DGIdb - CTLA4 Gene Record

CTLA4 1493 Druggable GenomeClinically Actionable

Alternate Names:

1493
CYTOTOXIC T-LYMPHOCYTE ASSOCIATED PROTEIN 4
CTLA4
ALPS5
CD
CD152
CELIAC3
CTLA-4
GRD4
GSE
IDDM12
123890
2505
ENSG00000163599
OTTHUMG00000132877
PA27006
P16410
CD_antigen=CD152
Cytotoxic T-lymphocyte protein 4
Cytotoxic T-lymphocyte-associated antigen 4
1285
T15000

Gene Info:

CancerCommons Reported Gene Name	Anti-CTLA4
Target Class	Receptors
Target Subclass	Miscellaneous
Target Subclass	CTLA4
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Yang et al., Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis., J. Immunother.
Oki et al., 1999, Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4., Int. Immunol.
Kasai et al., 1998, Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice., Int. Arch. Allergy Immunol.
Okazaki et al., 2001, Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice., J. Immunol.
Lai et al., 1994, CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin., J. Biol. Chem.
Vanasek et al., 2001, Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness., J. Immunol.
Laso et al., 2000, Alcoholic liver cirrhosis is associated with a decreased expression of the CD28 costimulatory molecule, a lower ability of T cells to bind exogenous IL-2, and increased soluble CD8 levels., Cytometry
Kusztal M et al., 2007, Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients., Transplant Proc
Umland et al., 1999, Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation., Am. J. Respir. Cell Mol. Biol.
Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics
Bossowski et al., 2004, [Analysis of costimulatory molecules (CD28-CTLA-4/B7) expression on chosen mononuclear cells in adolescents with Graves' disease during methimazole therapy]., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw
Juffermans et al., 2000, Thalidomide suppresses Up-regulation of human immunodeficiency virus coreceptors CXCR4 and CCR5 on CD4+ T cells in humans., J. Infect. Dis.
Herbst et al., 2014, Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients., Nature

TREMELIMUMAB CTLA4

Interaction Score: 17.17

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Tremelimumab

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
IPILIMUMAB CTLA4

Interaction Score: 5.5

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Ipilimumab

Novel drug target Established target

Notes

PMIDs:
18049334

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions CancerCommons TTD
ZALIFRELIMAB CTLA4

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ABATACEPT CTLA4

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9758890

Sources:
NCI
ANTIBIOTIC CTLA4

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10030847

Sources:
NCI
ATEZOLIZUMAB CTLA4

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25428504

Sources:
CIViC
METHIMAZOLE CTLA4

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15504312

Sources:
NCI
MELPHALAN CTLA4

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB
BLEOMYCIN CTLA4

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11489978

Sources:
NCI
WORTMANNIN CTLA4

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10464177

Sources:
NCI
PREDNISONE CTLA4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB
THALIDOMIDE CTLA4

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10823791

Sources:
NCI
SIROLIMUS CTLA4

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7982907 11698435

Sources:
NCI
CYCLOSPORINE CTLA4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18021981

Sources:
PharmGKB
TACROLIMUS CTLA4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DEXAMETHASONE CTLA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB
ALCOHOL CTLA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11025487

Sources:
NCI
BORTEZOMIB CTLA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB

Ensembl: ENSG00000163599
- Version: 101_38
Alternate Names:

CTLA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P16410
- Version: January-2014
Alternate Names:

CTLA4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Miscellaneous

Target Subclass CTLA4

Publications:
CancerCommons: CTLA4
- Version: 25-July-2013
Alternate Names:

1493 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Anti-CTLA4

Publications:

PharmGKB: CTLA4

Version: 18-August-2020

Alternate Names:

PA27006 PharmGKB ID

Gene Info:

Publications:

Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics

Ferreira Vasconcelos LM et al., 2018, Polymorphism of IL10, IL4, CTLA4, and DAO Genes in Cross-Reactive Nonsteroidal Anti-inflammatory Drug Hypersensitivity., J Clin Pharmacol

Cabaleiro T et al., 2016, Paradoxical psoriasiform reactions to anti-TNFα drugs are associated with genetic polymorphisms in patients with psoriasis., Pharmacogenomics J

CIViC: CTLA4
- Version: 14-September-2020
Alternate Names:

1493 Entrez Gene ID

1285 CIViC Gene ID

Gene Info:

Publications:

Herbst et al., 2014, Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients., Nature

NCI: CTLA4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kasai et al., 1998, Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice., Int. Arch. Allergy Immunol.

