DGIdb - CD86 Gene Record

CD86 942 Druggable Genome

Alternate Names:

942
CD86 MOLECULE
CD86
B7-2
B7.2
B70
CD28LG2
LAB72
601020
1705
ENSG00000114013
OTTHUMG00000159482
P42081
CTLA-4 counter-receptor B7.2
BU63
FUN-1
Activation B7-2 antigen
T-lymphocyte activation antigen CD86
CD_antigen=CD86
2745
CD86_HUMAN
FUN1
T50912
NM_175862
NP_787058

Gene Info:

Target Main Class	Other
Target Subclass	Other
Target Subclass	Butyrophylin
Transmembrane Helix Count	1
Target Class	Other
Target Subclass	T-lymphocyte activation antigen CD86
Target Class	Miscellaneous
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	CD molecules
GuideToPharmacology Gene Category ID	852
GuideToPharmacology Gene Category Name	Other immune checkpoint proteins
GuideToPharmacology Gene Category ID	949

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Conti et al., 2005, Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines., J. Immunol.
Nogid et al., 2006, Role of abatacept in the management of rheumatoid arthritis., Clin Ther
Kremer, 2005, Selective costimulation modulators: a novel approach for the treatment of rheumatoid arthritis., J Clin Rheumatol
Scheinfeld, 2006, Abatacept: A review of a new biologic agent for refractory rheumatoid arthritis for dermatologists., J Dermatolog Treat
Vincenti et al., 2007, T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation., Annu. Rev. Med.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Reynolds et al., 2007, Abatacept: a novel treatment for moderate-to-severe rheumatoid arthritis., Pharmacotherapy
Weyand et al., 2006, T-cell-targeted therapies in rheumatoid arthritis., Nat Clin Pract Rheumatol
Hervey et al., 2006, Abatacept., BioDrugs
Maxwell et al., 2010, Abatacept for rheumatoid arthritis: a Cochrane systematic review., J. Rheumatol.
Mohagheghpour et al., 1997, Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes., Cell. Immunol.
Vincenti, 2008, Costimulation blockade in autoimmunity and transplantation., J. Allergy Clin. Immunol.
Ohtani et al., 2003, Evaluation of the efficacy of antihistamines using human monocyte-derived dendritic cells stimulated with histamine., J. Am. Acad. Dermatol.
Kawazu et al., 2000, Suppressive activity of a macrolide antibiotic, roxithromycin on co-stimulatory molecule expression on mouse splenocytes in vivo., Mediators Inflamm.
Orlikowsky et al., 2005, Effect of dexamethasone on B7 regulation and T cell activation in neonates and adults., Pediatr. Res.

ABATACEPT CD86

Interaction Score: 42.53

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction T-lymphocyte activation antigen CD86 inhibitor

Direct Interaction? True

PMIDs:
17212998 16357751 16971318 17020493 11752352 18041889 16932686 16573350 20080922

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
BELATACEPT CD86

Interaction Score: 12.15

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction IC<sub>50</sub>= 0.120µg/mL

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
18269922

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology
PAMIDRONIC ACID CD86

Interaction Score: 3.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15611247

Sources:
NCI
ROXITHROMYCIN CD86

Interaction Score: 2.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10877454

Sources:
NCI
TERFENADINE CD86

Interaction Score: 1.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12894071

Sources:
NCI
INDOMETHACIN CD86

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9070321

Sources:
NCI
DEXAMETHASONE CD86

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15718366

Sources:
NCI

Ensembl: ENSG00000114013
- Version: 101_38
Alternate Names:

CD86 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P42081
- Version: 01-August-2011
Alternate Names:

942 Entrez Gene Id

CD86_HUMAN Uniprot Id

ENSG00000114013 Ensembl Gene Id

Gene Info:

Target Main Class Other

Target Subclass Other

Target Subclass Butyrophylin

Publications:
TdgClinicalTrial: P42081
- Version: January-2014
Alternate Names:

CD86 Gene Symbol

Gene Info:

Target Class Other

Target Subclass T-lymphocyte activation antigen CD86

Target Class Miscellaneous

Publications:
GuideToPharmacology: 942
- Version: 29-September-2020
Alternate Names:

1705 HUGO Gene ID

1705 HUGO Gene Symbol

CD86 molecule HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CD molecules

GuideToPharmacology Gene Category ID 852

GuideToPharmacology Gene Category Name Other immune checkpoint proteins

Publications:

NCI: CD86

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Conti et al., 2005, Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines., J. Immunol.

Jung et al., 2007, Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells., Int. Immunol.

Zhou et al., 2007, [Role of MG132, a proteasome inhibitor, in inducing expression of costimulatory molecules CD86 in leukemic cells and its effect on allogeneic mixed lymphocyte reaction]., Zhonghua Yi Xue Za Zhi

ChemblInteractions: CD28LG2
- Version: chembl_23
Alternate Names:

CD28LG2 GENE_SYMBOL

CD86 GENE_SYMBOL

T-lymphocyte activation antigen CD86 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000114013
- Version: 31-May-2017
Alternate Names:

ENSG00000114013 Gene Symbol

CD86 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: T-lymphocyte activation antigen CD86
- Version: 2020.06.01
Alternate Names:

FUN1 TTD Gene Abbreviation

T50912 TTD Target ID

Gene Info:

Publications:
GO: CD86
- Version: 01-May-2021
Alternate Names:

CD28LG2 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Direct Interaction	yes
Mechanism of Interaction	T-lymphocyte activation antigen CD86 inhibitor
Direct Interaction?	True

Details of the Assay for Interaction	IC<sub>50</sub>= 0.120µg/mL
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

942	Entrez Gene Id
CD86_HUMAN	Uniprot Id
ENSG00000114013	Ensembl Gene Id

1705	HUGO Gene ID
1705	HUGO Gene Symbol
CD86 molecule	HUGO Gene Name

CD28LG2	GENE_SYMBOL
CD86	GENE_SYMBOL
T-lymphocyte activation antigen CD86	UNIPROT

antagonist (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

CD86 Gene Record

CD86 942 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

ABATACEPT CD86

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction T-lymphocyte activation antigen CD86 inhibitor Direct Interaction? True

PMIDs: 17212998 16357751 16971318 17020493 11752352 18041889 16932686 16573350 20080922

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

BELATACEPT CD86

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction IC<sub>50</sub>= 0.120&micro;g/mL Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 18269922

Sources: TdgClinicalTrial ChemblInteractions GuideToPharmacology

PAMIDRONIC ACID CD86

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15611247

Sources: NCI

ROXITHROMYCIN CD86

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10877454

Sources: NCI

TERFENADINE CD86

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12894071

Sources: NCI

INDOMETHACIN CD86

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9070321

Sources: NCI

DEXAMETHASONE CD86

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15718366

Sources: NCI

Ensembl: ENSG00000114013

Alternate Names: CD86 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P42081

Alternate Names: 942 Entrez Gene Id CD86_HUMAN Uniprot Id ENSG00000114013 Ensembl Gene Id

Gene Info: Target Main Class Other Target Subclass Other Target Subclass Butyrophylin

Publications:

TdgClinicalTrial: P42081

Alternate Names: CD86 Gene Symbol

Gene Info: Target Class Other Target Subclass T-lymphocyte activation antigen CD86 Target Class Miscellaneous

Publications:

GuideToPharmacology: 942

Alternate Names: 1705 HUGO Gene ID 1705 HUGO Gene Symbol CD86 molecule HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name CD molecules GuideToPharmacology Gene Category ID 852 GuideToPharmacology Gene Category Name Other immune checkpoint proteins

Publications:

NCI: CD86

Alternate Names:

Gene Info:

ChemblInteractions: CD28LG2

Alternate Names: CD28LG2 GENE_SYMBOL CD86 GENE_SYMBOL T-lymphocyte activation antigen CD86 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000114013

Alternate Names: ENSG00000114013 Gene Symbol CD86 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: T-lymphocyte activation antigen CD86

Alternate Names: FUN1 TTD Gene Abbreviation T50912 TTD Target ID

Gene Info:

Publications:

GO: CD86

Alternate Names: CD28LG2 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction T-lymphocyte activation antigen CD86 inhibitor

Direct Interaction? True

PMIDs:
17212998 16357751 16971318 17020493 11752352 18041889 16932686 16573350 20080922

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction IC<sub>50</sub>= 0.120µg/mL

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
18269922

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
15611247

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10877454

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12894071

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9070321

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15718366

Sources:
NCI

Alternate Names:

CD86 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

942 Entrez Gene Id

CD86_HUMAN Uniprot Id

ENSG00000114013 Ensembl Gene Id

Gene Info:

Target Main Class Other

Target Subclass Other

Target Subclass Butyrophylin

Alternate Names:

CD86 Gene Symbol

Gene Info:

Target Class Other

Target Subclass T-lymphocyte activation antigen CD86

Target Class Miscellaneous

Alternate Names:

1705 HUGO Gene ID

1705 HUGO Gene Symbol

CD86 molecule HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name CD molecules

GuideToPharmacology Gene Category ID 852

GuideToPharmacology Gene Category Name Other immune checkpoint proteins

Alternate Names:

CD28LG2 GENE_SYMBOL

CD86 GENE_SYMBOL

T-lymphocyte activation antigen CD86 UNIPROT

Alternate Names:

ENSG00000114013 Gene Symbol

CD86 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

FUN1 TTD Gene Abbreviation

T50912 TTD Target ID

Alternate Names:

CD28LG2 GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE