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DNTT Gene Record

  • Summary
  • Interactions
  • Claims
  • DNTT 1791

    Alternate Names:

    1791
    DNA NUCLEOTIDYLEXOTRANSFERASE
    DNTT
    TDT
    187410
    2983
    ENSG00000107447
    OTTHUMG00000018832
    BE0004486
    P04053

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.7.31
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    ENZYME

    Publications:

    Ross et al., 1979, Loss of terminal deoxynucleotidyl transferase (TdT) activity as a predictor of emergence of resistance to chemotherapy in a case of chronic myelogenous leukemia in blast crisis., Cancer
    Takano et al., 1984, Disappearance of terminal deoxynucleotidyltransferase in human malignant T-lymphoblasts treated with a human alpha interferon preparation., Microbiol. Immunol.
    Kukhanova et al., 2005, Structural-functional relationships between terminal deoxynucleotidyltransferase and 5'-triphosphates of nucleoside analogs., Biochemistry Mosc.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • 2',3'-DIDEOXYADENOSINE TRIPHOSPHATE   DNTT

    Interaction Score: 45.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • ACYCLOVIR   DNTT

    Interaction Score: 4.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16212545


    Sources:
    NCI

  • CORDYCEPIN   DNTT

    Interaction Score: 3.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name cordycepin
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • HYDROXYUREA   DNTT

    Interaction Score: 1.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    291471


    Sources:
    NCI

  • CETUXIMAB   DNTT

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6335218


    Sources:
    NCI

  • Ensembl: ENSG00000107447

    • Version: 101_38

    Alternate Names:
    DNTT Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P04053

    • Version: January-2014

    Alternate Names:
    DNTT Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.7.31

    Publications:

  • DrugBank: BE0004486

    • Version: 5.1.7

    Alternate Names:
    DNTT DrugBank Gene Name
    P04053 UniProt Accession
    1791 Entrez Gene Id

    Gene Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • NCI: DNTT

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ho et al., 1982, Therapeutic and prognostic implications of glucocorticoid receptors and terminal deoxynucleotidyl transferase in acute leukemia., Leuk. Res.
    Ono, 1990, Inhibitory effects of various 2',3'-dideoxynucleoside 5'-triphosphates on the utilization of 2'-deoxynucleoside 5'-triphosphates by terminal deoxynucleotidyltransferase from calf thymus., Biochim. Biophys. Acta
    Ross et al., 1979, Loss of terminal deoxynucleotidyl transferase (TdT) activity as a predictor of emergence of resistance to chemotherapy in a case of chronic myelogenous leukemia in blast crisis., Cancer

  • Pharos: DNTT

    • Version: 03-September-2020

    Alternate Names:
    DNA nucleotidylexotransferase Gene Name
    P04053 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21