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CTSB Gene Record

  • Summary
  • Interactions
  • Claims
  • CTSB 1508 Druggable Genome

    Alternate Names:

    1508
    CATHEPSIN B
    CTSB
    APPS
    CPSB
    116810
    2527
    ENSG00000164733
    OTTHUMG00000090799
    2343
    P07858
    BE0000939
    NM_001908|NM_147780|NM_147781|NM_147782|NM_147783
    NP_001899|NP_680090|NP_680091|NP_680092|NP_680093
    CATHEPSIN B LIGHT CHAIN
    CATB_HUMAN
    CATHEPSIN B PRECURSOR (EC 3.4.22.1) (CATHEPSIN B1) (APP SECRETASE) (APPS). [SOURCE:UNIPROT/SWISSPROT;ACC:P07858]
    T61746

    Gene Info:

    GuideToPharmacology Gene Category Name C1: Papain
    GuideToPharmacology Gene Category ID 728
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name PROTEASE
    Interpro Acc IPR000169
    Uniprot Status Swiss-Prot
    Interpro Short Name Pept_cys_AS
    Interpro Name Cysteine peptidase, cysteine active site
    Interpro Type Active_site
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    PROTEASE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Lipps et al., 1996, Cathepsin B of Schistosoma mansoni. Purification and activation of the recombinant proenzyme secreted by Saccharomyces cerevisiae., J. Biol. Chem.
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • 2-MERCAPTOPYRIDINE   CTSB

    Interaction Score: 28.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • O-BENZYL-L-SERINE   CTSB

    Interaction Score: 28.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • DIPHENYLACETIC ACID   CTSB

    Interaction Score: 28.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL1231013   CTSB

    Interaction Score: 21.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • CHEMBL262103   CTSB

    Interaction Score: 14.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • COUMARIN   CTSB

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8576174


    Sources:
    NCI

  • UREA   CTSB

    Interaction Score: 1.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3223934


    Sources:
    NCI

  • BORTEZOMIB   CTSB

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC

  • Ensembl: ENSG00000164733

    • Version: 101_38

    Alternate Names:
    CTSB Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000164733

    • Version: 26-July-2011

    Alternate Names:
    CATHEPSIN B PRECURSOR (EC 3.4.22.1) (CATHEPSIN B1) (APP SECRETASE) (APPS). [SOURCE:UNIPROT/SWISSPROT;ACC:P07858] Description
    ENSG00000164733 Ensembl Gene Id
    CTSB Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P07858

    • Version: 11-September-2012

    Alternate Names:
    1508 Entrez Gene Id
    ENSG00000164733 Ensembl Gene Id
    P07858 Uniprot Accession

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name PROTEASE
    Interpro Acc IPR000169

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 1508

    • Version: 29-September-2020

    Alternate Names:
    2527 HUGO Gene ID
    2527 HUGO Gene Symbol
    cathepsin B HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name C1: Papain
    GuideToPharmacology Gene Category ID 728

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0000939

    • Version: 5.1.7

    Alternate Names:
    CTSB DrugBank Gene Name
    P07858 UniProt Accession
    1508 Entrez Gene Id

    Gene Info:

    Publications:
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • NCI: CTSB

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Agarwal et al., 1988, A probable mechanism of inactivation by urea of goat spleen cathepsin B. Unfolding and refolding studies., Biochem. J.
    Lipps et al., 1996, Cathepsin B of Schistosoma mansoni. Purification and activation of the recombinant proenzyme secreted by Saccharomyces cerevisiae., J. Biol. Chem.

  • DTC: CTSB

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000164733

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164733 Gene Symbol
    CTSB Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: CTSB

    • Version: 03-September-2020

    Alternate Names:
    Cathepsin B Gene Name
    P07858 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: CTSB

    • Version: 05-September-2020

    Alternate Names:
    CPSB GO Gene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: CTSB

    • Version: 27-Jun-2013

    Alternate Names:
    1508 Gene ID
    APPS dGene Synonym
    CPSB dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Cathepsin B

    • Version: 2020.06.01

    Alternate Names:
    CTSB TTD Gene Abbreviation
    T61746 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21