• Interaction Score: 20.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 inhibitor
    Direct Interaction yes
    Trial Name dacetuzumab, SGN-40

  • Interaction Score: 10.33

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured using a Biacore assay.
    Specific Action of the Ligand Binding
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 5.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 5.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 5.16

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 partial agonist

    PMIDs:
    None found


  • Interaction Score: 5.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name lucatumumab , HCD122, CHIR-12.12
    Novel drug target Novel Target

    PMIDs:
    None found


  • Interaction Score: 5.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 2.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17118622


    Sources:
    NCI

  • Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9450802


    Sources:
    NCI

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    NCI