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CLK1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CLK1 1195 Druggable Genome

    Alternate Names:

    1195
    CDC LIKE KINASE 1
    CLK1
    CLK
    CLK/STY
    STY
    601951
    2068
    ENSG00000013441
    OTTHUMG00000132784
    P49759
    DUAL SPECIFICITY PROTEIN KINASE CLK1 (EC 2.7.1.37) (EC 2.7.1.112) (CDC-LIKE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P49759]
    DUAL SPECIFICITY PROTEIN KINASE CLK1
    CLK1_HUMAN
    CDC-like kinase 1
    T46685

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Acc IPR002290
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name KINASE
    Interpro Type Domain
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME

    Publications:

    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Tahtouh T et al., 2012, Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B., J Med Chem
  • CHEMBL269881   CLK1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LEUCETTAMINE B   CLK1

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22998443


    Sources:
    DTC

  • HARMINE   CLK1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22998443


    Sources:
    DTC

  • HESPERADIN   CLK1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Ensembl: ENSG00000013441

    • Version: 101_38

    Alternate Names:
    CLK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000013441

    • Version: 26-July-2011

    Alternate Names:
    DUAL SPECIFICITY PROTEIN KINASE CLK1 (EC 2.7.1.37) (EC 2.7.1.112) (CDC-LIKE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P49759] Description
    CLK1 Display Id
    ENSG00000013441 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P49759

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000013441 Ensembl Gene Id
    1195 Entrez Gene Id
    CLK1_HUMAN Uniprot Id

    Gene Info:
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Acc IPR002290

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • DTC: CLK1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Tahtouh T et al., 2012, Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B., J Med Chem

  • HingoraniCasas: ENSG00000013441

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000013441 Gene Symbol
    CLK1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CLK1

    • Version: 01-February-2022

    Alternate Names:
    CLK GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE, TYROSINE KINASE

    Publications:

  • dGene: CLK1

    • Version: 27-Jun-2013

    Alternate Names:
    1195 Gene ID
    CLK dGene Synonym
    CLK/STY dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: CDC-like kinase 1

    • Version: 2020.06.01

    Alternate Names:
    CLK1 TTD Gene Abbreviation
    T46685 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CLK1

    • Version: 01-February-2022

    Alternate Names:
    Dual specificity protein kinase CLK1 Gene Name
    P49759 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21