DGIdb - CREBBP Gene Record

CREBBP 1387 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

1387
CREB BINDING PROTEIN
CREBBP
CBP
KAT3A
RSTS
RSTS1
600140
2348
ENSG00000005339
OTTHUMG00000129431
1193
Q92793
CREB-binding protein
T03634
RTS
MKHK1

Gene Info:

Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME
TRANSCRIPTION FACTOR

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
Milite C et al., 2011, Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)., Bioorg Med Chem

CHEMBL1797713 CREBBP

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
CHEMBL1797712 CREBBP

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
PRI-724 CREBBP

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1797711 CREBBP

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
CHEMBL1797708 CREBBP

Interaction Score: 2.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
CHEMBL1797707 CREBBP

Interaction Score: 2.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
CHEMBL257748 CREBBP

Interaction Score: 2.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
(-)-ROLIPRAM CREBBP

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1530911 CREBBP

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OXOGLAUCINE CREBBP

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRACAZOLATE CREBBP

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTAZOLAM CREBBP

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM CREBBP

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
PAPAVERINE CREBBP

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAZOLAM CREBBP

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ETAZOLATE CREBBP

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIDAZOLAM CREBBP

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
NOCODAZOLE CREBBP

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE CREBBP

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000005339
- Version: 101_38
Alternate Names:

CREBBP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

CIViC: CREBBP

Version: 14-September-2020

Alternate Names:

1387 Entrez Gene ID

1193 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Ogiwara et al., 2016, Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression., Cancer Discov

Mullighan CG et al., 2011, CREBBP mutations in relapsed acute lymphoblastic leukaemia., Nature

DTC: CREBBP

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Milite C et al., 2011, Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)., Bioorg Med Chem

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

HingoraniCasas: ENSG00000005339
- Version: 31-May-2017
Alternate Names:

ENSG00000005339 Gene Symbol

CREBBP Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: CREBBP
- Version: 19.3
Alternate Names:

ENSG00000005339 Ensembl Gene ID

CBP Human Protein Atlas Gene Synonym

KAT3A Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: CREBBP
- Version: 01-February-2022
Alternate Names:

CBP GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX

Publications:
Tempus: CREBBP
- Version: 11-November-2018
Alternate Names:

CREBBP Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: CREB-binding protein
- Version: 2020.06.01
Alternate Names:

CREBBP TTD Gene Abbreviation

T03634 TTD Target ID

Gene Info:

Publications:
Pharos: CREBBP
- Version: 01-February-2022
Alternate Names:

CREB-binding protein Gene Name

Q92793 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
MskImpact: CREBBP
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: CREBBP
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: CREBBP
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: CREBBP
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

ENSG00000005339	Ensembl Gene ID
CBP	Human Protein Atlas Gene Synonym
KAT3A	Human Protein Atlas Gene Synonym

CREBBP Gene Record

CREBBP 1387 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CREBBP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

1387 Entrez Gene ID

1193 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Ogiwara et al., 2016, Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression., Cancer Discov

Mullighan CG et al., 2011, CREBBP mutations in relapsed acute lymphoblastic leukaemia., Nature

Alternate Names:

ENSG00000005339 Gene Symbol

CREBBP Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000005339 Ensembl Gene ID

CBP Human Protein Atlas Gene Synonym

KAT3A Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

CBP GO Gene Synonym

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX

Alternate Names:

CREBBP Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

CREBBP TTD Gene Abbreviation

T03634 TTD Target ID

Alternate Names:

CREB-binding protein Gene Name

Q92793 UniProt ID

Gene Categories:

TRANSCRIPTION FACTOR

Gene Categories:

CLINICALLY ACTIONABLE