DGIdb - CHRM1 Gene Record

CHRM1 1128 Druggable Genome

Alternate Names:

1128
CHOLINERGIC RECEPTOR MUSCARINIC 1
CHRM1
HM1
M1
M1R
118510
1950
ENSG00000168539
OTTHUMG00000167765
P11229
ACM1_HUMAN
MUSCARINIC ACETYLCHOLINE RECEPTOR M1
MUSCARINIC ACETYLCHOLINE RECEPTOR M1. [SOURCE:UNIPROT/SWISSPROT;ACC:P11229]
T28893

Gene Info:

Transmembrane Helix Count	7
Target Subclass	GPCR
Target Main Class	Receptors
Target Subclass	Rhodopsin
Target Class	Receptors
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Short Name	7TM_GPCR_Rhodpsn
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Fisher, 1999, Clinical pharmacology of neuromuscular blocking agents., Am J Health Syst Pharm
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Hals et al., 1988, Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites., Life Sci.
Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
Nilvebrant, 2002, Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists., Pharmacol. Toxicol.
Mokry et al., 2005, Propantheline and in vitro reactivity of urinary bladder smooth muscle in guinea pigs., Bratisl Lek Listy
Saitoh et al., 1986, Interaction of tertiary amines and quaternary ammonium compounds with gastrointestinal mucin., J. Pharmacobio-dyn.
Lukacs et al., [Antiperspirants and deodorants--ingredients and evaluation]., Derm Beruf Umwelt
Trkulja et al., 2004, Involvement of the peripheral cholinergic muscarinic system in the compensatory ovarian hypertrophy in the rat., Exp. Biol. Med. (Maywood)
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Tokoro T, 1998, [Developmental mechanism of low myopia and therapeutic possibilities. A review]., Nippon Ganka Gakkai Zasshi
Cuprian-Beltechi AM et al., 2009, High spatial resolution studies of muscarinic neuroeffector junctions in mouse isolated vas deferens., Neuroscience
Kyei S et al., 2017, Onset and duration of cycloplegic action of 1% cyclopentolate - 1% tropicamide combination., Afr Health Sci
Solanki P et al., 2007, Cholinergic innervation of the guinea-pig isolated vas deferens., Naunyn Schmiedebergs Arch Pharmacol
Walkenbach RJ et al., 1991, Muscarinic cholinoceptor regulation of cyclic guanosine monophosphate in human corneal epithelium., Invest Ophthalmol Vis Sci
Eltze et al., 1994, Involvement of muscarinic M2 and M3, but not of M1 and M4 receptors in vagally stimulated contractions of rabbit bronchus/trachea., Pulm Pharmacol
Eltze, 1999, Multiple mechanisms of action: the pharmacological profile of budipine., J. Neural Transm. Suppl.
Hosoi et al., 1999, Evaluation of in vivo binding properties of 3H-NMPB and 3H-QNB in mouse brain., J Neural Transm (Vienna)
Pehl et al., 1998, Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus., Aliment. Pharmacol. Ther.
Snyder et al., 1974, Antischizophrenic drugs and brain cholinergic receptors. Affinity for muscarinic sites predicts extrapyramidal effects., Arch. Gen. Psychiatry
Fisher et al., 1996, M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update., Ann. N. Y. Acad. Sci.
Kim DH et al., 2009, Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia., Neurotherapeutics
Sharma A et al., 2003, Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view., Curr Drug Metab
POWE CE et al., 1962, Propiomazine hydrochloride in obstetrical analgesia. A controlled study of 520 patients., JAMA
Page CB et al., 2009, Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal., QJM
Almadhoun K et al., 2020, Bronchodilators,
Wellington, 2005, Ipratropium bromide HFA., Treat Respir Med
Rehder KJ, 2017, Adjunct Therapies for Refractory Status Asthmaticus in Children., Respir Care
Dörje et al., 1991, Antagonist binding profiles of five cloned human muscarinic receptor subtypes., J. Pharmacol. Exp. Ther.
Prus et al., 2009, The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats., Psychopharmacology (Berl.)
Tanda et al., 2007, Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats., Pharmacol. Biochem. Behav.
Freedman et al., 1988, Muscarinic M1, M2 receptor binding. Relationship with functional efficacy., Eur. J. Pharmacol.
Giachetti et al., 1986, Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine., Br. J. Pharmacol.
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett
Hammer, Gastroesophageal reflux and prokinetic agents., Neonatal Netw
Burger et al., 2006, Effect of anticholinergics (atropine, glycopyrrolate) and prokinetics (metoclopramide, cisapride) on gastric motility in beagles and labrador retrievers., J Vet Med A Physiol Pathol Clin Med
Lee A et al., 2010, Metoclopramide in the treatment of diabetic gastroparesis., Expert Rev Endocrinol Metab
Figueroa et al., 2009, Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes., J. Pharmacol. Exp. Ther.
Chen X et al., 2015, Rational design of partial agonists for the muscarinic m1 acetylcholine receptor., J Med Chem
Abbiati et al., 1988, Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics., Pharm. Res.
Klinkenberg et al., 2010, The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies., Neurosci Biobehav Rev
Murasaki et al., 2003, Site of action of the general anesthetic propofol in muscarinic M1 receptor-mediated signal transduction., J. Pharmacol. Exp. Ther.
Irmen M et al., 2018, Characterization of methanthelinium binding and function at human M<sub>1</sub>-M<sub>5</sub> muscarinic acetylcholine receptors., Naunyn Schmiedebergs Arch Pharmacol
Golembiewski et al., 2002, A systematic approach to the management of postoperative nausea and vomiting., J. Perianesth. Nurs.
Sinha et al., 2010, AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder., Br. J. Pharmacol.
Mansfield et al., 2009, Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa., J. Pharmacol. Exp. Ther.
Schneider et al., 2004, Signal transduction underlying carbachol-induced contraction of human urinary bladder., J. Pharmacol. Exp. Ther.
Vedasiromoni et al., 1976, Cycrimine on rat diaphragm., Arch Int Pharmacodyn Ther
Melancon BJ et al., 2012, Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor., Bioorg Med Chem Lett
Lebois EP et al., 2011, Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071., Bioorg Med Chem Lett
Weiner et al., 2004, Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias., Am J Pharmacogenomics
Jin et al., 2009, Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment., J. Neurosci. Res.
Clarke S et al., 1966, Therapeutic action of methixene hydrochloride on Parkinsonian tremor and a description of a new tremor-recording transducer., Br J Pharmacol Chemother
Norris JW et al., 1967, Mehixene hydrochloride and parkinsonian tremor., Acta Neurol Scand
ABRUZZI W, 1965, THE USE OF METHIXENE HYDROCHLORIDE TO RELIEVE FUNCTIONAL GASTROINTESTINAL DISORDERS., J New Drugs
1966, Evaluation of an antispasmodic agent. Methixene hydrochloride (Trest)., JAMA
Jakubík et al., 1997, Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors., Mol. Pharmacol.
Waelbroeck et al., 1991, Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors., Chirality
Eglen et al., 1987, Competitive and non-competitive antagonism exhibited by 'selective' antagonists at atrial and ileal muscarinic receptor subtypes., Br. J. Pharmacol.
Figueiredo et al., 1990, Mechanism of action of doxepin in the treatment of chronic urticaria., Fundam Clin Pharmacol
Stahl, 2008, Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines., CNS Spectr
Ehlert et al., 1990, The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart., J. Pharmacol. Exp. Ther.
Larson et al., 1991, Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart., Psychopharmacology (Berl.)
Waelbroeck et al., 1992, Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors., Eur. J. Pharmacol.
Waelbroeck et al., 1990, Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4., Eur. J. Pharmacol.
Myhrer, 2010, Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment., Neurotoxicology
Barnes et al., 1995, Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease., Life Sci.
Barnes, 2001, Tiotropium bromide., Expert Opin Investig Drugs
Hansel et al., 2002, Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD., Drugs Today
Rovner ES, 2004, Trospium chloride in the management of overactive bladder., Drugs
Tittor et al., 1982, [Effectiveness of octatropine methylbromide (OMB) in the treatment of gastritis, duodenal ulcer and spastic colon--a double blind study]., ZFA (Stuttgart)
Pace et al., 2010, Octatropine methyl bromide and diazepam combination (Valpinax) in patients with irritable bowel syndrome: a multicentre, randomized, placebo-controlled trial., Eur Rev Med Pharmacol Sci
Bachrach, 1972, Clinical evaluation of anisotropine methyl bromide (valpin), an anticholinergic drug., Am J Dig Dis
Burke, 1986, The relative selectivity of anticholinergic drugs for the M1 and M2 muscarinic receptor subtypes., Mov. Disord.
Katayama et al., 1990, Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain., Res. Commun. Chem. Pathol. Pharmacol.
Schjelderup et al., 1988, Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride., Pharm. Res.
Oki et al., 2007, Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder., J. Urol.
Maruyama et al., 2006, Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder., J. Urol.
Yarker YE et al., 1995, Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability., Drugs Aging
Ali-Melkkilä et al., 1993, Pharmacokinetics and related pharmacodynamics of anticholinergic drugs., Acta Anaesthesiol Scand
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Uchida et al., 2007, Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine., Life Sci.
Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
Pedretti et al., 2003, Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade., J. Cardiovasc. Pharmacol.

OXYPHENONIUM CHRM1

Interaction Score: 5.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3580704 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
CYCRIMINE CHRM1

Interaction Score: 5.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1267542 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
CLIDINIUM CHRM1

Interaction Score: 4.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
GLYCOPYRRONIUM CHRM1

Interaction Score: 3.68

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name NVA237, inhaled glycopyrronium bromide

Novel drug target Established target

PMIDs:
8249551 17016423 17139284 11752352

Sources:
TdgClinicalTrial
CYCLOPENTOLATE CHRM1

Interaction Score: 3.31

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 10025113 19486927 29085421 17992517 1848211

Sources:
TdgClinicalTrial TEND
TRIHEXYPHENIDYL CHRM1

Interaction Score: 2.7

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1994002 18685832 17631384 11752352 3208836 2432979 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
BIPERIDEN CHRM1

Interaction Score: 2.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8081071 10370904 10907719 11752352 9798802 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
ANISOTROPINE METHYLBROMIDE CHRM1

Interaction Score: 2.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
6897316 20391952 4555460 17016423 17139284

Sources:
ChemblInteractions
ARECOLINE CHRM1

Interaction Score: 2.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17016423 17139284

Sources:
TTD
PROPANTHELINE CHRM1

Interaction Score: 2.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16080359 3572714 2656175 15337834 11752352 17016423

Sources:
TdgClinicalTrial TEND TTD
TROSPIUM CHRM1

Interaction Score: 1.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name trospium chloride,Sanctura

Novel drug target Established target

PMIDs:
17016423 17139284 15482001

Sources:
TdgClinicalTrial TEND
SCOPOLAMINE CHRM1

Interaction Score: 1.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Novel drug target Established target

PMIDs:
20398692 14534362

Sources:
TdgClinicalTrial ChemblInteractions TEND
PROCYCLIDINE CHRM1

Interaction Score: 1.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2027917 1426023 2253700 20624420 17016423 17139284

Sources:
TdgClinicalTrial TEND
NGX-267 CHRM1

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name NGX267

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
BUCLIZINE CHRM1

Interaction Score: 1.47

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
GLYCOPYRROLATE CHRM1

Interaction Score: 1.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

Trial Name glycopyrrolate, FHPC-02,Cuvposa

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
METHIXENE CHRM1

Interaction Score: 1.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 5330346 4866169 14315148 12608172

Sources:
TdgClinicalTrial TEND TTD
METHANTHELINE CHRM1

Interaction Score: 1.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 29938305

Sources:
TdgClinicalTrial TEND
CEVIMELINE CHRM1

Interaction Score: 1.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
8624083 17016423 17139284

Sources:
TdgClinicalTrial TEND
OXYBUTYNIN CHRM1

Interaction Score: 1.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name AA-2010

Novel drug target Established target

Trial Name AP-1034,Anturol

PMIDs:
20590605 17222678 17016423 17139284 16406943 7620236

Sources:
TdgClinicalTrial TEND
OXYPHENCYCLIMINE CHRM1

Interaction Score: 1.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1426023 3247303 17016423 17139284

Sources:
TdgClinicalTrial TEND
ETHOPROPAZINE CHRM1

Interaction Score: 1.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2904117 2236897 17016423 11752352

Sources:
TdgClinicalTrial TEND
BETHANECHOL CHRM1

Interaction Score: 1.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9224827

Sources:
TdgClinicalTrial TEND
PIRENZEPINE CHRM1

Interaction Score: 0.92

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12717096 11752352

Sources:
TdgClinicalTrial TEND TTD
FLAVOXATE CHRM1

Interaction Score: 0.92

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3247311 17016423 17139284

Sources:
TdgClinicalTrial TEND
CARBACHOL CHRM1

Interaction Score: 0.88

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
22507963 21930376 15059034

Sources:
DTC TdgClinicalTrial TEND
SOLIFENACIN CHRM1

Interaction Score: 0.88

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Solifenacin succinate, YM-905,Vesicare

Novel drug target Established target

PMIDs:
20590605 17016423 17139284 19029429

Sources:
TdgClinicalTrial TEND
DICYCLOMINE CHRM1

Interaction Score: 0.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 11752352 19533734

Sources:
TdgClinicalTrial TEND TTD
PROCYCLIDINE HYDROCHLORIDE CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRIDIHEXETHYL CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
DIPHENIDOL HYDROCHLORIDE CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NEBRACETAM CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CYCRIMINE HYDROCHLORIDE CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRIHEXYPHENIDYL HYDROCHLORIDE CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BENZTROPINE CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND TTD
CARBINOXAMINE CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
DIPHENIDOL CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1863523 17016423 17139284

Sources:
TdgClinicalTrial TEND
BIPERIDEN HYDROCHLORIDE CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
BIPERIDEN LACTATE CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SUXAMETHONIUM CHRM1

Interaction Score: 0.74

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10437710 17016423 17139284

Sources:
TdgClinicalTrial TEND
TIOTROPIUM CHRM1

Interaction Score: 0.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tiotropium bromide,Spiriva

Novel drug target Established target

PMIDs:
10188785 11281822 12582447

Sources:
TdgClinicalTrial
ATROPINE CHRM1

Interaction Score: 0.54

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

Trial Name inhaled atropine

PMIDs:
7855217 17016423 17139284 23062550

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND
IPRATROPIUM CHRM1

Interaction Score: 0.53

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ipratropium bromide + albuterol sulfate,DuoNeb

Novel drug target Established target

PMIDs:
30085570 15987237 28546381

Sources:
TdgClinicalTrial TEND
METHSCOPOLAMINE CHRM1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
TRIFLUPROMAZINE CHRM1

Interaction Score: 0.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
4152054 17016423 17139284

Sources:
TdgClinicalTrial TEND
PILOCARPINE CHRM1

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 agonist

Direct Interaction yes

Trial Name THVD-201

PMIDs:
18824613 17016423 17139284 25478907

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND
PROPIOMAZINE CHRM1

Interaction Score: 0.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 19110200 12678691 14488364 19042969

Sources:
TdgClinicalTrial TEND
BENZQUINAMIDE CHRM1

Interaction Score: 0.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
TRIDIHEXETHYL CHLORIDE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BENZTROPINE MESYLATE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CEVIMELINE HYDROCHLORIDE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPHEMANIL METHYLSULFATE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHSCOPOLAMINE BROMIDE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPENZOLATE BROMIDE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOLTERODINE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
17016423 17139284 14769832

Sources:
TdgClinicalTrial TEND
CLIDINIUM BROMIDE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HEXOCYCLIUM METHYLSULFATE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
METOCLOPRAMIDE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 100

