1268 |
CANNABINOID RECEPTOR 1 |
CNR1 |
CANN6 |
CB-R |
CB1 |
CB1A |
CB1K5 |
CB1R |
CNR |
114610 |
2159 |
ENSG00000118432 |
OTTHUMG00000015184 |
P21554 |
CNR1_HUMAN |
PA26681 |
CANNABINOID RECEPTOR 1 (CB1) (CB-R) (CANN6). [SOURCE:UNIPROT/SWISSPROT;ACC:P21554] |
BE0000061 |
56 |
NP_057167 |
NM_016083 |
CB<sub>1</sub> receptor |
T76685 |
Interpro Acc | IPR000276 |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Status | Swiss-Prot |
Interpro Type | Family |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Target Main Class | Receptors |
Transmembrane Helix Count | 7 |
GuideToPharmacology Gene Category Name | Cannabinoid receptors |
GuideToPharmacology Gene Category ID | 13 |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
KINASE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
ENZYME |
partial agonist (activating) |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Inverse agonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cannabinoid CB1 receptor antagonist |
Novel drug target | Established target |
inverse agonist (inhibitory) |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Inverse agonist |
Details of the Assay for Interaction | Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells by liquid scintillation counting. |
antagonist (inhibitory) |
Mechanism of Interaction | Cannabinoid CB1 receptor antagonist |
Direct Interaction | yes |
Details of the Assay for Interaction | Inhibition of [3H]CP-55940 binding to human cannabinoid receptor 1 expressed in CHO cells |
antagonist (inhibitory) |
Trial Name | Rimonabant |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Trial Name | Sativex |
Novel drug target | Established target |
Mechanism of Interaction | Cannabinoid CB1 receptor agonist |
antagonist (inhibitory) |
Mechanism of Interaction | Cannabinoid CB1 receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Cannabinoid CB1 receptor antagonist |
Direct Interaction | yes |
Details of the Assay for Interaction | Displacement of CP-55940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells |
agonist (activating) |
Mechanism of Interaction | Cannabinoid CB1 receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Partial agonist |
agonist (activating) |
Mechanism of Interaction | Cannabinoid CB1 receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Details of the Assay for Interaction | In a DiscoverX PathHunter β-arrestin recruitment assay. |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
allosteric modulator |
antagonist (inhibitory) |
modulator |
Specific Action of the Ligand | Negative |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | True |
CNR1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
CNR1 | Uniprot Gene Name |
1268 | Entrez Gene Id |
ENSG00000118432 | Ensembl Gene Id |
Interpro Acc | IPR000276 |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Human Readable Name | DRUGGABLE GENOME |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
1268 | Entrez Gene Id |
ENSG00000118432 | Ensembl Gene Id |
CNR1_HUMAN | Uniprot Id |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Target Subclass | GPCR |
CNR1 | Display Id |
ENSG00000118432 | Ensembl Gene Id |
CANNABINOID RECEPTOR 1 (CB1) (CB-R) (CANN6). [SOURCE:UNIPROT/SWISSPROT;ACC:P21554] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
CNR1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
2159 | HUGO Gene ID |
2159 | HUGO Gene Symbol |
cannabinoid receptor 1 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Cannabinoid receptors |
GuideToPharmacology Gene Category ID | 13 |
G PROTEIN COUPLED RECEPTOR |
PA26681 | PharmGKB ID |
CNR1 | DrugBank Gene Name |
P21554 | UniProt Accession |
1268 | Entrez Gene Id |
ENSG00000118432 | Gene Symbol |
CNR1 | Ensembl Id |
DRUGGABLE GENOME |
CNR | GENE_SYMBOL |
CNR1 | GENE_SYMBOL |
Cannabinoid receptor 1 | UNIPROT |
Cannabinoid receptor 1 | Gene Name |
P21554 | UniProt ID |
KINASE, ENZYME |
CNR | GO Gene Synonym |
CELL SURFACE, G PROTEIN COUPLED RECEPTOR |
1268 | Gene ID |
CANN6 | dGene Synonym |
CB-R | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
CB1 | TTD Gene Abbreviation |
T76685 | TTD Target ID |