DGIdb - CTSB Gene Record

CTSB 1508 Druggable Genome

Alternate Names:

1508
CATHEPSIN B
CTSB
APPS
CPSB
116810
2527
ENSG00000164733
OTTHUMG00000090799
2343
P07858
BE0000939
NM_001908\|NM_147780\|NM_147781\|NM_147782\|NM_147783
NP_001899\|NP_680090\|NP_680091\|NP_680092\|NP_680093
CATHEPSIN B LIGHT CHAIN
CATB_HUMAN
CATHEPSIN B PRECURSOR (EC 3.4.22.1) (CATHEPSIN B1) (APP SECRETASE) (APPS). [SOURCE:UNIPROT/SWISSPROT;ACC:P07858]
T61746

Gene Info:

GuideToPharmacology Gene Category Name	C1: Papain
GuideToPharmacology Gene Category ID	728
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	PROTEASE
Interpro Acc	IPR000169
Uniprot Status	Swiss-Prot
Interpro Short Name	Pept_cys_AS
Interpro Name	Cysteine peptidase, cysteine active site
Interpro Type	Active_site
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

PROTEASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
ENZYME

Publications:

Lipps et al., 1996, Cathepsin B of Schistosoma mansoni. Purification and activation of the recombinant proenzyme secreted by Saccharomyces cerevisiae., J. Biol. Chem.
Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

2-MERCAPTOPYRIDINE CTSB

Interaction Score: 28.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
O-BENZYL-L-SERINE CTSB

Interaction Score: 28.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
DIPHENYLACETIC ACID CTSB

Interaction Score: 28.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL1231013 CTSB

Interaction Score: 21.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL262103 CTSB

Interaction Score: 14.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
COUMARIN CTSB

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8576174

Sources:
NCI
UREA CTSB

Interaction Score: 1.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3223934

Sources:
NCI
BORTEZOMIB CTSB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20875739

Sources:
DTC

Ensembl: ENSG00000164733
- Version: 101_38
Alternate Names:

CTSB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000164733
- Version: 26-July-2011
Alternate Names:

CATHEPSIN B PRECURSOR (EC 3.4.22.1) (CATHEPSIN B1) (APP SECRETASE) (APPS). [SOURCE:UNIPROT/SWISSPROT;ACC:P07858] Description

ENSG00000164733 Ensembl Gene Id

CTSB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P07858
- Version: 11-September-2012
Alternate Names:

1508 Entrez Gene Id

ENSG00000164733 Ensembl Gene Id

P07858 Uniprot Accession

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name PROTEASE

Interpro Acc IPR000169

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 1508
- Version: 29-September-2020
Alternate Names:

2527 HUGO Gene ID

2527 HUGO Gene Symbol

cathepsin B HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name C1: Papain

GuideToPharmacology Gene Category ID 728

Gene Categories:

ENZYME

Publications:

DrugBank: BE0000939

Version: 5.1.7

Alternate Names:

CTSB DrugBank Gene Name

P07858 UniProt Accession

1508 Entrez Gene Id

Gene Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: CTSB

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.

Lipps et al., 1996, Cathepsin B of Schistosoma mansoni. Purification and activation of the recombinant proenzyme secreted by Saccharomyces cerevisiae., J. Biol. Chem.

DTC: CTSB

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000164733
- Version: 31-May-2017
Alternate Names:

ENSG00000164733 Gene Symbol

CTSB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: CTSB
- Version: 03-September-2020
Alternate Names:

Cathepsin B Gene Name

P07858 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: CTSB
- Version: 05-September-2020
Alternate Names:

CPSB GO Gene Synonym

Gene Info:

Gene Categories:

PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
dGene: CTSB
- Version: 27-Jun-2013
Alternate Names:

1508 Gene ID

APPS dGene Synonym

CPSB dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Cathepsin B
- Version: 2020.06.01
Alternate Names:

CTSB TTD Gene Abbreviation

T61746 TTD Target ID

Gene Info:

Publications:

CATHEPSIN B PRECURSOR (EC 3.4.22.1) (CATHEPSIN B1) (APP SECRETASE) (APPS). [SOURCE:UNIPROT/SWISSPROT;ACC:P07858]	Description
ENSG00000164733	Ensembl Gene Id
CTSB	Display Id

1508	Entrez Gene Id
ENSG00000164733	Ensembl Gene Id
P07858	Uniprot Accession

2527	HUGO Gene ID
2527	HUGO Gene Symbol
cathepsin B	HUGO Gene Name

CTSB	DrugBank Gene Name
P07858	UniProt Accession
1508	Entrez Gene Id

CTSB Gene Record

CTSB 1508 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8576174

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3223934

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20875739

Sources: DTC

Ensembl: ENSG00000164733

Alternate Names: CTSB Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000164733

Alternate Names: CATHEPSIN B PRECURSOR (EC 3.4.22.1) (CATHEPSIN B1) (APP SECRETASE) (APPS). [SOURCE:UNIPROT/SWISSPROT;ACC:P07858] Description ENSG00000164733 Ensembl Gene Id CTSB Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P07858

Alternate Names: 1508 Entrez Gene Id ENSG00000164733 Ensembl Gene Id P07858 Uniprot Accession

Gene Info: Uniprot Evidence 1: Evidence at protein level Human Readable Name PROTEASE Interpro Acc IPR000169

Gene Categories: PROTEASE, DRUGGABLE GENOME

Publications:

GuideToPharmacology: 1508

Alternate Names: 2527 HUGO Gene ID 2527 HUGO Gene Symbol cathepsin B HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name C1: Papain GuideToPharmacology Gene Category ID 728

Gene Categories: ENZYME

Publications:

DrugBank: BE0000939

Alternate Names: CTSB DrugBank Gene Name P07858 UniProt Accession 1508 Entrez Gene Id

Gene Info:

Publications: Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: CTSB

Alternate Names:

Gene Info:

DTC: CTSB

Alternate Names:

Gene Info:

Publications: Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000164733

Alternate Names: ENSG00000164733 Gene Symbol CTSB Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: CTSB

Alternate Names: Cathepsin B Gene Name P07858 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

GO: CTSB

Alternate Names: CPSB GO Gene Synonym

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
8576174

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3223934

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20875739

Sources:
DTC

Alternate Names:

CTSB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CATHEPSIN B PRECURSOR (EC 3.4.22.1) (CATHEPSIN B1) (APP SECRETASE) (APPS). [SOURCE:UNIPROT/SWISSPROT;ACC:P07858] Description

ENSG00000164733 Ensembl Gene Id

CTSB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1508 Entrez Gene Id

ENSG00000164733 Ensembl Gene Id

P07858 Uniprot Accession

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name PROTEASE

Interpro Acc IPR000169

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

2527 HUGO Gene ID

2527 HUGO Gene Symbol

cathepsin B HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name C1: Papain

GuideToPharmacology Gene Category ID 728

Gene Categories:

ENZYME

Alternate Names:

CTSB DrugBank Gene Name

P07858 UniProt Accession

1508 Entrez Gene Id

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Publications:

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

Alternate Names:

ENSG00000164733 Gene Symbol

CTSB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Cathepsin B Gene Name

P07858 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

CPSB GO Gene Synonym

Gene Categories:

PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

1508 Gene ID

APPS dGene Synonym

CPSB dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

CTSB TTD Gene Abbreviation

T61746 TTD Target ID