Trial Name metoclopramide,Emitasol, Pramidin

Trial Name metoclopramide HCl,Metzoliv ODT

PMIDs:
15835479 16466463 17016423 17139284 21278804

Sources:
TdgClinicalTrial
FESOTERODINE CHRM1

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
12076307

Sources:
TEND
OXYPHENCYCLIMINE HYDROCHLORIDE CHRM1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXYPHENONIUM BROMIDE CHRM1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DICYCLOMINE HYDROCHLORIDE CHRM1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DESIPRAMINE CHRM1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7855217 17016423 17139284

Sources:
TdgClinicalTrial TEND
ATROPINE SULFATE CHRM1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
PILOCARPINE HYDROCHLORIDE CHRM1

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROMAZINE CHRM1

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 19110200

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE CHRM1

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2899826 2870716

Sources:
TdgClinicalTrial TEND
DOXEPIN CHRM1

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Silenor (SO-101)

Novel drug target Established target

PMIDs:
7855217 2141000 19179941 2329499

Sources:
TdgClinicalTrial
METHIXENE HYDROCHLORIDE CHRM1

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ISOPROPAMIDE IODIDE CHRM1

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDACATEROL CHRM1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name QVA149, glycopyrronium bromide + i/

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
DAROTROPIUM BROMIDE CHRM1

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIPERTRAMINE CHRM1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPANTHELINE BROMIDE CHRM1

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIPERTRAMINE AMIDE CHRM1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACLIDINIUM CHRM1

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Aclidinium

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
PROMETHAZINE CHRM1

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12476402

Sources:
TdgClinicalTrial TEND
ACECLIDINE CHRM1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
THIETHYLPERAZINE CHRM1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
N-DESMETHYLCLOZAPINE CHRM1

Interaction Score: 0.12

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

PMIDs:
None found

Sources:
TTD
ASM-024 CHRM1

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOPROPAZINE HYDROCHLORIDE CHRM1

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AFACIFENACIN CHRM1

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OLANZAPINE CHRM1

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

Novel drug target Established target

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919 17316700 10227113 25032030

Sources:
TdgClinicalTrial TEND

Ensembl: ENSG00000168539
- Version: 101_38
Alternate Names:

CHRM1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000168539
- Version: 26-July-2011
Alternate Names:

CHRM1 Display Id

MUSCARINIC ACETYLCHOLINE RECEPTOR M1. [SOURCE:UNIPROT/SWISSPROT;ACC:P11229] Description

ENSG00000168539 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P11229
- Version: 11-September-2012
Alternate Names:

1128 Entrez Gene Id

MUSCARINIC ACETYLCHOLINE RECEPTOR M1 Uniprot Protein Name

CHRM1 Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Acc IPR000276

Interpro Name GPCR, rhodopsin-like, 7TM

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P11229
- Version: January-2014
Alternate Names:

CHRM1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TEND: P11229
- Version: 01-August-2011
Alternate Names:

P11229 Uniprot Accession

1128 Entrez Gene Id

ENSG00000168539 Ensembl Gene Id

Gene Info:

Transmembrane Helix Count 7

Target Subclass GPCR

Target Main Class Receptors

Publications:
TTD: Muscarinic acetylcholine receptor M1
- Version: 2020.06.01
Alternate Names:

CHRM1 TTD Gene Abbreviation

T28893 TTD Target ID

Gene Info:

Publications:

Viberg A et al., 2012, Evaluation of an innovative population pharmacokinetic-based design for behavioral pharmacodynamic endpoints., AAPS J

DTC: CHRM1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett

Melancon BJ et al., 2012, Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor., Bioorg Med Chem Lett

Lebois EP et al., 2011, Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071., Bioorg Med Chem Lett

ChemblInteractions: CHRM1
- Version: chembl_23
Alternate Names:

CHRM1 GENE_SYMBOL

Muscarinic acetylcholine receptor M1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000168539
- Version: 31-May-2017
Alternate Names:

ENSG00000168539 Gene Symbol

CHRM1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: CHRM1
- Version: 27-Jun-2013
Alternate Names:

1128 Gene ID

HM1 dGene Synonym

M1 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Trial Name	NVA237, inhaled glycopyrronium bromide
Novel drug target	Established target

Mechanism of Interaction	Muscarinic acetylcholine receptor M1 antagonist
Direct Interaction	yes

Trial Name	trospium chloride,Sanctura
Novel drug target	Established target

Trial Name	AA-2010
Novel drug target	Established target
Trial Name	AP-1034,Anturol

Trial Name	Solifenacin succinate, YM-905,Vesicare
Novel drug target	Established target

Trial Name	tiotropium bromide,Spiriva
Novel drug target	Established target

Trial Name	ipratropium bromide + albuterol sulfate,DuoNeb
Novel drug target	Established target

Mechanism of Interaction	Muscarinic acetylcholine receptor M1 agonist
Direct Interaction	yes
Trial Name	THVD-201

Trial Name	MT 100
Trial Name	metoclopramide,Emitasol, Pramidin
Trial Name	metoclopramide HCl,Metzoliv ODT

Trial Name	Silenor (SO-101)
Novel drug target	Established target

antagonist (inhibitory)
inhibitor (inhibitory)

Trial Name	QVA149, glycopyrronium bromide + i/
Novel drug target	Established target

Mechanism of Interaction	Muscarinic acetylcholine receptor antagonist
Direct Interaction	yes

Trial Name	olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
Novel drug target	Established target
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

CHRM1	Display Id
MUSCARINIC ACETYLCHOLINE RECEPTOR M1. [SOURCE:UNIPROT/SWISSPROT;ACC:P11229]	Description
ENSG00000168539	Ensembl Gene Id

1128	Entrez Gene Id
MUSCARINIC ACETYLCHOLINE RECEPTOR M1	Uniprot Protein Name
CHRM1	Uniprot Gene Name

P11229	Uniprot Accession
1128	Entrez Gene Id
ENSG00000168539	Ensembl Gene Id

CHRM1 Gene Record

CHRM1 1128 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 3580704 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1267542 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name NVA237, inhaled glycopyrronium bromide Novel drug target Established target

PMIDs: 8249551 17016423 17139284 11752352

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 10025113 19486927 29085421 17992517 1848211

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1994002 18685832 17631384 11752352 3208836 2432979 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8081071 10370904 10907719 11752352 9798802 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist Direct Interaction yes

PMIDs: 6897316 20391952 4555460 17016423 17139284

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 17016423 17139284

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16080359 3572714 2656175 15337834 11752352 17016423

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name trospium chloride,Sanctura Novel drug target Established target

PMIDs: 17016423 17139284 15482001

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist Novel drug target Established target

PMIDs: 20398692 14534362

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2027917 1426023 2253700 20624420 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name NGX267 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist Direct Interaction yes Trial Name glycopyrrolate, FHPC-02,Cuvposa

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 5330346 4866169 14315148 12608172

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 29938305

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3580704 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1267542 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name NVA237, inhaled glycopyrronium bromide

Novel drug target Established target

PMIDs:
8249551 17016423 17139284 11752352

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 10025113 19486927 29085421 17992517 1848211

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1994002 18685832 17631384 11752352 3208836 2432979 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8081071 10370904 10907719 11752352 9798802 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

PMIDs:
6897316 20391952 4555460 17016423 17139284

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

PMIDs:
17016423 17139284

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16080359 3572714 2656175 15337834 11752352 17016423

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name trospium chloride,Sanctura

Novel drug target Established target

PMIDs:
17016423 17139284 15482001

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Novel drug target Established target

PMIDs:
20398692 14534362

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2027917 1426023 2253700 20624420 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name NGX267

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

Trial Name glycopyrrolate, FHPC-02,Cuvposa

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 5330346 4866169 14315148 12608172

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 29938305

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
8624083 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name AA-2010

Novel drug target Established target

Trial Name AP-1034,Anturol

PMIDs:
20590605 17222678 17016423 17139284 16406943 7620236

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)