• CHRNA1 1134 Druggable Genome

    Alternate Names:

    1134
    CHOLINERGIC RECEPTOR NICOTINIC ALPHA 1 SUBUNIT
    CHRNA1
    ACHRA
    ACHRD
    CHRNA
    CMS1A
    CMS1B
    CMS2A
    FCCMS
    SCCMS
    100690
    1955
    ENSG00000138435
    OTTHUMG00000132357
    P02708
    ACHA_HUMAN
    ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA
    CHNRA
    ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P02708]
    462
    nicotinic acetylcholine receptor α1 subunit
    PA26487
    Neuronal acetylcholine receptor alpha-1
    T04689
    NM_001039523
    NP_001034612

    Gene Info:

    Interpro Name Neurotransmitter-gated ion-channel ligand-binding
    Interpro Short Name Neur_chan_lig-bd
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name ION CHANNEL
    Interpro Acc IPR006201
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Short Name Neur_channel
    Uniprot Status Swiss-Prot
    Interpro Acc IPR006202
    Interpro Name Neurotransmitter-gated ion-channel
    Interpro Type Domain
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Nicotinic acetylcholine receptors
    GuideToPharmacology Gene Category ID 76
    (6 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

  • Interaction Score: 1.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Details of Interaction (&alpha;1)<sub>2</sub>&beta;1&gamma;&delta; and (&alpha;1)<sub>2</sub>&beta;1&delta;&epsilon;

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Details of Interaction selective for (&alpha;1)<sub>2</sub>&beta;1&gamma;&delta;
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscle-type nicotinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.32

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Details of Interaction (&alpha;1)<sub>2</sub>&beta;1&delta;&epsilon;

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    CHRNA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    CHRNA1 Uniprot Gene Name
    ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA Uniprot Protein Name
    P02708 Uniprot Accession

    Gene Info:
    Interpro Name Neurotransmitter-gated ion-channel ligand-binding
    Interpro Short Name Neur_chan_lig-bd
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000138435 Ensembl Gene Id
    ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P02708] Description
    CHRNA1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1955 HUGO Gene ID
    1955 HUGO Gene Symbol
    cholinergic receptor nicotinic alpha 1 subunit HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Nicotinic acetylcholine receptors
    GuideToPharmacology Gene Category ID 76

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000138435 Gene Symbol
    CHRNA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    CHNRA GENE_SYMBOL
    CHRNA1 GENE_SYMBOL
    Acetylcholine receptor subunit alpha UNIPROT

    Gene Info:

    Publications:

    • Version: 18-August-2020

    Alternate Names:
    PA26487 PharmGKB ID

    Gene Info:

    Publications:

  • Alternate Names:
    CHRNA1 TTD Gene Abbreviation
    T04689 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    ACHRA GO Gene Synonym
    CHNRA GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, ION CHANNEL

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Acetylcholine receptor subunit alpha Gene Name
    P02708 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: