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CFLAR Gene Record

  • Summary
  • Interactions
  • Claims
  • CFLAR 8837 Druggable GenomeDrug Resistance

    Alternate Names:

    8837
    CASP8 AND FADD LIKE APOPTOSIS REGULATOR
    CFLAR
    CASH
    CASP8AP1
    CLARP
    Casper
    FLAME
    FLAME-1
    FLAME1
    FLIP
    I-FLICE
    MRIT
    c-FLIP
    c-FLIPL
    c-FLIPR
    c-FLIPS
    603599
    1876
    ENSG00000003402
    OTTHUMG00000132819
    CFLAR_HUMAN
    O15519
    CASP8 AND FADD-LIKE APOPTOSIS REGULATOR SUBUNIT P43
    CASP8 AND FADD-LIKE APOPTOSIS REGULATOR PRECURSOR (CELLULAR FLICE-LIKE INHIBITORY PROTEIN) (C-FLIP) (CASPASE-EIGHT-RELATED PROTEIN) (CASPER) (CASPASE-LIKE APOPTOSIS REGULATORY PROTEIN) (CLARP) (MACH-RELATED INDUCER OF TOXICITY) (MRIT) (CASPASE HOMOLOG) (C
    7009
    cFLIP

    Gene Info:

    Interpro Short Name Pept_C14_p45
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Acc IPR002398
    Human Readable Name PROTEASE
    Interpro Name Peptidase C14, caspase precursor p45
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE
    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Zificsak CA et al., 2012, Synthesis and biological evaluation of sulfonyl acrylonitriles as novel inhibitors to peritoneal carcinomatosis., Bioorg Med Chem Lett
    McCourt et al., 2012, Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy., Clin. Cancer Res.
    Sawaya et al., Androgen responsive genes as they affect hair growth., Eur J Dermatol
  • BICALUTAMIDE   CFLAR

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22623731


    Sources:
    CIViC

  • IDRONOXIL   CFLAR

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • BAY-11-7085   CFLAR

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22326395


    Sources:
    DTC

  • FINASTERIDE   CFLAR

    Interaction Score: 1.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11399535


    Sources:
    NCI

  • CABOZANTINIB   CFLAR

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • NINTEDANIB   CFLAR

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • DOVITINIB   CFLAR

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • Ensembl: ENSG00000003402

    • Version: 101_38

    Alternate Names:
    CFLAR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: O15519

    • Version: 11-September-2012

    Alternate Names:
    8837 Entrez Gene Id
    ENSG00000003402 Ensembl Gene Id
    CFLAR_HUMAN Uniprot Id

    Gene Info:
    Interpro Short Name Pept_C14_p45
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000003402

    • Version: 26-July-2011

    Alternate Names:
    CASP8 AND FADD-LIKE APOPTOSIS REGULATOR PRECURSOR (CELLULAR FLICE-LIKE INHIBITORY PROTEIN) (C-FLIP) (CASPASE-EIGHT-RELATED PROTEIN) (CASPER) (CASPASE-LIKE APOPTOSIS REGULATORY PROTEIN) (CLARP) (MACH-RELATED INDUCER OF TOXICITY) (MRIT) (CASPASE HOMOLOG) (C Description
    ENSG00000003402 Ensembl Gene Id
    CFLAR Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • CIViC: CFLAR

    • Version: 14-September-2020

    Alternate Names:
    8837 Entrez Gene ID
    7009 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    McCourt et al., 2012, Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy., Clin. Cancer Res.

  • NCI: CFLAR

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Sawaya et al., Androgen responsive genes as they affect hair growth., Eur J Dermatol

  • DTC: CFLAR

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Zificsak CA et al., 2012, Synthesis and biological evaluation of sulfonyl acrylonitriles as novel inhibitors to peritoneal carcinomatosis., Bioorg Med Chem Lett

  • ClearityFoundationClinicalTrial: CFLAR

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21