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CREB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CREB1 1385 Clinically ActionableDrug Resistance

    Alternate Names:

    1385
    CAMP RESPONSIVE ELEMENT BINDING PROTEIN 1
    CREB1
    CREB
    CREB-1
    123810
    2345
    ENSG00000118260
    OTTHUMG00000132936
    BE0000958
    P16220
    PA26864
    Cyclic AMP-responsive element-binding protein 1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    KINASE
    DRUG RESISTANCE
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Serretti A et al., 2011, A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression., J Affect Disord
    Perlis RH et al., 2007, Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study., Arch Gen Psychiatry
    Perlis et al., 2007, Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder., Biol. Psychiatry
    Saha et al., 2006, Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB., Pigment Cell Res.
    Kozinn et al., 2006, Inhibition of glutamatergic activation of extracellular signal-regulated protein kinases in hippocampal neurons by the intravenous anesthetic propofol., Anesthesiology
    Brenhouse et al., 2007, Differential activation of cAMP response element binding protein in discrete nucleus accumbens subregions during early and late cocaine sensitization., Behav. Neurosci.
    Ulfhammer et al., 2006, TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB- and p38 MAPK-dependent., J. Thromb. Haemost.
    Chartoff et al., 2003, Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum., J. Neurochem.
    Walters et al., 2005, Mu-opioid receptor and CREB activation are required for nicotine reward., Neuron
    Li et al., 2003, Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal., Acta Pharmacol. Sin.
    Gao et al., 2003, Effects of ohmefentanyl stereoisomers on phosphorylation of cAMP- response element binding protein in cultured rat hippocampal neurons., Acta Pharmacol. Sin.
    Hawes et al., 2006, Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures., J. Neurochem.
    Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med
    Pandey et al., 2001, Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain., J. Neurochem.
    Pandey et al., 2001, Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex., J. Pharmacol. Exp. Ther.
  • ADENOSINE PHOSPHATE   CREB1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    17300755 17083486 17122581 17324065 16879221


    Sources:
    DrugBank

  • NALOXONE   CREB1

    Interaction Score: 3.79

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    12969258 15953421 12956944 14653953 16417577


    Sources:
    DrugBank

  • CITALOPRAM   CREB1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20643483 17548750


    Sources:
    PharmGKB

  • LITHIUM   CREB1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24885933


    Sources:
    PharmGKB

  • NICOTINE   CREB1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11331423


    Sources:
    NCI

  • ALCOHOL   CREB1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11181917


    Sources:
    NCI

  • Ensembl: ENSG00000118260

    • Version: 101_38

    Alternate Names:
    CREB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: CREB1

    • Version: 18-August-2020

    Alternate Names:
    PA26864 PharmGKB ID

    Gene Info:

    Publications:
    Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med
    Calati R et al., 2013, Evaluation of the role of MAPK1 and CREB1 polymorphisms on treatment resistance, response and remission in mood disorder patients., Prog Neuropsychopharmacol Biol Psychiatry
    Serretti A et al., 2011, A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression., J Affect Disord

  • DrugBank: BE0000958

    • Version: 5.1.7

    Alternate Names:
    CREB1 DrugBank Gene Name
    P16220 UniProt Accession
    1385 Entrez Gene Id

    Gene Info:

    Publications:
    Chartoff et al., 2003, Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum., J. Neurochem.
    Walters et al., 2005, Mu-opioid receptor and CREB activation are required for nicotine reward., Neuron
    Li et al., 2003, Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal., Acta Pharmacol. Sin.

  • NCI: CREB1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Pandey et al., 2001, Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex., J. Pharmacol. Exp. Ther.
    Pandey et al., 2001, Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain., J. Neurochem.

  • Pharos: CREB1

    • Version: 03-September-2020

    Alternate Names:
    Cyclic AMP-responsive element-binding protein 1 Gene Name
    P16220 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • CarisMolecularIntelligence: CREB1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: CREB1

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, DRUG RESISTANCE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21