DGIdb - CTLA4 Gene Record

CTLA4 1493 Druggable GenomeClinically Actionable

Alternate Names:

1493
CYTOTOXIC T-LYMPHOCYTE ASSOCIATED PROTEIN 4
CTLA4
ALPS5
CD
CD152
CELIAC3
CTLA-4
GRD4
GSE
IDDM12
123890
2505
ENSG00000163599
OTTHUMG00000132877
PA27006
P16410
CD_antigen=CD152
Cytotoxic T-lymphocyte protein 4
Cytotoxic T-lymphocyte-associated antigen 4
1285
2743
cytotoxic T-lymphocyte-associated protein 4 (CD152)
T15000
NM_005214
NP_005205

Gene Info:

CancerCommons Reported Gene Name	Anti-CTLA4
Target Class	Receptors
Target Subclass	Miscellaneous
Target Subclass	CTLA4
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	CD molecules
GuideToPharmacology Gene Category ID	852
GuideToPharmacology Gene Category Name	Other immune checkpoint proteins
GuideToPharmacology Gene Category ID	949

(13 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Yang et al., Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis., J. Immunother.
Oki et al., 1999, Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4., Int. Immunol.
Kasai et al., 1998, Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice., Int. Arch. Allergy Immunol.
Okazaki et al., 2001, Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice., J. Immunol.
Lai et al., 1994, CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin., J. Biol. Chem.
Vanasek et al., 2001, Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness., J. Immunol.
Laso et al., 2000, Alcoholic liver cirrhosis is associated with a decreased expression of the CD28 costimulatory molecule, a lower ability of T cells to bind exogenous IL-2, and increased soluble CD8 levels., Cytometry
Kusztal M et al., 2007, Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients., Transplant Proc
Umland et al., 1999, Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation., Am. J. Respir. Cell Mol. Biol.
Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics
Bossowski et al., 2004, [Analysis of costimulatory molecules (CD28-CTLA-4/B7) expression on chosen mononuclear cells in adolescents with Graves' disease during methimazole therapy]., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw
Juffermans et al., 2000, Thalidomide suppresses Up-regulation of human immunodeficiency virus coreceptors CXCR4 and CCR5 on CD4+ T cells in humans., J. Infect. Dis.
Herbst et al., 2014, Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients., Nature

TREMELIMUMAB CTLA4

Interaction Score: 21.26

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Average Kd from associated patent, for a competition ELISA assessing binding of the antibody to CTLA4.

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

IPILIMUMAB CTLA4

Interaction Score: 6.38

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Binding

Direct Interaction? True

PMIDs:
18049334

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology CancerCommons TTD
ZALIFRELIMAB CTLA4

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ABATACEPT CTLA4

Interaction Score: 2.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9758890

Sources:
NCI
ANTIBIOTIC CTLA4

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10030847

Sources:
NCI
ATEZOLIZUMAB CTLA4

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25428504

Sources:
CIViC
METHIMAZOLE CTLA4

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15504312

Sources:
NCI
MELPHALAN CTLA4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB
BLEOMYCIN CTLA4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11489978

Sources:
NCI
PREDNISONE CTLA4

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB
THALIDOMIDE CTLA4

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10823791

Sources:
NCI
WORTMANNIN CTLA4

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10464177

Sources:
NCI
SIROLIMUS CTLA4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7982907 11698435

Sources:
NCI
CYCLOSPORINE CTLA4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18021981

Sources:
PharmGKB
TACROLIMUS CTLA4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DEXAMETHASONE CTLA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB
ALCOHOL CTLA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11025487

Sources:
NCI
BORTEZOMIB CTLA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB

Ensembl: ENSG00000163599
- Version: 101_38
Alternate Names:

CTLA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P16410
- Version: January-2014
Alternate Names:

CTLA4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Miscellaneous

Target Subclass CTLA4

Publications:
CancerCommons: CTLA4
- Version: 25-July-2013
Alternate Names:

1493 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Anti-CTLA4

Publications:
GuideToPharmacology: 1493
- Version: 29-September-2020
Alternate Names:

2505 HUGO Gene ID

2505 HUGO Gene Symbol

cytotoxic T-lymphocyte associated protein 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CD molecules

GuideToPharmacology Gene Category ID 852

GuideToPharmacology Gene Category Name Other immune checkpoint proteins

Publications:

PharmGKB: CTLA4

Version: 18-August-2020

Alternate Names:

PA27006 PharmGKB ID

Gene Info:

Publications:

Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics

Ferreira Vasconcelos LM et al., 2018, Polymorphism of IL10, IL4, CTLA4, and DAO Genes in Cross-Reactive Nonsteroidal Anti-inflammatory Drug Hypersensitivity., J Clin Pharmacol

Cabaleiro T et al., 2016, Paradoxical psoriasiform reactions to anti-TNFα drugs are associated with genetic polymorphisms in patients with psoriasis., Pharmacogenomics J

CIViC: CTLA4
- Version: 14-September-2020
Alternate Names:

1493 Entrez Gene ID

1285 CIViC Gene ID

Gene Info:

Publications:

Herbst et al., 2014, Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients., Nature

NCI: CTLA4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kasai et al., 1998, Blockade of CD28/B7 interaction suppresses allergic eosinophilic inflammation in mice., Int. Arch. Allergy Immunol.

