DGIdb - CYP51A1 Gene Record

CYP51A1 1595 Druggable Genome

Alternate Names:

1595
CYTOCHROME P450 FAMILY 51 SUBFAMILY A MEMBER 1
CYP51A1
CP51
CYP51
CYPL1
LDM
P450-14DM
P450L1
601637
2649
ENSG00000001630
OTTHUMG00000131131
CYTOCHROME P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (LDM) (P450-14DM) (P45014DM). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16850]
1374
Q16850
BE0000875
CP51A_HUMAN
LANOSTEROL 14-ALPHA DEMETHYLASE
T32972

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	CYTOCHROME P450
Interpro Short Name	Cyt_P450
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Name	Cytochrome P450
Interpro Acc	IPR001128
GuideToPharmacology Gene Category Name	CYP39, CYP46 and CYP51 families
GuideToPharmacology Gene Category ID	268
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CYTOCHROME P450
ENZYME

Publications:

Fliri et al., 2005, Biological spectra analysis: Linking biological activity profiles to molecular structure., Proc. Natl. Acad. Sci. U.S.A.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Kelley et al., 2002, Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia., Am. J. Med. Genet.
Carrillo-Muñoz et al., 2006, Antifungal agents: mode of action in yeast cells., Rev Esp Quimioter
Cotrim et al., 1999, Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection., J. Biol. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

TIOCONAZOLE CYP51A1

Interaction Score: 28.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15625110 10592235 17139284 17016423

Sources:
DrugBank
LEVOKETOCONAZOLE CYP51A1

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
AZALANSTAT CYP51A1

Interaction Score: 5.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
ITRACONAZOLE CYP51A1

Interaction Score: 4.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16964330 10608831 11752352

Sources:
DrugBank
FLUCONAZOLE CYP51A1

Interaction Score: 2.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12116245

Sources:
NCI

Ensembl: ENSG00000001630
- Version: 101_38
Alternate Names:

CYP51A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000001630

Version: 26-July-2011

Alternate Names:

CYP51A1 Display Id

CYTOCHROME P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (LDM) (P450-14DM) (P45014DM). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16850] Description

ENSG00000001630 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q16850
- Version: 11-September-2012
Alternate Names:

Q16850 Uniprot Accession

ENSG00000001630 Ensembl Gene Id

LANOSTEROL 14-ALPHA DEMETHYLASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name CYTOCHROME P450

Interpro Short Name Cyt_P450

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Publications:
GuideToPharmacology: 1595
- Version: 29-September-2020
Alternate Names:

2649 HUGO Gene ID

2649 HUGO Gene Symbol

cytochrome P450 family 51 subfamily A member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CYP39, CYP46 and CYP51 families

GuideToPharmacology Gene Category ID 268

Gene Categories:

ENZYME

Publications:

DrugBank: BE0000875

Version: 5.1.7

Alternate Names:

CYP51A1 DrugBank Gene Name

Q16850 UniProt Accession

1595 Entrez Gene Id

Gene Info:

Publications:

Fliri et al., 2005, Biological spectra analysis: Linking biological activity profiles to molecular structure., Proc. Natl. Acad. Sci. U.S.A.

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

NCI: CYP51A1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Kelley et al., 2002, Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia., Am. J. Med. Genet.
HingoraniCasas: ENSG00000001630
- Version: 31-May-2017
Alternate Names:

ENSG00000001630 Gene Symbol

CYP51A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: CYP51A1
- Version: 03-September-2020
Alternate Names:

Lanosterol 14-alpha demethylase Gene Name

Q16850 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Lanosterol 14-alpha demethylase
- Version: 2020.06.01
Alternate Names:

CYP51A1 TTD Gene Abbreviation

T32972 TTD Target ID

Gene Info:

Publications:

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

CYP51A1	Display Id
CYTOCHROME P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (LDM) (P450-14DM) (P45014DM). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16850]	Description
ENSG00000001630	Ensembl Gene Id

