• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

CSF2 Gene Record

  • Summary
  • Interactions
  • Claims
  • CSF2 1437 Druggable Genome

    Alternate Names:

    1437
    COLONY STIMULATING FACTOR 2
    CSF2
    CSF
    GMCSF
    138960
    2434
    ENSG00000164400
    OTTHUMG00000059637
    Sargramostim
    Molgramostin
    Colony-stimulating factor
    Granulocyte-macrophage colony-stimulating factor
    GM-CSF
    P04141
    T74002

    Gene Info:

    Target Class ligand
    Target Subclass Ligand
    Target Subclass CSF2
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME

    Publications:

    Laver et al., 1992, Effects of radiation and 4-hydroperoxycyclophosphamide on production of G- and GM-CSF by stromal cells., Bone Marrow Transplant.
    Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.
    Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.
    Joseph et al., 1998, Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents., J. Natl. Cancer Inst.
    Bokemeyer et al., 1993, A phase I/II study of a stepwise dose-escalated regimen of cisplatin, etoposide and ifosfamide plus granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced germ cell tumours., Eur. J. Cancer
    Aglietta et al., 2000, Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease., Cancer
    Skowron et al., 1999, The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial., J. Infect. Dis.
    Borger et al., 1998, Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype., Am. J. Respir. Cell Mol. Biol.
    Agnholt et al., 2003, The effect of etanercept and infliximab on the production of tumour necrosis factor alpha, interferon-gamma and GM-CSF in in vivo activated intestinal T lymphocyte cultures., Cytokine
    Crampette et al., 1996, Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine., Allergy
    Molloy et al., Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa., Hepatogastroenterology
    Lewis et al., 2005, A phase II study of biochemotherapy for advanced melanoma incorporating temozolomide, decrescendo interleukin-2 and GM-CSF., Cancer Invest.
    de Gast et al., 2003, Temozolomide followed by combined immunotherapy with GM-CSF, low-dose IL2 and IFN alpha in patients with metastatic melanoma., Br. J. Cancer
    Hochhuth et al., 1992, Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells., Cell. Immunol.
    Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.
    Bermudez et al., 1994, Recombinant granulocyte-macrophage colony-stimulating factor enhances the effects of antibiotics against Mycobacterium avium complex infection in the beige mouse model., J. Infect. Dis.
    Mayordomo et al., 1995, Improving treatment of chemotherapy-induced neutropenic fever by administration of colony-stimulating factors., J. Natl. Cancer Inst.
    Wang et al., 2005, Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis., Biol. Pharm. Bull.
    Hrubec et al., 2006, Reduction in diabetes-induced craniofacial defects by maternal immune stimulation., Birth Defects Res. B Dev. Reprod. Toxicol.
    Kountouras et al., Omeprazole and regulation of cytokine profile in Helicobacter pylori-infected patients with duodenal ulcer disease., Hepatogastroenterology
    Hartmann et al., 1995, Phase I trial of diaziquone (AZQ) plus GM-CSF., Invest New Drugs
    Fruehauf et al., 2005, Docetaxel and vinorelbine plus GM-CSF in malignant melanoma., Oncology (Williston Park, N.Y.)
    Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect
    Aydin et al., 1998, Effects of high dose medroxyprogesterone acetate on endogenous granulocyte macrophage-colony stimulating factor secretion and bone marrow cellularity in patients under cytotoxic chemotherapy., J Chemother
    Perno et al., 1989, Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine., J. Exp. Med.
    Han et al., 2005, [The influence of mycophenolate mofetil upon the maturation and allostimulatory activity of cultured dendritic cell progenitors and the effects of tolerance induction in allograft recipients]., Zhonghua Yi Xue Za Zhi
    Colic et al., 2003, Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells., Clin. Exp. Immunol.
    Somogyi et al., 1996, Treatment of drug-induced bone marrow suppression with recombinant human granulocyte/monocyte colony stimulating factor., Adverse Drug React Toxicol Rev
    Somogyi et al., 1994, [Treatment of methimazole-induced agranulocytosis with granulocyte-macrophage colony stimulating factor]., Orv Hetil
    Joshi et al., 2005, Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage., J. Immunol.
    Asano et al., 1997, Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia., Life Sci.
    Kawai et al., 2005, Epigallocatechin gallate induces apoptosis of monocytes., J. Allergy Clin. Immunol.
    Harousseau et al., 1996, Treatment of acute myeloblastic leukemia in adults. The GOELAM experience., Hematol Cell Ther
    Bodey et al., 1994, Role of granulocyte-macrophage colony-stimulating factor as adjuvant treatment in neutropenic patients with bacterial and fungal infection., Eur. J. Clin. Microbiol. Infect. Dis.
    Oksenberg et al., 1990, Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells., Cancer Res.
    Katayama et al., 1990, A role for calmodulin in the growth of human hematopoietic progenitor cells., Blood
  • NAMILUMAB   CSF2

    Interaction Score: 4.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor
    Direct Interaction yes
    Trial Name MT203

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • NAVELBINE   CSF2

    Interaction Score: 3.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15934496


    Sources:
    NCI

  • FAMCICLOVIR   CSF2

    Interaction Score: 3.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10522033


    Sources:
    NCI

  • LENZILUMAB   CSF2

    Interaction Score: 3.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • MECHLORETHAMINE   CSF2

    Interaction Score: 3.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10640980


    Sources:
    NCI

  • OTILIMAB   CSF2

    Interaction Score: 2.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MOR103
    Novel drug target Novel Target
    Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • GIMSILUMAB   CSF2

    Interaction Score: 1.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TICARCILLIN   CSF2

    Interaction Score: 1.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7875147


    Sources:
    NCI

  • PEXASTIMOGENE DEVACIREPVEC   CSF2

    Interaction Score: 1.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DIAZIQUONE   CSF2

    Interaction Score: 1.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8617583


    Sources:
    NCI

  • ROQUINIMEX   CSF2

    Interaction Score: 1.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9811314


    Sources:
    NCI

  • ACLARUBICIN   CSF2

    Interaction Score: 1.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7689127


    Sources:
    NCI

  • AMIKACIN   CSF2

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8158029 7540696


    Sources:
    NCI

  • MYCOPHENOLATE MOFETIL   CSF2

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16029632 12974756


    Sources:
    NCI

  • CABIRALIZUMAB   CSF2

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LACTULOSE   CSF2

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11355146


    Sources:
    NCI

  • MAVRILIMUMAB   CSF2

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PROCARBAZINE   CSF2

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10640980


    Sources:
    NCI

  • CETIRIZINE   CSF2

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16783450


    Sources:
    NCI

  • MILTEFOSINE   CSF2

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1555249


    Sources:
    NCI

  • PERFOSFAMIDE   CSF2

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1283360


    Sources:
    NCI

  • INDINAVIR   CSF2

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10479132


    Sources:
    NCI

  • METHIMAZOLE   CSF2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8836317 7991239


    Sources:
    NCI

  • CILOSTAZOL   CSF2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15744080


    Sources:
    NCI

  • TEMOZOLOMIDE   CSF2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16100942 12610499


    Sources:
    NCI

  • STAVUDINE   CSF2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2538549


    Sources:
    NCI

  • TERFENADINE   CSF2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8836342


    Sources:
    NCI

  • PLATINUM   CSF2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8110490


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   CSF2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9000119 15637567


    Sources:
    NCI

  • ETANERCEPT   CSF2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12906870


    Sources:
    NCI

  • TRIFLUOPERAZINE   CSF2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1690578


    Sources:
    NCI

  • STAUROSPORINE   CSF2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9359403


    Sources:
    NCI

  • ISOPROTERENOL   CSF2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9730867


    Sources:
    NCI

  • REGRAMOSTIM   CSF2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name GVAX
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • VINBLASTINE   CSF2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10640980


    Sources:
    NCI

  • OMEPRAZOLE   CSF2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11100337


    Sources:
    NCI

  • IDARUBICIN   CSF2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8915668


    Sources:
    NCI

  • STREPTOZOCIN   CSF2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16342200


    Sources:
    NCI

  • INSULIN   CSF2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1698537


    Sources:
    NCI

  • PROGESTERONE   CSF2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9822358


    Sources:
    NCI

  • ALCOHOL   CSF2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16272341


    Sources:
    NCI

  • Ensembl: ENSG00000164400

    • Version: 101_38

    Alternate Names:
    CSF2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P04141

    • Version: January-2014

    Alternate Names:
    CSF2 Gene Symbol

    Gene Info:
    Target Class ligand
    Target Subclass Ligand
    Target Subclass CSF2

    Publications:

  • NCI: CSF2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.
    Melichar et al., 2001, Intestinal permeability in patients with chemotherapy-induced stomatitis., J. Cancer Res. Clin. Oncol.
    Nørgaard et al., 1993, Synergistic and antagonistic effects of myeloid growth factors on in vitro cellular killing by cytotoxic drugs., Leuk. Res.

  • ChemblInteractions: GMCSF

    • Version: chembl_23

    Alternate Names:
    GMCSF GENE_SYMBOL
    CSF2 GENE_SYMBOL
    Granulocyte-macrophage colony-stimulating factor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000164400

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164400 Gene Symbol
    CSF2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CSF2

    • Version: 01-February-2022

    Alternate Names:
    GMCSF GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

  • TTD: Granulocyte-macrophage colony-stimulating factor

    • Version: 2020.06.01

    Alternate Names:
    CSF2 TTD Gene Abbreviation
    T74002 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21