Okazaki et al., 2001, Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice., J. Immunol.

Umland et al., 1999, Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation., Am. J. Respir. Cell Mol. Biol.

HingoraniCasas: ENSG00000163599
- Version: 31-May-2017
Alternate Names:

ENSG00000163599 Gene Symbol

CTLA4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: CTLA4
- Version: 20-Jun-2017
Alternate Names:

1493 Entrez Gene Id

CTLA4 MyCancerGenome Gene Symbol

CTLA4 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: CD152
- Version: chembl_23
Alternate Names:

CD152 GENE_SYMBOL

CTLA4 GENE_SYMBOL

Cytotoxic T-lymphocyte protein 4 UNIPROT

Gene Info:

Publications:
TALC: CTLA-4
- Version: 12-May-2016
Alternate Names:

CTLA-4 Gene Symbol

Gene Info:

Publications:
GO: CTLA4
- Version: 01-February-2022
Alternate Names:

CD152 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
Tempus: CTLA4
- Version: 11-November-2018
Alternate Names:

CTLA4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Cytotoxic T-lymphocyte protein 4
- Version: 2020.06.01
Alternate Names:

CTLA-4 TTD Gene Abbreviation

T15000 TTD Target ID

Gene Info:

Publications:
MskImpact: CTLA4
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationClinicalTrial: CTLA-4
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
CarisMolecularIntelligence: CTLA4
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Notes
Trial Name	Tremelimumab
Novel drug target	Established target

Trial Name	Ipilimumab
Novel drug target	Established target
Notes

1493	Entrez Gene Id
CTLA4	MyCancerGenome Gene Symbol
CTLA4	MyCancerGenome Reported Gene Name

CD152	GENE_SYMBOL
CTLA4	GENE_SYMBOL
Cytotoxic T-lymphocyte protein 4	UNIPROT

antibody (inhibitory)
inhibitor (inhibitory)

antibody (inhibitory)
inhibitor (inhibitory)

CTLA4 Gene Record

CTLA4 1493 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Notes Trial Name Tremelimumab Novel drug target Established target

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name Ipilimumab Novel drug target Established target Notes

PMIDs: 18049334

Sources: TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions CancerCommons TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9758890

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10030847

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25428504

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15504312

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11489978

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10464177

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10823791

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7982907 11698435

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18021981

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11025487

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Ensembl: ENSG00000163599

Alternate Names: CTLA4 Ensembl Gene Name

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Tremelimumab

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Ipilimumab

Novel drug target Established target

Notes

PMIDs:
18049334

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions CancerCommons TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9758890

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10030847

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25428504

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
15504312

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11489978

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10464177

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10823791

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7982907 11698435

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18021981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11025487

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Alternate Names:

CTLA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CTLA4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Miscellaneous

Target Subclass CTLA4

Alternate Names:

1493 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Anti-CTLA4

Alternate Names:

PA27006 PharmGKB ID

Alternate Names:

1493 Entrez Gene ID

1285 CIViC Gene ID

Publications:

Herbst et al., 2014, Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients., Nature

Alternate Names:

ENSG00000163599 Gene Symbol

CTLA4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1493 Entrez Gene Id

CTLA4 MyCancerGenome Gene Symbol

CTLA4 MyCancerGenome Reported Gene Name

Alternate Names:

CD152 GENE_SYMBOL

CTLA4 GENE_SYMBOL

Cytotoxic T-lymphocyte protein 4 UNIPROT

Alternate Names:

CTLA-4 Gene Symbol

Alternate Names:

CD152 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

CTLA4 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

CTLA-4 TTD Gene Abbreviation

T15000 TTD Target ID