DGIdb - CYP7B1 Gene Record

CYP7B1 9420 Druggable Genome

Alternate Names:

9420
CYTOCHROME P450 FAMILY 7 SUBFAMILY B MEMBER 1
CYP7B1
CBAS3
CP7B
SPG5A
603711
2652
ENSG00000172817
OTTHUMG00000164387
O75881
25-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE
CP7B1_HUMAN
CYTOCHROME P450 7B1 (OXYSTEROL 7-ALPHA-HYDROXYLASE) (EC 1.14.13.-). [SOURCE:UNIPROT/SWISSPROT;ACC:O75881]

Gene Info:

Interpro Name	Cytochrome P450
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001128
Interpro Short Name	Cyt_P450
Human Readable Name	CYTOCHROME P450
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CYTOCHROME P450
ENZYME

Publications:

Oyekan et al., 1994, Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors., J. Pharmacol. Exp. Ther.
Prasad et al., 1990, Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats., Biochem. Pharmacol.
Goeptar et al., 1994, Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450., Cancer Res.
Chatterjee et al., 2005, Influence of the Ginkgo extract EGb 761 on rat liver cytochrome P450 and steroid metabolism and excretion in rats and man., J. Pharm. Pharmacol.
Caris-Veyrat et al., 2003, Cleavage products of lycopene produced by in vitro oxidations: characterization and mechanisms of formation., J. Agric. Food Chem.
Bergman et al., 1999, Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb., Toxicol. Appl. Pharmacol.
Uchida et al., 2004, An aromatase inhibitor or high water temperature induce oocyte apoptosis and depletion of P450 aromatase activity in the gonads of genetic female zebrafish during sex-reversal., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
Cheng et al., 1976, Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria., Endocrinology
Barnett et al., 1993, Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins., Biochem. Pharmacol.
Boffito et al., 2002, Pharmacokinetics of saquinavir co-administered with cimetidine., J. Antimicrob. Chemother.

GINKGO CYP7B1

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15901353

Sources:
NCI
FADROZOLE CYP7B1

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14720586

Sources:
NCI
SAQUINAVIR CYP7B1

Interaction Score: 1.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12461038

Sources:
NCI
LYCOPENE CYP7B1

Interaction Score: 1.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14640578

Sources:
NCI
DIAZOXIDE CYP7B1

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8301566

Sources:
NCI
METHIMAZOLE CYP7B1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10053173

Sources:
NCI
SPIRONOLACTONE CYP7B1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
976190

Sources:
NCI
ADRIAMYCIN CYP7B1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8162589

Sources:
NCI
ACETAMINOPHEN CYP7B1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2242029

Sources:
NCI
STREPTOZOCIN CYP7B1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8435090

Sources:
NCI

Ensembl: ENSG00000172817
- Version: 101_38
Alternate Names:

CYP7B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000172817
- Version: 26-July-2011
Alternate Names:

ENSG00000172817 Ensembl Gene Id

CYP7B1 Display Id

CYTOCHROME P450 7B1 (OXYSTEROL 7-ALPHA-HYDROXYLASE) (EC 1.14.13.-). [SOURCE:UNIPROT/SWISSPROT;ACC:O75881] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: O75881
- Version: 11-September-2012
Alternate Names:

O75881 Uniprot Accession

ENSG00000172817 Ensembl Gene Id

CP7B1_HUMAN Uniprot Id

Gene Info:

Interpro Name Cytochrome P450

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Publications:

NCI: CYP7B1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Oyekan et al., 1994, Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors., J. Pharmacol. Exp. Ther.

Prasad et al., 1990, Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats., Biochem. Pharmacol.

Goeptar et al., 1994, Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450., Cancer Res.

HingoraniCasas: ENSG00000172817
- Version: 31-May-2017
Alternate Names:

ENSG00000172817 Gene Symbol

CYP7B1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: CYP7B1
- Version: 19.3
Alternate Names:

ENSG00000172817 Ensembl Gene ID

SPG5A Human Protein Atlas Gene Synonym

Cytochrome P450 family 7 subfamily B member 1 Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: CYP7B1
- Version: 01-February-2022
Alternate Names:

25-hydroxycholesterol 7-alpha-hydroxylase Gene Name

O75881 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ENSG00000172817	Ensembl Gene Id
CYP7B1	Display Id
CYTOCHROME P450 7B1 (OXYSTEROL 7-ALPHA-HYDROXYLASE) (EC 1.14.13.-). [SOURCE:UNIPROT/SWISSPROT;ACC:O75881]	Description

O75881	Uniprot Accession
ENSG00000172817	Ensembl Gene Id
CP7B1_HUMAN	Uniprot Id

25-hydroxycholesterol 7-alpha-hydroxylase	Gene Name
O75881	UniProt ID

CYP7B1 Gene Record

CYP7B1 9420 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15901353

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14720586

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12461038

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14640578

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8301566

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10053173

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 976190

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8162589

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2242029

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8435090

Sources: NCI

Ensembl: ENSG00000172817

Alternate Names: CYP7B1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000172817

Alternate Names: ENSG00000172817 Ensembl Gene Id CYP7B1 Display Id CYTOCHROME P450 7B1 (OXYSTEROL 7-ALPHA-HYDROXYLASE) (EC 1.14.13.-). [SOURCE:UNIPROT/SWISSPROT;ACC:O75881] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: O75881

Alternate Names: O75881 Uniprot Accession ENSG00000172817 Ensembl Gene Id CP7B1_HUMAN Uniprot Id

Gene Info: Interpro Name Cytochrome P450 Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot

Gene Categories: DRUGGABLE GENOME, CYTOCHROME P450

Publications:

NCI: CYP7B1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000172817

Alternate Names: ENSG00000172817 Gene Symbol CYP7B1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: CYP7B1

Alternate Names: ENSG00000172817 Ensembl Gene ID SPG5A Human Protein Atlas Gene Synonym Cytochrome P450 family 7 subfamily B member 1 Human Protein Atlas Gene Description

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: CYP7B1

Alternate Names: 25-hydroxycholesterol 7-alpha-hydroxylase Gene Name O75881 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
15901353

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14720586

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12461038

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14640578

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8301566

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10053173

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
976190

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8162589

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2242029

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8435090

Sources:
NCI

Alternate Names:

CYP7B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000172817 Ensembl Gene Id

CYP7B1 Display Id

CYTOCHROME P450 7B1 (OXYSTEROL 7-ALPHA-HYDROXYLASE) (EC 1.14.13.-). [SOURCE:UNIPROT/SWISSPROT;ACC:O75881] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

O75881 Uniprot Accession

ENSG00000172817 Ensembl Gene Id

CP7B1_HUMAN Uniprot Id

Gene Info:

Interpro Name Cytochrome P450

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Alternate Names:

ENSG00000172817 Gene Symbol

CYP7B1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000172817 Ensembl Gene ID

SPG5A Human Protein Atlas Gene Synonym

Cytochrome P450 family 7 subfamily B member 1 Human Protein Atlas Gene Description

Gene Categories:

ENZYME

Alternate Names:

25-hydroxycholesterol 7-alpha-hydroxylase Gene Name

O75881 UniProt ID

Gene Categories:

ENZYME