Q16850	Uniprot Accession
ENSG00000001630	Ensembl Gene Id
LANOSTEROL 14-ALPHA DEMETHYLASE	Uniprot Protein Name

2649	HUGO Gene ID
2649	HUGO Gene Symbol
cytochrome P450 family 51 subfamily A member 1	HUGO Gene Name

CYP51A1	DrugBank Gene Name
Q16850	UniProt Accession
1595	Entrez Gene Id

CYP51A1 Gene Record

CYP51A1 1595 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

TIOCONAZOLE CYP51A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15625110 10592235 17139284 17016423

Sources: DrugBank

LEVOKETOCONAZOLE CYP51A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

AZALANSTAT CYP51A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

ITRACONAZOLE CYP51A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 16964330 10608831 11752352

Sources: DrugBank

FLUCONAZOLE CYP51A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12116245

Sources: NCI

Ensembl: ENSG00000001630

Alternate Names: CYP51A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000001630

Alternate Names: CYP51A1 Display Id CYTOCHROME P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (LDM) (P450-14DM) (P45014DM). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16850] Description ENSG00000001630 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q16850

Alternate Names: Q16850 Uniprot Accession ENSG00000001630 Ensembl Gene Id LANOSTEROL 14-ALPHA DEMETHYLASE Uniprot Protein Name

Gene Info: Uniprot Evidence 1: Evidence at protein level Human Readable Name CYTOCHROME P450 Interpro Short Name Cyt_P450

Gene Categories: DRUGGABLE GENOME, CYTOCHROME P450

Publications:

GuideToPharmacology: 1595

Alternate Names: 2649 HUGO Gene ID 2649 HUGO Gene Symbol cytochrome P450 family 51 subfamily A member 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name CYP39, CYP46 and CYP51 families GuideToPharmacology Gene Category ID 268

Gene Categories: ENZYME

Publications:

DrugBank: BE0000875

Alternate Names: CYP51A1 DrugBank Gene Name Q16850 UniProt Accession 1595 Entrez Gene Id

Gene Info:

Publications: Fliri et al., 2005, Biological spectra analysis: Linking biological activity profiles to molecular structure., Proc. Natl. Acad. Sci. U.S.A. Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

NCI: CYP51A1

Alternate Names:

Gene Info:

Publications: Kelley et al., 2002, Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia., Am. J. Med. Genet.

HingoraniCasas: ENSG00000001630

Alternate Names: ENSG00000001630 Gene Symbol CYP51A1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: CYP51A1

Alternate Names: Lanosterol 14-alpha demethylase Gene Name Q16850 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

TTD: Lanosterol 14-alpha demethylase

Alternate Names: CYP51A1 TTD Gene Abbreviation T32972 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15625110 10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16964330 10608831 11752352

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12116245

Sources:
NCI

Alternate Names:

CYP51A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CYP51A1 Display Id

CYTOCHROME P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (LDM) (P450-14DM) (P45014DM). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16850] Description

ENSG00000001630 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Q16850 Uniprot Accession

ENSG00000001630 Ensembl Gene Id

LANOSTEROL 14-ALPHA DEMETHYLASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name CYTOCHROME P450

Interpro Short Name Cyt_P450

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Alternate Names:

2649 HUGO Gene ID

2649 HUGO Gene Symbol

cytochrome P450 family 51 subfamily A member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CYP39, CYP46 and CYP51 families

GuideToPharmacology Gene Category ID 268

Gene Categories:

ENZYME

Alternate Names:

CYP51A1 DrugBank Gene Name

Q16850 UniProt Accession

1595 Entrez Gene Id

Publications:

Kelley et al., 2002, Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia., Am. J. Med. Genet.

Alternate Names:

ENSG00000001630 Gene Symbol

CYP51A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Lanosterol 14-alpha demethylase Gene Name

Q16850 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

CYP51A1 TTD Gene Abbreviation

T32972 TTD Target ID