• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

CYP19A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYP19A1 1588 Druggable Genome

    Alternate Names:

    1588
    CYTOCHROME P450 FAMILY 19 SUBFAMILY A MEMBER 1
    CYP19A1
    ARO
    ARO1
    CPV1
    CYAR
    CYP19
    CYPXIX
    P-450AROM
    107910
    2594
    ENSG00000137869
    OTTHUMG00000131747
    Cytochrome P450 19A1
    Aromatase
    Estrogen synthase
    Cytochrome P-450AROM
    P11511
    CP19A_HUMAN
    PA27091
    CYTOCHROME P450 19A1 (AROMATASE) (EC 1.14.14.1) (CYPXIX) (ESTROGEN SYNTHETASE) (P-450AROM). [SOURCE:UNIPROT/SWISSPROT;ACC:P11511]
    T13260

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:1.14.14
    Human Readable Name CYTOCHROME P450
    Interpro Acc IPR001128
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Cytochrome P450
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Cyt_P450
    Interpro Type Family
    Target Main Class Enzymes
    Transmembrane Helix Count 2
    Target Subclass 1.14.14
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    ENZYME

    Publications:

    Oesterreich S et al., 2015, Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover., Breast Cancer Res Treat
    Fontein DB et al., 2014, Germline variants in the CYP19A1 gene are related to specific adverse events in aromatase inhibitor users: a substudy of Dutch patients in the TEAM trial., Breast Cancer Res Treat
    Wang L et al., 2010, Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors., Cancer Res
    Abrial et al., 2009, Role of neo-adjuvant hormonal therapy in the treatment of breast cancer: a review of clinical trials., Int J Gen Med
    Nabholtz, 2008, Long-term safety of aromatase inhibitors in the treatment of breast cancer., Ther Clin Risk Manag
    Barnadas et al., 2009, Exemestane as primary treatment of oestrogen receptor-positive breast cancer in postmenopausal women: a phase II trial., Br. J. Cancer
    Untch et al., 2008, Exemestane in early breast cancer: a review., Ther Clin Risk Manag
    Koutras et al., 2009, Antiproliferative effect of exemestane in lung cancer cells., Mol. Cancer
    Brueggemeier et al., 2005, Aromatase inhibitors in the treatment of breast cancer., Endocr. Rev.
    Robinson, 2009, A review of the use of exemestane in early breast cancer., Ther Clin Risk Manag
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Brueggemeier, 2006, Update on the use of aromatase inhibitors in breast cancer., Expert Opin Pharmacother
    Ferlin MG et al., 2013, Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors., J Med Chem
    Santa-Maria CA et al., 2016, Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy., Clin Cancer Res
    Long et al., 2004, Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model., J. Natl. Cancer Inst.
    Murphy, 1998, Molecular Action and Clinical Relevance of Aromatase Inhibitors., Oncologist
    Ebert et al., [Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis]., Zentralbl Gynakol
    Tu et al., 1983, Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol., Chem. Biol. Interact.
    Mauras et al., 2009, Pharmacokinetics and pharmacodynamics of anastrozole in pubertal boys with recent-onset gynecomastia., J. Clin. Endocrinol. Metab.
    Gangadhara et al., 2009, Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women., Ther Clin Risk Manag
    Nabholtz, 2006, Role of anastrozole across the breast cancer continuum: from advanced to early disease and prevention., Oncology
    Milani et al., 2009, Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women., Clin Med Ther
    Santen et al., 2009, History of aromatase: saga of an important biological mediator and therapeutic target., Endocr. Rev.
    Cuzick, 2005, Anastrozole., Drugs Today
    Rugo, 2008, The breast cancer continuum in hormone-receptor-positive breast cancer in postmenopausal women: evolving management options focusing on aromatase inhibitors., Ann. Oncol.
    Jakesz et al., 2007, Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a., J. Natl. Cancer Inst.
    Powlin et al., 1998, Ex vivo and in vitro testis and ovary explants: utility for identifying steroid biosynthesis inhibitors and comparison to a Tier I screening battery., Toxicol. Sci.
    O'Connor et al., 1998, An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs)., Toxicol. Sci.
    Miller WR, 2003, Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer., Semin Oncol
    Kelly CM et al., 2010, Anastrozole., Expert Opin Drug Saf
    Buzdar AU et al., 2002, An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane., Cancer
    Ashirmetov et al., [The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats]., Fiziol Zh
    Siraki et al., 2007, Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis., Chem. Res. Toxicol.
    Shirakawa et al., 2006, Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons., Br. J. Pharmacol.
    Greco et al., HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines., J Drug Target
    Martínez-Campa et al., 2005, Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells., Breast Cancer Res. Treat.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Block et al., 1992, Aminoglutethimide in malignant melanoma. A phase II study., Am. J. Clin. Oncol.
    Iasinskaia, [Effect of reducing agents-antioxidants on rat uterine aromatase activity in vitro]., Ukr Biokhim Zh (1999)
    Raman et al., 2002, Aromatase inhibitors for male infertility., J. Urol.
    Cepa et al., 2005, Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation., J. Med. Chem.
    Dunkel, 2006, Use of aromatase inhibitors to increase final height., Mol. Cell. Endocrinol.
    Herzog et al., 1998, Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism., Neurology
    Yamamoto et al., 1990, Inhibitory effect of a new androstenedione derivative, 14 alpha-hydroxy-4-androstene-3,6,17-trione (14 alpha-OHAT) on aromatase activity of human uterine tumors., J. Steroid Biochem.
    Varela C et al., 2012, New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation., J Med Chem
    Edmunds et al., The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells., Reprod. Nutr. Dev.
    Ohnishi et al., 1997, Direct inhibitions of the activities of steroidogenic cytochrome P-450 mono-oxygenase systems by anticonvulsants., J. Steroid Biochem. Mol. Biol.
    Neves MA et al., 2009, An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors., Eur J Med Chem
    Chan et al., 1986, Inhibition of follicle-stimulating hormone induction of aromatase activity in porcine granulosa cells by thyroxine and triiodothyronine., Endocrinology
    Mendelson et al., 1984, Regulation of aromatase activity of cultured adipose stromal cells by catecholamines and adrenocorticotropin., Mol. Cell. Endocrinol.
    Horie et al., 1987, Sex difference in responsiveness to Aztreonam of monooxygenase system in liver microsomes from rats., Biochem. Pharmacol.
    Fiorelli et al., 1999, Estrogen synthesis in human colon cancer epithelial cells., J. Steroid Biochem. Mol. Biol.
    Maffei et al., 2004, Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment., J. Clin. Endocrinol. Metab.
    Brueggemeier et al., 2005, Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer., J. Steroid Biochem. Mol. Biol.
    Coombes et al., 1984, 4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer., Lancet
    Moretti et al., 1997, Alteration of cytochrome P-450 isozymes by captopril and idrapril in hepatic and renal microsomes of normotensive and spontaneously hypertensive rats., J. Cardiovasc. Pharmacol.
    Kao YC et al., 1998, Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study., Environ Health Perspect
  • TESTOLACTONE   CYP19A1

    Interaction Score: 5.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Cytochrome P450 19A1 inhibitor

    PMIDs:
    11792932 16190763 16766117 9521275 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CHEMBL572637   CYP19A1

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19500885


    Sources:
    DTC

  • CHEMBL1077603   CYP19A1

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22475216


    Sources:
    DTC

  • AMINOGLUTETHIMIDE   CYP19A1

    Interaction Score: 3.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cytochrome P450 19A1 inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    17602675 16474421 16332571 11752352 16244789 17016423 17139284 1590282


    Sources:
    TdgClinicalTrial ChemblInteractions NCI TEND TTD

  • ANASTROZOLE   CYP19A1

    Interaction Score: 2.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cytochrome P450 19A1 inhibitor
    Direct Interaction yes
    Trial Name anastrozole,Arimidex

    PMIDs:
    19470631 19753124 16439860 19794821 19389994 16034487 11752352 17693420 18073378 20048079 9928669 9928668 14513432 20923259 12404296


    Sources:
    TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD

  • EXEMESTANE   CYP19A1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name exemestane ,Aromasin
    Novel drug target Established target
    Mechanism of Interaction Cytochrome P450 19A1 inhibitor

    PMIDs:
    26536870 24590773 20048079 20360896 18728707 19156139 19337436 19930708 15814851 19436613 11752352 17020418


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • ARIMIDEX   CYP19A1

    Interaction Score: 1.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • ATAMESTANE   CYP19A1

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name atamestane-plus-toremifene

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LETROZOLE   CYP19A1

    Interaction Score: 1.82

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name letrozole ,Femara
    Novel drug target Established target
    Mechanism of Interaction Cytochrome P450 19A1 inhibitor

    PMIDs:
    24025069 26536870 26463708 20048079 15026471 10388095 11752352 14505258


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • ISOPROPYL ALCOHOL   CYP19A1

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6409434


    Sources:
    NCI

  • FORMESTANE   CYP19A1

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6150277


    Sources:
    NCI

  • AZTREONAM   CYP19A1

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3566801


    Sources:
    NCI

  • LIAROZOLE   CYP19A1

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NARINGENIN   CYP19A1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    9435150


    Sources:
    TTD

  • ALENDRONIC ACID   CYP19A1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14715828


    Sources:
    NCI

  • ANDROSTENEDIONE   CYP19A1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2214767


    Sources:
    NCI

  • FADROZOLE   CYP19A1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ATROPINE   CYP19A1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2128054


    Sources:
    NCI

  • CAPTOPRIL   CYP19A1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9268216


    Sources:
    NCI

  • HYDROQUINONE   CYP19A1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10979580


    Sources:
    NCI

  • ISOPROTERENOL   CYP19A1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6205918


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   CYP19A1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3095107


    Sources:
    NCI

  • IBUPROFEN   CYP19A1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15964185


    Sources:
    NCI

  • PHENYTOIN   CYP19A1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9182861


    Sources:
    NCI

  • GENISTEIN   CYP19A1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16285913


    Sources:
    NCI

  • EPIRUBICIN   CYP19A1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CAPECITABINE   CYP19A1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • QUERCETIN   CYP19A1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10704911


    Sources:
    NCI

  • TAMOXIFEN   CYP19A1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOCETAXEL   CYP19A1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   CYP19A1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOXORUBICIN   CYP19A1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PACLITAXEL   CYP19A1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUOROURACIL   CYP19A1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000137869

    • Version: 101_38

    Alternate Names:
    CYP19A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000137869

    • Version: 26-July-2011

    Alternate Names:
    CYTOCHROME P450 19A1 (AROMATASE) (EC 1.14.14.1) (CYPXIX) (ESTROGEN SYNTHETASE) (P-450AROM). [SOURCE:UNIPROT/SWISSPROT;ACC:P11511] Description
    ENSG00000137869 Ensembl Gene Id
    CYP19A1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P11511

    • Version: 01-August-2011

    Alternate Names:
    P11511 Uniprot Accession
    1588 Entrez Gene Id
    CYP19A1 Gene Symbol

    Gene Info:
    Target Main Class Enzymes
    Transmembrane Helix Count 2
    Target Subclass 1.14.14

    Publications:

  • HopkinsGroom: P11511

    • Version: 11-September-2012

    Alternate Names:
    1588 Entrez Gene Id
    ENSG00000137869 Ensembl Gene Id
    CP19A_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name CYTOCHROME P450
    Interpro Acc IPR001128
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • TdgClinicalTrial: P11511

    • Version: January-2014

    Alternate Names:
    CYP19A1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.14

    Publications:

  • PharmGKB: CYP19A1

    • Version: 18-August-2020

    Alternate Names:
    PA27091 PharmGKB ID

    Gene Info:

    Publications:
    Desta Z et al., 2009, Antiestrogen pathway (aromatase inhibitor)., Pharmacogenet Genomics
    Santa-Maria CA et al., 2016, Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy., Clin Cancer Res
    Oesterreich S et al., 2015, Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover., Breast Cancer Res Treat

  • NCI: CYP19A1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Tu et al., 1983, Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol., Chem. Biol. Interact.
    Ashirmetov et al., [The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats]., Fiziol Zh
    Brueggemeier et al., 2005, Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer., J. Steroid Biochem. Mol. Biol.

  • DTC: CYP19A1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Ferlin MG et al., 2013, Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors., J Med Chem
    Varela C et al., 2012, New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation., J Med Chem
    Neves MA et al., 2009, An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors., Eur J Med Chem

  • HingoraniCasas: ENSG00000137869

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000137869 Gene Symbol
    CYP19A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: AROMATASE

    • Version: 12-May-2016

    Alternate Names:
    AROMATASE Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: ARO1

    • Version: chembl_23

    Alternate Names:
    CYAR GENE_SYMBOL
    CYP19 GENE_SYMBOL
    CYP19A1 GENE_SYMBOL

    Gene Info:

    Publications:

  • TTD: Aromatase

    • Version: 2020.06.01

    Alternate Names:
    CYP19A1 TTD Gene Abbreviation
    T13260 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CYP19A1

    • Version: 01-February-2022

    Alternate Names:
    Aromatase Gene Name
    P11511 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21