DGIdb - CTSL Gene Record

CTSL 1514 Druggable Genome

Alternate Names:

1514
CATHEPSIN L
CTSL
CATL
CTSL1
MEP
116880
2537
ENSG00000135047
OTTHUMG00000020149
2351
P07711
NM_001257971\|NM_001257972\|NM_001912\|NM_145918
NP_001244900\|NP_001244901\|NP_001903\|NP_666023
CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711]
BE0002135
CATL1_HUMAN
cathepsin L1
T41141

Gene Info:

Human Readable Name	PROTEASE
GuideToPharmacology Gene Category Name	C1: Papain
GuideToPharmacology Gene Category ID	728
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Active_site
Interpro Name	Cysteine peptidase, cysteine active site
Interpro Acc	IPR000169
Interpro Short Name	Pept_cys_AS
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Miller B et al., 2014, The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L., J Nat Prod
Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

FELBINAC CTSL

Interaction Score: 28.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
GALLINAMIDE A CTSL

Interaction Score: 28.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24364476

Sources:
DTC
BORTEZOMIB CTSL

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20875739

Sources:
DTC
FOSTAMATINIB CTSL

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000135047
- Version: 101_38
Alternate Names:

CTSL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P07711
- Version: 11-September-2012
Alternate Names:

cathepsin L1 Uniprot Protein Name

P07711 Uniprot Accession

1514 Entrez Gene Id

Gene Info:

Interpro Type Active_site

Interpro Name Cysteine peptidase, cysteine active site

Interpro Acc IPR000169

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000135047
- Version: 26-July-2011
Alternate Names:

CTSL Display Id

ENSG00000135047 Ensembl Gene Id

CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 1514
- Version: 29-September-2020
Alternate Names:

2537 HUGO Gene ID

2537 HUGO Gene Symbol

cathepsin L HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name C1: Papain

GuideToPharmacology Gene Category ID 728

Gene Categories:

ENZYME

Publications:

DrugBank: BE0002135

Version: 5.1.7

Alternate Names:

CTSL DrugBank Gene Name

P07711 UniProt Accession

1514 Entrez Gene Id

Gene Info:

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: CTSL1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Song et al., 2005, Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau., Endocrinology

DTC: CTSL

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

Miller B et al., 2014, The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L., J Nat Prod

HingoraniCasas: ENSG00000135047
- Version: 31-May-2017
Alternate Names:

ENSG00000135047 Gene Symbol

CTSL Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: CTSL1
- Version: 27-Jun-2013
Alternate Names:

1514 Gene ID

CATL dGene Synonym

CTSL dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Cathepsin L
- Version: 2020.06.01
Alternate Names:

CTSL TTD Gene Abbreviation

T41141 TTD Target ID

Gene Info:

Publications:

cathepsin L1	Uniprot Protein Name
P07711	Uniprot Accession
1514	Entrez Gene Id

CTSL	Display Id
ENSG00000135047	Ensembl Gene Id
CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711]	Description

2537	HUGO Gene ID
2537	HUGO Gene Symbol
cathepsin L	HUGO Gene Name

CTSL	DrugBank Gene Name
P07711	UniProt Accession
1514	Entrez Gene Id

CTSL Gene Record

CTSL 1514 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

FELBINAC CTSL

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

GALLINAMIDE A CTSL

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24364476

Sources: DTC

BORTEZOMIB CTSL

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20875739

Sources: DTC

FOSTAMATINIB CTSL

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26516587

Sources: DrugBank

Ensembl: ENSG00000135047

Alternate Names: CTSL Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P07711

Alternate Names: cathepsin L1 Uniprot Protein Name P07711 Uniprot Accession 1514 Entrez Gene Id

Gene Info: Interpro Type Active_site Interpro Name Cysteine peptidase, cysteine active site Interpro Acc IPR000169

Gene Categories: PROTEASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000135047

Alternate Names: CTSL Display Id ENSG00000135047 Ensembl Gene Id CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 1514

Alternate Names: 2537 HUGO Gene ID 2537 HUGO Gene Symbol cathepsin L HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name C1: Papain GuideToPharmacology Gene Category ID 728

Gene Categories: ENZYME

Publications:

DrugBank: BE0002135

Alternate Names: CTSL DrugBank Gene Name P07711 UniProt Accession 1514 Entrez Gene Id

Gene Info:

Publications: Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: CTSL1

Alternate Names:

Gene Info:

Publications: Song et al., 2005, Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau., Endocrinology

DTC: CTSL

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000135047

Alternate Names: ENSG00000135047 Gene Symbol CTSL Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

dGene: CTSL1

Alternate Names: 1514 Gene ID CATL dGene Synonym CTSL dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

TTD: Cathepsin L

Alternate Names: CTSL TTD Gene Abbreviation T41141 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24364476

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20875739

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26516587

Sources:
DrugBank

Alternate Names:

CTSL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

cathepsin L1 Uniprot Protein Name

P07711 Uniprot Accession

1514 Entrez Gene Id

Gene Info:

Interpro Type Active_site

Interpro Name Cysteine peptidase, cysteine active site

Interpro Acc IPR000169

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

CTSL Display Id

ENSG00000135047 Ensembl Gene Id

CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

2537 HUGO Gene ID

2537 HUGO Gene Symbol

cathepsin L HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name C1: Papain

GuideToPharmacology Gene Category ID 728

Gene Categories:

ENZYME

Alternate Names:

CTSL DrugBank Gene Name

P07711 UniProt Accession

1514 Entrez Gene Id

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Publications:

Song et al., 2005, Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau., Endocrinology

Alternate Names:

ENSG00000135047 Gene Symbol

CTSL Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1514 Gene ID

CATL dGene Synonym

CTSL dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

CTSL TTD Gene Abbreviation

T41141 TTD Target ID