DGIdb - CYP17A1 Gene Record

CYP17A1 1586 Druggable GenomeClinically Actionable

Alternate Names:

1586
CYTOCHROME P450 FAMILY 17 SUBFAMILY A MEMBER 1
CYP17A1
CPT7
CYP17
P450C17
S17AH
609300
2593
ENSG00000148795
OTTHUMG00000018969
1361
P05093
cytochrome P450, family 17, subfamily A, polypeptide 1
BE0000344
CP17A_HUMAN
STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE
Cytochrome P450c17
Steroid 17-alpha-monooxygenase
Cytochrome P450-C17
Cytochrome P450 17A1
CYPXVII
17-alpha-hydroxyprogesterone aldolase
TTDS00241
17 ALPHA-HYDROXYLASE-C17, 20-LYASE
P450 17
P450-C17
17 ALPHA-HYDROXYLASE/C17-20-LYASE
CYP 17
CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093]
PA27090
T89041

Gene Info:

GuideToPharmacology Gene Category Name	CYP11, CYP17, CYP19, CYP20 and CYP21 families
GuideToPharmacology Gene Category ID	266
GuideToPharmacology Gene Type	enzyme
CancerCommons Reported Gene Name	CYP17
Interpro Short Name	Cyt_P450
Interpro Acc	IPR001128
Interpro Name	Cytochrome P450
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Type	Family
Human Readable Name	CYTOCHROME P450
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:1.14.99.9
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CYTOCHROME P450
CLINICALLY ACTIONABLE
ENZYME

Publications:

Vogiatzi et al., 2010, Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer., Expert Rev Anticancer Ther
Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol
Pandey et al., 2007, Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase., Mol. Endocrinol.
Haidar et al., 2002, C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation., Arch. Pharm. (Weinheim)
Auchus RJ et al., 2003, The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21., Arch Biochem Biophys
Vasaitis TS et al., 2011, CYP17 inhibitors for prostate cancer therapy., J Steroid Biochem Mol Biol
Watanabe K et al., 2005, Marijuana extracts possess the effects like the endocrine disrupting chemicals., Toxicology
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
Trachtenberg et al., 1988, Steroid synthesis inhibition by ketoconazole: sites of action., Clin Invest Med
Millington K et al., 2019, The Utility of Potassium Monitoring in Gender-Diverse Adolescents Taking Spironolactone., J Endocr Soc
1976, Spironolactone and endocrine dysfunction., Ann. Intern. Med.

ABIRATERONE CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:

Vogiatzi et al., 2010, Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer., Expert Rev Anticancer Ther

Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol

ORTERONEL CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name orteronel, TAK-700

Reported Cancer Type Prostate

Publications:
GALETERONE CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name TOK-001

Specific Action of the Ligand Inhibition

Publications:
ABIRATERONE ACETATE CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cytochrome P450 17A1 inhibitor

Publications:

PROGESTERONE CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

Publications:

Haidar et al., 2002, C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation., Arch. Pharm. (Weinheim)

Auchus RJ et al., 2003, The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21., Arch Biochem Biophys

Vasaitis TS et al., 2011, CYP17 inhibitors for prostate cancer therapy., J Steroid Biochem Mol Biol

CANNABIDIOL CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Watanabe K et al., 2005, Marijuana extracts possess the effects like the endocrine disrupting chemicals., Toxicology

Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

KETOCONAZOLE CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Trachtenberg et al., 1988, Steroid synthesis inhibition by ketoconazole: sites of action., Clin Invest Med

SPIRONOLACTONE CYP17A1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Publications:

Millington K et al., 2019, The Utility of Potassium Monitoring in Gender-Diverse Adolescents Taking Spironolactone., J Endocr Soc

1976, Spironolactone and endocrine dysfunction., Ann. Intern. Med.