Okazaki et al., 2001, Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice., J. Immunol.

Umland et al., 1999, Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation., Am. J. Respir. Cell Mol. Biol.

HingoraniCasas: ENSG00000163599
- Version: 31-May-2017
Alternate Names:

ENSG00000163599 Gene Symbol

CTLA4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: CTLA4
- Version: 20-Jun-2017
Alternate Names:

1493 Entrez Gene Id

CTLA4 MyCancerGenome Gene Symbol

CTLA4 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: CD152
- Version: chembl_23
Alternate Names:

CD152 GENE_SYMBOL

CTLA4 GENE_SYMBOL

Cytotoxic T-lymphocyte protein 4 UNIPROT

Gene Info:

Publications:
TALC: CTLA-4
- Version: 12-May-2016
Alternate Names:

CTLA-4 Gene Symbol

Gene Info:

Publications:
Tempus: CTLA4
- Version: 11-November-2018
Alternate Names:

CTLA4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Cytotoxic T-lymphocyte protein 4
- Version: 2020.06.01
Alternate Names:

CTLA-4 TTD Gene Abbreviation

T15000 TTD Target ID

Gene Info:

Publications:
GO: CTLA4
- Version: 01-May-2021
Alternate Names:

CD152 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
MskImpact: CTLA4
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationClinicalTrial: CTLA-4
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
CarisMolecularIntelligence: CTLA4
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Details of the Assay for Interaction	Average Kd from associated patent, for a competition ELISA assessing binding of the antibody to CTLA4.
Specific Action of the Ligand	Binding
Endogenous Drug?	False

2505	HUGO Gene ID
2505	HUGO Gene Symbol
cytotoxic T-lymphocyte associated protein 4	HUGO Gene Name

1493	Entrez Gene Id
CTLA4	MyCancerGenome Gene Symbol
CTLA4	MyCancerGenome Reported Gene Name

CD152	GENE_SYMBOL
CTLA4	GENE_SYMBOL
Cytotoxic T-lymphocyte protein 4	UNIPROT

CTLA4 Gene Record

CTLA4 1493 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Average Kd from associated patent, for a competition ELISA assessing binding of the antibody to CTLA4. Specific Action of the Ligand Binding Endogenous Drug? False

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Binding Direct Interaction? True

PMIDs: 18049334

Sources: TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology CancerCommons TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9758890

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10030847

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25428504

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15504312

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11489978

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10823791

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10464177

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7982907 11698435

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18021981

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11025487

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Ensembl: ENSG00000163599

Alternate Names: CTLA4 Ensembl Gene Name

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Average Kd from associated patent, for a competition ELISA assessing binding of the antibody to CTLA4.

Specific Action of the Ligand Binding

Endogenous Drug? False

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Binding

Direct Interaction? True

PMIDs:
18049334

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology CancerCommons TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9758890

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10030847

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25428504

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
15504312

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11489978

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10823791

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10464177

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7982907 11698435

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18021981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11025487

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Alternate Names:

CTLA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CTLA4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Miscellaneous

Target Subclass CTLA4

Alternate Names:

1493 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Anti-CTLA4

Alternate Names:

2505 HUGO Gene ID

2505 HUGO Gene Symbol

cytotoxic T-lymphocyte associated protein 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CD molecules

GuideToPharmacology Gene Category ID 852

GuideToPharmacology Gene Category Name Other immune checkpoint proteins

Alternate Names:

PA27006 PharmGKB ID

Alternate Names:

1493 Entrez Gene ID

1285 CIViC Gene ID

Publications:

Herbst et al., 2014, Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients., Nature

Alternate Names:

ENSG00000163599 Gene Symbol

CTLA4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1493 Entrez Gene Id

CTLA4 MyCancerGenome Gene Symbol

CTLA4 MyCancerGenome Reported Gene Name

Alternate Names:

CD152 GENE_SYMBOL

CTLA4 GENE_SYMBOL

Cytotoxic T-lymphocyte protein 4 UNIPROT

Alternate Names:

CTLA-4 Gene Symbol

Alternate Names:

CTLA4 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

CTLA-4 TTD Gene Abbreviation

T15000 TTD Target ID