DGIdb - CYP1B1 Gene Record

CYP1B1 1545 Druggable Genome

Alternate Names:

1545
CYTOCHROME P450 FAMILY 1 SUBFAMILY B MEMBER 1
CYP1B1
ASGD6
CP1B
CYPIB1
GLC3A
P4501B1
601771
2597
ENSG00000138061
OTTHUMG00000100970
1320
Q16678
PA27094
BE0001111
CP1B1_HUMAN
CYTOCHROME P450 1B1
CYTOCHROME P450 1B1 (EC 1.14.14.1) (CYPIB1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16678]
T92521

Gene Info:

GuideToPharmacology Gene Category Name	CYP1 family
GuideToPharmacology Gene Category ID	261
Target Class	Enzymes
Target Subclass	EC:1.14.14.1
Interpro Acc	IPR001128
Interpro Short Name	Cyt_P450
Interpro Name	Cytochrome P450
Human Readable Name	CYTOCHROME P450
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CYTOCHROME P450
ENZYME

Publications:

Rahman et al., 2008, CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma., Drug Metab. Dispos.
Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
Abraham JE et al., 2014, Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel., Clin Cancer Res
Le Morvan V et al., 2015, Identification of SNPs associated with response of breast cancer patients to neoadjuvant chemotherapy in the EORTC-10994 randomized phase III trial., Pharmacogenomics J
Androutsopoulos VP et al., 2011, Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids., Bioorg Med Chem
Pyykkö et al., 1994, Aryl hydrocarbon hydroxylase activity in chemically induced and toremifene-treated mammary tumors in rats., Int. J. Cancer
Liu J et al., 2013, Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1., J Med Chem
Tu et al., 1983, Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol., Chem. Biol. Interact.
Fujita et al., 1982, Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities., Res. Commun. Chem. Pathol. Pharmacol.
Wu et al., 1983, Non-competitive inhibition of hepatic and intestinal aryl hydrocarbon hydroxylase activities from rats by rifampin., J. Nat. Prod.
Shimada T et al., 2010, Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives., Chem Res Toxicol
Bulun et al., 2000, Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues., Am. J. Obstet. Gynecol.
Dawling et al., 2003, Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1., Cancer Res.
Shimada T et al., 2009, Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study., Chem Res Toxicol
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
Stout SM et al., 2014, Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review., Drug Metab Rev

2'H,4H-[2,5'-BICHROMEN]-4-ONE CYP1B1

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23600958

Sources:
DTC
CHEMBL2347759 CYP1B1

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23600958

Sources:
DTC
2'H,4H-[2,8'-BICHROMEN]-4-ONE CYP1B1

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23600958

Sources:
DTC
PINOCEMBRIN CYP1B1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BETA-NAPHTHOFLAVONE CYP1B1

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19563207 23600958

Sources:
DTC DrugBank
ISOPROPYL ALCOHOL CYP1B1

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6409434

Sources:
NCI
FORMESTANE CYP1B1

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18256205

Sources:
NCI
FLAVONE CYP1B1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19563207 21053930

Sources:
DrugBank
FADROZOLE CYP1B1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18256205

Sources:
NCI
AMINOGLUTETHIMIDE CYP1B1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18256205

Sources:
NCI
NARINGENIN CYP1B1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21053930

Sources:
TTD DrugBank
ALPHA-NAPHTHOFLAVONE CYP1B1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23600958

Sources:
DTC
TOREMIFENE CYP1B1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8262671

Sources:
NCI
AMODIAQUINE CYP1B1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CHRYSIN CYP1B1

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
23600958

Sources:
DTC GuideToPharmacology
MEDROXYPROGESTERONE ACETATE CYP1B1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10764452

Sources:
NCI
EXEMESTANE CYP1B1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18256205

Sources:
NCI
ANASTROZOLE CYP1B1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18256205

Sources:
NCI
LETROZOLE CYP1B1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18256205

Sources:
NCI
2-METHOXYESTRADIOL CYP1B1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12810639

Sources:
DrugBank
ACACETIN CYP1B1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21482471

Sources:
DTC
EPIRUBICIN CYP1B1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24599932 24958282

Sources:
PharmGKB
RIFAMPIN CYP1B1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6854335

Sources:
NCI
SPIRONOLACTONE CYP1B1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7079590

Sources:
NCI
CANNABIDIOL CYP1B1

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
24160757 26264914

Sources:
DrugBank
NABIXIMOLS CYP1B1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank
CYCLOPHOSPHAMIDE CYP1B1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24599932 24958282

Sources:
PharmGKB
GENISTEIN CYP1B1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21053930

Sources:
DrugBank
PACLITAXEL CYP1B1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21151855 24599932

Sources:
PharmGKB
DOCETAXEL CYP1B1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21151855

Sources:
PharmGKB
QUERCETIN CYP1B1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21053930

Sources:
DrugBank
FLUOROURACIL CYP1B1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24958282

Sources:
PharmGKB
RISPERIDONE CYP1B1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DOXORUBICIN CYP1B1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000138061
- Version: 101_38
Alternate Names:

CYP1B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000138061
- Version: 26-July-2011
Alternate Names:

CYP1B1 Display Id

CYTOCHROME P450 1B1 (EC 1.14.14.1) (CYPIB1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16678] Description

ENSG00000138061 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q16678
- Version: January-2014
Alternate Names:

CYP1B1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.14.1

Publications:
HopkinsGroom: Q16678
- Version: 11-September-2012
Alternate Names:

CYTOCHROME P450 1B1 Uniprot Protein Name

CYP1B1 Uniprot Gene Name

1545 Entrez Gene Id

Gene Info:

Interpro Acc IPR001128

Interpro Short Name Cyt_P450

Interpro Name Cytochrome P450

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Publications:
GuideToPharmacology: 1545
- Version: 29-September-2020
Alternate Names:

2597 HUGO Gene ID

2597 HUGO Gene Symbol

cytochrome P450 family 1 subfamily B member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CYP1 family

GuideToPharmacology Gene Category ID 261

Gene Categories:

ENZYME

Publications:

PharmGKB: CYP1B1

Version: 18-August-2020

Alternate Names:

PA27094 PharmGKB ID

Gene Info:

Publications:

Le Morvan V et al., 2015, Identification of SNPs associated with response of breast cancer patients to neoadjuvant chemotherapy in the EORTC-10994 randomized phase III trial., Pharmacogenomics J

Abraham JE et al., 2014, Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel., Clin Cancer Res

Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics

DrugBank: BE0001111

Version: 5.1.7

Alternate Names:

CYP1B1 DrugBank Gene Name

Q16678 UniProt Accession

1545 Entrez Gene Id

Gene Info:

Publications:

Dawling et al., 2003, Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1., Cancer Res.

Shimada T et al., 2010, Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives., Chem Res Toxicol

Shimada T et al., 2009, Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study., Chem Res Toxicol

NCI: CYP1B1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Rahman et al., 2008, CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma., Drug Metab. Dispos.

Korsova et al., [The cytochrome P-450-dependent mono-oxygenase system of the liver and interleukin-1 production by the macrophages in adjuvant arthritis in rats under the influence of beta-carotene]., Eksp Klin Farmakol

Wu et al., 1983, Non-competitive inhibition of hepatic and intestinal aryl hydrocarbon hydroxylase activities from rats by rifampin., J. Nat. Prod.

DTC: CYP1B1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Liu J et al., 2013, Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1., J Med Chem

Androutsopoulos VP et al., 2011, Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids., Bioorg Med Chem

HingoraniCasas: ENSG00000138061
- Version: 31-May-2017
Alternate Names:

ENSG00000138061 Gene Symbol

CYP1B1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: CYP1B1
- Version: 19.3
Alternate Names:

ENSG00000138061 Ensembl Gene ID

CP1B Human Protein Atlas Gene Synonym

GLC3A Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: CYP1B1
- Version: 03-September-2020
Alternate Names:

Cytochrome P450 1B1 Gene Name

Q16678 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: CYP1B1
- Version: 11-November-2018
Alternate Names:

CYP1B1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Cytochrome P450 1B1
- Version: 2020.06.01
Alternate Names:

CYP1B1 TTD Gene Abbreviation

T92521 TTD Target ID

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

CYP1B1	Display Id
CYTOCHROME P450 1B1 (EC 1.14.14.1) (CYPIB1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16678]	Description
ENSG00000138061	Ensembl Gene Id

CYTOCHROME P450 1B1	Uniprot Protein Name
CYP1B1	Uniprot Gene Name
1545	Entrez Gene Id

2597	HUGO Gene ID
2597	HUGO Gene Symbol
cytochrome P450 family 1 subfamily B member 1	HUGO Gene Name

CYP1B1	DrugBank Gene Name
Q16678	UniProt Accession
1545	Entrez Gene Id

CYP1B1 Gene Record

CYP1B1 1545 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23600958

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23600958

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23600958

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19563207 23600958

Sources: DTC DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6409434

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18256205

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19563207 21053930

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18256205

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18256205

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21053930

Sources: TTD DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23600958

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8262671

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 23600958

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10764452

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18256205

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18256205

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
23600958

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23600958

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23600958

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
19563207 23600958

Sources:
DTC DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
6409434

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18256205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19563207 21053930

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
18256205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18256205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21053930

Sources:
TTD DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23600958

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
8262671

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
23600958

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10764452

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18256205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18256205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18256205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12810639

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21482471

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24599932 24958282

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
6854335

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7079590

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
24160757 26264914

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26264914

Sources:
DrugBank

Interaction Types & Directionality:

n/a