DGIdb - CSF2 Gene Record

CSF2 1437 Druggable Genome

Alternate Names:

1437
COLONY STIMULATING FACTOR 2
CSF2
CSF
GMCSF
138960
2434
ENSG00000164400
OTTHUMG00000059637
Sargramostim
Molgramostin
Colony-stimulating factor
Granulocyte-macrophage colony-stimulating factor
GM-CSF
P04141
CSF2_HUMAN
BE0002481
T74002

Gene Info:

Target Class	ligand
Target Subclass	Ligand
Target Subclass	CSF2
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
GROWTH FACTOR
DRUGGABLE GENOME

Publications:

Laver et al., 1992, Effects of radiation and 4-hydroperoxycyclophosphamide on production of G- and GM-CSF by stromal cells., Bone Marrow Transplant.
Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.
Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.
Joseph et al., 1998, Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents., J. Natl. Cancer Inst.
Bokemeyer et al., 1993, A phase I/II study of a stepwise dose-escalated regimen of cisplatin, etoposide and ifosfamide plus granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced germ cell tumours., Eur. J. Cancer
Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer
Skowron et al., 1999, The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial., J. Infect. Dis.
Borger et al., 1998, Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype., Am. J. Respir. Cell Mol. Biol.
Agnholt et al., 2003, The effect of etanercept and infliximab on the production of tumour necrosis factor alpha, interferon-gamma and GM-CSF in in vivo activated intestinal T lymphocyte cultures., Cytokine
Crampette et al., 1996, Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine., Allergy
Molloy et al., Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa., Hepatogastroenterology
Lewis et al., 2005, A phase II study of biochemotherapy for advanced melanoma incorporating temozolomide, decrescendo interleukin-2 and GM-CSF., Cancer Invest.
de Gast et al., 2003, Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFN alpha in patients with metastatic melanoma., Br. J. Cancer
Hochhuth et al., 1992, Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells., Cell. Immunol.
Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.
Bermudez et al., 1994, Recombinant granulocyte-macrophage colony-stimulating factor enhances the effects of antibiotics against Mycobacterium avium complex infection in the beige mouse model., J. Infect. Dis.
Mayordomo et al., 1995, Improving treatment of chemotherapy-induced neutropenic fever by administration of colony-stimulating factors., J. Natl. Cancer Inst.
Wang et al., 2005, Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis., Biol. Pharm. Bull.
Hrubec et al., 2006, Reduction in diabetes-induced craniofacial defects by maternal immune stimulation., Birth Defects Res. B Dev. Reprod. Toxicol.
Kountouras et al., Omeprazole and regulation of cytokine profile in Helicobacter pylori-infected patients with duodenal ulcer disease., Hepatogastroenterology
Hartmann et al., 1995, Phase I trial of diaziquone (AZQ) plus GM-CSF., Invest New Drugs
Fruehauf et al., 2005, Docetaxel and vinorelbine plus GM-CSF in malignant melanoma., Oncology (Williston Park, N.Y.)
Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect
Aydin et al., 1998, Effects of high dose medroxyprogesterone acetate on endogenous granulocyte macrophage-colony stimulating factor secretion and bone marrow cellularity in patients under cytotoxic chemotherapy., J Chemother
Perno et al., 1989, Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine., J. Exp. Med.
Han et al., 2005, [The influence of mycophenolate mofetil upon the maturation and allostimulatory activity of cultured dendritic cell progenitors and the effects of tolerance induction in allograft recipients]., Zhonghua Yi Xue Za Zhi
Colic et al., 2003, Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells., Clin. Exp. Immunol.
Somogyi et al., 1996, Treatment of drug-induced bone marrow suppression with recombinant human granulocyte/monocyte colony stimulating factor., Adverse Drug React Toxicol Rev
Somogyi et al., 1994, [Treatment of methimazole-induced agranulocytosis with granulocyte-macrophage colony stimulating factor]., Orv Hetil
Joshi et al., 2005, Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage., J. Immunol.
Asano et al., 1997, Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia., Life Sci.
Kawai et al., 2005, Epigallocatechin gallate induces apoptosis of monocytes., J. Allergy Clin. Immunol.
Harousseau et al., 1996, Treatment of acute myeloblastic leukemia in adults. The GOELAM experience., Hematol Cell Ther
Bodey et al., 1994, Role of granulocyte-macrophage colony-stimulating factor as adjuvant treatment in neutropenic patients with bacterial and fungal infection., Eur. J. Clin. Microbiol. Infect. Dis.
Oksenberg et al., 1990, Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells., Cancer Res.
Katayama et al., 1990, A role for calmodulin in the growth of human hematopoietic progenitor cells., Blood

LENZILUMAB CSF2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Publications:
OTILIMAB CSF2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MOR103

Novel drug target Novel Target

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Publications:
NAMILUMAB CSF2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Direct Interaction yes

Trial Name MT203

Publications:
REGRAMOSTIM CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GVAX

Novel drug target Novel Target

Publications:
PERFOSFAMIDE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Laver et al., 1992, Effects of radiation and 4-hydroperoxycyclophosphamide on production of G- and GM-CSF by stromal cells., Bone Marrow Transplant.
STAUROSPORINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.
LACTULOSE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.
ROQUINIMEX CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Joseph et al., 1998, Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents., J. Natl. Cancer Inst.

PLATINUM CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bokemeyer et al., 1993, A phase I/II study of a stepwise dose-escalated regimen of cisplatin, etoposide and ifosfamide plus granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced germ cell tumours., Eur. J. Cancer

MECHLORETHAMINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer

INDINAVIR CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Skowron et al., 1999, The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial., J. Infect. Dis.

ISOPROTERENOL CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Borger et al., 1998, Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype., Am. J. Respir. Cell Mol. Biol.

ETANERCEPT CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Agnholt et al., 2003, The effect of etanercept and infliximab on the production of tumour necrosis factor alpha, interferon-gamma and GM-CSF in in vivo activated intestinal T lymphocyte cultures., Cytokine

TERFENADINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Crampette et al., 1996, Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine., Allergy
FAMCICLOVIR CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Molloy et al., Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa., Hepatogastroenterology

TEMOZOLOMIDE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lewis et al., 2005, A phase II study of biochemotherapy for advanced melanoma incorporating temozolomide, decrescendo interleukin-2 and GM-CSF., Cancer Invest.

de Gast et al., 2003, Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFN alpha in patients with metastatic melanoma., Br. J. Cancer

MILTEFOSINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hochhuth et al., 1992, Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells., Cell. Immunol.
ACLARUBICIN CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.

AMIKACIN CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bermudez et al., 1994, Recombinant granulocyte-macrophage colony-stimulating factor enhances the effects of antibiotics against Mycobacterium avium complex infection in the beige mouse model., J. Infect. Dis.

Mayordomo et al., 1995, Improving treatment of chemotherapy-induced neutropenic fever by administration of colony-stimulating factors., J. Natl. Cancer Inst.

CILOSTAZOL CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wang et al., 2005, Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis., Biol. Pharm. Bull.
VINBLASTINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer
STREPTOZOCIN CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hrubec et al., 2006, Reduction in diabetes-induced craniofacial defects by maternal immune stimulation., Birth Defects Res. B Dev. Reprod. Toxicol.
OMEPRAZOLE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kountouras et al., Omeprazole and regulation of cytokine profile in Helicobacter pylori-infected patients with duodenal ulcer disease., Hepatogastroenterology
DIAZIQUONE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hartmann et al., 1995, Phase I trial of diaziquone (AZQ) plus GM-CSF., Invest New Drugs
NAVELBINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Fruehauf et al., 2005, Docetaxel and vinorelbine plus GM-CSF in malignant melanoma., Oncology (Williston Park, N.Y.)

CETIRIZINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect

PROGESTERONE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Aydin et al., 1998, Effects of high dose medroxyprogesterone acetate on endogenous granulocyte macrophage-colony stimulating factor secretion and bone marrow cellularity in patients under cytotoxic chemotherapy., J Chemother

STAVUDINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Perno et al., 1989, Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine., J. Exp. Med.

MYCOPHENOLATE MOFETIL CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Han et al., 2005, [The influence of mycophenolate mofetil upon the maturation and allostimulatory activity of cultured dendritic cell progenitors and the effects of tolerance induction in allograft recipients]., Zhonghua Yi Xue Za Zhi

Colic et al., 2003, Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells., Clin. Exp. Immunol.

METHIMAZOLE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Somogyi et al., 1996, Treatment of drug-induced bone marrow suppression with recombinant human granulocyte/monocyte colony stimulating factor., Adverse Drug React Toxicol Rev

Somogyi et al., 1994, [Treatment of methimazole-induced agranulocytosis with granulocyte-macrophage colony stimulating factor]., Orv Hetil

ALCOHOL CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Joshi et al., 2005, Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage., J. Immunol.

