DGIdb - DBH Gene Record

DBH 1621 Druggable Genome

Alternate Names:

1621
DOPAMINE BETA-HYDROXYLASE
DBH
DBM
609312
2689
ENSG00000123454
OTTHUMG00000020878
DOPAMINE BETA-MONOOXYGENASE PRECURSOR (EC 1.14.17.1) (DOPAMINE BETA- HYDROXYLASE) (DBH). [SOURCE:UNIPROT/SWISSPROT;ACC:P09172]
P09172
DOPO_HUMAN
SOLUBLE DOPAMINE BETA-HYDROXYLASE
PA136
Dopamine beta hydroxylase
T74937
ORTHYP1

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:1.14.17
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000323
Interpro Short Name	Cu2_ascorb_mOase_N
Interpro Name	Copper type II, ascorbate-dependent monooxygenase, N-terminal
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
Redmond et al., The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey., Psychosom Med
Gaval-Cruz et al., 2009, mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse., Mol. Interv.
Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol
Liu S et al., 2014, The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study., Pharmacogenet Genomics

NEPICASTAT DBH

Interaction Score: 8.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name nepicastat, SYN-117

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
SUMATRIPTAN DBH

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25096645

Sources:
PharmGKB
NALTREXONE DBH

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
BUPROPION DBH

Interaction Score: 1.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22947179

Sources:
PharmGKB
LEVODOPA DBH

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24809448

Sources:
PharmGKB
TESTOSTERONE DBH

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
824661

Sources:
NCI
DISULFIRAM DBH

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19720750

Sources:
PharmGKB

Ensembl: ENSG00000123454
- Version: 101_38
Alternate Names:

DBH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P09172
- Version: January-2014
Alternate Names:

DBH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.17

Publications:
HopkinsGroom: P09172
- Version: 11-September-2012
Alternate Names:

DBH Uniprot Gene Name

ENSG00000123454 Ensembl Gene Id

SOLUBLE DOPAMINE BETA-HYDROXYLASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR000323

Interpro Short Name Cu2_ascorb_mOase_N

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000123454

Version: 26-July-2011

Alternate Names:

DBH Display Id

ENSG00000123454 Ensembl Gene Id

DOPAMINE BETA-MONOOXYGENASE PRECURSOR (EC 1.14.17.1) (DOPAMINE BETA- HYDROXYLASE) (DBH). [SOURCE:UNIPROT/SWISSPROT;ACC:P09172] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: DBH

Version: 18-August-2020

Alternate Names:

PA136 PharmGKB ID

Gene Info:

Publications:

Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol

Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol

Randesi M et al., 2018, Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls., Pharmacogenomics

NCI: DBH
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Redmond et al., The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey., Psychosom Med
HingoraniCasas: ENSG00000123454
- Version: 31-May-2017
Alternate Names:

ENSG00000123454 Gene Symbol

DBH Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Dopamine beta hydroxylase
- Version: 2020.06.01
Alternate Names:

DBH TTD Gene Abbreviation

T74937 TTD Target ID

Gene Info:

Publications:
Pharos: DBH
- Version: 01-February-2022
Alternate Names:

Dopamine beta-hydroxylase Gene Name

P09172 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

DBH	Uniprot Gene Name
ENSG00000123454	Ensembl Gene Id
SOLUBLE DOPAMINE BETA-HYDROXYLASE	Uniprot Protein Name

DBH	Display Id
ENSG00000123454	Ensembl Gene Id
DOPAMINE BETA-MONOOXYGENASE PRECURSOR (EC 1.14.17.1) (DOPAMINE BETA- HYDROXYLASE) (DBH). [SOURCE:UNIPROT/SWISSPROT;ACC:P09172]	Description

Trial Name	nepicastat, SYN-117
Novel drug target	Novel Target

DBH Gene Record

DBH 1621 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

NEPICASTAT DBH

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name nepicastat, SYN-117 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

SUMATRIPTAN DBH

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25096645

Sources: PharmGKB

NALTREXONE DBH

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

BUPROPION DBH

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22947179

Sources: PharmGKB

LEVODOPA DBH

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24809448

Sources: PharmGKB

TESTOSTERONE DBH

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 824661

Sources: NCI

DISULFIRAM DBH

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19720750

Sources: PharmGKB

Ensembl: ENSG00000123454

Alternate Names: DBH Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P09172

Alternate Names: DBH Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.14.17

Publications:

HopkinsGroom: P09172

Alternate Names: DBH Uniprot Gene Name ENSG00000123454 Ensembl Gene Id SOLUBLE DOPAMINE BETA-HYDROXYLASE Uniprot Protein Name

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR000323 Interpro Short Name Cu2_ascorb_mOase_N

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000123454

Alternate Names: DBH Display Id ENSG00000123454 Ensembl Gene Id DOPAMINE BETA-MONOOXYGENASE PRECURSOR (EC 1.14.17.1) (DOPAMINE BETA- HYDROXYLASE) (DBH). [SOURCE:UNIPROT/SWISSPROT;ACC:P09172] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: DBH

Alternate Names: PA136 PharmGKB ID

Gene Info:

NCI: DBH

Alternate Names:

Gene Info:

Publications: Redmond et al., The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey., Psychosom Med

HingoraniCasas: ENSG00000123454

Alternate Names: ENSG00000123454 Gene Symbol DBH Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Dopamine beta hydroxylase

Alternate Names: DBH TTD Gene Abbreviation T74937 TTD Target ID

Gene Info:

Publications:

Pharos: DBH

Alternate Names: Dopamine beta-hydroxylase Gene Name P09172 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name nepicastat, SYN-117

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
25096645

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22947179

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24809448

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
824661

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19720750

Sources:
PharmGKB

Alternate Names:

DBH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

DBH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.17

Alternate Names:

DBH Uniprot Gene Name

ENSG00000123454 Ensembl Gene Id

SOLUBLE DOPAMINE BETA-HYDROXYLASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR000323

Interpro Short Name Cu2_ascorb_mOase_N

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

DBH Display Id

ENSG00000123454 Ensembl Gene Id

DOPAMINE BETA-MONOOXYGENASE PRECURSOR (EC 1.14.17.1) (DOPAMINE BETA- HYDROXYLASE) (DBH). [SOURCE:UNIPROT/SWISSPROT;ACC:P09172] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA136 PharmGKB ID

Publications:

Redmond et al., The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey., Psychosom Med

Alternate Names:

ENSG00000123454 Gene Symbol

DBH Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

DBH TTD Gene Abbreviation

T74937 TTD Target ID

Alternate Names:

Dopamine beta-hydroxylase Gene Name

P09172 UniProt ID

Gene Categories:

ENZYME