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CDK7 1022 Druggable Genome
Alternate Names:
1022 CYCLIN DEPENDENT KINASE 7 CDK7 CAK CAK1 CDKN7 HCAK MO15 STK1 p39MO15 601955 1778 ENSG00000134058 OTTHUMG00000099358 1979 P50613 cyclin-dependent kinase 7 NM_001799 NP_001790 p39 Mo15 39 kDa protein kinase CDK-activating kinase 1 Cell division protein kinase 7 Serine/threonine-protein kinase 1 TFIIH basal transcription factor complex kinase subunit CDK 1,2,4,5,6,7,9 (pan-CDK) CDK 2,7,9 CDK7_HUMAN BE0001913 CELL DIVISION PROTEIN KINASE 7 (EC 2.7.1.37) (CDK-ACTIVATING KINASE) (CAK) (TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX KINASE SUBUNIT) (39 KDA PROTEIN KINASE) (P39 MO15) (STK1) (CAK1). [SOURCE:UNIPROT/SWISSPROT;ACC:P50613] T58449 Gene Info:
GuideToPharmacology Gene Category Name CDK7 subfamily GuideToPharmacology Gene Category ID 496 Target Subclass EC:2.7.11.22 Target Subclass 2.7.11.23 Target Class Enzymes CancerCommons Reported Gene Name CDK2,7,9 Uniprot Status Swiss-Prot Interpro Short Name Ser/Thr_dual-sp_kinase_dom Uniprot Evidence 1: Evidence at protein level Human Readable Name DRUGGABLE GENOME Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain Human Readable Name KINASE Interpro Acc IPR002290 Interpro Type Domain Gene Biotype PROTEIN_CODING Gene Categories: Category Details
KINASE SERINE THREONINE KINASE DRUGGABLE GENOME ENZYME TRANSCRIPTION FACTOR Publications:
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Interaction Score: 0.87
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Novel drug target Novel Target Trial Name seliciclib, R-roscovitine, CYC202 Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor -
Interaction Score: 0.82
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Reported Cancer Type Melanoma Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor Direct Interaction yes Trial Name flavopiridol, alvocidib, HMR-1275 -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Details of the Assay for Interaction In a biochemical assay. Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 0.36
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Details of the Assay for Interaction Inhibition of CDK7/cyclinM/Mat1 Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 0.34
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor Details of the Assay for Interaction in association with cyclin H -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Details of the Assay for Interaction <i>In vitro</i> inhibition of CDK7/cyclin H. Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 0.2
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor Direct Interaction yes -
Interaction Score: 0.17
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Interaction Score: 0.11
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase inhibitor Direct Interaction yes -
Interaction Score: 0.1
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor -
Interaction Score: 0.07
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Interaction Score: 0.07
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Interaction Score: 0.05
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Interaction Score: 0.04
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Interaction Score: 0.04
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Interaction Score: 0.02
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Interaction Score: 0.02
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- Version: 101_38
Alternate Names:
CDK7 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
ENSG00000134058 Ensembl Gene Id 1022 Entrez Gene Id CDK7_HUMAN Uniprot Id Gene Info:
Uniprot Status Swiss-Prot Interpro Short Name Ser/Thr_dual-sp_kinase_dom Uniprot Evidence 1: Evidence at protein level Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
CDK7 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:2.7.11.22 Target Subclass 2.7.11.23 Publications:
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- Version: 26-July-2011
Alternate Names:
CDK7 Display Id ENSG00000134058 Ensembl Gene Id CELL DIVISION PROTEIN KINASE 7 (EC 2.7.1.37) (CDK-ACTIVATING KINASE) (CAK) (TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX KINASE SUBUNIT) (39 KDA PROTEIN KINASE) (P39 MO15) (STK1) (CAK1). [SOURCE:UNIPROT/SWISSPROT;ACC:P50613] Description Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 25-July-2013
Alternate Names:
1022 Entrez Gene ID Gene Info:
CancerCommons Reported Gene Name CDK2,7,9 Publications:
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- Version: 29-September-2020
Alternate Names:
1778 HUGO Gene ID 1778 HUGO Gene Symbol cyclin dependent kinase 7 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name CDK7 subfamily GuideToPharmacology Gene Category ID 496 Gene Categories:
ENZYME Publications:
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Alternate Names:
CDK7 DrugBank Gene Name P50613 UniProt Accession 1022 Entrez Gene Id Gene Info:
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Alternate Names:
Gene Info:
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- Version: 31-May-2017
Alternate Names:
ENSG00000134058 Gene Symbol CDK7 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 20-Jun-2017
Alternate Names:
1022 Entrez Gene Id CDK7 MyCancerGenome Gene Symbol CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name Gene Info:
Publications:
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- Version: chembl_23
Alternate Names:
CAK1 GENE_SYMBOL CDKN7 GENE_SYMBOL MO15 GENE_SYMBOL Gene Info:
Publications:
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Alternate Names:
Cyclin-dependent kinase 7 Gene Name P50613 UniProt ID Gene Info:
Gene Categories:
KINASE, TRANSCRIPTION FACTOR Publications:
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Alternate Names:
CAK GO Gene Synonym CAK1 GO Gene Synonym CDKN7 GO Gene Synonym Gene Info:
Gene Categories:
KINASE, SERINE THREONINE KINASE Publications:
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Alternate Names:
1022 Gene ID CAK1 dGene Synonym CDKN7 dGene Synonym Gene Info:
Gene Categories:
KINASE, SERINE THREONINE KINASE Publications:
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- Version: 2020.06.01
Alternate Names:
CDK7 TTD Gene Abbreviation T58449 TTD Target ID Gene Info:
Publications:
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- Version: 15-June-2013
Alternate Names:
Gene Info:
Publications: