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CHUK Gene Record

  • Summary
  • Interactions
  • Claims
  • CHUK 1147 Druggable Genome

    Alternate Names:

    1147
    CONSERVED HELIX-LOOP-HELIX UBIQUITOUS KINASE
    CHUK
    IKBKA
    IKK-alpha
    IKK1
    IKKA
    NFKBIKA
    TCF16
    600664
    1974
    ENSG00000213341
    OTTHUMG00000018899
    O15111
    IKKA_HUMAN
    INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA
    ENSG00000107566
    INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE ALPHA SUBUNIT (EC 2.7.1.-) (I KAPPA-B KINASE ALPHA) (IKBKA) (IKK-ALPHA) (IKK-A) (IKAPPAB KINASE) (I-KAPPA-B KINASE 1) (IKK1) (CONSERVED HELIX-LOOP-HELIX UBIQUITOUS KINASE) (NUCLEAR FACTOR NFKAPPAB INHIBITOR KINAS
    component of inhibitor of nuclear factor kappa B kinase complex
    BPS2

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.11.10
    Interpro Acc IPR002290
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
    Beutler JA et al., 2009, Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition., J Nat Prod
    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.
    Bantel et al., 2000, Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis., Am. J. Gastroenterol.
    Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology
    Tsutsui C et al., 2009, Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway., Bioorg Med Chem Lett
  • 2,6-DIDEHYDROPEPEROMIN B   CHUK

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19559609


    Sources:
    DTC

  • AILANTHINONE   CHUK

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19199792


    Sources:
    DTC

  • GLAUCARUBINONE   CHUK

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19199792


    Sources:
    DTC

  • CHEMBL564009   CHUK

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19199792


    Sources:
    DTC

  • PEPEROMIN E   CHUK

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19559609


    Sources:
    DTC

  • CHEMBL8483   CHUK

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18566250


    Sources:
    DTC

  • MESALAMINE   CHUK

    Interaction Score: 1.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name SPD476,Lialda
    Novel drug target Established target

    PMIDs:
    12950415 11151876 11054378


    Sources:
    TdgClinicalTrial

  • LAUROGUADINE   CHUK

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000213341

    • Version: 101_38

    Alternate Names:
    CHUK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: O15111

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000213341 Ensembl Gene Id
    IKKA_HUMAN Uniprot Id
    CHUK Uniprot Gene Name

    Gene Info:
    Interpro Acc IPR002290
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000107566

    • Version: 26-July-2011

    Alternate Names:
    CHUK Display Id
    INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE ALPHA SUBUNIT (EC 2.7.1.-) (I KAPPA-B KINASE ALPHA) (IKBKA) (IKK-ALPHA) (IKK-A) (IKAPPAB KINASE) (I-KAPPA-B KINASE 1) (IKK1) (CONSERVED HELIX-LOOP-HELIX UBIQUITOUS KINASE) (NUCLEAR FACTOR NFKAPPAB INHIBITOR KINAS Description
    ENSG00000107566 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: O15111

    • Version: January-2014

    Alternate Names:
    CHUK Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.10

    Publications:

  • NCI: CHUK

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bowie et al., 2000, Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase., J. Immunol.

  • DTC: CHUK

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
    Beutler JA et al., 2009, Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition., J Nat Prod
    Tsutsui C et al., 2009, Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000213341

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000213341 Gene Symbol
    CHUK Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: CHUK

    • Version: 19.3

    Alternate Names:
    ENSG00000213341 Ensembl Gene ID
    IkBKA Human Protein Atlas Gene Synonym
    IKK-alpha Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: CHUK

    • Version: 01-February-2022

    Alternate Names:
    IKKA GO Gene Synonym
    TCF16 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: CHUK

    • Version: 27-Jun-2013

    Alternate Names:
    1147 Gene ID
    IKBKA dGene Synonym
    IKK-alpha dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: CHUK

    • Version: 01-February-2022

    Alternate Names:
    Inhibitor of nuclear factor kappa-B kinase subunit alpha Gene Name
    O15111 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21