DGIdb - CD80 Gene Record

CD80 941 Druggable Genome

Alternate Names:

941
CD80 MOLECULE
CD80
B7
B7-1
B7.1
BB1
CD28LG
CD28LG1
LAB7
112203
1700
ENSG00000121594
OTTHUMG00000159419
P33681
T-LYMPHOCYTE ACTIVATION ANTIGEN CD80
ACTIVATION B7-1 ANTIGEN
CTLA-4 COUNTER-RECEPTOR B7.1
CD80_HUMAN
CD_antigen=CD80
T58238

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	T-cell surface receptor
Target Subclass	Other
Transmembrane Helix Count	1
Target Subclass	Ig
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Tedesco Silva et al., 2006, Immunotherapy for De Novo renal transplantation: what's in the pipeline?, Drugs
Yabu et al., 2007, Novel immunosuppression: small molecules and biologics., Semin. Nephrol.
Lumsden et al., 2000, Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection., J. Immunol.
Nogid et al., 2006, Role of abatacept in the management of rheumatoid arthritis., Clin Ther
Kremer, 2005, Selective costimulation modulators: a novel approach for the treatment of rheumatoid arthritis., J Clin Rheumatol
Scheinfeld, 2006, Abatacept: A review of a new biologic agent for refractory rheumatoid arthritis for dermatologists., J Dermatolog Treat
Vincenti et al., 2007, T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation., Annu. Rev. Med.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Reynolds et al., 2007, Abatacept: a novel treatment for moderate-to-severe rheumatoid arthritis., Pharmacotherapy
Weyand et al., 2006, T-cell-targeted therapies in rheumatoid arthritis., Nat Clin Pract Rheumatol
Hervey et al., 2006, Abatacept., BioDrugs
Maxwell et al., 2010, Abatacept for rheumatoid arthritis: a Cochrane systematic review., J. Rheumatol.
Komi et al., 2000, Toremifene increases the expression of intercellular adhesion molecule-1 (ICAM-1) on MCF-7 breast cancer cells and Jurkat cells., Scand. J. Immunol.
Kawazu et al., 2000, Suppressive activity of a macrolide antibiotic, roxithromycin on co-stimulatory molecule expression on mouse splenocytes in vivo., Mediators Inflamm.
Yang et al., 2002, Hyaluronic acid and chondroitin sulphate A rapidly promote differentiation of immature DC with upregulation of costimulatory and antigen-presenting molecules, and enhancement of NF-kappaB and protein kinase activity., Scand. J. Immunol.
Gottlieb et al., 2004, Evaluation of safety and clinical activity of multiple doses of the anti-CD80 monoclonal antibody, galiximab, in patients with moderate to severe plaque psoriasis., Clin. Immunol.
Leonard et al., 2007, A phase I/II study of galiximab (an anti-CD80 monoclonal antibody) in combination with rituximab for relapsed or refractory, follicular lymphoma., Ann. Oncol.
Czuczman et al., 2005, Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma., J. Clin. Oncol.
Boylan et al., 1999, CD80 (B7-1) and CD86 (B7-2) expression in multiple sclerosis patients: clinical subtype specific variation in peripheral monocytes and B cells and lack of modulation by high dose methylprednisolone., J. Neurol. Sci.

GALIXIMAB CD80

Interaction Score: 46.37

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-lymphocyte activation antigen CD80 inhibitor

Direct Interaction yes

Trial Name galiximab

PMIDs:
15093549 17470451 15994148

Sources:
TdgClinicalTrial ChemblInteractions TTD
ABATACEPT CD80

Interaction Score: 38.64

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name CTLA4

Novel drug target Established target

Direct Interaction yes

PMIDs:
10604996 17212998 16357751 16971318 17020493 11752352 18041889 16932686 16573350 20080922

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND TTD
BELATACEPT CD80

Interaction Score: 10.3

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name belatacept, BMS-224818, LEA29y

Novel drug target Established target

Mechanism of Interaction T-lymphocyte activation antigen CD80 inhibitor

PMIDs:
16978033 17616278

Sources:
TdgClinicalTrial ChemblInteractions
VIAGENPUMATUCEL-L CD80

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TOREMIFENE CD80

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10632979

Sources:
NCI
ROXITHROMYCIN CD80

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10877454

Sources:
NCI
METHYLPREDNISOLONE CD80

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10521545

Sources:
NCI
CYCLOSPORINE CD80

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11841687

Sources:
NCI

Ensembl: ENSG00000121594
- Version: 101_38
Alternate Names:

CD80 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P33681
- Version: 01-August-2011
Alternate Names:

P33681 Uniprot Accession

CD80 Gene Symbol

ENSG00000121594 Ensembl Gene Id

Gene Info:

Target Subclass Other

Transmembrane Helix Count 1

Target Subclass Ig

Publications:
TdgClinicalTrial: P33681
- Version: January-2014
Alternate Names:

CD80 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass T-cell surface receptor

Publications:

NCI: CD80

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Lumsden et al., 2000, Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection., J. Immunol.

Komi et al., 2000, Toremifene increases the expression of intercellular adhesion molecule-1 (ICAM-1) on MCF-7 breast cancer cells and Jurkat cells., Scand. J. Immunol.

Poloso et al., 2001, Development of therapeutic vaccines by direct modification of cell membranes from surgically removed human tumor tissue with immunostimulatory molecules., Vaccine

HingoraniCasas: ENSG00000121594
- Version: 31-May-2017
Alternate Names:

ENSG00000121594 Gene Symbol

CD80 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CD28LG
- Version: chembl_23
Alternate Names:

CD28LG1 GENE_SYMBOL

LAB7 GENE_SYMBOL

CD80 GENE_SYMBOL

Gene Info:

Publications:
GO: CD80
- Version: 01-February-2022
Alternate Names:

CD28LG GO Gene Synonym

CD28LG1 GO Gene Synonym

LAB7 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Activation B7-1 antigen
- Version: 2020.06.01
Alternate Names:

CD80 TTD Gene Abbreviation

T58238 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	T-lymphocyte activation antigen CD80 inhibitor
Direct Interaction	yes
Trial Name	galiximab

Trial Name	CTLA4
Novel drug target	Established target
Direct Interaction	yes

Trial Name	belatacept, BMS-224818, LEA29y
Novel drug target	Established target
Mechanism of Interaction	T-lymphocyte activation antigen CD80 inhibitor

P33681	Uniprot Accession
CD80	Gene Symbol
ENSG00000121594	Ensembl Gene Id

CD28LG	GO Gene Synonym
CD28LG1	GO Gene Synonym
LAB7	GO Gene Synonym

antibody (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

CD28LG1	GENE_SYMBOL
LAB7	GENE_SYMBOL
CD80	GENE_SYMBOL

CD80 Gene Record

CD80 941 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction T-lymphocyte activation antigen CD80 inhibitor Direct Interaction yes Trial Name galiximab

PMIDs: 15093549 17470451 15994148

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name CTLA4 Novel drug target Established target Direct Interaction yes

PMIDs: 10604996 17212998 16357751 16971318 17020493 11752352 18041889 16932686 16573350 20080922

Sources: TdgClinicalTrial ChemblInteractions NCI TEND TTD

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name belatacept, BMS-224818, LEA29y Novel drug target Established target Mechanism of Interaction T-lymphocyte activation antigen CD80 inhibitor

PMIDs: 16978033 17616278

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10632979

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10877454

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10521545

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11841687

Sources: NCI

Ensembl: ENSG00000121594

Alternate Names: CD80 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P33681

Alternate Names: P33681 Uniprot Accession CD80 Gene Symbol ENSG00000121594 Ensembl Gene Id

Gene Info: Target Subclass Other Transmembrane Helix Count 1 Target Subclass Ig

Publications:

TdgClinicalTrial: P33681

Alternate Names: CD80 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass T-cell surface receptor

Publications:

NCI: CD80

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000121594

Alternate Names: ENSG00000121594 Gene Symbol CD80 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: CD28LG

Alternate Names: CD28LG1 GENE_SYMBOL LAB7 GENE_SYMBOL CD80 GENE_SYMBOL

Gene Info:

Publications:

GO: CD80

Alternate Names: CD28LG GO Gene Synonym CD28LG1 GO Gene Synonym LAB7 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

TTD: Activation B7-1 antigen

Alternate Names: CD80 TTD Gene Abbreviation T58238 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-lymphocyte activation antigen CD80 inhibitor

Direct Interaction yes

Trial Name galiximab

PMIDs:
15093549 17470451 15994148

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name CTLA4

Novel drug target Established target

Direct Interaction yes

PMIDs:
10604996 17212998 16357751 16971318 17020493 11752352 18041889 16932686 16573350 20080922

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name belatacept, BMS-224818, LEA29y

Novel drug target Established target

Mechanism of Interaction T-lymphocyte activation antigen CD80 inhibitor

PMIDs:
16978033 17616278

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
10632979

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10877454

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10521545

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11841687

Sources:
NCI

Alternate Names:

CD80 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P33681 Uniprot Accession

CD80 Gene Symbol

ENSG00000121594 Ensembl Gene Id

Gene Info:

Target Subclass Other

Transmembrane Helix Count 1

Target Subclass Ig

Alternate Names:

CD80 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass T-cell surface receptor

Alternate Names:

ENSG00000121594 Gene Symbol

CD80 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CD28LG1 GENE_SYMBOL

LAB7 GENE_SYMBOL

CD80 GENE_SYMBOL

Alternate Names:

CD28LG GO Gene Synonym

CD28LG1 GO Gene Synonym

LAB7 GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

CD80 TTD Gene Abbreviation

T58238 TTD Target ID