• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

CYP1B1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYP1B1 1545 Druggable Genome

    Alternate Names:

    1545
    CYTOCHROME P450 FAMILY 1 SUBFAMILY B MEMBER 1
    CYP1B1
    ASGD6
    CP1B
    CYPIB1
    GLC3A
    P4501B1
    601771
    2597
    ENSG00000138061
    OTTHUMG00000100970
    Q16678
    PA27094
    CP1B1_HUMAN
    CYTOCHROME P450 1B1
    CYTOCHROME P450 1B1 (EC 1.14.14.1) (CYPIB1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16678]
    T92521

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:1.14.14.1
    Interpro Acc IPR001128
    Interpro Short Name Cyt_P450
    Interpro Name Cytochrome P450
    Human Readable Name CYTOCHROME P450
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    ENZYME

    Publications:

    Rahman et al., 2008, CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma., Drug Metab. Dispos.
    Abraham JE et al., 2014, Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel., Clin Cancer Res
    Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
    Le Morvan V et al., 2015, Identification of SNPs associated with response of breast cancer patients to neoadjuvant chemotherapy in the EORTC-10994 randomized phase III trial., Pharmacogenomics J
    Androutsopoulos VP et al., 2011, Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids., Bioorg Med Chem
    Pyykkö et al., 1994, Aryl hydrocarbon hydroxylase activity in chemically induced and toremifene-treated mammary tumors in rats., Int. J. Cancer
    Liu J et al., 2013, Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1., J Med Chem
    Tu et al., 1983, Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol., Chem. Biol. Interact.
    Fujita et al., 1982, Effect of spironolactone on hepatic microsomal monooxygenase and azoreductase activities., Res. Commun. Chem. Pathol. Pharmacol.
    Wu et al., 1983, Non-competitive inhibition of hepatic and intestinal aryl hydrocarbon hydroxylase activities from rats by rifampin., J. Nat. Prod.
    Shimada T et al., 2010, Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives., Chem Res Toxicol
    Bulun et al., 2000, Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues., Am. J. Obstet. Gynecol.
    Shimada T et al., 2009, Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study., Chem Res Toxicol
  • 2'H,4H-[2,5'-BICHROMEN]-4-ONE   CYP1B1

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23600958


    Sources:
    DTC

  • CHEMBL2347759   CYP1B1

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23600958


    Sources:
    DTC

  • 2'H,4H-[2,8'-BICHROMEN]-4-ONE   CYP1B1

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23600958


    Sources:
    DTC

  • BETA-NAPHTHOFLAVONE   CYP1B1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23600958 19563207


    Sources:
    DTC

  • PINOCEMBRIN   CYP1B1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ISOPROPYL ALCOHOL   CYP1B1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6409434


    Sources:
    NCI

  • FORMESTANE   CYP1B1

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18256205


    Sources:
    NCI

  • FADROZOLE   CYP1B1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18256205


    Sources:
    NCI

  • NARINGENIN   CYP1B1

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21053930


    Sources:
    TTD

  • ALPHA-NAPHTHOFLAVONE   CYP1B1

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23600958


    Sources:
    DTC

  • TOREMIFENE   CYP1B1

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8262671


    Sources:
    NCI

  • AMINOGLUTETHIMIDE   CYP1B1

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18256205


    Sources:
    NCI

  • AMODIAQUINE   CYP1B1

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ANASTROZOLE   CYP1B1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18256205


    Sources:
    NCI

  • LETROZOLE   CYP1B1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18256205


    Sources:
    NCI

  • MEDROXYPROGESTERONE ACETATE   CYP1B1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10764452


    Sources:
    NCI

  • EXEMESTANE   CYP1B1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18256205


    Sources:
    NCI

  • CHRYSIN   CYP1B1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23600958


    Sources:
    DTC

  • ACACETIN   CYP1B1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21482471


    Sources:
    DTC

  • RIFAMPIN   CYP1B1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6854335


    Sources:
    NCI

  • SPIRONOLACTONE   CYP1B1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7079590


    Sources:
    NCI

  • EPIRUBICIN   CYP1B1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24958282 24599932


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   CYP1B1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24958282 24599932


    Sources:
    PharmGKB

  • PACLITAXEL   CYP1B1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24599932 21151855


    Sources:
    PharmGKB

  • DOCETAXEL   CYP1B1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21151855


    Sources:
    PharmGKB

  • FLUOROURACIL   CYP1B1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24958282


    Sources:
    PharmGKB

  • RISPERIDONE   CYP1B1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOXORUBICIN   CYP1B1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000138061

    • Version: 101_38

    Alternate Names:
    CYP1B1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000138061

    • Version: 26-July-2011

    Alternate Names:
    CYP1B1 Display Id
    CYTOCHROME P450 1B1 (EC 1.14.14.1) (CYPIB1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16678] Description
    ENSG00000138061 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q16678

    • Version: January-2014

    Alternate Names:
    CYP1B1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.14.1

    Publications:

  • HopkinsGroom: Q16678

    • Version: 11-September-2012

    Alternate Names:
    CYTOCHROME P450 1B1 Uniprot Protein Name
    CYP1B1 Uniprot Gene Name
    1545 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR001128
    Interpro Short Name Cyt_P450
    Interpro Name Cytochrome P450

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • PharmGKB: CYP1B1

    • Version: 18-August-2020

    Alternate Names:
    PA27094 PharmGKB ID

    Gene Info:

    Publications:
    Le Morvan V et al., 2015, Identification of SNPs associated with response of breast cancer patients to neoadjuvant chemotherapy in the EORTC-10994 randomized phase III trial., Pharmacogenomics J
    Abraham JE et al., 2014, Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel., Clin Cancer Res
    Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics

  • NCI: CYP1B1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Rahman et al., 2008, CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma., Drug Metab. Dispos.
    Korsova et al., [The cytochrome P-450-dependent mono-oxygenase system of the liver and interleukin-1 production by the macrophages in adjuvant arthritis in rats under the influence of beta-carotene]., Eksp Klin Farmakol
    Wu et al., 1983, Non-competitive inhibition of hepatic and intestinal aryl hydrocarbon hydroxylase activities from rats by rifampin., J. Nat. Prod.

  • DTC: CYP1B1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Liu J et al., 2013, Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1., J Med Chem
    Androutsopoulos VP et al., 2011, Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids., Bioorg Med Chem

  • HingoraniCasas: ENSG00000138061

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000138061 Gene Symbol
    CYP1B1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: CYP1B1

    • Version: 19.3

    Alternate Names:
    ENSG00000138061 Ensembl Gene ID
    CP1B Human Protein Atlas Gene Synonym
    GLC3A Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Tempus: CYP1B1

    • Version: 11-November-2018

    Alternate Names:
    CYP1B1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Cytochrome P450 1B1

    • Version: 2020.06.01

    Alternate Names:
    CYP1B1 TTD Gene Abbreviation
    T92521 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CYP1B1

    • Version: 01-February-2022

    Alternate Names:
    Cytochrome P450 1B1 Gene Name
    Q16678 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21