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CD86 Gene Record

  • Summary
  • Interactions
  • Claims
  • CD86 942 Druggable Genome

    Alternate Names:

    942
    CD86 MOLECULE
    CD86
    B7-2
    B7.2
    B70
    CD28LG2
    LAB72
    601020
    1705
    ENSG00000114013
    OTTHUMG00000159482
    P42081
    CTLA-4 counter-receptor B7.2
    BU63
    FUN-1
    Activation B7-2 antigen
    T-lymphocyte activation antigen CD86
    CD_antigen=CD86
    CD86_HUMAN
    FUN1
    T50912

    Gene Info:

    Target Main Class Other
    Target Subclass Other
    Target Subclass Butyrophylin
    Transmembrane Helix Count 1
    Target Class Other
    Target Subclass T-lymphocyte activation antigen CD86
    Target Class Miscellaneous
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Conti et al., 2005, Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines., J. Immunol.
    Nogid et al., 2006, Role of abatacept in the management of rheumatoid arthritis., Clin Ther
    Kremer, 2005, Selective costimulation modulators: a novel approach for the treatment of rheumatoid arthritis., J Clin Rheumatol
    Scheinfeld, 2006, Abatacept: A review of a new biologic agent for refractory rheumatoid arthritis for dermatologists., J Dermatolog Treat
    Vincenti et al., 2007, T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation., Annu. Rev. Med.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Reynolds et al., 2007, Abatacept: a novel treatment for moderate-to-severe rheumatoid arthritis., Pharmacotherapy
    Weyand et al., 2006, T-cell-targeted therapies in rheumatoid arthritis., Nat Clin Pract Rheumatol
    Hervey et al., 2006, Abatacept., BioDrugs
    Maxwell et al., 2010, Abatacept for rheumatoid arthritis: a Cochrane systematic review., J. Rheumatol.
    Mohagheghpour et al., 1997, Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes., Cell. Immunol.
    Vincenti, 2008, Costimulation blockade in autoimmunity and transplantation., J. Allergy Clin. Immunol.
    Ohtani et al., 2003, Evaluation of the efficacy of antihistamines using human monocyte-derived dendritic cells stimulated with histamine., J. Am. Acad. Dermatol.
    Kawazu et al., 2000, Suppressive activity of a macrolide antibiotic, roxithromycin on co-stimulatory molecule expression on mouse splenocytes in vivo., Mediators Inflamm.
    Orlikowsky et al., 2005, Effect of dexamethasone on B7 regulation and T cell activation in neonates and adults., Pediatr. Res.
  • ABATACEPT   CD86

    Interaction Score: 38.28

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction T-lymphocyte activation antigen CD86 inhibitor
    Trial Name Orencia

    PMIDs:
    17212998 16357751 16971318 17020493 11752352 18041889 16932686 16573350 20080922


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • BELATACEPT   CD86

    Interaction Score: 8.83

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction T-lymphocyte activation antigen CD86 inhibitor
    Direct Interaction yes
    Trial Name belatacept, BMS-224818, LEA29y

    PMIDs:
    18269922


    Sources:
    TdgClinicalTrial ChemblInteractions

  • PAMIDRONIC ACID   CD86

    Interaction Score: 3.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15611247


    Sources:
    NCI

  • ROXITHROMYCIN   CD86

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10877454


    Sources:
    NCI

  • TERFENADINE   CD86

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12894071


    Sources:
    NCI

  • INDOMETHACIN   CD86

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9070321


    Sources:
    NCI

  • DEXAMETHASONE   CD86

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15718366


    Sources:
    NCI

  • Ensembl: ENSG00000114013

    • Version: 101_38

    Alternate Names:
    CD86 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P42081

    • Version: 01-August-2011

    Alternate Names:
    942 Entrez Gene Id
    CD86_HUMAN Uniprot Id
    ENSG00000114013 Ensembl Gene Id

    Gene Info:
    Target Main Class Other
    Target Subclass Other
    Target Subclass Butyrophylin

    Publications:

  • TdgClinicalTrial: P42081

    • Version: January-2014

    Alternate Names:
    CD86 Gene Symbol

    Gene Info:
    Target Class Other
    Target Subclass T-lymphocyte activation antigen CD86
    Target Class Miscellaneous

    Publications:

  • NCI: CD86

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Conti et al., 2005, Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines., J. Immunol.
    Jung et al., 2007, Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells., Int. Immunol.
    Zhou et al., 2007, [Role of MG132, a proteasome inhibitor, in inducing expression of costimulatory molecules CD86 in leukemic cells and its effect on allogeneic mixed lymphocyte reaction]., Zhonghua Yi Xue Za Zhi

  • ChemblInteractions: CD28LG2

    • Version: chembl_23

    Alternate Names:
    CD28LG2 GENE_SYMBOL
    CD86 GENE_SYMBOL
    T-lymphocyte activation antigen CD86 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000114013

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000114013 Gene Symbol
    CD86 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CD86

    • Version: 01-February-2022

    Alternate Names:
    CD28LG2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: T-lymphocyte activation antigen CD86

    • Version: 2020.06.01

    Alternate Names:
    FUN1 TTD Gene Abbreviation
    T50912 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21