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CDC25C Gene Record

  • Summary
  • Interactions
  • Claims
  • CDC25C 995 Druggable Genome

    Alternate Names:

    995
    CELL DIVISION CYCLE 25C
    CDC25C
    CDC25
    PPP1R60
    157680
    1727
    ENSG00000158402
    OTTHUMG00000129203
    MPIP3_HUMAN
    P30307
    M-PHASE INDUCER PHOSPHATASE 3
    M-PHASE INDUCER PHOSPHATASE 3 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25C). [SOURCE:UNIPROT/SWISSPROT;ACC:P30307]

    Gene Info:

    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Name Rhodanese-like domain
    Interpro Acc IPR001763
    Interpro Short Name Rhodanese-like_dom
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    PROTEIN PHOSPHATASE
    KINASE
    DRUGGABLE GENOME

    Publications:

    Nylén et al., 1998, Cisplatin-induced inhibition of p34cdc2 is abolished by 5-fluorouracil., Acta Oncol
    Aligiannis et al., 2001, Flavonoids as cycline-dependent kinase inhibitors: inhibition of cdc 25 phosphatase activity by flavonoids belonging to the quercetin and kaempferol series., Planta Med.
    Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod
  • WITHAFERIN A   CDC25C

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • FLUOROURACIL   CDC25C

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9743457


    Sources:
    NCI

  • QUERCETIN   CDC25C

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11488465


    Sources:
    NCI

  • CISPLATIN   CDC25C

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9743457


    Sources:
    NCI

  • Ensembl: ENSG00000158402

    • Version: 101_38

    Alternate Names:
    CDC25C Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P30307

    • Version: 11-September-2012

    Alternate Names:
    CDC25C Uniprot Gene Name
    MPIP3_HUMAN Uniprot Id
    P30307 Uniprot Accession

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000158402

    • Version: 26-July-2011

    Alternate Names:
    CDC25C Display Id
    M-PHASE INDUCER PHOSPHATASE 3 (EC 3.1.3.48) (DUAL SPECIFICITY PHOSPHATASE CDC25C). [SOURCE:UNIPROT/SWISSPROT;ACC:P30307] Description
    ENSG00000158402 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: CDC25C

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Aligiannis et al., 2001, Flavonoids as cycline-dependent kinase inhibitors: inhibition of cdc 25 phosphatase activity by flavonoids belonging to the quercetin and kaempferol series., Planta Med.
    Nylén et al., 1998, Cisplatin-induced inhibition of p34cdc2 is abolished by 5-fluorouracil., Acta Oncol

  • DTC: CDC25C

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod

  • HingoraniCasas: ENSG00000158402

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000158402 Gene Symbol
    CDC25C Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: CDC25C

    • Version: 03-September-2020

    Alternate Names:
    M-phase inducer phosphatase 3 Gene Name
    P30307 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • dGene: CDC25C

    • Version: 27-Jun-2013

    Alternate Names:
    995 Gene ID
    CDC25 dGene Synonym
    PPP1R60 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEIN PHOSPHATASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21