DGIdb - CSF2 Gene Record

CSF2 1437 Druggable Genome

Alternate Names:

1437
COLONY STIMULATING FACTOR 2
CSF2
CSF
GMCSF
138960
2434
ENSG00000164400
OTTHUMG00000059637
Sargramostim
Molgramostin
Colony-stimulating factor
Granulocyte-macrophage colony-stimulating factor
GM-CSF
P04141
BE0002481
T74002

Gene Info:

Target Class	ligand
Target Subclass	Ligand
Target Subclass	CSF2
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
DRUGGABLE GENOME

Publications:

Laver et al., 1992, Effects of radiation and 4-hydroperoxycyclophosphamide on production of G- and GM-CSF by stromal cells., Bone Marrow Transplant.
Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.
Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.
Joseph et al., 1998, Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents., J. Natl. Cancer Inst.
Bokemeyer et al., 1993, A phase I/II study of a stepwise dose-escalated regimen of cisplatin, etoposide and ifosfamide plus granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced germ cell tumours., Eur. J. Cancer
Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer
Skowron et al., 1999, The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial., J. Infect. Dis.
Borger et al., 1998, Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype., Am. J. Respir. Cell Mol. Biol.
Agnholt et al., 2003, The effect of etanercept and infliximab on the production of tumour necrosis factor alpha, interferon-gamma and GM-CSF in in vivo activated intestinal T lymphocyte cultures., Cytokine
Crampette et al., 1996, Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine., Allergy
Molloy et al., Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa., Hepatogastroenterology
de Gast et al., 2003, Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFN alpha in patients with metastatic melanoma., Br. J. Cancer
Lewis et al., 2005, A phase II study of biochemotherapy for advanced melanoma incorporating temozolomide, decrescendo interleukin-2 and GM-CSF., Cancer Invest.
Hochhuth et al., 1992, Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells., Cell. Immunol.
Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.
Mayordomo et al., 1995, Improving treatment of chemotherapy-induced neutropenic fever by administration of colony-stimulating factors., J. Natl. Cancer Inst.
Bermudez et al., 1994, Recombinant granulocyte-macrophage colony-stimulating factor enhances the effects of antibiotics against Mycobacterium avium complex infection in the beige mouse model., J. Infect. Dis.
Wang et al., 2005, Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis., Biol. Pharm. Bull.
Hrubec et al., 2006, Reduction in diabetes-induced craniofacial defects by maternal immune stimulation., Birth Defects Res. B Dev. Reprod. Toxicol.
Kountouras et al., Omeprazole and regulation of cytokine profile in Helicobacter pylori-infected patients with duodenal ulcer disease., Hepatogastroenterology
Hartmann et al., 1995, Phase I trial of diaziquone (AZQ) plus GM-CSF., Invest New Drugs
Fruehauf et al., 2005, Docetaxel and vinorelbine plus GM-CSF in malignant melanoma., Oncology (Williston Park, N.Y.)
Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect
Aydin et al., 1998, Effects of high dose medroxyprogesterone acetate on endogenous granulocyte macrophage-colony stimulating factor secretion and bone marrow cellularity in patients under cytotoxic chemotherapy., J Chemother
Perno et al., 1989, Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine., J. Exp. Med.
Han et al., 2005, [The influence of mycophenolate mofetil upon the maturation and allostimulatory activity of cultured dendritic cell progenitors and the effects of tolerance induction in allograft recipients]., Zhonghua Yi Xue Za Zhi
Colic et al., 2003, Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells., Clin. Exp. Immunol.
Somogyi et al., 1996, Treatment of drug-induced bone marrow suppression with recombinant human granulocyte/monocyte colony stimulating factor., Adverse Drug React Toxicol Rev
Somogyi et al., 1994, [Treatment of methimazole-induced agranulocytosis with granulocyte-macrophage colony stimulating factor]., Orv Hetil
Joshi et al., 2005, Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage., J. Immunol.
Asano et al., 1997, Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia., Life Sci.
Kawai et al., 2005, Epigallocatechin gallate induces apoptosis of monocytes., J. Allergy Clin. Immunol.
Harousseau et al., 1996, Treatment of acute myeloblastic leukemia in adults. The GOELAM experience., Hematol Cell Ther
Bodey et al., 1994, Role of granulocyte-macrophage colony-stimulating factor as adjuvant treatment in neutropenic patients with bacterial and fungal infection., Eur. J. Clin. Microbiol. Infect. Dis.
Oksenberg et al., 1990, Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells., Cancer Res.
Katayama et al., 1990, A role for calmodulin in the growth of human hematopoietic progenitor cells., Blood

NAMILUMAB CSF2

Interaction Score: 4.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Direct Interaction yes

Trial Name MT203

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
NAVELBINE CSF2

Interaction Score: 2.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15934496

Sources:
NCI
FAMCICLOVIR CSF2

Interaction Score: 2.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10522033

Sources:
NCI
LENZILUMAB CSF2

Interaction Score: 2.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

PMIDs:
None found

Sources:
TTD ChemblInteractions
MECHLORETHAMINE CSF2

Interaction Score: 2.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10640980

Sources:
NCI
OTILIMAB CSF2

Interaction Score: 2.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MOR103

Novel drug target Novel Target

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
GIMSILUMAB CSF2

Interaction Score: 1.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TICARCILLIN CSF2

Interaction Score: 1.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7875147

Sources:
NCI
PEXASTIMOGENE DEVACIREPVEC CSF2

Interaction Score: 1.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIAZIQUONE CSF2

Interaction Score: 1.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8617583

Sources:
NCI
ROQUINIMEX CSF2

Interaction Score: 1.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9811314

Sources:
NCI
ACLARUBICIN CSF2

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7689127

Sources:
NCI
AMIKACIN CSF2

Interaction Score: 0.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7540696 8158029

Sources:
NCI
MYCOPHENOLATE MOFETIL CSF2

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16029632 12974756

Sources:
NCI
CABIRALIZUMAB CSF2

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LACTULOSE CSF2

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11355146

Sources:
NCI
MAVRILIMUMAB CSF2

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CETIRIZINE CSF2

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16783450

Sources:
NCI
MILTEFOSINE CSF2

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1555249

Sources:
NCI
PROCARBAZINE CSF2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10640980

Sources:
NCI
PERFOSFAMIDE CSF2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1283360

Sources:
NCI
INDINAVIR CSF2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10479132

Sources:
NCI
METHIMAZOLE CSF2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8836317 7991239

Sources:
NCI
CILOSTAZOL CSF2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15744080

Sources:
NCI
TEMOZOLOMIDE CSF2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12610499 16100942

Sources:
NCI
STAVUDINE CSF2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2538549

Sources:
NCI
PLATINUM CSF2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8110490

Sources:
NCI
EPIGALOCATECHIN GALLATE CSF2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9000119 15637567

Sources:
NCI
TERFENADINE CSF2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8836342

Sources:
NCI
ETANERCEPT CSF2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12906870

Sources:
NCI
TRIFLUOPERAZINE CSF2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1690578

Sources:
NCI
REGRAMOSTIM CSF2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GVAX

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
OMEPRAZOLE CSF2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11100337

Sources:
NCI
ISOPROTERENOL CSF2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9730867

Sources:
NCI
VINBLASTINE CSF2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10640980

Sources:
NCI
IDARUBICIN CSF2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8915668

Sources:
NCI
STREPTOZOCIN CSF2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16342200

Sources:
NCI
INSULIN CSF2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1698537

Sources:
NCI
STAUROSPORINE CSF2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9359403

Sources:
NCI
PROGESTERONE CSF2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9822358

Sources:
NCI
ALCOHOL CSF2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16272341

Sources:
NCI

Ensembl: ENSG00000164400
- Version: 101_38
Alternate Names:

CSF2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P04141
- Version: January-2014
Alternate Names:

CSF2 Gene Symbol

Gene Info:

Target Class ligand

Target Subclass Ligand

Target Subclass CSF2

Publications:

NCI: CSF2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.

Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.

Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.

ChemblInteractions: GMCSF
- Version: chembl_23
Alternate Names:

GMCSF GENE_SYMBOL

CSF2 GENE_SYMBOL

Granulocyte-macrophage colony-stimulating factor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000164400
- Version: 31-May-2017
Alternate Names:

ENSG00000164400 Gene Symbol

CSF2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: CSF2
- Version: 05-September-2020
Alternate Names:

GMCSF GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:
DrugBank: BE0002481
- Version: 5.1.7
Alternate Names:

CSF2 DrugBank Gene Name

P04141 UniProt Accession

1437 Entrez Gene Id

Gene Info:

Publications:
TTD: Granulocyte-macrophage colony-stimulating factor
- Version: 2020.06.01
Alternate Names:

CSF2 TTD Gene Abbreviation

T74002 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Granulocyte-macrophage colony-stimulating factor inhibitor
Direct Interaction	yes
Trial Name	MT203

Trial Name	MOR103
Novel drug target	Novel Target
Mechanism of Interaction	Granulocyte-macrophage colony-stimulating factor inhibitor

GMCSF	GENE_SYMBOL
CSF2	GENE_SYMBOL
Granulocyte-macrophage colony-stimulating factor	UNIPROT

CSF2	DrugBank Gene Name
P04141	UniProt Accession
1437	Entrez Gene Id

CSF2 Gene Record

CSF2 1437 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor Direct Interaction yes Trial Name MT203

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15934496

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10522033

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

PMIDs: None found

Sources: TTD ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10640980

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MOR103 Novel drug target Novel Target Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7875147

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8617583

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9811314

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7689127

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7540696 8158029

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16029632 12974756

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11355146

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16783450

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

Direct Interaction yes

Trial Name MT203

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15934496

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10522033

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10640980

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MOR103

Novel drug target Novel Target

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
7875147

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8617583

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9811314

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7689127

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7540696 8158029

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16029632 12974756

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
11355146

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
16783450

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1555249

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10640980

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1283360

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10479132

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8836317 7991239

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15744080

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12610499 16100942

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2538549