• Interaction Score: 2.99

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 2.99

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of CDK6/cyclin D3 complex
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.68

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor
    Direct Interaction yes
    Drug family CDK4/6 inhibitor

  • Interaction Score: 1.49

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

    PMIDs:
    None found


  • Interaction Score: 1.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction CDK6/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

  • Interaction Score: 1.0

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of CDK6/cyclin D3
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor
    Direct Interaction yes
    Trial Name flavopiridol, alvocidib, HMR-1275

  • Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

  • Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27252418


    Sources:
    CIViC

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of CDK6/cyclinD3.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29408328


    Sources:
    CIViC