DGIdb - CNR1 Gene Record

CNR1 1268 Druggable Genome

Alternate Names:

1268
CANNABINOID RECEPTOR 1
CNR1
CANN6
CB-R
CB1
CB1A
CB1K5
CB1R
CNR
114610
2159
ENSG00000118432
OTTHUMG00000015184
P21554
CNR1_HUMAN
PA26681
CANNABINOID RECEPTOR 1 (CB1) (CB-R) (CANN6). [SOURCE:UNIPROT/SWISSPROT;ACC:P21554]
T76685

Gene Info:

Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Target Main Class	Receptors
Transmembrane Helix Count	7
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME
ENZYME

Publications:

Davis et al., 2007, The emerging role of cannabinoid neuromodulators in symptom management., Support Care Cancer
Hirst et al., 1996, Characterisation of the rat cerebella CB1 receptor using SR141716A, a central cannabinoid receptor antagonist., Neurosci. Lett.
Darmani, 2001, The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2., Eur. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Pertwee et al., 1996, Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder., Br. J. Pharmacol.
Pertwee, 1999, Cannabis and cannabinoids: pharmacology and rationale for clinical use., Forsch Komplementarmed
Heimann AS et al., 2007, Hemopressin is an inverse agonist of CB1 cannabinoid receptors., Proc Natl Acad Sci U S A
Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem
Lambeng N et al., 2007, Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: identification of a lead and initial SAR studies., Bioorg Med Chem Lett
Laprairie RB et al., 2015, Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor., Br J Pharmacol
Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol
Tiwari AK et al., 2010, A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia., Neuropsychopharmacology
Urbani P et al., 2008, Novel sterically hindered cannabinoid CB1 receptor ligands., Bioorg Med Chem
Suhara Y et al., 2007, Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand., Bioorg Med Chem
Wu CH et al., 2009, Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice., J Med Chem
Manca I et al., 2013, Novel pyrazole derivatives as neutral CB₁ antagonists with significant activity towards food intake., Eur J Med Chem
Cawston EE et al., 2015, Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors., J Med Chem
Tseng SL et al., 2008, Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists., J Med Chem
Kumar Srivastava B et al., 2008, Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist., Bioorg Med Chem Lett
Shire et al., 1996, Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A., J. Biol. Chem.
Pryce et al., 2003, Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice., Neurosci. Lett.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Tsai et al., 2000, Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia., Psychiatr. Genet.
Gorriti et al., 2005, Acute delta9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion., Pharmacol. Biochem. Behav.
Zamponi GW et al., 2009, Scaffold-based design and synthesis of potent N-type calcium channel blockers., Bioorg Med Chem Lett

NABILONE CNR1

Interaction Score: 9.66

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cannabinoid CB1 receptor agonist

Trial Name nabilone,Cesamet

PMIDs:
17139494 8981483 11698062 11752352 8864542 10575283

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
MARINOL CNR1

Interaction Score: 5.8

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND TTD
SURINABANT CNR1

Interaction Score: 5.8

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Direct Interaction yes

Trial Name surinabant, SR 147778

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
CHEMBL498746 CNR1

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19530697

Sources:
DTC
CHEMBL146346 CNR1

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17110113

Sources:
DTC
CANNABIDIOL CNR1

Interaction Score: 3.86

Interaction Types & Directionality:

allosteric modulator

antagonist (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor Negative allosteric modulator

Direct Interaction yes

PMIDs:
26218440

Sources:
ChemblInteractions
TARANABANT CNR1

Interaction Score: 3.86

Interaction Types & Directionality:

inverse agonist (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor inverse agonist

Direct Interaction yes

Trial Name taranabant, MK-0364

PMIDs:
20423086

Sources:
DTC TdgClinicalTrial ChemblInteractions
HEMOPRESSIN CNR1

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18077343

Sources:
DTC
DRINABANT CNR1

Interaction Score: 3.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RIMONABANT CNR1

Interaction Score: 2.76

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Rimonabant

Novel drug target Established target

PMIDs:
19530697 23357307 26203658 18712856 18585913 8636122 11752352

Sources:
DTC TdgClinicalTrial TEND
DRONABINOL CNR1

Interaction Score: 2.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Sativex

Novel drug target Established target

Mechanism of Interaction Cannabinoid CB1 receptor agonist

PMIDs:
11752352 12686391 17016423 17139284 11204352 15894066

Sources:
TdgClinicalTrial ChemblInteractions NCI
AMAUROMINE CNR1

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD2207 CNR1

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IBIPINABANT CNR1

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TEBIPENEM CNR1

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX) CNR1

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20423086

Sources:
DTC
OTENABANT CNR1

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
Z160 CNR1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19815411

Sources:
DTC
SAD448 CNR1

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NONABINE CNR1

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
2-ARACHIDONOYLGLYCEROL CNR1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17110113

Sources:
DTC
ARIPIPRAZOLE CNR1

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB
CONATUMUMAB CNR1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CP-55940 CNR1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17027269

Sources:
DTC
WIN-552122 CNR1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17027269 18579386

Sources:
DTC
QUETIAPINE CNR1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB
ORLISTAT CNR1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RISPERIDONE CNR1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB
CLOZAPINE CNR1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB
HALOPERIDOL CNR1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB
OLANZAPINE CNR1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB
COCAINE CNR1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000118432
- Version: 101_38
Alternate Names:

CNR1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P21554
- Version: 11-September-2012
Alternate Names:

CNR1 Uniprot Gene Name

1268 Entrez Gene Id

ENSG00000118432 Ensembl Gene Id

Gene Info:

Interpro Acc IPR000276

Interpro Name GPCR, rhodopsin-like, 7TM

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TEND: P21554
- Version: 01-August-2011
Alternate Names:

1268 Entrez Gene Id

ENSG00000118432 Ensembl Gene Id

CNR1_HUMAN Uniprot Id

Gene Info:

Target Main Class Receptors

Target Subclass Rhodopsin

Target Subclass GPCR

Publications:
RussLampel: ENSG00000118432
- Version: 26-July-2011
Alternate Names:

CNR1 Display Id

ENSG00000118432 Ensembl Gene Id

CANNABINOID RECEPTOR 1 (CB1) (CB-R) (CANN6). [SOURCE:UNIPROT/SWISSPROT;ACC:P21554] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P21554
- Version: January-2014
Alternate Names:

CNR1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:

PharmGKB: CNR1

Version: 18-August-2020

Alternate Names:

PA26681 PharmGKB ID

Gene Info:

Publications:

Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry

Tiwari AK et al., 2010, A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia., Neuropsychopharmacology

Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol

NCI: CNR1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Gorriti et al., 2005, Acute delta9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion., Pharmacol. Biochem. Behav.

DTC: CNR1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Heimann AS et al., 2007, Hemopressin is an inverse agonist of CB1 cannabinoid receptors., Proc Natl Acad Sci U S A

Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem

Wu CH et al., 2009, Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice., J Med Chem

HingoraniCasas: ENSG00000118432
- Version: 31-May-2017
Alternate Names:

ENSG00000118432 Gene Symbol

CNR1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CNR
- Version: chembl_23
Alternate Names:

CNR GENE_SYMBOL

CNR1 GENE_SYMBOL

Cannabinoid receptor 1 UNIPROT

Gene Info:

Publications:
GO: CNR1
- Version: 01-February-2022
Alternate Names:

CNR GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: CNR1
- Version: 27-Jun-2013
Alternate Names:

1268 Gene ID

CANN6 dGene Synonym

CB-R dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Cannabinoid receptor 1
- Version: 2020.06.01
Alternate Names:

CB1 TTD Gene Abbreviation

T76685 TTD Target ID

Gene Info:

Publications:
Pharos: CNR1
- Version: 01-February-2022
Alternate Names:

Cannabinoid receptor 1 Gene Name

P21554 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME

Publications:

Direct Interaction	yes
Mechanism of Interaction	Cannabinoid CB1 receptor agonist
Trial Name	nabilone,Cesamet

Mechanism of Interaction	Cannabinoid CB1 receptor antagonist
Direct Interaction	yes
Trial Name	surinabant, SR 147778

Mechanism of Interaction	Cannabinoid CB1 receptor Negative allosteric modulator
Direct Interaction	yes

Mechanism of Interaction	Cannabinoid CB1 receptor inverse agonist
Direct Interaction	yes
Trial Name	taranabant, MK-0364

Trial Name	Sativex
Novel drug target	Established target
Mechanism of Interaction	Cannabinoid CB1 receptor agonist

CNR1	Uniprot Gene Name
1268	Entrez Gene Id
ENSG00000118432	Ensembl Gene Id

CNR1	Display Id
ENSG00000118432	Ensembl Gene Id
CANNABINOID RECEPTOR 1 (CB1) (CB-R) (CANN6). [SOURCE:UNIPROT/SWISSPROT;ACC:P21554]	Description

partial agonist (activating)
agonist (activating)

CNR1 Gene Record

CNR1 1268 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cannabinoid CB1 receptor agonist Trial Name nabilone,Cesamet

PMIDs: 17139494 8981483 11698062 11752352 8864542 10575283

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: None found

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cannabinoid CB1 receptor antagonist Direct Interaction yes Trial Name surinabant, SR 147778

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19530697

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17110113

Sources: DTC

Interaction Types & Directionality: allosteric modulator antagonist (inhibitory) modulator

Interaction Info: Mechanism of Interaction Cannabinoid CB1 receptor Negative allosteric modulator Direct Interaction yes

PMIDs: 26218440

Sources: ChemblInteractions

Interaction Types & Directionality: inverse agonist (inhibitory) antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cannabinoid CB1 receptor inverse agonist Direct Interaction yes Trial Name taranabant, MK-0364

PMIDs: 20423086

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18077343

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cannabinoid CB1 receptor antagonist Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Rimonabant Novel drug target Established target

PMIDs: 19530697 23357307 26203658 18712856 18585913 8636122 11752352

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Sativex Novel drug target Established target Mechanism of Interaction Cannabinoid CB1 receptor agonist

PMIDs: 11752352 12686391 17016423 17139284 11204352 15894066

Sources: TdgClinicalTrial ChemblInteractions NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cannabinoid CB1 receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cannabinoid CB1 receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20423086

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cannabinoid CB1 receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19815411

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Cannabinoid CB1 receptor agonist Direct Interaction yes

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cannabinoid CB1 receptor agonist

Trial Name nabilone,Cesamet

PMIDs:
17139494 8981483 11698062 11752352 8864542 10575283

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Direct Interaction yes

Trial Name surinabant, SR 147778

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
19530697

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17110113

Sources:
DTC

Interaction Types & Directionality:

allosteric modulator

antagonist (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor Negative allosteric modulator

Direct Interaction yes

PMIDs:
26218440

Sources:
ChemblInteractions

Interaction Types & Directionality:

inverse agonist (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor inverse agonist

Direct Interaction yes

Trial Name taranabant, MK-0364

PMIDs:
20423086

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18077343

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Rimonabant

Novel drug target Established target

PMIDs:
19530697 23357307 26203658 18712856 18585913 8636122 11752352

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Sativex

Novel drug target Established target

Mechanism of Interaction Cannabinoid CB1 receptor agonist

PMIDs:
11752352 12686391 17016423 17139284 11204352 15894066

Sources:
TdgClinicalTrial ChemblInteractions NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20423086

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19815411

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17110113

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB

Interaction Types & Directionality:

n/a