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CHRM1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CHRM1 1128 Druggable Genome

    Alternate Names:

    1128
    CHOLINERGIC RECEPTOR MUSCARINIC 1
    CHRM1
    HM1
    M1
    M1R
    118510
    1950
    ENSG00000168539
    OTTHUMG00000167765
    P11229
    ACM1_HUMAN
    MUSCARINIC ACETYLCHOLINE RECEPTOR M1
    MUSCARINIC ACETYLCHOLINE RECEPTOR M1. [SOURCE:UNIPROT/SWISSPROT;ACC:P11229]
    T28893

    Gene Info:

    Transmembrane Helix Count 7
    Target Subclass GPCR
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Target Class Receptors
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Fisher, 1999, Clinical pharmacology of neuromuscular blocking agents., Am J Health Syst Pharm
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Hals et al., 1988, Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites., Life Sci.
    Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
    Nilvebrant, 2002, Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists., Pharmacol. Toxicol.
    Mokry et al., 2005, Propantheline and in vitro reactivity of urinary bladder smooth muscle in guinea pigs., Bratisl Lek Listy
    Saitoh et al., 1986, Interaction of tertiary amines and quaternary ammonium compounds with gastrointestinal mucin., J. Pharmacobio-dyn.
    Lukacs et al., [Antiperspirants and deodorants--ingredients and evaluation]., Derm Beruf Umwelt
    Trkulja et al., 2004, Involvement of the peripheral cholinergic muscarinic system in the compensatory ovarian hypertrophy in the rat., Exp. Biol. Med. (Maywood)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Tokoro T, 1998, [Developmental mechanism of low myopia and therapeutic possibilities. A review]., Nippon Ganka Gakkai Zasshi
    Cuprian-Beltechi AM et al., 2009, High spatial resolution studies of muscarinic neuroeffector junctions in mouse isolated vas deferens., Neuroscience
    Kyei S et al., 2017, Onset and duration of cycloplegic action of 1% cyclopentolate - 1% tropicamide combination., Afr Health Sci
    Solanki P et al., 2007, Cholinergic innervation of the guinea-pig isolated vas deferens., Naunyn Schmiedebergs Arch Pharmacol
    Walkenbach RJ et al., 1991, Muscarinic cholinoceptor regulation of cyclic guanosine monophosphate in human corneal epithelium., Invest Ophthalmol Vis Sci
    Eltze et al., 1994, Involvement of muscarinic M2 and M3, but not of M1 and M4 receptors in vagally stimulated contractions of rabbit bronchus/trachea., Pulm Pharmacol
    Eltze, 1999, Multiple mechanisms of action: the pharmacological profile of budipine., J. Neural Transm. Suppl.
    Hosoi et al., 1999, Evaluation of in vivo binding properties of 3H-NMPB and 3H-QNB in mouse brain., J Neural Transm (Vienna)
    Pehl et al., 1998, Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus., Aliment. Pharmacol. Ther.
    Snyder et al., 1974, Antischizophrenic drugs and brain cholinergic receptors. Affinity for muscarinic sites predicts extrapyramidal effects., Arch. Gen. Psychiatry
    Fisher et al., 1996, M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update., Ann. N. Y. Acad. Sci.
    Kim DH et al., 2009, Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia., Neurotherapeutics
    Sharma A et al., 2003, Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view., Curr Drug Metab
    POWE CE et al., 1962, Propiomazine hydrochloride in obstetrical analgesia. A controlled study of 520 patients., JAMA
    Page CB et al., 2009, Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal., QJM
    Almadhoun K et al., 2020, Bronchodilators,
    Wellington, 2005, Ipratropium bromide HFA., Treat Respir Med
    Rehder KJ, 2017, Adjunct Therapies for Refractory Status Asthmaticus in Children., Respir Care
    Dörje et al., 1991, Antagonist binding profiles of five cloned human muscarinic receptor subtypes., J. Pharmacol. Exp. Ther.
    Prus et al., 2009, The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats., Psychopharmacology (Berl.)
    Tanda et al., 2007, Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats., Pharmacol. Biochem. Behav.
    Freedman et al., 1988, Muscarinic M1, M2 receptor binding. Relationship with functional efficacy., Eur. J. Pharmacol.
    Giachetti et al., 1986, Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine., Br. J. Pharmacol.
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett
    Hammer, Gastroesophageal reflux and prokinetic agents., Neonatal Netw
    Burger et al., 2006, Effect of anticholinergics (atropine, glycopyrrolate) and prokinetics (metoclopramide, cisapride) on gastric motility in beagles and labrador retrievers., J Vet Med A Physiol Pathol Clin Med
    Lee A et al., 2010, Metoclopramide in the treatment of diabetic gastroparesis., Expert Rev Endocrinol Metab
    Figueroa et al., 2009, Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes., J. Pharmacol. Exp. Ther.
    Chen X et al., 2015, Rational design of partial agonists for the muscarinic m1 acetylcholine receptor., J Med Chem
    Abbiati et al., 1988, Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics., Pharm. Res.
    Klinkenberg et al., 2010, The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies., Neurosci Biobehav Rev
    Murasaki et al., 2003, Site of action of the general anesthetic propofol in muscarinic M1 receptor-mediated signal transduction., J. Pharmacol. Exp. Ther.
    Irmen M et al., 2018, Characterization of methanthelinium binding and function at human M<sub>1</sub>-M<sub>5</sub> muscarinic acetylcholine receptors., Naunyn Schmiedebergs Arch Pharmacol
    Golembiewski et al., 2002, A systematic approach to the management of postoperative nausea and vomiting., J. Perianesth. Nurs.
    Sinha et al., 2010, AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder., Br. J. Pharmacol.
    Mansfield et al., 2009, Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa., J. Pharmacol. Exp. Ther.
    Schneider et al., 2004, Signal transduction underlying carbachol-induced contraction of human urinary bladder., J. Pharmacol. Exp. Ther.
    Vedasiromoni et al., 1976, Cycrimine on rat diaphragm., Arch Int Pharmacodyn Ther
    Melancon BJ et al., 2012, Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor., Bioorg Med Chem Lett
    Lebois EP et al., 2011, Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071., Bioorg Med Chem Lett
    Weiner et al., 2004, Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias., Am J Pharmacogenomics
    Jin et al., 2009, Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment., J. Neurosci. Res.
    Clarke S et al., 1966, Therapeutic action of methixene hydrochloride on Parkinsonian tremor and a description of a new tremor-recording transducer., Br J Pharmacol Chemother
    Norris JW et al., 1967, Mehixene hydrochloride and parkinsonian tremor., Acta Neurol Scand
    ABRUZZI W, 1965, THE USE OF METHIXENE HYDROCHLORIDE TO RELIEVE FUNCTIONAL GASTROINTESTINAL DISORDERS., J New Drugs
    1966, Evaluation of an antispasmodic agent. Methixene hydrochloride (Trest)., JAMA
    Jakubík et al., 1997, Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors., Mol. Pharmacol.
    Waelbroeck et al., 1991, Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors., Chirality
    Eglen et al., 1987, Competitive and non-competitive antagonism exhibited by 'selective' antagonists at atrial and ileal muscarinic receptor subtypes., Br. J. Pharmacol.
    Figueiredo et al., 1990, Mechanism of action of doxepin in the treatment of chronic urticaria., Fundam Clin Pharmacol
    Stahl, 2008, Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines., CNS Spectr
    Ehlert et al., 1990, The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart., J. Pharmacol. Exp. Ther.
    Larson et al., 1991, Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart., Psychopharmacology (Berl.)
    Waelbroeck et al., 1992, Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors., Eur. J. Pharmacol.
    Waelbroeck et al., 1990, Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4., Eur. J. Pharmacol.
    Myhrer, 2010, Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment., Neurotoxicology
    Barnes et al., 1995, Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease., Life Sci.
    Barnes, 2001, Tiotropium bromide., Expert Opin Investig Drugs
    Hansel et al., 2002, Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD., Drugs Today
    Rovner ES, 2004, Trospium chloride in the management of overactive bladder., Drugs
    Tittor et al., 1982, [Effectiveness of octatropine methylbromide (OMB) in the treatment of gastritis, duodenal ulcer and spastic colon--a double blind study]., ZFA (Stuttgart)
    Pace et al., 2010, Octatropine methyl bromide and diazepam combination (Valpinax) in patients with irritable bowel syndrome: a multicentre, randomized, placebo-controlled trial., Eur Rev Med Pharmacol Sci
    Bachrach, 1972, Clinical evaluation of anisotropine methyl bromide (valpin), an anticholinergic drug., Am J Dig Dis
    Burke, 1986, The relative selectivity of anticholinergic drugs for the M1 and M2 muscarinic receptor subtypes., Mov. Disord.
    Katayama et al., 1990, Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain., Res. Commun. Chem. Pathol. Pharmacol.
    Schjelderup et al., 1988, Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride., Pharm. Res.
    Oki et al., 2007, Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder., J. Urol.
    Maruyama et al., 2006, Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder., J. Urol.
    Yarker YE et al., 1995, Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability., Drugs Aging
    Ali-Melkkilä et al., 1993, Pharmacokinetics and related pharmacodynamics of anticholinergic drugs., Acta Anaesthesiol Scand
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Uchida et al., 2007, Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine., Life Sci.
    Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
    Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
    Pedretti et al., 2003, Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade., J. Cardiovasc. Pharmacol.
  • OXYPHENONIUM   CHRM1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    3580704 17016423 17139284 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • CYCRIMINE   CHRM1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1267542 17016423 17139284 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • CLIDINIUM   CHRM1

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • GLYCOPYRRONIUM   CHRM1

    Interaction Score: 3.68

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name NVA237, inhaled glycopyrronium bromide
    Novel drug target Established target

    PMIDs:
    8249551 17016423 17139284 11752352


    Sources:
    TdgClinicalTrial

  • CYCLOPENTOLATE   CHRM1

    Interaction Score: 3.31

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 10025113 19486927 29085421 17992517 1848211


    Sources:
    TdgClinicalTrial TEND

  • TRIHEXYPHENIDYL   CHRM1

    Interaction Score: 2.7

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1994002 18685832 17631384 11752352 3208836 2432979 17016423 17139284


    Sources:
    TdgClinicalTrial TEND TTD

  • BIPERIDEN   CHRM1

    Interaction Score: 2.45

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8081071 10370904 10907719 11752352 9798802 17016423 17139284


    Sources:
    TdgClinicalTrial TEND TTD

  • ANISOTROPINE METHYLBROMIDE   CHRM1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    6897316 20391952 4555460 17016423 17139284


    Sources:
    ChemblInteractions

  • ARECOLINE   CHRM1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17016423 17139284


    Sources:
    TTD

  • PROPANTHELINE   CHRM1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16080359 3572714 2656175 15337834 11752352 17016423


    Sources:
    TdgClinicalTrial TEND TTD

  • TROSPIUM   CHRM1

    Interaction Score: 1.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name trospium chloride,Sanctura
    Novel drug target Established target

    PMIDs:
    17016423 17139284 15482001


    Sources:
    TdgClinicalTrial TEND

  • SCOPOLAMINE   CHRM1

    Interaction Score: 1.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Novel drug target Established target

    PMIDs:
    20398692 14534362


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PROCYCLIDINE   CHRM1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2027917 1426023 2253700 20624420 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • NGX-267   CHRM1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name NGX267
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • BUCLIZINE   CHRM1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • GLYCOPYRROLATE   CHRM1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes
    Trial Name glycopyrrolate, FHPC-02,Cuvposa

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • METHIXENE   CHRM1

    Interaction Score: 1.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 5330346 4866169 14315148 12608172


    Sources:
    TdgClinicalTrial TEND TTD

  • METHANTHELINE   CHRM1

    Interaction Score: 1.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17016423 17139284 29938305


    Sources:
    TdgClinicalTrial TEND

  • CEVIMELINE   CHRM1

    Interaction Score: 1.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    8624083 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • OXYBUTYNIN   CHRM1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name AA-2010
    Novel drug target Established target
    Trial Name AP-1034,Anturol

    PMIDs:
    20590605 17222678 17016423 17139284 16406943 7620236


    Sources:
    TdgClinicalTrial TEND

  • OXYPHENCYCLIMINE   CHRM1

    Interaction Score: 1.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1426023 3247303 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ETHOPROPAZINE   CHRM1

    Interaction Score: 1.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2904117 2236897 17016423 11752352


    Sources:
    TdgClinicalTrial TEND

  • BETHANECHOL   CHRM1

    Interaction Score: 1.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9224827


    Sources:
    TdgClinicalTrial TEND

  • PIRENZEPINE   CHRM1

    Interaction Score: 0.92

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12717096 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • FLAVOXATE   CHRM1

    Interaction Score: 0.92

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    3247311 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • CARBACHOL   CHRM1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    22507963 21930376 15059034


    Sources:
    DTC TdgClinicalTrial TEND

  • SOLIFENACIN   CHRM1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Solifenacin succinate, YM-905,Vesicare
    Novel drug target Established target

    PMIDs:
    20590605 17016423 17139284 19029429


    Sources:
    TdgClinicalTrial TEND

  • DICYCLOMINE   CHRM1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17016423 17139284 11752352 19533734


    Sources:
    TdgClinicalTrial TEND TTD

  • PROCYCLIDINE HYDROCHLORIDE   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIDIHEXETHYL   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • DIPHENIDOL HYDROCHLORIDE   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NEBRACETAM   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CYCRIMINE HYDROCHLORIDE   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIHEXYPHENIDYL HYDROCHLORIDE   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BENZTROPINE   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND TTD

  • CARBINOXAMINE   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • DIPHENIDOL   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1863523 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • BIPERIDEN HYDROCHLORIDE   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BIPERIDEN LACTATE   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SUXAMETHONIUM   CHRM1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10437710 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • TIOTROPIUM   CHRM1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tiotropium bromide,Spiriva
    Novel drug target Established target

    PMIDs:
    10188785 11281822 12582447


    Sources:
    TdgClinicalTrial

  • ATROPINE   CHRM1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes
    Trial Name inhaled atropine

    PMIDs:
    7855217 17016423 17139284 23062550


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • IPRATROPIUM   CHRM1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ipratropium bromide + albuterol sulfate,DuoNeb
    Novel drug target Established target

    PMIDs:
    30085570 15987237 28546381


    Sources:
    TdgClinicalTrial TEND

  • METHSCOPOLAMINE   CHRM1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • TRIFLUPROMAZINE   CHRM1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    4152054 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • PILOCARPINE   CHRM1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 agonist
    Direct Interaction yes
    Trial Name THVD-201

    PMIDs:
    18824613 17016423 17139284 25478907


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • PROPIOMAZINE   CHRM1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17016423 17139284 19110200 12678691 14488364 19042969


    Sources:
    TdgClinicalTrial TEND

  • BENZQUINAMIDE   CHRM1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • TRIDIHEXETHYL CHLORIDE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BENZTROPINE MESYLATE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CEVIMELINE HYDROCHLORIDE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIPHEMANIL METHYLSULFATE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METHSCOPOLAMINE BROMIDE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPENZOLATE BROMIDE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOLTERODINE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name THVD-201
    Novel drug target Established target
    Trial Name tolterodine extended release capsules,Detrol LA

    PMIDs:
    17016423 17139284 14769832


    Sources:
    TdgClinicalTrial TEND

  • CLIDINIUM BROMIDE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HEXOCYCLIUM METHYLSULFATE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METOCLOPRAMIDE   CHRM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MT 100
    Trial Name metoclopramide,Emitasol, Pramidin
    Trial Name metoclopramide HCl,Metzoliv ODT

    PMIDs:
    15835479 16466463 17016423 17139284 21278804


    Sources:
    TdgClinicalTrial

  • FESOTERODINE   CHRM1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    12076307


    Sources:
    TEND

  • OXYPHENCYCLIMINE HYDROCHLORIDE   CHRM1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXYPHENONIUM BROMIDE   CHRM1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DICYCLOMINE HYDROCHLORIDE   CHRM1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DESIPRAMINE   CHRM1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7855217 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ATROPINE SULFATE   CHRM1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PILOCARPINE HYDROCHLORIDE   CHRM1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROMAZINE   CHRM1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 19110200


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   CHRM1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2899826 2870716


    Sources:
    TdgClinicalTrial TEND

  • DOXEPIN   CHRM1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Silenor (SO-101)
    Novel drug target Established target

    PMIDs:
    7855217 2141000 19179941 2329499


    Sources:
    TdgClinicalTrial

  • METHIXENE HYDROCHLORIDE   CHRM1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOPROPAMIDE IODIDE   CHRM1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDACATEROL   CHRM1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name QVA149, glycopyrronium bromide + i/
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DAROTROPIUM BROMIDE   CHRM1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PIPERTRAMINE   CHRM1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPANTHELINE BROMIDE   CHRM1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PIPERTRAMINE AMIDE   CHRM1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ACLIDINIUM   CHRM1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Aclidinium
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PROMETHAZINE   CHRM1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12476402


    Sources:
    TdgClinicalTrial TEND

  • ACECLIDINE   CHRM1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • THIETHYLPERAZINE   CHRM1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • N-DESMETHYLCLOZAPINE   CHRM1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ASM-024   CHRM1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETHOPROPAZINE HYDROCHLORIDE   CHRM1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AFACIFENACIN   CHRM1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OLANZAPINE   CHRM1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
    Novel drug target Established target
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    17848919 17316700 10227113 25032030


    Sources:
    TdgClinicalTrial TEND

  • Ensembl: ENSG00000168539

    • Version: 101_38

    Alternate Names:
    CHRM1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000168539

    • Version: 26-July-2011

    Alternate Names:
    CHRM1 Display Id
    MUSCARINIC ACETYLCHOLINE RECEPTOR M1. [SOURCE:UNIPROT/SWISSPROT;ACC:P11229] Description
    ENSG00000168539 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P11229

    • Version: 11-September-2012

    Alternate Names:
    1128 Entrez Gene Id
    MUSCARINIC ACETYLCHOLINE RECEPTOR M1 Uniprot Protein Name
    CHRM1 Uniprot Gene Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P11229

    • Version: January-2014

    Alternate Names:
    CHRM1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TEND: P11229

    • Version: 01-August-2011

    Alternate Names:
    P11229 Uniprot Accession
    1128 Entrez Gene Id
    ENSG00000168539 Ensembl Gene Id

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass GPCR
    Target Main Class Receptors

    Publications:

  • TTD: Muscarinic acetylcholine receptor M1

    • Version: 2020.06.01

    Alternate Names:
    CHRM1 TTD Gene Abbreviation
    T28893 TTD Target ID

    Gene Info:

    Publications:
    Viberg A et al., 2012, Evaluation of an innovative population pharmacokinetic-based design for behavioral pharmacodynamic endpoints., AAPS J

  • DTC: CHRM1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett
    Melancon BJ et al., 2012, Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor., Bioorg Med Chem Lett
    Lebois EP et al., 2011, Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071., Bioorg Med Chem Lett

  • ChemblInteractions: CHRM1

    • Version: chembl_23

    Alternate Names:
    CHRM1 GENE_SYMBOL
    Muscarinic acetylcholine receptor M1 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000168539

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000168539 Gene Symbol
    CHRM1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: CHRM1

    • Version: 27-Jun-2013

    Alternate Names:
    1128 Gene ID
    HM1 dGene Synonym
    M1 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21