1269 |
CANNABINOID RECEPTOR 2 |
CNR2 |
CB-2 |
CB2 |
CX5 |
605051 |
2160 |
ENSG00000188822 |
OTTHUMG00000013892 |
CANNABINOID RECEPTOR 2 (CB2) (CB-2) (CX5). [SOURCE:UNIPROT/SWISSPROT;ACC:P34972] |
P34972 |
hCB2 |
CB2B |
CB2A |
CNR2_HUMAN |
BE0000095 |
57 |
NP_001832 |
NM_001841 |
CB<sub>2</sub> receptor |
T37693 |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
GuideToPharmacology Gene Category Name | Cannabinoid receptors |
GuideToPharmacology Gene Category ID | 13 |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR000276 |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Interpro Type | Family |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Uniprot Status | Swiss-Prot |
Gene Biotype | PROTEIN_CODING |
KINASE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
partial agonist (activating) |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Agonist |
agonist (activating) |
Mechanism of Interaction | Cannabinoid CB2 receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Trial Name | cannabinor |
Novel drug target | Established target |
Mechanism of Interaction | Cannabinoid CB2 receptor agonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Cannabinoid CB2 receptor agonist |
agonist (activating) |
Specific Action of the Ligand | None |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Mechanism of Interaction | Cannabinoid CB2 receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Mechanism of Interaction | Cannabinoid CB2 receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | True |
agonist (activating) |
Trial Name | CAT-310,Relivar |
Novel drug target | Established target |
Trial Name | Sativex |
antagonist (inhibitory) |
Details of the Assay for Interaction | Inhbition of [3H]-CP 55,940 binding to human CB2 receptors expressed in CHO cells |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Details of the Assay for Interaction | In a DiscoverX PathHunter β-arrestin recruitment assay. |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Cannabinoid CB2 receptor agonist |
antagonist (inhibitory) |
Details of the Assay for Interaction | Displacement of specific CP-55,940 binding in CHO cells stably transfected with human CB2 receptor |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Agonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Endogenous Drug? | True |
Specific Action of the Ligand | Partial agonist |
antagonist (inhibitory) |
CNR2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
CNR2 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
ENSG00000188822 | Ensembl Gene Id |
1269 | Entrez Gene Id |
CNR2_HUMAN | Uniprot Id |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR000276 |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
1269 | Entrez Gene Id |
P34972 | Uniprot Accession |
CNR2_HUMAN | Uniprot Id |
Transmembrane Helix Count | 7 |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
CANNABINOID RECEPTOR 2 (CB2) (CB-2) (CX5). [SOURCE:UNIPROT/SWISSPROT;ACC:P34972] | Description |
CNR2 | Display Id |
ENSG00000188822 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
2160 | HUGO Gene ID |
2160 | HUGO Gene Symbol |
cannabinoid receptor 2 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Cannabinoid receptors |
GuideToPharmacology Gene Category ID | 13 |
G PROTEIN COUPLED RECEPTOR |
CNR2 | DrugBank Gene Name |
P34972 | UniProt Accession |
1269 | Entrez Gene Id |
ENSG00000188822 | Gene Symbol |
CNR2 | Ensembl Id |
DRUGGABLE GENOME |
CB2B | GENE_SYMBOL |
CNR2 | GENE_SYMBOL |
Cannabinoid receptor 2 | UNIPROT |
Cannabinoid receptor 2 | Gene Name |
P34972 | UniProt ID |
KINASE |
CB2A | GO Gene Synonym |
CB2B | GO Gene Synonym |
G PROTEIN COUPLED RECEPTOR |
1269 | Gene ID |
CB-2 | dGene Synonym |
CB2 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
CB2 | TTD Gene Abbreviation |
T37693 | TTD Target ID |