EPIGALOCATECHIN GALLATE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Asano et al., 1997, Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia., Life Sci.

Kawai et al., 2005, Epigallocatechin gallate induces apoptosis of monocytes., J. Allergy Clin. Immunol.

IDARUBICIN CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Harousseau et al., 1996, Treatment of acute myeloblastic leukemia in adults. The GOELAM experience., Hematol Cell Ther
PROCARBAZINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer

TICARCILLIN CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bodey et al., 1994, Role of granulocyte-macrophage colony-stimulating factor as adjuvant treatment in neutropenic patients with bacterial and fungal infection., Eur. J. Clin. Microbiol. Infect. Dis.

INSULIN CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Oksenberg et al., 1990, Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells., Cancer Res.
TRIFLUOPERAZINE CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Katayama et al., 1990, A role for calmodulin in the growth of human hematopoietic progenitor cells., Blood
MAVRILIMUMAB CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CABIRALIZUMAB CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PEXASTIMOGENE DEVACIREPVEC CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GIMSILUMAB CSF2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000164400
- Version: 101_38
Alternate Names:

CSF2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P04141
- Version: January-2014
Alternate Names:

CSF2 Gene Symbol

Gene Info:

Target Class ligand

Target Subclass Ligand

Target Subclass CSF2

Publications:

NCI: CSF2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.

Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.

Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.

ChemblInteractions: GMCSF
- Version: chembl_23
Alternate Names:

GMCSF GENE_SYMBOL

CSF2 GENE_SYMBOL

Granulocyte-macrophage colony-stimulating factor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000164400
- Version: 31-May-2017
Alternate Names:

ENSG00000164400 Gene Symbol

CSF2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Granulocyte-macrophage colony-stimulating factor
- Version: 2020.06.01
Alternate Names:

CSF2 TTD Gene Abbreviation

T74002 TTD Target ID

Gene Info:

Publications:
GO: CSF2
- Version: 05-September-2020
Alternate Names:

GMCSF GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:
DrugBank: BE0002481
- Version: 5.1.7
Alternate Names:

CSF2 DrugBank Gene Name

P04141 UniProt Accession

1437 Entrez Gene Id

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Granulocyte-macrophage colony-stimulating factor inhibitor

Trial Name	MOR103
Novel drug target	Novel Target
Mechanism of Interaction	Granulocyte-macrophage colony-stimulating factor inhibitor

GMCSF	GENE_SYMBOL
CSF2	GENE_SYMBOL
Granulocyte-macrophage colony-stimulating factor	UNIPROT

CSF2	DrugBank Gene Name
P04141	UniProt Accession
1437	Entrez Gene Id

CSF2 Gene Record

CSF2 1437 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MOR103 Novel drug target Novel Target Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor Direct Interaction yes Trial Name MT203

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name GVAX Novel drug target Novel Target

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Laver et al., 1992, Effects of radiation and 4-hydroperoxycyclophosphamide on production of G- and GM-CSF by stromal cells., Bone Marrow Transplant.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Joseph et al., 1998, Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents., J. Natl. Cancer Inst.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Bokemeyer et al., 1993, A phase I/II study of a stepwise dose-escalated regimen of cisplatin, etoposide and ifosfamide plus granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced germ cell tumours., Eur. J. Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Skowron et al., 1999, The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial., J. Infect. Dis.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Borger et al., 1998, Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype., Am. J. Respir. Cell Mol. Biol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Agnholt et al., 2003, The effect of etanercept and infliximab on the production of tumour necrosis factor alpha, interferon-gamma and GM-CSF in in vivo activated intestinal T lymphocyte cultures., Cytokine

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Crampette et al., 1996, Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine., Allergy

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Molloy et al., Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa., Hepatogastroenterology

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hochhuth et al., 1992, Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells., Cell. Immunol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wang et al., 2005, Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis., Biol. Pharm. Bull.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hrubec et al., 2006, Reduction in diabetes-induced craniofacial defects by maternal immune stimulation., Birth Defects Res. B Dev. Reprod. Toxicol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kountouras et al., Omeprazole and regulation of cytokine profile in Helicobacter pylori-infected patients with duodenal ulcer disease., Hepatogastroenterology

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hartmann et al., 1995, Phase I trial of diaziquone (AZQ) plus GM-CSF., Invest New Drugs

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Fruehauf et al., 2005, Docetaxel and vinorelbine plus GM-CSF in malignant melanoma., Oncology (Williston Park, N.Y.)

Interaction Types & Directionality: n/a

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MOR103

Novel drug target Novel Target

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Direct Interaction yes

Trial Name MT203

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GVAX

Novel drug target Novel Target

Interaction Types & Directionality:

n/a

Publications:

Laver et al., 1992, Effects of radiation and 4-hydroperoxycyclophosphamide on production of G- and GM-CSF by stromal cells., Bone Marrow Transplant.

Interaction Types & Directionality:

n/a

Publications:

Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.

Interaction Types & Directionality:

n/a

Publications:

Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.

Interaction Types & Directionality:

n/a

Publications:

Joseph et al., 1998, Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents., J. Natl. Cancer Inst.

Interaction Types & Directionality:

n/a

Publications:

Bokemeyer et al., 1993, A phase I/II study of a stepwise dose-escalated regimen of cisplatin, etoposide and ifosfamide plus granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced germ cell tumours., Eur. J. Cancer

Interaction Types & Directionality:

n/a

Publications:

Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer

Interaction Types & Directionality:

n/a

Publications:

Skowron et al., 1999, The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial., J. Infect. Dis.

Interaction Types & Directionality:

n/a

Publications:

Borger et al., 1998, Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype., Am. J. Respir. Cell Mol. Biol.

Interaction Types & Directionality:

n/a

Publications:

Agnholt et al., 2003, The effect of etanercept and infliximab on the production of tumour necrosis factor alpha, interferon-gamma and GM-CSF in in vivo activated intestinal T lymphocyte cultures., Cytokine

Interaction Types & Directionality:

n/a

Publications:

Crampette et al., 1996, Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine., Allergy

Interaction Types & Directionality:

n/a

Publications:

Molloy et al., Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa., Hepatogastroenterology

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Hochhuth et al., 1992, Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells., Cell. Immunol.

Interaction Types & Directionality:

n/a

Publications:

Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Wang et al., 2005, Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis., Biol. Pharm. Bull.

Interaction Types & Directionality:

n/a

Publications:

Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer

Interaction Types & Directionality:

n/a

Publications:

Hrubec et al., 2006, Reduction in diabetes-induced craniofacial defects by maternal immune stimulation., Birth Defects Res. B Dev. Reprod. Toxicol.

Interaction Types & Directionality:

n/a

Publications:

Kountouras et al., Omeprazole and regulation of cytokine profile in Helicobacter pylori-infected patients with duodenal ulcer disease., Hepatogastroenterology

Interaction Types & Directionality:

n/a

Publications:

Hartmann et al., 1995, Phase I trial of diaziquone (AZQ) plus GM-CSF., Invest New Drugs

Interaction Types & Directionality:

n/a

Publications:

Fruehauf et al., 2005, Docetaxel and vinorelbine plus GM-CSF in malignant melanoma., Oncology (Williston Park, N.Y.)

Interaction Types & Directionality:

n/a

Publications:

Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect

Interaction Types & Directionality:

n/a

Publications:

Aydin et al., 1998, Effects of high dose medroxyprogesterone acetate on endogenous granulocyte macrophage-colony stimulating factor secretion and bone marrow cellularity in patients under cytotoxic chemotherapy., J Chemother

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Joshi et al., 2005, Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage., J. Immunol.

Interaction Types & Directionality:

n/a

Publications:

Asano et al., 1997, Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia., Life Sci.

Kawai et al., 2005, Epigallocatechin gallate induces apoptosis of monocytes., J. Allergy Clin. Immunol.

Interaction Types & Directionality:

n/a

Publications:

Harousseau et al., 1996, Treatment of acute myeloblastic leukemia in adults. The GOELAM experience., Hematol Cell Ther

Interaction Types & Directionality:

n/a

Publications:

Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer

Interaction Types & Directionality:

n/a

Publications:

Bodey et al., 1994, Role of granulocyte-macrophage colony-stimulating factor as adjuvant treatment in neutropenic patients with bacterial and fungal infection., Eur. J. Clin. Microbiol. Infect. Dis.

Interaction Types & Directionality:

n/a

Publications:

Oksenberg et al., 1990, Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells., Cancer Res.