DGIdb - CSNK1E Gene Record

CSNK1E 1454 Druggable Genome

Alternate Names:

1454
CASEIN KINASE 1 EPSILON
CSNK1E
CKIepsilon
HCKIE
600863
2453
ENSG00000213923
OTTHUMG00000151135
1998
P49674
NM_001894
NP_001885
ENSG00000100181
CASEIN KINASE I, EPSILON ISOFORM (EC 2.7.1.-) (CKI-EPSILON) (CKIE). [SOURCE:UNIPROT/SWISSPROT;ACC:P49674]
PA26953
Casein kinase I isoform epsilon
BE0003512

Gene Info:

GuideToPharmacology Gene Category Name	Casein kinase 1 (CK1) family
GuideToPharmacology Gene Category ID	564
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DNA REPAIR
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res

UMBRALISIB CSNK1E

Interaction Score: 3.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL2069623 CSNK1E

Interaction Score: 3.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL261454 CSNK1E

Interaction Score: 3.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
CHEMBL1951415 CSNK1E

Interaction Score: 1.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical kinase assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SELICICLIB CSNK1E

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17108108

Sources:
DrugBank
IC261 CSNK1E

Interaction Score: 0.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
DIACETYLMORPHINE CSNK1E

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SB-202190 CSNK1E

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22951114

Sources:
DTC

Ensembl: ENSG00000213923
- Version: 101_38
Alternate Names:

CSNK1E Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000100181
- Version: 26-July-2011
Alternate Names:

ENSG00000100181 Ensembl Gene Id

CASEIN KINASE I, EPSILON ISOFORM (EC 2.7.1.-) (CKI-EPSILON) (CKIE). [SOURCE:UNIPROT/SWISSPROT;ACC:P49674] Description

CSNK1E Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 1454
- Version: 29-September-2020
Alternate Names:

2453 HUGO Gene ID

2453 HUGO Gene Symbol

casein kinase 1 epsilon HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Casein kinase 1 (CK1) family

GuideToPharmacology Gene Category ID 564

Gene Categories:

ENZYME

Publications:
DrugBank: BE0003512
- Version: 5.1.7
Alternate Names:

CSNK1E DrugBank Gene Name

P49674 UniProt Accession

1454 Entrez Gene Id

Gene Info:

Publications:

Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res

DTC: CSNK1E

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

HingoraniCasas: ENSG00000213923
- Version: 31-May-2017
Alternate Names:

ENSG00000213923 Gene Symbol

CSNK1E Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: CSNK1E
- Version: 18-August-2020
Alternate Names:

PA26953 PharmGKB ID

Gene Info:

Publications:
Pharos: CSNK1E
- Version: 03-September-2020
Alternate Names:

Casein kinase I isoform epsilon Gene Name

P49674 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
dGene: CSNK1E
- Version: 27-Jun-2013
Alternate Names:

1454 Gene ID

CKIepsilon dGene Synonym

HCKIE dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
GO: CSNK1E
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

DNA REPAIR, SERINE THREONINE KINASE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Details of the Assay for Interaction	In a biochemical kinase assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

ENSG00000100181	Ensembl Gene Id
CASEIN KINASE I, EPSILON ISOFORM (EC 2.7.1.-) (CKI-EPSILON) (CKIE). [SOURCE:UNIPROT/SWISSPROT;ACC:P49674]	Description
CSNK1E	Display Id

2453	HUGO Gene ID
2453	HUGO Gene Symbol
casein kinase 1 epsilon	HUGO Gene Name

CSNK1E	DrugBank Gene Name
P49674	UniProt Accession
1454	Entrez Gene Id

CSNK1E Gene Record

CSNK1E 1454 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction In a biochemical kinase assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17108108

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22951114

Sources: DTC

Ensembl: ENSG00000213923

Alternate Names: CSNK1E Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000100181

Alternate Names: ENSG00000100181 Ensembl Gene Id CASEIN KINASE I, EPSILON ISOFORM (EC 2.7.1.-) (CKI-EPSILON) (CKIE). [SOURCE:UNIPROT/SWISSPROT;ACC:P49674] Description CSNK1E Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 1454

Alternate Names: 2453 HUGO Gene ID 2453 HUGO Gene Symbol casein kinase 1 epsilon HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Casein kinase 1 (CK1) family GuideToPharmacology Gene Category ID 564

Gene Categories: ENZYME

Publications:

DrugBank: BE0003512

Alternate Names: CSNK1E DrugBank Gene Name P49674 UniProt Accession 1454 Entrez Gene Id

Gene Info:

Publications: Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res

DTC: CSNK1E

Alternate Names:

Gene Info:

Publications: Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem. Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

HingoraniCasas: ENSG00000213923

Alternate Names: ENSG00000213923 Gene Symbol CSNK1E Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: CSNK1E

Alternate Names: PA26953 PharmGKB ID

Gene Info:

Publications:

Pharos: CSNK1E

Alternate Names: Casein kinase I isoform epsilon Gene Name P49674 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

dGene: CSNK1E

Alternate Names: 1454 Gene ID CKIepsilon dGene Synonym HCKIE dGene Synonym

Gene Info:

Gene Categories: KINASE, SERINE THREONINE KINASE

Publications:

GO: CSNK1E

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical kinase assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
17108108

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22951114

Sources:
DTC

Alternate Names:

CSNK1E Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000100181 Ensembl Gene Id

CASEIN KINASE I, EPSILON ISOFORM (EC 2.7.1.-) (CKI-EPSILON) (CKIE). [SOURCE:UNIPROT/SWISSPROT;ACC:P49674] Description

CSNK1E Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

2453 HUGO Gene ID

2453 HUGO Gene Symbol

casein kinase 1 epsilon HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Casein kinase 1 (CK1) family

GuideToPharmacology Gene Category ID 564

Gene Categories:

ENZYME

Alternate Names:

CSNK1E DrugBank Gene Name

P49674 UniProt Accession

1454 Entrez Gene Id

Publications:

Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

Alternate Names:

ENSG00000213923 Gene Symbol

CSNK1E Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA26953 PharmGKB ID

Alternate Names:

Casein kinase I isoform epsilon Gene Name

P49674 UniProt ID

Gene Categories:

KINASE

Alternate Names:

1454 Gene ID

CKIepsilon dGene Synonym

HCKIE dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Gene Categories:

DNA REPAIR, SERINE THREONINE KINASE