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CRHR2 Gene Record

  • Summary
  • Interactions
  • Claims
  • CRHR2 1395 Druggable Genome

    Alternate Names:

    1395
    CORTICOTROPIN RELEASING HORMONE RECEPTOR 2
    CRHR2
    CRF-RB
    CRF2
    CRFR2
    HM-CRF
    602034
    2358
    ENSG00000106113
    OTTHUMG00000023218
    213
    CRF<sub>2</sub> receptor
    NM_001883
    NP_001874
    Q13324
    PA26875
    CRFR2_HUMAN
    CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R 2) (CRF2) (CORTICOTROPIN-RELEASING HORMONE RECEPTOR 2) (CRH-R 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13324]
    CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2
    T11011

    Gene Info:

    GuideToPharmacology Gene Category Name Corticotropin-releasing factor receptors
    GuideToPharmacology Gene Category ID 19
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Secretin
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000832
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, family 2, secretin-like
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Short Name GPCR_2_secretin-like
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Bale et al., 2003, Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold., Endocrinology
    Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
  • SAUVAGINE   CRHR2

    Interaction Score: 5.68

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CORTICOTROPIN RELEASING HORMONE   CRHR2

    Interaction Score: 3.79

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? True
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ALBUTEROL   CRHR2

    Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CITALOPRAM   CRHR2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17467808


    Sources:
    PharmGKB

  • INSULIN   CRHR2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12746321


    Sources:
    NCI

  • Ensembl: ENSG00000106113

    • Version: 101_38

    Alternate Names:
    CRHR2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q13324

    • Version: January-2014

    Alternate Names:
    CRHR2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Secretin

    Publications:

  • HopkinsGroom: Q13324

    • Version: 11-September-2012

    Alternate Names:
    1395 Entrez Gene Id
    ENSG00000106113 Ensembl Gene Id
    CRHR2 Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000832
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000106113

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000106113 Ensembl Gene Id
    CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R 2) (CRF2) (CORTICOTROPIN-RELEASING HORMONE RECEPTOR 2) (CRH-R 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13324] Description
    CRHR2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 1395

    • Version: 29-September-2020

    Alternate Names:
    2358 HUGO Gene ID
    2358 HUGO Gene Symbol
    corticotropin releasing hormone receptor 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Corticotropin-releasing factor receptors
    GuideToPharmacology Gene Category ID 19

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • PharmGKB: CRHR2

    • Version: 18-August-2020

    Alternate Names:
    PA26875 PharmGKB ID

    Gene Info:

    Publications:
    Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord

  • NCI: CRHR2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bale et al., 2003, Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold., Endocrinology
    Poon et al., 2008, Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma., Pharmacogenet. Genomics

  • HingoraniCasas: ENSG00000106113

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000106113 Gene Symbol
    CRHR2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: CRHR2

    • Version: 27-Jun-2013

    Alternate Names:
    1395 Gene ID
    CRF-RB dGene Synonym
    CRF2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Corticotropin-releasing factor receptor 2

    • Version: 2020.06.01

    Alternate Names:
    CRHR2 TTD Gene Abbreviation
    T11011 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21