-2020
Alternate Names:

DNA nucleotidylexotransferase Gene Name

P04053 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

DNTT	DrugBank Gene Name
P04053	UniProt Accession
1791	Entrez Gene Id

Trial Name	cordycepin
Novel drug target	Novel Target

DNTT Gene Record

DNTT 1791

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

2',3'-DIDEOXYADENOSINE TRIPHOSPHATE DNTT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

ACYCLOVIR DNTT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16212545

Sources: NCI

CORDYCEPIN DNTT

Interaction Types & Directionality: n/a

Interaction Info: Trial Name cordycepin Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

HYDROXYUREA DNTT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 291471

Sources: NCI

CETUXIMAB DNTT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6335218

Sources: NCI

Ensembl: ENSG00000107447

Alternate Names: DNTT Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P04053

Alternate Names: DNTT Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.7.7.31

Publications:

DrugBank: BE0004486

Alternate Names: DNTT DrugBank Gene Name P04053 UniProt Accession 1791 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

NCI: DNTT

Alternate Names:

Gene Info:

Pharos: DNTT

Alternate Names: DNA nucleotidylexotransferase Gene Name P04053 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16212545

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name cordycepin

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
291471

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6335218

Sources:
NCI

Alternate Names:

DNTT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

DNTT Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.7.31

Alternate Names:

DNTT DrugBank Gene Name

P04053 UniProt Accession

1791 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Alternate Names:

DNA nucleotidylexotransferase Gene Name

P04053 UniProt ID

Gene Categories:

ENZYME