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CYP3A7 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYP3A7 1551 Druggable Genome

    Alternate Names:

    1551
    CYTOCHROME P450 FAMILY 3 SUBFAMILY A MEMBER 7
    CYP3A7
    CP37
    CYPIIIA7
    P-450(HFL33)
    P-450111A7
    P450-HFLA
    605340
    2640
    ENSG00000160870
    OTTHUMG00000156726
    CYTOCHROME P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA). [SOURCE:UNIPROT/SWISSPROT;ACC:P24462]
    P24462
    Cytochrome P450-HFLA
    Cytochrome P450 3A7
    1339
    PA122
    CP3A7_HUMAN
    BE0003612

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:1.14.14.1
    GuideToPharmacology Gene Category Name CYP3 family
    GuideToPharmacology Gene Category ID 263
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Human Readable Name CYTOCHROME P450
    Interpro Name Cytochrome P450
    Interpro Type Family
    Interpro Acc IPR001128
    Interpro Short Name Cyt_P450
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    ENZYME

    Publications:

    Lazorwitz A et al., 2019, Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users., Obstet Gynecol
    Pasanen et al., 1988, Inhibition of human hepatic and placental xenobiotic monooxygenases by imidazole antimycotics., Biochem. Pharmacol.
    Tu et al., 1996, Inhibitory effects of quinidine and quinine on liver microsome oxidation enzymes in man and rat., Zhongguo Yao Li Xue Bao
    Awney et al., 2002, Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1)., Toxicology
    Knops N et al., 2017, Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation., Br J Clin Pharmacol
    Rettie et al., 1985, Stereoselective and regioselective hydroxylation of warfarin and selective O-dealkylation of phenoxazone ethers in human placenta., Biochem. Biophys. Res. Commun.
    Sun B et al., 2017, Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients., Pharmacogenomics
    Stout SM et al., 2014, Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review., Drug Metab Rev
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
  • ETONOGESTREL   CYP3A7

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30870275


    Sources:
    PharmGKB

  • COBICISTAT   CYP3A7

    Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cytochrome P450 3A inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUININE   CYP3A7

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9863152


    Sources:
    NCI

  • TESMILIFENE   CYP3A7

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name tesmilifene
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MICONAZOLE   CYP3A7

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3263862


    Sources:
    NCI

  • QUINIDINE   CYP3A7

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9863152


    Sources:
    NCI

  • CANNABIDIOL   CYP3A7

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24160757 26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CYP3A7

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24160757 26264914


    Sources:
    DrugBank

  • TACROLIMUS   CYP3A7

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27966227


    Sources:
    PharmGKB

  • MELATONIN   CYP3A7

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11882353


    Sources:
    NCI

  • WARFARIN   CYP3A7

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3977899


    Sources:
    NCI

  • CYCLOSPORINE   CYP3A7

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28952408


    Sources:
    PharmGKB

  • Ensembl: ENSG00000160870

    • Version: 101_38

    Alternate Names:
    CYP3A7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000160870

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000160870 Ensembl Gene Id
    CYP3A7 Display Id
    CYTOCHROME P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA). [SOURCE:UNIPROT/SWISSPROT;ACC:P24462] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P24462

    • Version: January-2014

    Alternate Names:
    CYP3A7 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.14.1

    Publications:

  • HopkinsGroom: P24462

    • Version: 11-September-2012

    Alternate Names:
    P24462 Uniprot Accession
    ENSG00000160870 Ensembl Gene Id
    CYP3A7 Uniprot Gene Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • GuideToPharmacology: 1551

    • Version: 29-September-2020

    Alternate Names:
    2640 HUGO Gene ID
    2640 HUGO Gene Symbol
    cytochrome P450 family 3 subfamily A member 7 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name CYP3 family
    GuideToPharmacology Gene Category ID 263

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: CYP3A7

    • Version: 18-August-2020

    Alternate Names:
    PA122 PharmGKB ID

    Gene Info:

    Publications:
    Sun B et al., 2017, Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients., Pharmacogenomics
    Lazorwitz A et al., 2019, Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users., Obstet Gynecol
    Knops N et al., 2017, Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation., Br J Clin Pharmacol

  • DrugBank: BE0003612

    • Version: 5.1.7

    Alternate Names:
    CYP3A7 DrugBank Gene Name
    P24462 UniProt Accession
    1551 Entrez Gene Id

    Gene Info:

    Publications:
    Stout SM et al., 2014, Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review., Drug Metab Rev
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

  • NCI: CYP3A7

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lee et al., 1980, Hormonal regulation of cytochrome P-450-dependent monooxygenase activity and epoxide-metabolizing enzyme activities in testis of hypophysectomized rats., Cancer Res.
    Tu et al., 1996, Inhibitory effects of quinidine and quinine on liver microsome oxidation enzymes in man and rat., Zhongguo Yao Li Xue Bao
    Pasanen et al., 1988, Inhibition of human hepatic and placental xenobiotic monooxygenases by imidazole antimycotics., Biochem. Pharmacol.

  • HingoraniCasas: ENSG00000160870

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000160870 Gene Symbol
    CYP3A7 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CYP3A7

    • Version: chembl_23

    Alternate Names:
    CYP3A7 GENE_SYMBOL
    Cytochrome P450 3A7 UNIPROT
    CYPIIIA7 UNIPROT

    Gene Info:

    Publications:

  • Pharos: CYP3A7

    • Version: 03-September-2020

    Alternate Names:
    Cytochrome P450 3A7 Gene Name
    P24462 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21