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CEL Gene Record

  • Summary
  • Interactions
  • Claims
  • CEL 1056 Druggable Genome

    Alternate Names:

    1056
    CARBOXYL ESTER LIPASE
    CEL
    BAL
    BSDL
    BSSL
    CELL
    CEase
    FAP
    FAPP
    LIPA
    MODY8
    114840
    1848
    ENSG00000170835
    OTTHUMG00000020855
    P19835
    BILE SALT-ACTIVATED LIPASE
    CEL_HUMAN
    BILE-SALT-ACTIVATED LIPASE PRECURSOR (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (BILE-SALT-STIMULATED LIPASE) (BSSL) (CARBOXYL ESTER LIPASE) (STEROL ESTERASE) (CHOLESTEROL ESTERASE) (PANCREATIC LYSOPHOSPHOLIPASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P19835]
    Bile-salt-activated lipase
    T39677

    Gene Info:

    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name CarbesteraseB
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR002018
    Interpro Name Carboxylesterase, type B
    Target Class Enzymes
    Target Subclass EC:3.1.1.13
    Target Subclass 3.1.1.3
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME

    Publications:

    Pasqualini et al., 2000, Phosphorylation of the rat pancreatic bile-salt-dependent lipase by casein kinase II is essential for secretion., Biochem. J.
    Sbarra et al., 2005, In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim. Biophys. Acta
    Chiou et al., 2006, Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro., Indian J. Biochem. Biophys.
    Nganga et al., 2000, Control of pancreatic bile-salt-dependent-lipase secretion by the glucose-regulated protein of 94 kDa (Grp94)., Biochem. J.
  • GELDANAMYCIN   CEL

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11104697


    Sources:
    NCI

  • RESVERATROL   CEL

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16099206


    Sources:
    NCI

  • GENISTEIN   CEL

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10600647


    Sources:
    NCI

  • SIMVASTATIN   CEL

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16955753


    Sources:
    NCI

  • Ensembl: ENSG00000170835

    • Version: 101_38

    Alternate Names:
    CEL Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P19835

    • Version: January-2014

    Alternate Names:
    CEL Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.1.13
    Target Subclass 3.1.1.3

    Publications:

  • RussLampel: ENSG00000170835

    • Version: 26-July-2011

    Alternate Names:
    BILE-SALT-ACTIVATED LIPASE PRECURSOR (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (BILE-SALT-STIMULATED LIPASE) (BSSL) (CARBOXYL ESTER LIPASE) (STEROL ESTERASE) (CHOLESTEROL ESTERASE) (PANCREATIC LYSOPHOSPHOLIPASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P19835] Description
    ENSG00000170835 Ensembl Gene Id
    CEL Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P19835

    • Version: 11-September-2012

    Alternate Names:
    P19835 Uniprot Accession
    CEL_HUMAN Uniprot Id
    1056 Entrez Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: CEL

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Huang et al., 1991, Cholesterol esterase biosynthesis in rat pancreatic AR42J cells. Post-transcriptional activation by gastric hormones., J. Biol. Chem.
    Pasqualini et al., 2000, Phosphorylation of the rat pancreatic bile-salt-dependent lipase by casein kinase II is essential for secretion., Biochem. J.
    Sbarra et al., 2005, In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim. Biophys. Acta

  • HingoraniCasas: ENSG00000170835

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000170835 Gene Symbol
    CEL Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CEL

    • Version: 01-February-2022

    Alternate Names:
    BAL GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • TTD: Bile-salt-activated lipase

    • Version: 2020.06.01

    Alternate Names:
    CEL TTD Gene Abbreviation
    T39677 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21