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CYBA Gene Record

  • Summary
  • Interactions
  • Claims
  • CYBA 1535

    Alternate Names:

    1535
    CYTOCHROME B-245 ALPHA CHAIN
    CYBA
    p22-PHOX
    608508
    2577
    ENSG00000051523
    OTTHUMG00000173320
    PA27075
    P13498
    CGD4

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    TRANSPORTER

    Publications:

    Shin MJ et al., 2005, A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients., Clin Chim Acta
    Megías-Vericat JE et al., 2018, Impact of NADPH oxidase functional polymorphisms in acute myeloid leukemia induction chemotherapy., Pharmacogenomics J
    Reichwagen A et al., 2015, Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma., Pharmacogenomics
    Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia
    Wojnowski L et al., 2005, NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity., Circulation
    Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
  • IDARUBICIN   CYBA

    Interaction Score: 2.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28485375 25823784 19448608 16330681


    Sources:
    PharmGKB

  • DOXORUBICIN   CYBA

    Interaction Score: 1.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28485375 25823784 21048526 19448608 16330681


    Sources:
    PharmGKB

  • SIMVASTATIN   CYBA

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15936011


    Sources:
    PharmGKB

  • Ensembl: ENSG00000051523

    • Version: 101_38

    Alternate Names:
    CYBA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: CYBA

    • Version: 18-August-2020

    Alternate Names:
    PA27075 PharmGKB ID

    Gene Info:

    Publications:
    Shin MJ et al., 2005, A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients., Clin Chim Acta
    Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia
    Megías-Vericat JE et al., 2018, Impact of NADPH oxidase functional polymorphisms in acute myeloid leukemia induction chemotherapy., Pharmacogenomics J

  • HumanProteinAtlas: CYBA

    • Version: 19.3

    Alternate Names:
    ENSG00000051523 Ensembl Gene ID
    p22-PHOX Human Protein Atlas Gene Synonym
    Cytochrome b-245 alpha chain Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21