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CHRM2 Gene Record

  • Summary
  • Interactions
  • Claims
  • CHRM2 1129 Druggable Genome

    Alternate Names:

    1129
    CHOLINERGIC RECEPTOR MUSCARINIC 2
    CHRM2
    HM2
    118493
    1951
    ENSG00000181072
    OTTHUMG00000155658
    P08172
    ACM2_HUMAN
    MUSCARINIC ACETYLCHOLINE RECEPTOR M2. [SOURCE:UNIPROT/SWISSPROT;ACC:P08172]
    MUSCARINIC ACETYLCHOLINE RECEPTOR M2
    PA111
    T46185

    Gene Info:

    Target Main Class Receptors
    Target Subclass Rhodopsin
    Transmembrane Helix Count 6
    Target Subclass GPCR
    Human Readable Name DRUGGABLE GENOME
    Target Class Receptors
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Hou et al., 1998, Neuromuscular relaxants as antagonists for M2 and M3 muscarinic receptors., Anesthesiology
    Milchert et al., 2009, Skeletal muscle relaxants inhibit rat tracheal smooth muscle tone in vitro., J. Physiol. Pharmacol.
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
    Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
    Barnes et al., 1995, Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease., Life Sci.
    Hansel et al., 2002, Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD., Drugs Today
    Snyder et al., 1974, Antischizophrenic drugs and brain cholinergic receptors. Affinity for muscarinic sites predicts extrapyramidal effects., Arch. Gen. Psychiatry
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Figueiredo et al., 1990, Mechanism of action of doxepin in the treatment of chronic urticaria., Fundam Clin Pharmacol
    Ehlert et al., 1990, The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart., J. Pharmacol. Exp. Ther.
    Nelson et al., 2006, Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor., J. Pharmacol. Exp. Ther.
    Roman et al., 2005, Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors., Brain Res.
    Minaba et al., 2006, Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype. Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals., FEBS J.
    Cembala et al., 2007, Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors., Eur. J. Pharmacol.
    May et al., 2005, Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators., J. Pharmacol. Exp. Ther.
    McNamara et al., 2009, Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist., Eur. J. Pharmacol.
    Sellers et al., 2000, M3 muscarinic receptors but not M2 mediate contraction of the porcine detrusor muscle in vitro., J Auton Pharmacol
    Schneider et al., 2004, Signal transduction underlying carbachol-induced contraction of human urinary bladder., J. Pharmacol. Exp. Ther.
    Mobascher A et al., 2010, Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction., Am J Med Genet B Neuropsychiatr Genet
    Golembiewski et al., 2002, A systematic approach to the management of postoperative nausea and vomiting., J. Perianesth. Nurs.
    Larson et al., 1991, Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart., Psychopharmacology (Berl.)
    Waelbroeck et al., 1992, Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors., Eur. J. Pharmacol.
    Waelbroeck et al., 1990, Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4., Eur. J. Pharmacol.
    Myhrer, 2010, Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment., Neurotoxicology
    Ito et al., 2009, Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice., Eur. J. Pharmacol.
    Dmochowski, 2005, Improving the tolerability of anticholinergic agents in the treatment of overactive bladder., Drug Saf
    Oki et al., 2007, Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder., J. Urol.
    Sinha et al., 2010, AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder., Br. J. Pharmacol.
    Yarker YE et al., 1995, Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability., Drugs Aging
    Sawatzky et al., 2003, Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells., Am. J. Physiol. Lung Cell Mol. Physiol.
    Peter et al., 2004, Modulation of the M2 muscarinic acetylcholine receptor activity with monoclonal anti-M2 receptor antibody fragments., J. Biol. Chem.
    Zuchner et al., 2005, Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins., J. Neurochem.
    Sterin-Borda et al., 2002, Therapeutic use of muscarinic acetylcholine receptor peptide to prevent mice chagasic cardiac dysfunction., J. Mol. Cell. Cardiol.
    Almadhoun K et al., 2020, Bronchodilators,
    Wellington, 2005, Ipratropium bromide HFA., Treat Respir Med
    Rehder KJ, 2017, Adjunct Therapies for Refractory Status Asthmaticus in Children., Respir Care
    Hals et al., 1988, Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites., Life Sci.
    Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
    Jovanović et al., 1994, Endothelium-dependent relaxation in response to acetylcholine in the human uterine artery., Eur. J. Pharmacol.
    Pavía et al., 1997, Pharmacological characterization and distribution of muscarinic receptors in human placental syncytiotrophoblast brush-border and basal plasma membranes., Eur. J. Pharmacol.
    Varoli et al., 1999, Synthesis and antagonistic activity at muscarinic receptor subtypes of some 2-carbonyl derivatives of diphenidol., Bioorg. Med. Chem.
    Braverman et al., 2002, Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Kovacs et al., 1998, Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line., J. Pharmacol. Exp. Ther.
    Pelat et al., 1999, Characterization of the central muscarinic cholinoceptors involved in the cholinergic pressor response in anesthetized dogs., Eur. J. Pharmacol.
    Waelbroeck et al., 1991, Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors., Chirality
    Lazartigues et al., 1998, Pressor and bradycardic effects of tacrine and other acetylcholinesterase inhibitors in the rat., Eur. J. Pharmacol.
    Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
    Abbiati et al., 1988, Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics., Pharm. Res.
    Uckert et al., 2000, Responses of isolated normal human detrusor muscle to various spasmolytic drugs commonly used in the treatment of the overactive bladder., Arzneimittelforschung
    Moreno-Vinasco et al., 2009, Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects., Am. J. Physiol. Lung Cell Mol. Physiol.
    Figueroa et al., 2009, Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes., J. Pharmacol. Exp. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Mansfield et al., 2009, Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa., J. Pharmacol. Exp. Ther.
    Schmitz J et al., 2014, Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity., J Med Chem
    Schjelderup et al., 1988, Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride., Pharm. Res.
    Johnson et al., 2005, The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release., Eur. J. Pharmacol.
  • DOXACURIUM   CHRM2

    Interaction Score: 3.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 17016423 9523819


    Sources:
    TdgClinicalTrial TEND

  • NAPHMETHONIUM   CHRM2

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25051097


    Sources:
    DTC

  • DIPHENIDOL   CHRM2

    Interaction Score: 2.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8050463 9059856 10530931 12185001 9454790 10497897 1863523 9851542


    Sources:
    TdgClinicalTrial TEND

  • PROCYCLIDINE   CHRM2

    Interaction Score: 2.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2027917 1426023 2253700 20624420 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • OXYBUTYNIN   CHRM2

    Interaction Score: 2.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name AA-2010
    Novel drug target Established target
    Trial Name AP-1034,Anturol

    PMIDs:
    19446545 15963006 17222678 16188951 20590605 7620236


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • FLAVOXATE   CHRM2

    Interaction Score: 2.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19002123 3247311 17016423 17139284 10858873


    Sources:
    TdgClinicalTrial TEND

  • MIVACURIUM   CHRM2

    Interaction Score: 2.02

    Interaction Types & Directionality:
    partial agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 9523819


    Sources:
    TdgClinicalTrial TEND

  • SCOPOLAMINE   CHRM2

    Interaction Score: 1.82

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15627430 11752352


    Sources:
    TTD

  • OXYPHENCYCLIMINE   CHRM2

    Interaction Score: 1.82

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1426023 3247303 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • CARBACHOL   CHRM2

    Interaction Score: 1.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12948933 15485827 15333678 16181410 12505062


    Sources:
    TdgClinicalTrial TEND

  • TRIDIHEXETHYL   CHRM2

    Interaction Score: 1.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ROCURONIUM   CHRM2

    Interaction Score: 1.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name rocuronium bromide,Esmeron, Zemuron, Eslax
    Novel drug target Established target

    PMIDs:
    20400785 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ATROPINE   CHRM2

    Interaction Score: 0.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Trial Name inhaled atropine

    PMIDs:
    7855217 16188951 16248990 17087737 17588565 15333678


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • METHIXENE   CHRM2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • IPRATROPIUM   CHRM2

    Interaction Score: 0.87

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ipratropium bromide + albuterol sulfate,DuoNeb
    Novel drug target Established target

    PMIDs:
    30085570 15987237 28546381


    Sources:
    TdgClinicalTrial TEND

  • TRIFLUPROMAZINE   CHRM2

    Interaction Score: 0.76

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    4152054 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • SOLIFENACIN   CHRM2

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Solifenacin succinate, YM-905,Vesicare
    Novel drug target Established target

    PMIDs:
    19029429 20590605


    Sources:
    TdgClinicalTrial

  • TOLTERODINE   CHRM2

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name THVD-201
    Novel drug target Established target
    Trial Name tolterodine extended release capsules,Detrol LA

    PMIDs:
    19168050 11193006 16188951 14769832


    Sources:
    TdgClinicalTrial TEND

  • TIOTROPIUM   CHRM2

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tiotropium bromide,Spiriva
    Novel drug target Established target

    PMIDs:
    10188785 12582447


    Sources:
    TdgClinicalTrial

  • BENZQUINAMIDE   CHRM2

    Interaction Score: 0.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • DARIFENACIN HYDROBROMIDE   CHRM2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SOLIFENACIN SUCCINATE   CHRM2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TROSPIUM CHLORIDE   CHRM2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZAMIFENACIN   CHRM2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BETHANECHOL CHLORIDE   CHRM2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOLTERODINE TARTRATE   CHRM2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FESOTERODINE FUMARATE   CHRM2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ENDO-ATROPINE   CHRM2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25051097


    Sources:
    DTC

  • FESOTERODINE   CHRM2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    19029429


    Sources:
    TEND

  • PILOCARPINE   CHRM2

    Interaction Score: 0.47

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name THVD-201

    PMIDs:
    19465517 18824613 11752352


    Sources:
    TdgClinicalTrial TEND

  • BATEFENTEROL   CHRM2

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ATROPINE SULFATE   CHRM2

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXYBUTYNIN CHLORIDE   CHRM2

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DESIPRAMINE   CHRM2

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7855217 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • METHSCOPOLAMINE   CHRM2

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PROPIOMAZINE   CHRM2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 17016423


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   CHRM2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2899826 2870716


    Sources:
    TdgClinicalTrial TEND

  • PROMAZINE   CHRM2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • DOXEPIN   CHRM2

    Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Silenor (SO-101)
    Novel drug target Established target

    PMIDs:
    7855217 2141000 2329499


    Sources:
    TdgClinicalTrial

  • ACECLIDINE   CHRM2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PIPERTRAMINE   CHRM2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPANTHELINE BROMIDE   CHRM2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ACLIDINIUM   CHRM2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Aclidinium
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DAROTROPIUM BROMIDE   CHRM2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROMETHAZINE   CHRM2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12476402


    Sources:
    TdgClinicalTrial TEND

  • PIPERTRAMINE AMIDE   CHRM2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIETHYLPERAZINE   CHRM2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • AFACIFENACIN   CHRM2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ASM-024   CHRM2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OLANZAPINE   CHRM2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ALKS 3831
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    17848919 10227113 25032030


    Sources:
    TdgClinicalTrial TEND

  • NICOTINE   CHRM2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19644963


    Sources:
    PharmGKB

  • Ensembl: ENSG00000181072

    • Version: 101_38

    Alternate Names:
    CHRM2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000181072

    • Version: 26-July-2011

    Alternate Names:
    CHRM2 Display Id
    MUSCARINIC ACETYLCHOLINE RECEPTOR M2. [SOURCE:UNIPROT/SWISSPROT;ACC:P08172] Description
    ENSG00000181072 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P08172

    • Version: January-2014

    Alternate Names:
    CHRM2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P08172

    • Version: 11-September-2012

    Alternate Names:
    P08172 Uniprot Accession
    MUSCARINIC ACETYLCHOLINE RECEPTOR M2 Uniprot Protein Name
    CHRM2 Uniprot Gene Name

    Gene Info:
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: P08172

    • Version: 01-August-2011

    Alternate Names:
    1129 Entrez Gene Id
    P08172 Uniprot Accession
    ACM2_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Transmembrane Helix Count 6

    Publications:

  • PharmGKB: CHRM2

    • Version: 18-August-2020

    Alternate Names:
    PA111 PharmGKB ID

    Gene Info:

    Publications:
    Mobascher A et al., 2010, Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction., Am J Med Genet B Neuropsychiatr Genet

  • DTC: CHRM2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Schmitz J et al., 2014, Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity., J Med Chem

  • ChemblInteractions: CHRM2

    • Version: chembl_23

    Alternate Names:
    CHRM2 GENE_SYMBOL
    Muscarinic acetylcholine receptor M2 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000181072

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000181072 Gene Symbol
    CHRM2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: CHRM2

    • Version: 27-Jun-2013

    Alternate Names:
    1129 Gene ID
    HM2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Muscarinic acetylcholine receptor M2

    • Version: 2020.06.01

    Alternate Names:
    CHRM2 TTD Gene Abbreviation
    T46185 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21