DGIdb - CD4 Gene Record

CD4 920 Druggable Genome

Alternate Names:

920
CD4 MOLECULE
CD4
CD4mut
186940
1678
ENSG00000010610
OTTHUMG00000168514
T-cell surface glycoprotein CD4
T-cell surface antigen T4/Leu-3
CD_antigen=CD4
P01730
T10191
IMD79
OKT4D

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	T-cell surface receptor
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

KINASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Thuillier et al., 1991, Opposing effects of protein tyrosine kinase inhibitors on the monoclonal antibody induced internalization of CD3 and CD4 antigens., Eur. J. Immunol.

TREGALIZUMAB CD4

Interaction Score: 20.61

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Trial Name BT-061

Novel drug target Established target

Mechanism of Interaction T-cell surface antigen CD4 agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
ZANOLIMUMAB CD4

Interaction Score: 20.61

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name zanolimumab, HuMax-CD4

Novel drug target Established target

Mechanism of Interaction T-cell surface antigen CD4 other

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
IBALIZUMAB CD4

Interaction Score: 13.74

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
HERBIMYCIN CD4

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1833207

Sources:
NCI
KELIXIMAB CD4

Interaction Score: 6.87

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 negative modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CEDELIZUMAB CD4

Interaction Score: 6.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRX-1 CD4

Interaction Score: 6.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLENOLIXIMAB CD4

Interaction Score: 6.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILIXIMAB CD4

Interaction Score: 6.87

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction T-cell surface antigen CD4 negative modulator

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000010610
- Version: 101_38
Alternate Names:

CD4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P01730
- Version: January-2014
Alternate Names:

CD4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass T-cell surface receptor

Publications:

NCI: CD4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Rabanal et al., 2003, CD4 expression decrease by antisense oligonucleotides: inhibition of rat T CD4+ cell reactivity., Oligonucleotides

Thuillier et al., 1991, Opposing effects of protein tyrosine kinase inhibitors on the monoclonal antibody induced internalization of CD3 and CD4 antigens., Eur. J. Immunol.

Handa et al., 1991, Inhibition of infection with human immunodeficiency virus type 1 by sulfated gangliosides., Biochem. Biophys. Res. Commun.

HingoraniCasas: ENSG00000010610
- Version: 31-May-2017
Alternate Names:

ENSG00000010610 Gene Symbol

CD4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CD4
- Version: chembl_23
Alternate Names:

CD4 GENE_SYMBOL

T-cell surface glycoprotein CD4 UNIPROT

T-cell surface antigen T4/Leu-3 UNIPROT

Gene Info:

Publications:
TTD: T-cell surface glycoprotein CD4
- Version: 2020.06.01
Alternate Names:

CD4 TTD Gene Abbreviation

T10191 TTD Target ID

Gene Info:

Publications:
Pharos: CD4
- Version: 01-February-2022
Alternate Names:

T-cell surface glycoprotein CD4 Gene Name

P01730 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: CD4
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Trial Name	BT-061
Novel drug target	Established target
Mechanism of Interaction	T-cell surface antigen CD4 agonist

Trial Name	zanolimumab, HuMax-CD4
Novel drug target	Established target
Mechanism of Interaction	T-cell surface antigen CD4 other

Mechanism of Interaction	T-cell surface antigen CD4 inhibitor
Direct Interaction	yes

Mechanism of Interaction	T-cell surface antigen CD4 negative modulator
Direct Interaction	yes

CD4	GENE_SYMBOL
T-cell surface glycoprotein CD4	UNIPROT
T-cell surface antigen T4/Leu-3	UNIPROT

agonist (activating)
antibody (inhibitory)

antibody (inhibitory)
antagonist (inhibitory)
inhibitor (inhibitory)

CD4 Gene Record

CD4 920 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating) antibody (inhibitory)

Interaction Info: Trial Name BT-061 Novel drug target Established target Mechanism of Interaction T-cell surface antigen CD4 agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name zanolimumab, HuMax-CD4 Novel drug target Established target Mechanism of Interaction T-cell surface antigen CD4 other

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction T-cell surface antigen CD4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1833207

Sources: NCI

Interaction Types & Directionality: negative modulator (inhibitory)

Interaction Info: Mechanism of Interaction T-cell surface antigen CD4 negative modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction T-cell surface antigen CD4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction T-cell surface antigen CD4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction T-cell surface antigen CD4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: negative modulator (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction T-cell surface antigen CD4 negative modulator

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000010610

Alternate Names: CD4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P01730

Alternate Names: CD4 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass T-cell surface receptor

Publications:

NCI: CD4

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000010610

Alternate Names: ENSG00000010610 Gene Symbol CD4 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: CD4

Alternate Names: CD4 GENE_SYMBOL T-cell surface glycoprotein CD4 UNIPROT T-cell surface antigen T4/Leu-3 UNIPROT

Gene Info:

Publications:

TTD: T-cell surface glycoprotein CD4

Alternate Names: CD4 TTD Gene Abbreviation T10191 TTD Target ID

Gene Info:

Publications:

Pharos: CD4

Alternate Names: T-cell surface glycoprotein CD4 Gene Name P01730 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

GO: CD4

Alternate Names:

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Trial Name BT-061

Novel drug target Established target

Mechanism of Interaction T-cell surface antigen CD4 agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name zanolimumab, HuMax-CD4

Novel drug target Established target

Mechanism of Interaction T-cell surface antigen CD4 other

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
1833207

Sources:
NCI

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 negative modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction T-cell surface antigen CD4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction T-cell surface antigen CD4 negative modulator

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

CD4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CD4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass T-cell surface receptor

Alternate Names:

ENSG00000010610 Gene Symbol

CD4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CD4 GENE_SYMBOL

T-cell surface glycoprotein CD4 UNIPROT

T-cell surface antigen T4/Leu-3 UNIPROT

Alternate Names:

CD4 TTD Gene Abbreviation

T10191 TTD Target ID

Alternate Names:

T-cell surface glycoprotein CD4 Gene Name

P01730 UniProt ID

Gene Categories:

KINASE

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE