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DBH Gene Record

  • Summary
  • Interactions
  • Claims
  • DBH 1621 Druggable Genome

    Alternate Names:

    1621
    DOPAMINE BETA-HYDROXYLASE
    DBH
    DBM
    609312
    2689
    ENSG00000123454
    OTTHUMG00000020878
    DOPAMINE BETA-MONOOXYGENASE PRECURSOR (EC 1.14.17.1) (DOPAMINE BETA- HYDROXYLASE) (DBH). [SOURCE:UNIPROT/SWISSPROT;ACC:P09172]
    P09172
    DOPO_HUMAN
    SOLUBLE DOPAMINE BETA-HYDROXYLASE
    PA136
    Dopamine beta hydroxylase
    T74937
    ORTHYP1

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:1.14.17
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000323
    Interpro Short Name Cu2_ascorb_mOase_N
    Interpro Name Copper type II, ascorbate-dependent monooxygenase, N-terminal
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
    Redmond et al., The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey., Psychosom Med
    Gaval-Cruz et al., 2009, mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse., Mol. Interv.
    Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol
    Liu S et al., 2014, The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study., Pharmacogenet Genomics
  • NEPICASTAT   DBH

    Interaction Score: 8.83

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name nepicastat, SYN-117
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • SUMATRIPTAN   DBH

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25096645


    Sources:
    PharmGKB

  • NALTREXONE   DBH

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BUPROPION   DBH

    Interaction Score: 1.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22947179


    Sources:
    PharmGKB

  • LEVODOPA   DBH

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24809448


    Sources:
    PharmGKB

  • TESTOSTERONE   DBH

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    824661


    Sources:
    NCI

  • DISULFIRAM   DBH

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19720750


    Sources:
    PharmGKB

  • Ensembl: ENSG00000123454

    • Version: 101_38

    Alternate Names:
    DBH Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P09172

    • Version: January-2014

    Alternate Names:
    DBH Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.17

    Publications:

  • HopkinsGroom: P09172

    • Version: 11-September-2012

    Alternate Names:
    DBH Uniprot Gene Name
    ENSG00000123454 Ensembl Gene Id
    SOLUBLE DOPAMINE BETA-HYDROXYLASE Uniprot Protein Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000323
    Interpro Short Name Cu2_ascorb_mOase_N

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000123454

    • Version: 26-July-2011

    Alternate Names:
    DBH Display Id
    ENSG00000123454 Ensembl Gene Id
    DOPAMINE BETA-MONOOXYGENASE PRECURSOR (EC 1.14.17.1) (DOPAMINE BETA- HYDROXYLASE) (DBH). [SOURCE:UNIPROT/SWISSPROT;ACC:P09172] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: DBH

    • Version: 18-August-2020

    Alternate Names:
    PA136 PharmGKB ID

    Gene Info:

    Publications:
    Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
    Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol
    Randesi M et al., 2018, Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls., Pharmacogenomics

  • NCI: DBH

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Redmond et al., The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey., Psychosom Med

  • HingoraniCasas: ENSG00000123454

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000123454 Gene Symbol
    DBH Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Dopamine beta hydroxylase

    • Version: 2020.06.01

    Alternate Names:
    DBH TTD Gene Abbreviation
    T74937 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: DBH

    • Version: 01-February-2022

    Alternate Names:
    Dopamine beta-hydroxylase Gene Name
    P09172 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21