DGIdb - CNR2 Gene Record

CNR2 1269 Druggable Genome

Alternate Names:

1269
CANNABINOID RECEPTOR 2
CNR2
CB-2
CB2
CX5
605051
2160
ENSG00000188822
OTTHUMG00000013892
CANNABINOID RECEPTOR 2 (CB2) (CB-2) (CX5). [SOURCE:UNIPROT/SWISSPROT;ACC:P34972]
P34972
hCB2
CB2B
CB2A
CNR2_HUMAN
BE0000095
57
NP_001832
NM_001841
CB<sub>2</sub> receptor
T37693

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Human Readable Name	G PROTEIN COUPLED RECEPTOR
GuideToPharmacology Gene Category Name	Cannabinoid receptors
GuideToPharmacology Gene Category ID	13
Transmembrane Helix Count	7
Target Main Class	Receptors
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000276
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Type	Family
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Seephonkai P et al., 2011, Ferruginenes A-C from Rhododendron ferrugineum and their cytotoxic evaluation., J Nat Prod
Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem
Mendizábal et al., 2007, Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions., Br. J. Pharmacol.
Darmani, 2001, The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2., Eur. J. Pharmacol.
Conti et al., 2002, Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat., Br. J. Pharmacol.
Kraft et al., 2004, [Cannabinoids and the immune system. Of men, mice and cells]., Schmerz
Davis et al., 2007, The emerging role of cannabinoid neuromodulators in symptom management., Support Care Cancer
Ogawa G et al., 2015, 3'-functionalized adamantyl cannabinoid receptor probes., J Med Chem
Pertwee, 2009, Emerging strategies for exploiting cannabinoid receptor agonists as medicines., Br. J. Pharmacol.
Manera C et al., 2009, Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists., J Med Chem
Suhara Y et al., 2007, Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand., Bioorg Med Chem
Pinna G et al., 2014, Tricyclic pyrazoles part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands., Eur J Med Chem
Kumar P et al., 2014, CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene., Biochem Biophys Res Commun
Morales P et al., 2017, Molecular Targets of the Phytocannabinoids: A Complex Picture., Prog Chem Org Nat Prod
Appendino G et al., 2006, First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands., FEBS Lett

NABILONE CNR2

Interaction Score: 8.35

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
17450170 11698062 11786493 15221424 17139494

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
LY2828360 CNR2

Interaction Score: 3.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB2 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
PRS-211375 CNR2

Interaction Score: 3.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name cannabinor

Novel drug target Established target

Mechanism of Interaction Cannabinoid CB2 receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
FERRUGINENE C CNR2

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21443171

Sources:
DTC
TEDALINAB CNR2

Interaction Score: 3.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cannabinoid CB2 receptor agonist

PMIDs:
None found

Sources:
TTD ChemblInteractions
TARANABANT CNR2

Interaction Score: 2.51

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? False

PMIDs:
20423086

Sources:
DTC GuideToPharmacology
S-777469 CNR2

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL371214 CNR2

Interaction Score: 1.67

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
GW842166X CNR2

Interaction Score: 1.67

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB2 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX) CNR2

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20423086

Sources:
DTC
CHEMBL3186422 CNR2

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16406364

Sources:
DrugBank
LASOFOXIFENE CNR2

Interaction Score: 1.11

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

PMIDs:
24275139

Sources:
DrugBank
CHEMBL1354658 CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
SAD448 CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB2 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
2-ARACHIDONOYLGLYCEROL CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? True

PMIDs:
17110113

Sources:
DTC GuideToPharmacology
DRONABINOL CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name CAT-310,Relivar

Novel drug target Established target

Trial Name Sativex

PMIDs:
19226257 17139494

Sources:
TdgClinicalTrial DrugBank
SURINABANT CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhbition of [3H]-CP 55,940 binding to human CB2 receptors expressed in CHO cells

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
OLORINAB CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction In a DiscoverX PathHunter β-arrestin recruitment assay.

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NONABINE CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cannabinoid CB2 receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

IBIPINABANT CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of specific CP-55,940 binding in CHO cells stably transfected with human CB2 receptor

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

CHEMBL561013 CNR2

Interaction Score: 0.84

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL285932 CNR2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19435366

Sources:
DTC
LENABASUM CNR2

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology
TETRAHYDROCANNABIVARIN CNR2

Interaction Score: 0.48

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
28120232

Sources:
DrugBank
CHEMBL497392 CNR2

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL306764 CNR2

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CP-55940 CNR2

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25760146

Sources:
DTC
HONOKIOL CNR2

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL181633 CNR2

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
WIN-552122 CNR2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25134064

Sources:
DTC
DEXANABINOL CNR2

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ANANDAMIDE CNR2

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Partial agonist

PMIDs:
None found

Sources:
GuideToPharmacology
CANNABIDIOL CNR2

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
NABIXIMOLS CNR2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank

Ensembl: ENSG00000188822
- Version: 101_38
Alternate Names:

CNR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P34972
- Version: January-2014
Alternate Names:

CNR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P34972
- Version: 11-September-2012
Alternate Names:

ENSG00000188822 Ensembl Gene Id

1269 Entrez Gene Id

CNR2_HUMAN Uniprot Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR000276

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TEND: P34972
- Version: 01-August-2011
Alternate Names:

1269 Entrez Gene Id

P34972 Uniprot Accession

CNR2_HUMAN Uniprot Id

Gene Info:

Transmembrane Helix Count 7

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
RussLampel: ENSG00000188822
- Version: 26-July-2011
Alternate Names:

CANNABINOID RECEPTOR 2 (CB2) (CB-2) (CX5). [SOURCE:UNIPROT/SWISSPROT;ACC:P34972] Description

CNR2 Display Id

ENSG00000188822 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 1269
- Version: 29-September-2020
Alternate Names:

2160 HUGO Gene ID

2160 HUGO Gene Symbol

cannabinoid receptor 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Cannabinoid receptors

GuideToPharmacology Gene Category ID 13

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

DrugBank: BE0000095

Version: 5.1.7

Alternate Names:

CNR2 DrugBank Gene Name

P34972 UniProt Accession

1269 Entrez Gene Id

Gene Info:

Publications:

Pertwee, 2009, Emerging strategies for exploiting cannabinoid receptor agonists as medicines., Br. J. Pharmacol.

Davis et al., 2007, The emerging role of cannabinoid neuromodulators in symptom management., Support Care Cancer

Mendizábal et al., 2007, Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions., Br. J. Pharmacol.

DTC: CNR2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Seephonkai P et al., 2011, Ferruginenes A-C from Rhododendron ferrugineum and their cytotoxic evaluation., J Nat Prod

Pinna G et al., 2014, Tricyclic pyrazoles part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands., Eur J Med Chem

Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem

HingoraniCasas: ENSG00000188822
- Version: 31-May-2017
Alternate Names:

ENSG00000188822 Gene Symbol

CNR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CB2A
- Version: chembl_23
Alternate Names:

CB2B GENE_SYMBOL

CNR2 GENE_SYMBOL

Cannabinoid receptor 2 UNIPROT

Gene Info:

Publications:
Pharos: CNR2
- Version: 03-September-2020
Alternate Names:

Cannabinoid receptor 2 Gene Name

P34972 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: CNR2
- Version: 05-September-2020
Alternate Names:

CB2A GO Gene Synonym

CB2B GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: CNR2
- Version: 27-Jun-2013
Alternate Names:

1269 Gene ID

CB-2 dGene Synonym

CB2 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Cannabinoid receptor 2
- Version: 2020.06.01
Alternate Names:

CB2 TTD Gene Abbreviation

T37693 TTD Target ID

Gene Info:

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Agonist

Mechanism of Interaction	Cannabinoid CB2 receptor agonist
Direct Interaction	yes

Trial Name	cannabinor
Novel drug target	Established target
Mechanism of Interaction	Cannabinoid CB2 receptor agonist

Specific Action of the Ligand	None
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	CAT-310,Relivar
Novel drug target	Established target
Trial Name	Sativex

Details of the Assay for Interaction	Inhbition of [3H]-CP 55,940 binding to human CB2 receptors expressed in CHO cells
Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Details of the Assay for Interaction	In a DiscoverX PathHunter β-arrestin recruitment assay.
Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Details of the Assay for Interaction	Displacement of specific CP-55,940 binding in CHO cells stably transfected with human CB2 receptor
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

partial agonist (activating)
agonist (activating)

Endogenous Drug?	True
Specific Action of the Ligand	Partial agonist

ENSG00000188822	Ensembl Gene Id
1269	Entrez Gene Id
CNR2_HUMAN	Uniprot Id

CANNABINOID RECEPTOR 2 (CB2) (CB-2) (CX5). [SOURCE:UNIPROT/SWISSPROT;ACC:P34972]	Description
CNR2	Display Id
ENSG00000188822	Ensembl Gene Id

2160	HUGO Gene ID
2160	HUGO Gene Symbol
cannabinoid receptor 2	HUGO Gene Name

CNR2	DrugBank Gene Name
P34972	UniProt Accession
1269	Entrez Gene Id

CNR2 Gene Record

CNR2 1269 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Agonist

PMIDs: 17450170 11698062 11786493 15221424 17139494

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Cannabinoid CB2 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: TTD ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name cannabinor Novel drug target Established target Mechanism of Interaction Cannabinoid CB2 receptor agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21443171

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cannabinoid CB2 receptor agonist

PMIDs: None found

Sources: TTD ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False

PMIDs: 20423086

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Cannabinoid CB2 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20423086

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16406364

Sources: DrugBank

Interaction Types & Directionality: inverse agonist (inhibitory)

Interaction Info:

PMIDs: 24275139

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Cannabinoid CB2 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? True

PMIDs: 17110113

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name CAT-310,Relivar Novel drug target Established target Trial Name Sativex

PMIDs: 19226257 17139494

Sources: TdgClinicalTrial DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhbition of [3H]-CP 55,940 binding to human CB2 receptors expressed in CHO cells Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Details of the Assay for Interaction In a DiscoverX PathHunter &beta;-arrestin recruitment assay. Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cannabinoid CB2 receptor agonist

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
17450170 11698062 11786493 15221424 17139494

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB2 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name cannabinor

Novel drug target Established target

Mechanism of Interaction Cannabinoid CB2 receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21443171

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cannabinoid CB2 receptor agonist

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? False

PMIDs:
20423086

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB2 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20423086

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16406364

Sources:
DrugBank

Interaction Types & Directionality:

inverse agonist (inhibitory)

PMIDs:
24275139

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB2 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? True

PMIDs:
17110113

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name CAT-310,Relivar

Novel drug target Established target

Trial Name Sativex

PMIDs:
19226257 17139494

Sources:
TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhbition of [3H]-CP 55,940 binding to human CB2 receptors expressed in CHO cells

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction In a DiscoverX PathHunter β-arrestin recruitment assay.

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cannabinoid CB2 receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of specific CP-55,940 binding in CHO cells stably transfected with human CB2 receptor

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a