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CNR2 Gene Record

  • Summary
  • Interactions
  • Claims
  • CNR2 1269 Druggable Genome

    Alternate Names:

    1269
    CANNABINOID RECEPTOR 2
    CNR2
    CB-2
    CB2
    CX5
    605051
    2160
    ENSG00000188822
    OTTHUMG00000013892
    CANNABINOID RECEPTOR 2 (CB2) (CB-2) (CX5). [SOURCE:UNIPROT/SWISSPROT;ACC:P34972]
    P34972
    hCB2
    CB2B
    CB2A
    CNR2_HUMAN
    T37693

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Transmembrane Helix Count 7
    Target Main Class Receptors
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Seephonkai P et al., 2011, Ferruginenes A-C from Rhododendron ferrugineum and their cytotoxic evaluation., J Nat Prod
    Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem
    Darmani, 2001, The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2., Eur. J. Pharmacol.
    Mendizábal et al., 2007, Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions., Br. J. Pharmacol.
    Conti et al., 2002, Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat., Br. J. Pharmacol.
    Davis et al., 2007, The emerging role of cannabinoid neuromodulators in symptom management., Support Care Cancer
    Kraft et al., 2004, [Cannabinoids and the immune system. Of men, mice and cells]., Schmerz
    Ogawa G et al., 2015, 3'-functionalized adamantyl cannabinoid receptor probes., J Med Chem
    Pertwee, 2009, Emerging strategies for exploiting cannabinoid receptor agonists as medicines., Br. J. Pharmacol.
    Manera C et al., 2009, Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists., J Med Chem
    Suhara Y et al., 2007, Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand., Bioorg Med Chem
    Pinna G et al., 2014, Tricyclic pyrazoles part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands., Eur J Med Chem
  • NABILONE   CNR2

    Interaction Score: 13.74

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Trial Name nabilone,Cesamet
    Novel drug target Established target
    Trial Name Sativex

    PMIDs:
    11698062 17450170 11786493 17139494 15221424


    Sources:
    TdgClinicalTrial TEND TTD

  • LY2828360   CNR2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB2 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • PRS-211375   CNR2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name cannabinor
    Novel drug target Established target
    Mechanism of Interaction Cannabinoid CB2 receptor agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FERRUGINENE C   CNR2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21443171


    Sources:
    DTC

  • TEDALINAB   CNR2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cannabinoid CB2 receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • S-777469   CNR2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TARANABANT   CNR2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    20423086


    Sources:
    DTC

  • GW842166X   CNR2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB2 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX)   CNR2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20423086


    Sources:
    DTC

  • SAD448   CNR2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB2 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NONABINE   CNR2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cannabinoid CB2 receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • 2-ARACHIDONOYLGLYCEROL   CNR2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17110113


    Sources:
    DTC

  • DRONABINOL   CNR2

    Interaction Score: 1.29

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name CAT-310,Relivar
    Novel drug target Established target
    Trial Name Sativex

    PMIDs:
    17139494 19226257


    Sources:
    TdgClinicalTrial

  • CHEMBL285932   CNR2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19435366


    Sources:
    DTC

  • CHEMBL306764   CNR2

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CP-55940   CNR2

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25760146


    Sources:
    DTC

  • HONOKIOL   CNR2

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WIN-552122   CNR2

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25134064


    Sources:
    DTC

  • Ensembl: ENSG00000188822

    • Version: 101_38

    Alternate Names:
    CNR2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P34972

    • Version: January-2014

    Alternate Names:
    CNR2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P34972

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000188822 Ensembl Gene Id
    1269 Entrez Gene Id
    CNR2_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000276

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: P34972

    • Version: 01-August-2011

    Alternate Names:
    1269 Entrez Gene Id
    P34972 Uniprot Accession
    CNR2_HUMAN Uniprot Id

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000188822

    • Version: 26-July-2011

    Alternate Names:
    CANNABINOID RECEPTOR 2 (CB2) (CB-2) (CX5). [SOURCE:UNIPROT/SWISSPROT;ACC:P34972] Description
    CNR2 Display Id
    ENSG00000188822 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DTC: CNR2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Seephonkai P et al., 2011, Ferruginenes A-C from Rhododendron ferrugineum and their cytotoxic evaluation., J Nat Prod
    Pinna G et al., 2014, Tricyclic pyrazoles part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands., Eur J Med Chem
    Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem

  • HingoraniCasas: ENSG00000188822

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000188822 Gene Symbol
    CNR2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CB2A

    • Version: chembl_23

    Alternate Names:
    CB2B GENE_SYMBOL
    CNR2 GENE_SYMBOL
    Cannabinoid receptor 2 UNIPROT

    Gene Info:

    Publications:

  • GO: CNR2

    • Version: 01-February-2022

    Alternate Names:
    CB2A GO Gene Synonym
    CB2B GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: CNR2

    • Version: 27-Jun-2013

    Alternate Names:
    1269 Gene ID
    CB-2 dGene Synonym
    CB2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Cannabinoid receptor 2

    • Version: 2020.06.01

    Alternate Names:
    CB2 TTD Gene Abbreviation
    T37693 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21