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CFTR 1080 Druggable Genome
Alternate Names:
1080 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 602421 1884 ENSG00000001626 OTTHUMG00000023076 707 P13569 cAMP-dependent chloride channel Channel conductance-controlling ATPase ATP-binding cassette sub-family C member 7 PA109 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) (CAMP- DEPENDENT CHLORIDE CHANNEL). [SOURCE:UNIPROT/SWISSPROT;ACC:P13569] CFTR_HUMAN T55654 CF transmembrane conductance regulator Gene Info:
GuideToPharmacology Gene Category Name CFTR GuideToPharmacology Gene Category ID 129 Target Class Transporters Target Subclass TC:3.A.1.202.1 Human Readable Name DRUGGABLE GENOME Interpro Type Domain Uniprot Evidence 1: Evidence at protein level Human Readable Name ABC TRANSPORTER Interpro Acc IPR001140 Uniprot Status Swiss-Prot Interpro Short Name ABC_transptr_TM_dom Interpro Name ABC transporter, transmembrane domain Gene Biotype PROTEIN_CODING Gene Categories: Category Details
TRANSPORTER CELL SURFACE ION CHANNEL ABC TRANSPORTER DRUGGABLE GENOME Publications:
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Interaction Score: 63.79
Interaction Types & Directionality:
modulator Interaction Info:
Trial Name VX-809 Novel drug target Established target Trial Name VX-809 + VX-770 -
Interaction Score: 24.96
Interaction Types & Directionality:
activator (activating) Interaction Info:
Mechanism of Interaction Cystic fibrosis transmembrane conductance regulator positive modulator Direct Interaction yes Details of the Assay for Interaction Measuring the increase in cAMP/genistein-dependent current amplitude via the ΔF508-CFTR mutant expressed in NIH/3T3 cells by patch-clamp recording, in response to tezacaftor exposure.
Sources:
ChemblInteractions GuideToPharmacology PharmGKB TTD FDA -
Interaction Types & Directionality:
activator (activating) potentiator Interaction Info:
Trial Name VX-809 + VX-770 Novel drug target Established target Trial Name VX-770 -
Interaction Score: 6.93
Interaction Types & Directionality:
antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cystic fibrosis transmembrane conductance regulator inhibitor Direct Interaction yes Trial Name crofelemer -
Interaction Score: 5.55
Interaction Types & Directionality:
modulator Interaction Info:
Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? False -
Interaction Score: 2.77
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Interaction Score: 2.77
Interaction Types & Directionality:
n/a Interaction Info:
Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? False -
Interaction Types & Directionality:
activator (activating) Interaction Info:
Direct Interaction yes Mechanism of Interaction Cystic fibrosis transmembrane conductance regulator activator -
Interaction Score: 1.85
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Interaction Score: 1.39
Interaction Types & Directionality:
activator (activating) Interaction Info:
Specific Action of the Ligand Potentiation Endogenous Drug? False -
Interaction Score: 0.31
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Interaction Score: 0.29
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Interaction Types & Directionality:
activator (activating) Interaction Info:
Specific Action of the Ligand Potentiation Endogenous Drug? False -
Interaction Score: 0.2
Interaction Types & Directionality:
activator (activating) Interaction Info:
Specific Action of the Ligand Potentiation Endogenous Drug? False Direct Interaction? False -
Interaction Types & Directionality:
activator (activating) Interaction Info:
Specific Action of the Ligand Potentiation Endogenous Drug? False -
Interaction Score: 0.17
Interaction Types & Directionality:
activator (activating) Interaction Info:
Endogenous Drug? False Specific Action of the Ligand Potentiation -
Interaction Score: 0.12
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Interaction Types & Directionality:
activator (activating) Interaction Info:
Specific Action of the Ligand Potentiation Endogenous Drug? False
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- Version: 101_38
Alternate Names:
CFTR Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
CFTR Uniprot Gene Name CFTR_HUMAN Uniprot Id 1080 Entrez Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Interpro Type Domain Uniprot Evidence 1: Evidence at protein level Gene Categories:
ABC TRANSPORTER, DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
CFTR Gene Symbol Gene Info:
Target Class Transporters Target Subclass TC:3.A.1.202.1 Publications:
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- Version: 26-July-2011
Alternate Names:
ENSG00000001626 Ensembl Gene Id CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) (CAMP- DEPENDENT CHLORIDE CHANNEL). [SOURCE:UNIPROT/SWISSPROT;ACC:P13569] Description CFTR Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 29-September-2020
Alternate Names:
1884 HUGO Gene ID 1884 HUGO Gene Symbol CF transmembrane conductance regulator HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name CFTR GuideToPharmacology Gene Category ID 129 Gene Categories:
ION CHANNEL Publications:
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Alternate Names:
PA109 PharmGKB ID Gene Info:
Publications:
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Alternate Names:
Gene Info:
Publications:
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Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000001626 Gene Symbol CFTR Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
ABCC7 GENE_SYMBOL CFTR GENE_SYMBOL Cystic fibrosis transmembrane conductance regulator UNIPROT Gene Info:
Publications:
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Alternate Names:
CFTR Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 2020.06.01
Alternate Names:
CFTR TTD Gene Abbreviation T55654 TTD Target ID Gene Info:
Publications:
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Alternate Names:
ABCC7 GO Gene Synonym Gene Info:
Gene Categories:
CELL SURFACE, ABC TRANSPORTER Publications:
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Alternate Names:
Cystic fibrosis transmembrane conductance regulator Gene Name P13569 UniProt ID Gene Info:
Gene Categories:
TRANSPORTER, ION CHANNEL Publications:
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Alternate Names:
Gene Info:
Publications: