DGIdb - DDIT3 Gene Record

DDIT3 1649 Clinically Actionable

Alternate Names:

1649
DNA DAMAGE INDUCIBLE TRANSCRIPT 3
DDIT3
C/EBPzeta
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
126337
2726
ENSG00000175197
OTTHUMG00000170046
PA27193
1413
AltDDIT3
P35638
DDIT3 upstream open reading frame protein
P0DPQ6
DNA damage-inducible transcript 3 protein

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
TRANSCRIPTION FACTOR BINDING
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Kouhara et al., 2007, Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines., Int. J. Oncol.
Lovat et al., 2002, GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma., Cancer Res.
Gately et al., 1996, Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153., Br. J. Cancer
Tsutsumi et al., 2004, Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis., Cell Death Differ.
Carrier et al., 1998, Evidence for distinct kinase-mediated pathways in gadd gene responses., Biochem. Pharmacol.
Kim et al., Introduction of gadd153 gene into gastric cancer cells can modulate sensitivity to anticancer agents in association with apoptosis., Anticancer Res.
Johnsson et al., 1999, Expression of GADD153 in tumor cells and stromal cells from xenografted tumors in nude mice treated with cisplatin: correlations with cisplatin-DNA adducts., Cancer Chemother. Pharmacol.
Namba et al., 2007, Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells., Mol. Pharmacol.
Niederer et al., 2005, Cypermethrin blocks a mitochondria-dependent apoptotic signal initiated by deficient N-linked glycosylation within the endoplasmic reticulum., Cell. Signal.
Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis
Kim et al., 2007, GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells., Carcinogenesis
Kim et al., 2006, GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells., Carcinogenesis
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Entingh et al., 2001, Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling., Endocrinology
Eizirik et al., 1993, Genotoxic agents increase expression of growth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets., Diabetes
Onoda et al., 2001, Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents., Head Neck
Guyton et al., 1996, Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element., Biochem. J.
Delmastro et al., 1997, DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell lines., Cancer Chemother. Pharmacol.
Towndrow et al., 2000, Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E(2) synthesis in renal epithelial cells., Chem. Res. Toxicol.
Jeong et al., 1996, Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells., Mol. Pharmacol.
Eymin et al., 1997, Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide., Cancer Res.
Huang et al., 1999, Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine., Biochem. J.
Nawrocki et al., 2005, Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells., Cancer Res.
Oyadomari et al., 2001, Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway., Proc. Natl. Acad. Sci. U.S.A.
Trautmann M et al., 2017, FUS-DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma., Clin Cancer Res

TAXOTERE DDIT3

Interaction Score: 4.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10470115

Sources:
NCI
6-DIAZO-5-OXO-L-NORLEUCINE DDIT3

Interaction Score: 2.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10377266

Sources:
NCI
AEW-541 DDIT3

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28637688

Sources:
CIViC
MANNITOL DDIT3

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8670069

Sources:
NCI
PENICILLAMINE DDIT3

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11526215

Sources:
NCI
GLUTAMINE DDIT3

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10377266

Sources:
NCI
VITAMIN E DDIT3

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15271854

Sources:
NCI
DEFEROXAMINE DDIT3

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8794898

Sources:
NCI
PLATINUM DDIT3

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8996528

Sources:
NCI
FENRETINIDE DDIT3

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17273769 12234979

Sources:
NCI
CELECOXIB DDIT3

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17167033 17166886 16597647 15131590 22336956

Sources:
NCI PharmGKB
DICLOFENAC DDIT3

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15131590

Sources:
NCI
IBUPROFEN DDIT3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15131590

Sources:
NCI
INDOMETHACIN DDIT3

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15131590

Sources:
NCI
SURAMIN DDIT3

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9586958

Sources:
NCI
STAUROSPORINE DDIT3

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17167033

Sources:
NCI
STREPTOZOCIN DDIT3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8482431

Sources:
NCI
NICOTINE DDIT3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11592233

Sources:
NCI
ETOPOSIDE DDIT3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9044846

Sources:
NCI
SIROLIMUS DDIT3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11145585

Sources:
NCI
CYCLOSPORINE DDIT3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15494209

Sources:
NCI
CURCUMIN DDIT3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15271854

Sources:
NCI
ASPIRIN DDIT3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10688535

Sources:
NCI
BORTEZOMIB DDIT3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16357160

Sources:
NCI
PACLITAXEL DDIT3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8554977

Sources:
NCI
CISPLATIN DDIT3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8554977 10071988

Sources:
NCI

Ensembl: ENSG00000175197
- Version: 101_38
Alternate Names:

DDIT3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: DDIT3
- Version: 18-August-2020
Alternate Names:

PA27193 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
CIViC: DDIT3
- Version: 14-September-2020
Alternate Names:

1649 Entrez Gene ID

1413 CIViC Gene ID

Gene Info:

Publications:

Trautmann M et al., 2017, FUS-DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma., Clin Cancer Res

NCI: DDIT3

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Lovat et al., 2002, GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma., Cancer Res.

Kouhara et al., 2007, Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines., Int. J. Oncol.

Gately et al., 1996, Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153., Br. J. Cancer

GO: DDIT3
- Version: 01-May-2021
Alternate Names:

CHOP GO Gene Synonym

CHOP10 GO Gene Synonym

GADD153 GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING

Publications:
Pharos: DDIT3
- Version: 01-May-2021
Alternate Names:

DDIT3 upstream open reading frame protein Gene Name

P0DPQ6 UniProt ID

DNA damage-inducible transcript 3 protein Gene Name

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
FoundationOneGenes: DDIT3
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: DDIT3
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

CHOP	GO Gene Synonym
CHOP10	GO Gene Synonym
GADD153	GO Gene Synonym

DDIT3 upstream open reading frame protein	Gene Name
P0DPQ6	UniProt ID
DNA damage-inducible transcript 3 protein	Gene Name

DDIT3 Gene Record

DDIT3 1649 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10470115

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10377266

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28637688

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8670069

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11526215

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10377266

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15271854

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8794898

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8996528

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17273769 12234979

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17167033 17166886 16597647 15131590 22336956

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15131590

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15131590

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15131590

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9586958

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17167033

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8482431

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11592233

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10470115

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10377266

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
28637688

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
8670069

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11526215

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10377266

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15271854

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8794898

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8996528

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17273769 12234979

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17167033 17166886 16597647 15131590 22336956

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15131590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15131590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15131590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9586958

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17167033

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8482431

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11592233

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9044846

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11145585

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15494209

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15271854

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10688535

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16357160

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8554977

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8554977 10071988

Sources:
NCI

Alternate Names:

DDIT3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING