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CNR1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CNR1 1268 Druggable Genome

    Alternate Names:

    1268
    CANNABINOID RECEPTOR 1
    CNR1
    CANN6
    CB-R
    CB1
    CB1A
    CB1K5
    CB1R
    CNR
    114610
    2159
    ENSG00000118432
    OTTHUMG00000015184
    P21554
    CNR1_HUMAN
    PA26681
    CANNABINOID RECEPTOR 1 (CB1) (CB-R) (CANN6). [SOURCE:UNIPROT/SWISSPROT;ACC:P21554]
    T76685

    Gene Info:

    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Transmembrane Helix Count 7
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    KINASE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Davis et al., 2007, The emerging role of cannabinoid neuromodulators in symptom management., Support Care Cancer
    Hirst et al., 1996, Characterisation of the rat cerebella CB1 receptor using SR141716A, a central cannabinoid receptor antagonist., Neurosci. Lett.
    Darmani, 2001, The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2., Eur. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Pertwee et al., 1996, Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder., Br. J. Pharmacol.
    Pertwee, 1999, Cannabis and cannabinoids: pharmacology and rationale for clinical use., Forsch Komplementarmed
    Heimann AS et al., 2007, Hemopressin is an inverse agonist of CB1 cannabinoid receptors., Proc Natl Acad Sci U S A
    Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem
    Lambeng N et al., 2007, Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: identification of a lead and initial SAR studies., Bioorg Med Chem Lett
    Laprairie RB et al., 2015, Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor., Br J Pharmacol
    Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
    Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol
    Tiwari AK et al., 2010, A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia., Neuropsychopharmacology
    Urbani P et al., 2008, Novel sterically hindered cannabinoid CB1 receptor ligands., Bioorg Med Chem
    Suhara Y et al., 2007, Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand., Bioorg Med Chem
    Wu CH et al., 2009, Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice., J Med Chem
    Manca I et al., 2013, Novel pyrazole derivatives as neutral CB₁ antagonists with significant activity towards food intake., Eur J Med Chem
    Cawston EE et al., 2015, Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors., J Med Chem
    Tseng SL et al., 2008, Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists., J Med Chem
    Kumar Srivastava B et al., 2008, Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist., Bioorg Med Chem Lett
    Shire et al., 1996, Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A., J. Biol. Chem.
    Pryce et al., 2003, Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice., Neurosci. Lett.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Tsai et al., 2000, Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia., Psychiatr. Genet.
    Gorriti et al., 2005, Acute delta9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion., Pharmacol. Biochem. Behav.
    Zamponi GW et al., 2009, Scaffold-based design and synthesis of potent N-type calcium channel blockers., Bioorg Med Chem Lett
  • NABILONE   CNR1

    Interaction Score: 9.66

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cannabinoid CB1 receptor agonist
    Trial Name nabilone,Cesamet

    PMIDs:
    17139494 8981483 11698062 11752352 8864542 10575283


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • MARINOL   CNR1

    Interaction Score: 5.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND TTD

  • SURINABANT   CNR1

    Interaction Score: 5.8

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB1 receptor antagonist
    Direct Interaction yes
    Trial Name surinabant, SR 147778

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • CHEMBL498746   CNR1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19530697


    Sources:
    DTC

  • CHEMBL146346   CNR1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17110113


    Sources:
    DTC

  • CANNABIDIOL   CNR1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    allosteric modulator
    antagonist (inhibitory)
    modulator

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB1 receptor Negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    26218440


    Sources:
    ChemblInteractions

  • TARANABANT   CNR1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    inverse agonist (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB1 receptor inverse agonist
    Direct Interaction yes
    Trial Name taranabant, MK-0364

    PMIDs:
    20423086


    Sources:
    DTC TdgClinicalTrial ChemblInteractions

  • HEMOPRESSIN   CNR1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18077343


    Sources:
    DTC

  • DRINABANT   CNR1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cannabinoid CB1 receptor antagonist
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • RIMONABANT   CNR1

    Interaction Score: 2.76

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Rimonabant
    Novel drug target Established target

    PMIDs:
    19530697 23357307 26203658 18712856 18585913 8636122 11752352


    Sources:
    DTC TdgClinicalTrial TEND

  • DRONABINOL   CNR1

    Interaction Score: 2.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Sativex
    Novel drug target Established target
    Mechanism of Interaction Cannabinoid CB1 receptor agonist

    PMIDs:
    11752352 12686391 17016423 17139284 11204352 15894066


    Sources:
    TdgClinicalTrial ChemblInteractions NCI

  • AMAUROMINE   CNR1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZD2207   CNR1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IBIPINABANT   CNR1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TEBIPENEM   CNR1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX)   CNR1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20423086


    Sources:
    DTC

  • OTENABANT   CNR1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Z160   CNR1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19815411


    Sources:
    DTC

  • SAD448   CNR1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NONABINE   CNR1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Cannabinoid CB1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • 2-ARACHIDONOYLGLYCEROL   CNR1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17110113


    Sources:
    DTC

  • ARIPIPRAZOLE   CNR1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23799528 20631561 20107430


    Sources:
    PharmGKB

  • CONATUMUMAB   CNR1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CP-55940   CNR1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17027269


    Sources:
    DTC

  • WIN-552122   CNR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17027269 18579386


    Sources:
    DTC

  • QUETIAPINE   CNR1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23799528 20631561 20107430


    Sources:
    PharmGKB

  • ORLISTAT   CNR1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RISPERIDONE   CNR1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23799528 20631561 20107430


    Sources:
    PharmGKB

  • CLOZAPINE   CNR1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23799528 20631561 20107430


    Sources:
    PharmGKB

  • HALOPERIDOL   CNR1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23799528 20631561 20107430


    Sources:
    PharmGKB

  • OLANZAPINE   CNR1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23799528 20631561 20107430


    Sources:
    PharmGKB

  • COCAINE   CNR1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000118432

    • Version: 101_38

    Alternate Names:
    CNR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P21554

    • Version: 11-September-2012

    Alternate Names:
    CNR1 Uniprot Gene Name
    1268 Entrez Gene Id
    ENSG00000118432 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: P21554

    • Version: 01-August-2011

    Alternate Names:
    1268 Entrez Gene Id
    ENSG00000118432 Ensembl Gene Id
    CNR1_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Target Subclass GPCR

    Publications:

  • RussLampel: ENSG00000118432

    • Version: 26-July-2011

    Alternate Names:
    CNR1 Display Id
    ENSG00000118432 Ensembl Gene Id
    CANNABINOID RECEPTOR 1 (CB1) (CB-R) (CANN6). [SOURCE:UNIPROT/SWISSPROT;ACC:P21554] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P21554

    • Version: January-2014

    Alternate Names:
    CNR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • PharmGKB: CNR1

    • Version: 18-August-2020

    Alternate Names:
    PA26681 PharmGKB ID

    Gene Info:

    Publications:
    Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
    Tiwari AK et al., 2010, A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia., Neuropsychopharmacology
    Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol

  • NCI: CNR1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Gorriti et al., 2005, Acute delta9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion., Pharmacol. Biochem. Behav.

  • DTC: CNR1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Heimann AS et al., 2007, Hemopressin is an inverse agonist of CB1 cannabinoid receptors., Proc Natl Acad Sci U S A
    Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem
    Wu CH et al., 2009, Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice., J Med Chem

  • HingoraniCasas: ENSG00000118432

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000118432 Gene Symbol
    CNR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CNR

    • Version: chembl_23

    Alternate Names:
    CNR GENE_SYMBOL
    CNR1 GENE_SYMBOL
    Cannabinoid receptor 1 UNIPROT

    Gene Info:

    Publications:

  • GO: CNR1

    • Version: 01-February-2022

    Alternate Names:
    CNR GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: CNR1

    • Version: 27-Jun-2013

    Alternate Names:
    1268 Gene ID
    CANN6 dGene Synonym
    CB-R dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Cannabinoid receptor 1

    • Version: 2020.06.01

    Alternate Names:
    CB1 TTD Gene Abbreviation
    T76685 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CNR1

    • Version: 01-February-2022

    Alternate Names:
    Cannabinoid receptor 1 Gene Name
    P21554 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21