• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

DDIT3 Gene Record

  • Summary
  • Interactions
  • Claims
  • DDIT3 1649 Clinically Actionable

    Alternate Names:

    1649
    DNA DAMAGE INDUCIBLE TRANSCRIPT 3
    DDIT3
    C/EBPzeta
    CEBPZ
    CHOP
    CHOP-10
    CHOP10
    GADD153
    126337
    2726
    ENSG00000175197
    OTTHUMG00000170046
    PA27193
    1413
    AltDDIT3
    P0DPQ6
    DNA damage-inducible transcript 3 protein
    P35638
    DDIT3 upstream open reading frame protein

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    TRANSCRIPTION FACTOR BINDING
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Kouhara et al., 2007, Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines., Int. J. Oncol.
    Lovat et al., 2002, GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma., Cancer Res.
    Gately et al., 1996, Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153., Br. J. Cancer
    Tsutsumi et al., 2004, Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis., Cell Death Differ.
    Carrier et al., 1998, Evidence for distinct kinase-mediated pathways in gadd gene responses., Biochem. Pharmacol.
    Kim et al., Introduction of gadd153 gene into gastric cancer cells can modulate sensitivity to anticancer agents in association with apoptosis., Anticancer Res.
    Johnsson et al., 1999, Expression of GADD153 in tumor cells and stromal cells from xenografted tumors in nude mice treated with cisplatin: correlations with cisplatin-DNA adducts., Cancer Chemother. Pharmacol.
    Namba et al., 2007, Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells., Mol. Pharmacol.
    Niederer et al., 2005, Cypermethrin blocks a mitochondria-dependent apoptotic signal initiated by deficient N-linked glycosylation within the endoplasmic reticulum., Cell. Signal.
    Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis
    Kim et al., 2007, GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells., Carcinogenesis
    Kim et al., 2006, GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells., Carcinogenesis
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Entingh et al., 2001, Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling., Endocrinology
    Eizirik et al., 1993, Genotoxic agents increase expression of growth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets., Diabetes
    Onoda et al., 2001, Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents., Head Neck
    Guyton et al., 1996, Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element., Biochem. J.
    Delmastro et al., 1997, DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell lines., Cancer Chemother. Pharmacol.
    Towndrow et al., 2000, Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E(2) synthesis in renal epithelial cells., Chem. Res. Toxicol.
    Jeong et al., 1996, Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells., Mol. Pharmacol.
    Eymin et al., 1997, Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide., Cancer Res.
    Huang et al., 1999, Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine., Biochem. J.
    Nawrocki et al., 2005, Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells., Cancer Res.
    Oyadomari et al., 2001, Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway., Proc. Natl. Acad. Sci. U.S.A.
    Trautmann M et al., 2017, FUS-DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma., Clin Cancer Res
  • TAXOTERE   DDIT3

    Interaction Score: 4.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10470115


    Sources:
    NCI

  • 6-DIAZO-5-OXO-L-NORLEUCINE   DDIT3

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10377266


    Sources:
    NCI

  • AEW-541   DDIT3

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28637688


    Sources:
    CIViC

  • GLUTAMINE   DDIT3

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10377266


    Sources:
    NCI

  • MANNITOL   DDIT3

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8670069


    Sources:
    NCI

  • PENICILLAMINE   DDIT3

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11526215


    Sources:
    NCI

  • VITAMIN E   DDIT3

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15271854


    Sources:
    NCI

  • DEFEROXAMINE   DDIT3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8794898


    Sources:
    NCI

  • PLATINUM   DDIT3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8996528


    Sources:
    NCI

  • FENRETINIDE   DDIT3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17273769 12234979


    Sources:
    NCI

  • CELECOXIB   DDIT3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17167033 17166886 16597647 15131590 22336956


    Sources:
    NCI PharmGKB

  • DICLOFENAC   DDIT3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15131590


    Sources:
    NCI

  • STAUROSPORINE   DDIT3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17167033


    Sources:
    NCI

  • SURAMIN   DDIT3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9586958


    Sources:
    NCI

  • IBUPROFEN   DDIT3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15131590


    Sources:
    NCI

  • INDOMETHACIN   DDIT3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15131590


    Sources:
    NCI

  • STREPTOZOCIN   DDIT3

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8482431


    Sources:
    NCI

  • NICOTINE   DDIT3

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11592233


    Sources:
    NCI

  • ETOPOSIDE   DDIT3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9044846


    Sources:
    NCI

  • SIROLIMUS   DDIT3

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11145585


    Sources:
    NCI

  • CYCLOSPORINE   DDIT3

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15494209


    Sources:
    NCI

  • CURCUMIN   DDIT3

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15271854


    Sources:
    NCI

  • ASPIRIN   DDIT3

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10688535


    Sources:
    NCI

  • BORTEZOMIB   DDIT3

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16357160


    Sources:
    NCI

  • CISPLATIN   DDIT3

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8554977 10071988


    Sources:
    NCI

  • PACLITAXEL   DDIT3

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8554977


    Sources:
    NCI

  • Ensembl: ENSG00000175197

    • Version: 101_38

    Alternate Names:
    DDIT3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: DDIT3

    • Version: 18-August-2020

    Alternate Names:
    PA27193 PharmGKB ID

    Gene Info:

    Publications:
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • CIViC: DDIT3

    • Version: 14-September-2020

    Alternate Names:
    1649 Entrez Gene ID
    1413 CIViC Gene ID

    Gene Info:

    Publications:
    Trautmann M et al., 2017, FUS-DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma., Clin Cancer Res

  • NCI: DDIT3

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lovat et al., 2002, GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma., Cancer Res.
    Kouhara et al., 2007, Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines., Int. J. Oncol.
    Gately et al., 1996, Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153., Br. J. Cancer

  • GO: DDIT3

    • Version: 01-February-2022

    Alternate Names:
    CHOP GO Gene Synonym
    CHOP10 GO Gene Synonym
    GADD153 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING

    Publications:

  • Pharos: DDIT3

    • Version: 01-February-2022

    Alternate Names:
    DDIT3 upstream open reading frame protein Gene Name
    P0DPQ6 UniProt ID
    DNA damage-inducible transcript 3 protein Gene Name

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • FoundationOneGenes: DDIT3

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: DDIT3

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21