ZYTIGA CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Publications:
NABIXIMOLS CYP17A1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:
ENZALUTAMIDE CYP17A1

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family AR inhibitor

Alteration CYP17A1:norm

Publications:
chembl:CHEMBL1161866 CYP17A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Pandey et al., 2007, Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase., Mol. Endocrinol.
ISOCONAZOLE CYP17A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CFG-920 CYP17A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SEVITERONEL CYP17A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000148795
- Version: 101_38
Alternate Names:

CYP17A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacologyGenes: 1361
- Version: 4-March-2015
Alternate Names:

cytochrome P450, family 17, subfamily A, polypeptide 1 HUGO Gene Name

2593 HUGO Gene ID

CYP17A1 Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name CYP11, CYP17, CYP19, CYP20 and CYP21 families

GuideToPharmacology Gene Category ID 266

GuideToPharmacology Gene Type enzyme

Gene Categories:

CYTOCHROME P450

Publications:
HopkinsGroom: P05093
- Version: 11-September-2012
Alternate Names:

STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE Uniprot Protein Name

CYP17A1 Uniprot Gene Name

CP17A_HUMAN Uniprot Id

Gene Info:

Interpro Name Cytochrome P450

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Publications:
TdgClinicalTrial: P05093
- Version: January-2014
Alternate Names:

CYP17A1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.99.9

Publications:
CancerCommons: CYP17A1
- Version: 25-July-2013
Alternate Names:

1586 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CYP17

Publications:

RussLampel: ENSG00000148795

Version: 26-July-2011

Alternate Names:

ENSG00000148795 Ensembl Gene Id

CYP17A1 Display Id

CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: CYP17A1
- Version: 18-August-2020
Alternate Names:

PA27090 PharmGKB ID

Gene Info:

Publications:

Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol

DrugBank: BE0000344

Version: 5.1.7

Alternate Names:

CYP17A1 DrugBank Gene Name

P05093 UniProt Accession

1586 Entrez Gene Id

Gene Info:

Publications:

Pandey et al., 2007, Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase., Mol. Endocrinol.

Vasaitis TS et al., 2011, CYP17 inhibitors for prostate cancer therapy., J Steroid Biochem Mol Biol

Auchus RJ et al., 2003, The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21., Arch Biochem Biophys

HingoraniCasas: ENSG00000148795
- Version: 31-May-2017
Alternate Names:

ENSG00000148795 Gene Symbol

CYP17A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CYP17
- Version: chembl_23
Alternate Names:

Cytochrome P450c17 UNIPROT

S17AH GENE_SYMBOL

CYP17A1 GENE_SYMBOL

Gene Info:

Publications:
GuideToPharmacologyInteractions: ENSG00000148795
- Version: 20-July-2020
Alternate Names:

CYP17A1 GuideToPharmacology Name

P05093 UniProtKB ID

Gene Info:

Publications:
TTD: Steroid 17-alpha-monooxygenase
- Version: 2020.06.01
Alternate Names:

S17AH TTD Gene Abbreviation

T89041 TTD Target ID

Gene Info:

Publications:
Pharos: CYP17A1
- Version: 03-September-2020
Alternate Names:

Steroid 17-alpha-hydroxylase/17,20 lyase Gene Name

P05093 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
FoundationOneGenes: CYP17A1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CGI: CYP17A1
- Version: 14-September-2020
Alternate Names:

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Novel drug target	Established target
Trial Name	orteronel, TAK-700
Reported Cancer Type	Prostate

Direct Interaction	yes
Mechanism of Interaction	Cytochrome P450 17A1 inhibitor

cytochrome P450, family 17, subfamily A, polypeptide 1	HUGO Gene Name
2593	HUGO Gene ID
CYP17A1	Gene Symbol

STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE	Uniprot Protein Name
CYP17A1	Uniprot Gene Name
CP17A_HUMAN	Uniprot Id

ENSG00000148795	Ensembl Gene Id
CYP17A1	Display Id
CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093]	Description

CYP17A1	DrugBank Gene Name
P05093	UniProt Accession
1586	Entrez Gene Id

Steroid 17-alpha-hydroxylase/17,20 lyase	Gene Name
P05093	UniProt ID

Drug family	AR inhibitor
Alteration	CYP17A1:norm

CYP17A1 Gene Record

CYP17A1 1586 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

Publications: Vogiatzi et al., 2010, Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer., Expert Rev Anticancer Ther Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name orteronel, TAK-700 Reported Cancer Type Prostate

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name TOK-001 Specific Action of the Ligand Inhibition

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cytochrome P450 17A1 inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) substrate

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Watanabe K et al., 2005, Marijuana extracts possess the effects like the endocrine disrupting chemicals., Toxicology Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Trachtenberg et al., 1988, Steroid synthesis inhibition by ketoconazole: sites of action., Clin Invest Med

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

Publications: Millington K et al., 2019, The Utility of Potassium Monitoring in Gender-Diverse Adolescents Taking Spironolactone., J Endocr Soc 1976, Spironolactone and endocrine dysfunction., Ann. Intern. Med.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Drug family AR inhibitor Alteration CYP17A1:norm

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Pandey et al., 2007, Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase., Mol. Endocrinol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Ensembl: ENSG00000148795

Alternate Names: CYP17A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacologyGenes: 1361

Alternate Names: cytochrome P450, family 17, subfamily A, polypeptide 1 HUGO Gene Name 2593 HUGO Gene ID CYP17A1 Gene Symbol

Gene Info: GuideToPharmacology Gene Category Name CYP11, CYP17, CYP19, CYP20 and CYP21 families GuideToPharmacology Gene Category ID 266 GuideToPharmacology Gene Type enzyme

Gene Categories: CYTOCHROME P450

Publications:

HopkinsGroom: P05093

Alternate Names: STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE Uniprot Protein Name CYP17A1 Uniprot Gene Name CP17A_HUMAN Uniprot Id

Gene Info: Interpro Name Cytochrome P450 Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot

Gene Categories: DRUGGABLE GENOME, CYTOCHROME P450

Publications:

TdgClinicalTrial: P05093

Alternate Names: CYP17A1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.14.99.9

Publications:

CancerCommons: CYP17A1

Alternate Names: 1586 Entrez Gene ID

Gene Info: CancerCommons Reported Gene Name CYP17

Publications:

RussLampel: ENSG00000148795

Alternate Names: ENSG00000148795 Ensembl Gene Id CYP17A1 Display Id CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: CYP17A1

Alternate Names: PA27090 PharmGKB ID

Gene Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:

Vogiatzi et al., 2010, Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer., Expert Rev Anticancer Ther

Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name orteronel, TAK-700

Reported Cancer Type Prostate

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name TOK-001

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cytochrome P450 17A1 inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Watanabe K et al., 2005, Marijuana extracts possess the effects like the endocrine disrupting chemicals., Toxicology

Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Trachtenberg et al., 1988, Steroid synthesis inhibition by ketoconazole: sites of action., Clin Invest Med

Interaction Types & Directionality:

antagonist (inhibitory)

Publications:

Millington K et al., 2019, The Utility of Potassium Monitoring in Gender-Diverse Adolescents Taking Spironolactone., J Endocr Soc

1976, Spironolactone and endocrine dysfunction., Ann. Intern. Med.

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family AR inhibitor

Alteration CYP17A1:norm

Interaction Types & Directionality:

n/a

Publications:

Pandey et al., 2007, Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase., Mol. Endocrinol.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

CYP17A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

cytochrome P450, family 17, subfamily A, polypeptide 1 HUGO Gene Name

2593 HUGO Gene ID

CYP17A1 Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name CYP11, CYP17, CYP19, CYP20 and CYP21 families

GuideToPharmacology Gene Category ID 266

GuideToPharmacology Gene Type enzyme

Gene Categories:

CYTOCHROME P450

Alternate Names:

STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE Uniprot Protein Name

CYP17A1 Uniprot Gene Name

CP17A_HUMAN Uniprot Id

Gene Info:

Interpro Name Cytochrome P450

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Alternate Names:

CYP17A1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.99.9

Alternate Names:

1586 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CYP17

Alternate Names:

ENSG00000148795 Ensembl Gene Id

CYP17A1 Display Id

CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA27090 PharmGKB ID

Publications:

Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol

Alternate Names:

CYP17A1 DrugBank Gene Name

P05093 UniProt Accession

1586 Entrez Gene Id

Alternate Names:

ENSG00000148795 Gene Symbol

CYP17A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Cytochrome P450c17 UNIPROT

S17AH GENE_SYMBOL

CYP17A1 GENE_SYMBOL

Alternate Names:

CYP17A1 GuideToPharmacology Name

P05093 UniProtKB ID

Alternate Names:

S17AH TTD Gene Abbreviation

T89041 TTD Target ID

Alternate Names:

Steroid 17-alpha-hydroxylase/17,20 lyase Gene Name

P05093 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CLINICALLY ACTIONABLE