DGIdb - CLK1 Gene Record

CLK1 1195 Druggable Genome

Alternate Names:

1195
CDC LIKE KINASE 1
CLK1
CLK
CLK/STY
STY
601951
2068
ENSG00000013441
OTTHUMG00000132784
BE0001824
P49759
DUAL SPECIFICITY PROTEIN KINASE CLK1 (EC 2.7.1.37) (EC 2.7.1.112) (CDC-LIKE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P49759]
1990
DUAL SPECIFICITY PROTEIN KINASE CLK1
CLK1_HUMAN
CDC-like kinase 1
NM_001162407
NP_001155879
T46685

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Acc	IPR002290
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	KINASE
Interpro Type	Domain
GuideToPharmacology Gene Category Name	CLK family
GuideToPharmacology Gene Category ID	568
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Tahtouh T et al., 2012, Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B., J Med Chem
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

DEBROMOHYMENIALDISINE CLK1

Interaction Score: 12.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17016423 17139284

Sources:
DrugBank
CHEMBL1236620 CLK1

Interaction Score: 8.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
LEUCETTAMINE B CLK1

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22998443

Sources:
DTC
CHEMBL269881 CLK1

Interaction Score: 1.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HARMINE CLK1

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22998443

Sources:
DTC
HESPERADIN CLK1

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
FOSTAMATINIB CLK1

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000013441
- Version: 101_38
Alternate Names:

CLK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000013441

Version: 26-July-2011

Alternate Names:

DUAL SPECIFICITY PROTEIN KINASE CLK1 (EC 2.7.1.37) (EC 2.7.1.112) (CDC-LIKE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P49759] Description

CLK1 Display Id

ENSG00000013441 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P49759
- Version: 11-September-2012
Alternate Names:

ENSG00000013441 Ensembl Gene Id

1195 Entrez Gene Id

CLK1_HUMAN Uniprot Id

Gene Info:

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Interpro Acc IPR002290

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 1195
- Version: 29-September-2020
Alternate Names:

2068 HUGO Gene ID

2068 HUGO Gene Symbol

CDC like kinase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CLK family

GuideToPharmacology Gene Category ID 568

Gene Categories:

ENZYME

Publications:

DrugBank: BE0001824

Version: 5.1.7

Alternate Names:

CLK1 DrugBank Gene Name

P49759 UniProt Accession

1195 Entrez Gene Id

Gene Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

DTC: CLK1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Tahtouh T et al., 2012, Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B., J Med Chem

HingoraniCasas: ENSG00000013441
- Version: 31-May-2017
Alternate Names:

ENSG00000013441 Gene Symbol

CLK1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: CLK1
- Version: 03-September-2020
Alternate Names:

Dual specificity protein kinase CLK1 Gene Name

P49759 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: CLK1
- Version: 05-September-2020
Alternate Names:

CLK GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: CLK1
- Version: 27-Jun-2013
Alternate Names:

1195 Gene ID

CLK dGene Synonym

CLK/STY dGene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, KINASE

Publications:
TTD: CDC-like kinase 1
- Version: 2020.06.01
Alternate Names:

CLK1 TTD Gene Abbreviation

T46685 TTD Target ID

Gene Info:

Publications:

DUAL SPECIFICITY PROTEIN KINASE CLK1 (EC 2.7.1.37) (EC 2.7.1.112) (CDC-LIKE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P49759]	Description
CLK1	Display Id
ENSG00000013441	Ensembl Gene Id

2068	HUGO Gene ID
2068	HUGO Gene Symbol
CDC like kinase 1	HUGO Gene Name

CLK1	DrugBank Gene Name
P49759	UniProt Accession
1195	Entrez Gene Id

Dual specificity protein kinase CLK1	Gene Name
P49759	UniProt ID

CLK1 Gene Record

CLK1 1195 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DEBROMOHYMENIALDISINE CLK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17016423 17139284

Sources: DrugBank

CHEMBL1236620 CLK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

LEUCETTAMINE B CLK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22998443

Sources: DTC

CHEMBL269881 CLK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

HARMINE CLK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22998443

Sources: DTC

HESPERADIN CLK1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

FOSTAMATINIB CLK1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26516587

Sources: DrugBank

Ensembl: ENSG00000013441

Alternate Names: CLK1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000013441

Alternate Names: DUAL SPECIFICITY PROTEIN KINASE CLK1 (EC 2.7.1.37) (EC 2.7.1.112) (CDC-LIKE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P49759] Description CLK1 Display Id ENSG00000013441 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P49759

Alternate Names: ENSG00000013441 Ensembl Gene Id 1195 Entrez Gene Id CLK1_HUMAN Uniprot Id

Gene Info: Interpro Short Name Ser/Thr_dual-sp_kinase_dom Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain Interpro Acc IPR002290

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

GuideToPharmacology: 1195

Alternate Names: 2068 HUGO Gene ID 2068 HUGO Gene Symbol CDC like kinase 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name CLK family GuideToPharmacology Gene Category ID 568

Gene Categories: ENZYME

Publications:

DrugBank: BE0001824

Alternate Names: CLK1 DrugBank Gene Name P49759 UniProt Accession 1195 Entrez Gene Id

Gene Info:

Publications: Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

DTC: CLK1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000013441

Alternate Names: ENSG00000013441 Gene Symbol CLK1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: CLK1

Alternate Names: Dual specificity protein kinase CLK1 Gene Name P49759 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

GO: CLK1

Alternate Names: CLK GO Gene Synonym

Gene Info:

Interaction Types & Directionality:

n/a

PMIDs:
17016423 17139284

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
22998443

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22998443

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26516587

Sources:
DrugBank

Alternate Names:

CLK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

DUAL SPECIFICITY PROTEIN KINASE CLK1 (EC 2.7.1.37) (EC 2.7.1.112) (CDC-LIKE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P49759] Description

CLK1 Display Id

ENSG00000013441 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000013441 Ensembl Gene Id

1195 Entrez Gene Id

CLK1_HUMAN Uniprot Id

Gene Info:

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Interpro Acc IPR002290

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

2068 HUGO Gene ID

2068 HUGO Gene Symbol

CDC like kinase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CLK family

GuideToPharmacology Gene Category ID 568

Gene Categories:

ENZYME

Alternate Names:

CLK1 DrugBank Gene Name

P49759 UniProt Accession

1195 Entrez Gene Id

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Alternate Names:

ENSG00000013441 Gene Symbol

CLK1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Dual specificity protein kinase CLK1 Gene Name

P49759 UniProt ID

Gene Categories:

KINASE

Alternate Names:

CLK GO Gene Synonym

Gene Categories:

SERINE THREONINE KINASE

Alternate Names:

1195 Gene ID

CLK dGene Synonym

CLK/STY dGene Synonym

Gene Categories:

SERINE THREONINE KINASE, KINASE

Alternate Names:

CLK1 TTD Gene Abbreviation

T46685 TTD Target ID