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CTSL Gene Record

  • Summary
  • Interactions
  • Claims
  • CTSL 1514 Druggable Genome

    Alternate Names:

    1514
    CATHEPSIN L
    CTSL
    CATL
    CTSL1
    MEP
    116880
    2537
    ENSG00000135047
    OTTHUMG00000020149
    2351
    P07711
    NM_001257971|NM_001257972|NM_001912|NM_145918
    NP_001244900|NP_001244901|NP_001903|NP_666023
    CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711]
    BE0002135
    CATL1_HUMAN
    cathepsin L1
    T41141

    Gene Info:

    Human Readable Name PROTEASE
    GuideToPharmacology Gene Category Name C1: Papain
    GuideToPharmacology Gene Category ID 728
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Active_site
    Interpro Name Cysteine peptidase, cysteine active site
    Interpro Acc IPR000169
    Interpro Short Name Pept_cys_AS
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Miller B et al., 2014, The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L., J Nat Prod
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
  • FELBINAC   CTSL

    Interaction Score: 28.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • GALLINAMIDE A   CTSL

    Interaction Score: 28.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24364476


    Sources:
    DTC

  • BORTEZOMIB   CTSL

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC

  • FOSTAMATINIB   CTSL

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

  • Ensembl: ENSG00000135047

    • Version: 101_38

    Alternate Names:
    CTSL Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P07711

    • Version: 11-September-2012

    Alternate Names:
    cathepsin L1 Uniprot Protein Name
    P07711 Uniprot Accession
    1514 Entrez Gene Id

    Gene Info:
    Interpro Type Active_site
    Interpro Name Cysteine peptidase, cysteine active site
    Interpro Acc IPR000169

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000135047

    • Version: 26-July-2011

    Alternate Names:
    CTSL Display Id
    ENSG00000135047 Ensembl Gene Id
    CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP). [SOURCE:UNIPROT/SWISSPROT;ACC:P07711] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 1514

    • Version: 29-September-2020

    Alternate Names:
    2537 HUGO Gene ID
    2537 HUGO Gene Symbol
    cathepsin L HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name C1: Papain
    GuideToPharmacology Gene Category ID 728

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0002135

    • Version: 5.1.7

    Alternate Names:
    CTSL DrugBank Gene Name
    P07711 UniProt Accession
    1514 Entrez Gene Id

    Gene Info:

    Publications:
    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • NCI: CTSL1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Song et al., 2005, Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau., Endocrinology

  • DTC: CTSL

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Miller B et al., 2014, The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L., J Nat Prod

  • HingoraniCasas: ENSG00000135047

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000135047 Gene Symbol
    CTSL Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: CTSL1

    • Version: 27-Jun-2013

    Alternate Names:
    1514 Gene ID
    CATL dGene Synonym
    CTSL dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Cathepsin L

    • Version: 2020.06.01

    Alternate Names:
    CTSL TTD Gene Abbreviation
    T41141 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21