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CDK6 1021 Druggable GenomeClinically ActionableDrug Resistance
Alternate Names:
1021 CYCLIN DEPENDENT KINASE 6 CDK6 MCPH12 PLSTIRE 603368 1777 ENSG00000105810 OTTHUMG00000131697 CDK 4,6 CDK 1,2,4,5,6,7,9 (pan-CDK) CELL DIVISION PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE PLSTIRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00534] CDKN6 Cyclin-dependent kinase 6 Cell division protein kinase 6 Serine/threonine-protein kinase PLSTIRE Q00534 CDK6_HUMAN 1978 NP_001138778 NM_001145306 12 T89361 Gene Info:
Human Readable Name DRUGGABLE GENOME Target Class Enzymes Target Subclass EC:2.7.11.22 GuideToPharmacology Gene Category Name CDK4 subfamily GuideToPharmacology Gene Category ID 488 Interpro Acc IPR002290 Uniprot Status Swiss-Prot Interpro Type Domain Interpro Short Name Ser/Thr_dual-sp_kinase_dom Uniprot Evidence 1: Evidence at protein level Human Readable Name KINASE Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain CancerCommons Reported Gene Name CDK4/6 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
TUMOR SUPPRESSOR KINASE SERINE THREONINE KINASE DRUG RESISTANCE DRUGGABLE GENOME CLINICALLY ACTIONABLE ENZYME Publications:
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes -
Interaction Score: 3.54
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Details of the Assay for Interaction Inhibition of CDK6/cyclin D3 complex Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 1.77
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor -
Interaction Score: 1.77
Interaction Types & Directionality:
antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes Drug family CDK4/6 inhibitor -
Interaction Score: 1.27
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Details of the Assay for Interaction CDK6/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound. Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 1.18
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Details of the Assay for Interaction Inhibition of CDK6/cyclin D3 Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes Trial Name flavopiridol, alvocidib, HMR-1275 -
Interaction Score: 0.59
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Interaction Score: 0.53
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True -
Interaction Score: 0.51
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor Specific Action of the Ligand Inhibition -
Interaction Score: 0.27
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition -
Interaction Score: 0.24
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Details of the Assay for Interaction Inhibition of CDK6/cyclinD3. Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 0.18
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor -
Interaction Score: 0.17
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor -
Interaction Score: 0.08
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- Version: 101_38
Alternate Names:
CDK6 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
CDK6 Uniprot Gene Name Q00534 Uniprot Accession ENSG00000105810 Ensembl Gene Id Gene Info:
Interpro Acc IPR002290 Uniprot Status Swiss-Prot Interpro Type Domain Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
CDK6 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:2.7.11.22 Publications:
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- Version: 26-July-2011
Alternate Names:
CDK6 Display Id ENSG00000105810 Ensembl Gene Id CELL DIVISION PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE PLSTIRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00534] Description Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 25-July-2013
Alternate Names:
1021 Entrez Gene ID Gene Info:
CancerCommons Reported Gene Name CDK4/6 Publications:
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- Version: 29-September-2020
Alternate Names:
1777 HUGO Gene ID 1777 HUGO Gene Symbol cyclin dependent kinase 6 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name CDK4 subfamily GuideToPharmacology Gene Category ID 488 Gene Categories:
ENZYME Publications:
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Alternate Names:
1021 Entrez Gene ID 12 CIViC Gene ID Gene Info:
Gene Categories:
DRUG RESISTANCE Publications:
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Alternate Names:
CDK6 Gene Symbol Gene Info:
Publications:
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- Version: 20-Jun-2017
Alternate Names:
1021 Entrez Gene Id CDK6 MyCancerGenome Gene Symbol CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name Gene Info:
Publications:
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- Version: chembl_23
Alternate Names:
CDKN6 GENE_SYMBOL CDK6 GENE_SYMBOL Cyclin-dependent kinase 6 UNIPROT Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000105810 Gene Symbol CDK6 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
-
Alternate Names:
CDK6 Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
1021 Gene ID PLSTIRE dGene Synonym Gene Info:
Gene Categories:
KINASE, SERINE THREONINE KINASE Publications:
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- Version: 2020.06.01
Alternate Names:
CDK6 TTD Gene Abbreviation T89361 TTD Target ID Gene Info:
Publications:
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Alternate Names:
CDKN6 GO Gene Synonym Gene Info:
Gene Categories:
TUMOR SUPPRESSOR Publications:
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Alternate Names:
Cyclin-dependent kinase 6 Gene Name Q00534 UniProt ID Gene Info:
Gene Categories:
KINASE Publications:
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Alternate Names:
Gene Info:
Publications:
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- Version: 15-June-2013
Alternate Names:
Gene Info:
Publications:
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- Version: 30-February-2014
Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
Gene Info:
Publications:
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- Version: 03-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 04-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications: