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CYP17A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CYP17A1 1586 Druggable GenomeClinically Actionable

    Alternate Names:

    1586
    CYTOCHROME P450 FAMILY 17 SUBFAMILY A MEMBER 1
    CYP17A1
    CPT7
    CYP17
    P450C17
    S17AH
    609300
    2593
    ENSG00000148795
    OTTHUMG00000018969
    1361
    P05093
    BE0000344
    CP17A_HUMAN
    STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE
    Cytochrome P450c17
    Steroid 17-alpha-monooxygenase
    Cytochrome P450-C17
    Cytochrome P450 17A1
    CYPXVII
    17-alpha-hydroxyprogesterone aldolase
    CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093]
    PA27090
    T89041

    Gene Info:

    GuideToPharmacology Gene Category Name CYP11, CYP17, CYP19, CYP20 and CYP21 families
    GuideToPharmacology Gene Category ID 266
    CancerCommons Reported Gene Name CYP17
    Interpro Short Name Cyt_P450
    Interpro Acc IPR001128
    Interpro Name Cytochrome P450
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Human Readable Name CYTOCHROME P450
    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:1.14.99.9
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Vogiatzi et al., 2010, Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer., Expert Rev Anticancer Ther
    Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol
    Pandey et al., 2007, Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase., Mol. Endocrinol.
    Auchus RJ et al., 2003, The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21., Arch Biochem Biophys
    Haidar et al., 2002, C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation., Arch. Pharm. (Weinheim)
    Vasaitis TS et al., 2011, CYP17 inhibitors for prostate cancer therapy., J Steroid Biochem Mol Biol
    Trachtenberg et al., 1988, Steroid synthesis inhibition by ketoconazole: sites of action., Clin Invest Med
    Millington K et al., 2019, The Utility of Potassium Monitoring in Gender-Diverse Adolescents Taking Spironolactone., J Endocr Soc
    1976, Spironolactone and endocrine dysfunction., Ann. Intern. Med.
    Watanabe K et al., 2005, Marijuana extracts possess the effects like the endocrine disrupting chemicals., Toxicology
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
  • ORTERONEL   CYP17A1

    Interaction Score: 16.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name orteronel, TAK-700
    Reported Cancer Type Prostate

    PMIDs:
    None found


    Sources:
    CancerCommons TdgClinicalTrial TTD ChemblInteractions

  • ABIRATERONE   CYP17A1

    Interaction Score: 6.49

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    20645691 25157341


    Sources:
    PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology CGI

  • GALETERONE   CYP17A1

    Interaction Score: 6.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name TOK-001
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology ChemblInteractions

  • ZYTIGA   CYP17A1

    Interaction Score: 4.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Reported Cancer Type Prostate

    PMIDs:
    None found


    Sources:
    CancerCommons

  • SEVITERONEL   CYP17A1

    Interaction Score: 4.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CFG-920   CYP17A1

    Interaction Score: 4.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ABIRATERONE ACETATE   CYP17A1

    Interaction Score: 4.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cytochrome P450 17A1 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ENZALUTAMIDE   CYP17A1

    Interaction Score: 1.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family AR inhibitor
    Alteration CYP17A1:norm

    PMIDs:
    None found


    Sources:
    CGI

  • SPIRONOLACTONE   CYP17A1

    Interaction Score: 0.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    31065620 984618


    Sources:
    DrugBank

  • KETOCONAZOLE   CYP17A1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    2966691


    Sources:
    DrugBank

  • CANNABIDIOL   CYP17A1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15588936 26264914


    Sources:
    DrugBank

  • PROGESTERONE   CYP17A1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    substrate

    Interaction Info:

    PMIDs:
    12464252 12596217 21092758


    Sources:
    DrugBank

  • NABIXIMOLS   CYP17A1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CHEMBL1161866   CYP17A1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17595315


    Sources:
    DrugBank

  • Ensembl: ENSG00000148795

    • Version: 101_38

    Alternate Names:
    CYP17A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P05093

    • Version: 11-September-2012

    Alternate Names:
    STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE Uniprot Protein Name
    CYP17A1 Uniprot Gene Name
    CP17A_HUMAN Uniprot Id

    Gene Info:
    Interpro Name Cytochrome P450
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • TdgClinicalTrial: P05093

    • Version: January-2014

    Alternate Names:
    CYP17A1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.99.9

    Publications:

  • CancerCommons: CYP17A1

    • Version: 25-July-2013

    Alternate Names:
    1586 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name CYP17

    Publications:

  • RussLampel: ENSG00000148795

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000148795 Ensembl Gene Id
    CYP17A1 Display Id
    CYTOCHROME P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P05093] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 1586

    • Version: 29-September-2020

    Alternate Names:
    2593 HUGO Gene ID
    2593 HUGO Gene Symbol
    cytochrome P450 family 17 subfamily A member 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name CYP11, CYP17, CYP19, CYP20 and CYP21 families
    GuideToPharmacology Gene Category ID 266

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: CYP17A1

    • Version: 18-August-2020

    Alternate Names:
    PA27090 PharmGKB ID

    Gene Info:

    Publications:
    Zobniw CM et al., 2014, Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer., Res Rep Urol

  • DrugBank: BE0000344

    • Version: 5.1.7

    Alternate Names:
    CYP17A1 DrugBank Gene Name
    P05093 UniProt Accession
    1586 Entrez Gene Id

    Gene Info:

    Publications:
    Auchus RJ et al., 2003, The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21., Arch Biochem Biophys
    Haidar et al., 2002, C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation., Arch. Pharm. (Weinheim)
    Vasaitis TS et al., 2011, CYP17 inhibitors for prostate cancer therapy., J Steroid Biochem Mol Biol

  • HingoraniCasas: ENSG00000148795

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000148795 Gene Symbol
    CYP17A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CYP17

    • Version: chembl_23

    Alternate Names:
    Cytochrome P450c17 UNIPROT
    S17AH GENE_SYMBOL
    CYP17A1 GENE_SYMBOL

    Gene Info:

    Publications:

  • Pharos: CYP17A1

    • Version: 03-September-2020

    Alternate Names:
    Steroid 17-alpha-hydroxylase/17,20 lyase Gene Name
    P05093 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Steroid 17-alpha-monooxygenase

    • Version: 2020.06.01

    Alternate Names:
    S17AH TTD Gene Abbreviation
    T89041 TTD Target ID

    Gene Info:

    Publications:

  • CGI: CYP17A1

    • Version: 27-September-2017

    Alternate Names:

    Gene Info:

    Publications:

  • FoundationOneGenes: CYP17A1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21