DGIdb - DDR2 Gene Record

DDR2 4921 Druggable GenomeClinically Actionable

Alternate Names:

4921
DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASE 2
DDR2
MIG20a
NTRKR3
TKT
TYRO10
191311
2731
ENSG00000162733
OTTHUMG00000034423
Q16832
DDR2_HUMAN
Discoidin domain receptor 2
Tyrosine-protein kinase TYRO10
Receptor protein-tyrosine kinase TKT
Neurotrophic tyrosine kinase, receptor-related 3
Discoidin domain-containing receptor tyrosine kinase 2
CD167 antigen-like family member B
Discoidin domain-containing receptor 2
CD_antigen=CD167b
DISCOIDIN DOMAIN RECEPTOR 2 PRECURSOR (EC 2.7.1.112) (RECEPTOR PROTEIN-TYROSINE KINASE TKT) (TYROSINE-PROTEIN KINASE TYRO 10) (NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16832]
51
T11764
WRCN

Gene Info:

Interpro Type	Domain
Human Readable Name	KINASE
Interpro Acc	IPR001245
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Gene Biotype	PROTEIN_CODING

(13 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Pitini et al., 2013, Response to dasatinib in a patient with SQCC of the lung harboring a discoid-receptor-2 and synchronous chronic myelogenous leukemia., Lung Cancer
Day et al., 2008, Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib., Eur. J. Pharmacol.
Hammerman et al., 2011, Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer., Cancer Discov
Murray CW et al., 2015, Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors., ACS Med Chem Lett

NILOTINIB DDR2

Interaction Score: 2.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26191369

Sources:
DTC
SARACATINIB DDR2

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26191369

Sources:
DTC
ERLOTINIB DDR2

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

Clinical Status case report

Pathway activation

Variant Effect gain-of-function

PMIDs:
22328973 23932362 18938156

Sources:
DoCM CIViC
DASATINIB DDR2

Interaction Score: 1.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Clinical Status preclinical

Pathway activation

Variant Effect gain-of-function

PMIDs:
23932362 18938156 22328973

Sources:
DoCM CIViC MyCancerGenomeClinicalTrial
REGORAFENIB DDR2

Interaction Score: 0.88

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Discoidin domain-containing receptor 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial

Ensembl: ENSG00000162733
- Version: 101_38
Alternate Names:

DDR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q16832
- Version: 11-September-2012
Alternate Names:

DDR2 Uniprot Gene Name

DISCOIDIN DOMAIN-CONTAINING RECEPTOR 2 Uniprot Protein Name

DDR2_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Human Readable Name KINASE

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000162733

Version: 26-July-2011

Alternate Names:

DDR2 Display Id

DISCOIDIN DOMAIN RECEPTOR 2 PRECURSOR (EC 2.7.1.112) (RECEPTOR PROTEIN-TYROSINE KINASE TKT) (TYROSINE-PROTEIN KINASE TYRO 10) (NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16832] Description

ENSG00000162733 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

CIViC: DDR2
- Version: 14-September-2020
Alternate Names:

4921 Entrez Gene ID

51 CIViC Gene ID

Gene Info:

Publications:

Hammerman et al., 2011, Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer., Cancer Discov

DoCM: DDR2

Version: 27-September-2017

Alternate Names:

Gene Info:

Publications:

Hammerman et al., 2011, Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer., Cancer Discov

Pitini et al., 2013, Response to dasatinib in a patient with SQCC of the lung harboring a discoid-receptor-2 and synchronous chronic myelogenous leukemia., Lung Cancer

Day et al., 2008, Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib., Eur. J. Pharmacol.

DTC: DDR2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Murray CW et al., 2015, Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors., ACS Med Chem Lett
HingoraniCasas: ENSG00000162733
- Version: 31-May-2017
Alternate Names:

ENSG00000162733 Gene Symbol

DDR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NTRKR3
- Version: chembl_23
Alternate Names:

TKT GENE_SYMBOL

TYRO10 GENE_SYMBOL

DDR2 GENE_SYMBOL

Gene Info:

Publications:
Tempus: DDR2
- Version: 11-November-2018
Alternate Names:

DDR2 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: DDR2
- Version: 27-Jun-2013
Alternate Names:

4921 Gene ID

MIG20a dGene Synonym

NTRKR3 dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Discoidin domain-containing receptor 2
- Version: 2020.06.01
Alternate Names:

DDR2 TTD Gene Abbreviation

T11764 TTD Target ID

Gene Info:

Publications:
Pharos: DDR2
- Version: 01-February-2022
Alternate Names:

Discoidin domain-containing receptor 2 Gene Name

Q16832 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
MyCancerGenomeClinicalTrial: DDR2
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
MskImpact: DDR2
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: DDR2
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: DDR2
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: DDR2
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Clinical Status	case report
Pathway	activation
Variant Effect	gain-of-function

Clinical Status	preclinical
Pathway	activation
Variant Effect	gain-of-function

Mechanism of Interaction	Discoidin domain-containing receptor 2 inhibitor
Direct Interaction	yes

DDR2	Uniprot Gene Name
DISCOIDIN DOMAIN-CONTAINING RECEPTOR 2	Uniprot Protein Name
DDR2_HUMAN	Uniprot Id

DDR2	Display Id
DISCOIDIN DOMAIN RECEPTOR 2 PRECURSOR (EC 2.7.1.112) (RECEPTOR PROTEIN-TYROSINE KINASE TKT) (TYROSINE-PROTEIN KINASE TYRO 10) (NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16832]	Description
ENSG00000162733	Ensembl Gene Id

Discoidin domain-containing receptor 2	Gene Name
Q16832	UniProt ID

TKT	GENE_SYMBOL
TYRO10	GENE_SYMBOL
DDR2	GENE_SYMBOL

DDR2 Gene Record

DDR2 4921 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

NILOTINIB DDR2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26191369

Sources: DTC

SARACATINIB DDR2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26191369

Sources: DTC

ERLOTINIB DDR2

Interaction Types & Directionality: n/a

Interaction Info: Clinical Status case report Pathway activation Variant Effect gain-of-function

PMIDs: 22328973 23932362 18938156

Sources: DoCM CIViC

DASATINIB DDR2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Clinical Status preclinical Pathway activation Variant Effect gain-of-function

PMIDs: 23932362 18938156 22328973

Sources: DoCM CIViC MyCancerGenomeClinicalTrial

REGORAFENIB DDR2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Discoidin domain-containing receptor 2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions MyCancerGenomeClinicalTrial

Ensembl: ENSG00000162733

Alternate Names: DDR2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q16832

Alternate Names: DDR2 Uniprot Gene Name DISCOIDIN DOMAIN-CONTAINING RECEPTOR 2 Uniprot Protein Name DDR2_HUMAN Uniprot Id

Gene Info: Interpro Type Domain Human Readable Name KINASE Interpro Acc IPR001245

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000162733

Alternate Names: DDR2 Display Id DISCOIDIN DOMAIN RECEPTOR 2 PRECURSOR (EC 2.7.1.112) (RECEPTOR PROTEIN-TYROSINE KINASE TKT) (TYROSINE-PROTEIN KINASE TYRO 10) (NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16832] Description ENSG00000162733 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

CIViC: DDR2

Alternate Names: 4921 Entrez Gene ID 51 CIViC Gene ID

Gene Info:

Publications: Hammerman et al., 2011, Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer., Cancer Discov

DoCM: DDR2

Alternate Names:

Gene Info:

DTC: DDR2

Alternate Names:

Gene Info:

Publications: Murray CW et al., 2015, Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors., ACS Med Chem Lett

HingoraniCasas: ENSG00000162733

Alternate Names: ENSG00000162733 Gene Symbol DDR2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: NTRKR3

Alternate Names: TKT GENE_SYMBOL TYRO10 GENE_SYMBOL DDR2 GENE_SYMBOL

Gene Info:

Publications:

Tempus: DDR2

Alternate Names: DDR2 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

dGene: DDR2

Alternate Names: 4921 Gene ID MIG20a dGene Synonym NTRKR3 dGene Synonym

Gene Info:

Gene Categories: KINASE, TYROSINE KINASE

Publications:

TTD: Discoidin domain-containing receptor 2

Alternate Names: DDR2 TTD Gene Abbreviation T11764 TTD Target ID

Gene Info:

Publications:

Pharos: DDR2

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26191369

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26191369

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Clinical Status case report

Pathway activation

Variant Effect gain-of-function

PMIDs:
22328973 23932362 18938156

Sources:
DoCM CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Clinical Status preclinical

Pathway activation

Variant Effect gain-of-function

PMIDs:
23932362 18938156 22328973

Sources:
DoCM CIViC MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Discoidin domain-containing receptor 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial

Alternate Names:

DDR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

DDR2 Uniprot Gene Name

DISCOIDIN DOMAIN-CONTAINING RECEPTOR 2 Uniprot Protein Name

DDR2_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Human Readable Name KINASE

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

DDR2 Display Id

DISCOIDIN DOMAIN RECEPTOR 2 PRECURSOR (EC 2.7.1.112) (RECEPTOR PROTEIN-TYROSINE KINASE TKT) (TYROSINE-PROTEIN KINASE TYRO 10) (NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16832] Description

ENSG00000162733 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

4921 Entrez Gene ID

51 CIViC Gene ID

Publications:

Hammerman et al., 2011, Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer., Cancer Discov

Publications:

Murray CW et al., 2015, Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors., ACS Med Chem Lett

Alternate Names:

ENSG00000162733 Gene Symbol

DDR2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TKT GENE_SYMBOL

TYRO10 GENE_SYMBOL

DDR2 GENE_SYMBOL

Alternate Names:

DDR2 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

4921 Gene ID

MIG20a dGene Synonym

NTRKR3 dGene Synonym

Gene Categories:

KINASE, TYROSINE KINASE

Alternate Names:

DDR2 TTD Gene Abbreviation

T11764 TTD Target ID

Alternate Names:

Discoidin domain-containing receptor 2 Gene Name

Q16832 UniProt ID

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE