DGIdb - CREB1 Gene Record

CREB1 1385 Clinically ActionableDrug Resistance

Alternate Names:

1385
CAMP RESPONSIVE ELEMENT BINDING PROTEIN 1
CREB1
CREB
CREB-1
123810
2345
ENSG00000118260
OTTHUMG00000132936
BE0000958
P16220
PA26864
Cyclic AMP-responsive element-binding protein 1

Gene Info:

Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
KINASE
DRUG RESISTANCE
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Serretti A et al., 2011, A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression., J Affect Disord
Perlis RH et al., 2007, Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study., Arch Gen Psychiatry
Perlis et al., 2007, Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder., Biol. Psychiatry
Saha et al., 2006, Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB., Pigment Cell Res.
Kozinn et al., 2006, Inhibition of glutamatergic activation of extracellular signal-regulated protein kinases in hippocampal neurons by the intravenous anesthetic propofol., Anesthesiology
Brenhouse et al., 2007, Differential activation of cAMP response element binding protein in discrete nucleus accumbens subregions during early and late cocaine sensitization., Behav. Neurosci.
Ulfhammer et al., 2006, TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB- and p38 MAPK-dependent., J. Thromb. Haemost.
Chartoff et al., 2003, Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum., J. Neurochem.
Walters et al., 2005, Mu-opioid receptor and CREB activation are required for nicotine reward., Neuron
Li et al., 2003, Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal., Acta Pharmacol. Sin.
Gao et al., 2003, Effects of ohmefentanyl stereoisomers on phosphorylation of cAMP- response element binding protein in cultured rat hippocampal neurons., Acta Pharmacol. Sin.
Hawes et al., 2006, Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures., J. Neurochem.
Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med
Pandey et al., 2001, Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain., J. Neurochem.
Pandey et al., 2001, Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex., J. Pharmacol. Exp. Ther.

ADENOSINE PHOSPHATE CREB1

Interaction Score: 4.73

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
17300755 17083486 17122581 17324065 16879221

Sources:
DrugBank
NALOXONE CREB1

Interaction Score: 3.79

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
12969258 15953421 12956944 14653953 16417577

Sources:
DrugBank
CITALOPRAM CREB1

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20643483 17548750

Sources:
PharmGKB
LITHIUM CREB1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24885933

Sources:
PharmGKB
NICOTINE CREB1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11331423

Sources:
NCI
ALCOHOL CREB1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11181917

Sources:
NCI

Ensembl: ENSG00000118260
- Version: 101_38
Alternate Names:

CREB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: CREB1

Version: 18-August-2020

Alternate Names:

PA26864 PharmGKB ID

Gene Info:

Publications:

Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med

Calati R et al., 2013, Evaluation of the role of MAPK1 and CREB1 polymorphisms on treatment resistance, response and remission in mood disorder patients., Prog Neuropsychopharmacol Biol Psychiatry

Serretti A et al., 2011, A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression., J Affect Disord

DrugBank: BE0000958

Version: 5.1.7

Alternate Names:

CREB1 DrugBank Gene Name

P16220 UniProt Accession

1385 Entrez Gene Id

Gene Info:

Publications:

Chartoff et al., 2003, Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum., J. Neurochem.

Walters et al., 2005, Mu-opioid receptor and CREB activation are required for nicotine reward., Neuron

Li et al., 2003, Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal., Acta Pharmacol. Sin.

NCI: CREB1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Pandey et al., 2001, Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex., J. Pharmacol. Exp. Ther.

Pandey et al., 2001, Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain., J. Neurochem.

Pharos: CREB1
- Version: 03-September-2020
Alternate Names:

Cyclic AMP-responsive element-binding protein 1 Gene Name

P16220 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
CarisMolecularIntelligence: CREB1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: CREB1
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, DRUG RESISTANCE

Publications:

CREB1	DrugBank Gene Name
P16220	UniProt Accession
1385	Entrez Gene Id

Cyclic AMP-responsive element-binding protein 1	Gene Name
P16220	UniProt ID

CREB1 Gene Record

CREB1 1385 Clinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

ADENOSINE PHOSPHATE CREB1

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 17300755 17083486 17122581 17324065 16879221

Sources: DrugBank

NALOXONE CREB1

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: 12969258 15953421 12956944 14653953 16417577

Sources: DrugBank

CITALOPRAM CREB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20643483 17548750

Sources: PharmGKB

LITHIUM CREB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24885933

Sources: PharmGKB

NICOTINE CREB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11331423

Sources: NCI

ALCOHOL CREB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11181917

Sources: NCI

Ensembl: ENSG00000118260

Alternate Names: CREB1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: CREB1

Alternate Names: PA26864 PharmGKB ID

Gene Info:

DrugBank: BE0000958

Alternate Names: CREB1 DrugBank Gene Name P16220 UniProt Accession 1385 Entrez Gene Id

Gene Info:

NCI: CREB1

Alternate Names:

Gene Info:

Pharos: CREB1

Alternate Names: Cyclic AMP-responsive element-binding protein 1 Gene Name P16220 UniProt ID

Gene Info:

Gene Categories: KINASE, TRANSCRIPTION FACTOR

Publications:

CarisMolecularIntelligence: CREB1

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

GO: CREB1

Alternate Names:

Gene Info:

Gene Categories: TRANSCRIPTION FACTOR COMPLEX, DRUG RESISTANCE

Publications:

Interaction Types & Directionality:

activator (activating)

PMIDs:
17300755 17083486 17122581 17324065 16879221

Sources:
DrugBank

Interaction Types & Directionality:

other/unknown

PMIDs:
12969258 15953421 12956944 14653953 16417577

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
20643483 17548750

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24885933

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11331423

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11181917

Sources:
NCI

Alternate Names:

CREB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA26864 PharmGKB ID

Alternate Names:

CREB1 DrugBank Gene Name

P16220 UniProt Accession

1385 Entrez Gene Id

Alternate Names:

Cyclic AMP-responsive element-binding protein 1 Gene Name

P16220 UniProt ID

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, DRUG RESISTANCE