DGIdb - CYP17A1 Gene Record

CYP17A1 1586 Druggable GenomeClinically Actionable

Alternate Names:

1586
CYTOCHROME P450 FAMILY 17 SUBFAMILY A MEMBER 1
CYP17A1
CPT7
CYP17
P450C17
S17AH
609300
2593
ENSG00000148795
OTTHUMG00000018969
1361
P05093
BE0000344
CP17A_HUMAN
STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE
Cytochrome P450c17
Steroid 17-alpha-monooxygenase
Cytochrome P450-C17
Cytochrome P450 17A1
CYPXVII
17-alpha-hydroxyprogesterone aldolase
CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093]
PA27090
T89041

Gene Info:

GuideToPharmacology Gene Category Name	CYP11, CYP17, CYP19, CYP20 and CYP21 families
GuideToPharmacology Gene Category ID	266
CancerCommons Reported Gene Name	CYP17
Interpro Short Name	Cyt_P450
Interpro Acc	IPR001128
Interpro Name	Cytochrome P450
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Type	Family
Human Readable Name	CYTOCHROME P450
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:1.14.99.9
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CYTOCHROME P450
CLINICALLY ACTIONABLE
ENZYME

Publications:

Vogiatzi et al., 2010, Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer., Expert Rev Anticancer Ther
Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol
Pandey et al., 2007, Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase., Mol. Endocrinol.
Auchus RJ et al., 2003, The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21., Arch Biochem Biophys
Haidar et al., 2002, C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation., Arch. Pharm. (Weinheim)
Vasaitis TS et al., 2011, CYP17 inhibitors for prostate cancer therapy., J Steroid Biochem Mol Biol
Trachtenberg et al., 1988, Steroid synthesis inhibition by ketoconazole: sites of action., Clin Invest Med
Millington K et al., 2019, The Utility of Potassium Monitoring in Gender-Diverse Adolescents Taking Spironolactone., J Endocr Soc
1976, Spironolactone and endocrine dysfunction., Ann. Intern. Med.
Watanabe K et al., 2005, Marijuana extracts possess the effects like the endocrine disrupting chemicals., Toxicology
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

ORTERONEL CYP17A1

Interaction Score: 16.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name orteronel, TAK-700

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
CancerCommons TdgClinicalTrial TTD ChemblInteractions
ABIRATERONE CYP17A1

Interaction Score: 6.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
20645691 25157341

Sources:
PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology CGI
GALETERONE CYP17A1

Interaction Score: 6.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name TOK-001

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions
ZYTIGA CYP17A1

Interaction Score: 4.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
CancerCommons
SEVITERONEL CYP17A1

Interaction Score: 4.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CFG-920 CYP17A1

Interaction Score: 4.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ABIRATERONE ACETATE CYP17A1

Interaction Score: 4.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cytochrome P450 17A1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ENZALUTAMIDE CYP17A1

Interaction Score: 1.35

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family AR inhibitor

Alteration CYP17A1:norm

PMIDs:
None found

Sources:
CGI
SPIRONOLACTONE CYP17A1

Interaction Score: 0.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
31065620 984618

Sources:
DrugBank
KETOCONAZOLE CYP17A1

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
2966691

Sources:
DrugBank
CANNABIDIOL CYP17A1

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15588936 26264914

Sources:
DrugBank
PROGESTERONE CYP17A1

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

PMIDs:
12464252 12596217 21092758

Sources:
DrugBank
NABIXIMOLS CYP17A1

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
CHEMBL1161866 CYP17A1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17595315

Sources:
DrugBank

Ensembl: ENSG00000148795
- Version: 101_38
Alternate Names:

CYP17A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P05093
- Version: 11-September-2012
Alternate Names:

STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE Uniprot Protein Name

CYP17A1 Uniprot Gene Name

CP17A_HUMAN Uniprot Id

Gene Info:

Interpro Name Cytochrome P450

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Publications:
TdgClinicalTrial: P05093
- Version: January-2014
Alternate Names:

CYP17A1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.99.9

Publications:
CancerCommons: CYP17A1
- Version: 25-July-2013
Alternate Names:

1586 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CYP17

Publications:

RussLampel: ENSG00000148795

Version: 26-July-2011

Alternate Names:

ENSG00000148795 Ensembl Gene Id

CYP17A1 Display Id

CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 1586
- Version: 29-September-2020
Alternate Names:

2593 HUGO Gene ID

2593 HUGO Gene Symbol

cytochrome P450 family 17 subfamily A member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CYP11, CYP17, CYP19, CYP20 and CYP21 families

GuideToPharmacology Gene Category ID 266

Gene Categories:

ENZYME

Publications:
PharmGKB: CYP17A1
- Version: 18-August-2020
Alternate Names:

PA27090 PharmGKB ID

Gene Info:

Publications:

Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol

DrugBank: BE0000344

Version: 5.1.7

Alternate Names:

CYP17A1 DrugBank Gene Name

P05093 UniProt Accession

1586 Entrez Gene Id

Gene Info:

Publications:

Auchus RJ et al., 2003, The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21., Arch Biochem Biophys

Haidar et al., 2002, C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation., Arch. Pharm. (Weinheim)

Vasaitis TS et al., 2011, CYP17 inhibitors for prostate cancer therapy., J Steroid Biochem Mol Biol

HingoraniCasas: ENSG00000148795
- Version: 31-May-2017
Alternate Names:

ENSG00000148795 Gene Symbol

CYP17A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CYP17
- Version: chembl_23
Alternate Names:

Cytochrome P450c17 UNIPROT

S17AH GENE_SYMBOL

CYP17A1 GENE_SYMBOL

Gene Info:

Publications:
Pharos: CYP17A1
- Version: 03-September-2020
Alternate Names:

Steroid 17-alpha-hydroxylase/17,20 lyase Gene Name

P05093 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Steroid 17-alpha-monooxygenase
- Version: 2020.06.01
Alternate Names:

S17AH TTD Gene Abbreviation

T89041 TTD Target ID

Gene Info:

Publications:
CGI: CYP17A1
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: CYP17A1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Novel drug target	Established target
Trial Name	orteronel, TAK-700
Reported Cancer Type	Prostate

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Direct Interaction	yes
Mechanism of Interaction	Cytochrome P450 17A1 inhibitor

STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE	Uniprot Protein Name
CYP17A1	Uniprot Gene Name
CP17A_HUMAN	Uniprot Id

ENSG00000148795	Ensembl Gene Id
CYP17A1	Display Id
CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093]	Description

2593	HUGO Gene ID
2593	HUGO Gene Symbol
cytochrome P450 family 17 subfamily A member 1	HUGO Gene Name

CYP17A1	DrugBank Gene Name
P05093	UniProt Accession
1586	Entrez Gene Id

Steroid 17-alpha-hydroxylase/17,20 lyase	Gene Name
P05093	UniProt ID

Drug family	AR inhibitor
Alteration	CYP17A1:norm

inhibitor (inhibitory)
substrate

CYP17A1 Gene Record

CYP17A1 1586 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name orteronel, TAK-700 Reported Cancer Type Prostate

PMIDs: None found

Sources: CancerCommons TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 20645691 25157341

Sources: PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology CGI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name TOK-001 Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate

PMIDs: None found

Sources: CancerCommons

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cytochrome P450 17A1 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Drug family AR inhibitor Alteration CYP17A1:norm

PMIDs: None found

Sources: CGI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 31065620 984618

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 2966691

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15588936 26264914

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory) substrate

Interaction Info:

PMIDs: 12464252 12596217 21092758

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17595315

Sources: DrugBank

Ensembl: ENSG00000148795

Alternate Names: CYP17A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P05093

Alternate Names: STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE Uniprot Protein Name CYP17A1 Uniprot Gene Name CP17A_HUMAN Uniprot Id

Gene Info: Interpro Name Cytochrome P450 Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot

Gene Categories: DRUGGABLE GENOME, CYTOCHROME P450

Publications:

TdgClinicalTrial: P05093

Alternate Names: CYP17A1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.14.99.9

Publications:

CancerCommons: CYP17A1

Alternate Names: 1586 Entrez Gene ID

Gene Info: CancerCommons Reported Gene Name CYP17

Publications:

RussLampel: ENSG00000148795

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name orteronel, TAK-700

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
CancerCommons TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
20645691 25157341

Sources:
PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology CGI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name TOK-001

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
CancerCommons

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cytochrome P450 17A1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family AR inhibitor

Alteration CYP17A1:norm

PMIDs:
None found

Sources:
CGI

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
31065620 984618

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
2966691

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15588936 26264914

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

PMIDs:
12464252 12596217 21092758

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17595315

Sources:
DrugBank

Alternate Names:

CYP17A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE Uniprot Protein Name

CYP17A1 Uniprot Gene Name

CP17A_HUMAN Uniprot Id

Gene Info:

Interpro Name Cytochrome P450

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME, CYTOCHROME P450

Alternate Names:

CYP17A1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.99.9

Alternate Names:

1586 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CYP17

Alternate Names:

ENSG00000148795 Ensembl Gene Id

CYP17A1 Display Id

CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

2593 HUGO Gene ID

2593 HUGO Gene Symbol

cytochrome P450 family 17 subfamily A member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CYP11, CYP17, CYP19, CYP20 and CYP21 families

GuideToPharmacology Gene Category ID 266

Gene Categories:

ENZYME

Alternate Names:

PA27090 PharmGKB ID

Publications:

Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol

Alternate Names:

CYP17A1 DrugBank Gene Name

P05093 UniProt Accession

1586 Entrez Gene Id

Alternate Names:

ENSG00000148795 Gene Symbol

CYP17A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Cytochrome P450c17 UNIPROT

S17AH GENE_SYMBOL

CYP17A1 GENE_SYMBOL

Alternate Names:

Steroid 17-alpha-hydroxylase/17,20 lyase Gene Name

P05093 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

S17AH TTD Gene Abbreviation

T89041 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE