DGIdb - CD274 Gene Record

CD274 29126 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

29126
CD274 MOLECULE
CD274
B7-H
B7H1
PD-L1
PDCD1L1
PDCD1LG1
PDL1
605402
17635
ENSG00000120217
OTTHUMG00000019503
11335
B7-H1
Programmed death ligand 1
PDCD1 ligand 1
CD_antigen=CD274
B7 homolog 1
Programmed cell death 1 ligand 1
PA134915280
T99948
hPD-L1

Gene Info:

CancerCommons Reported Gene Name	Anti-PD-L1
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Carbognin et al., 2015, Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers., PLoS ONE
Aguiar et al., 2017, PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: updated survival data., Immunotherapy
Passiglia et al., 2016, PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis., Oncotarget
McDermott DF et al., 2013, PD-1 as a potential target in cancer therapy., Cancer Med
Vasekar M et al., 2014, Targeted immunotherapy for non-small cell lung cancer., World J Clin Oncol
Fehrenbacher et al., 2016, Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial., Lancet
Rosenberg et al., 2016, Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial., Lancet
Markham A, 2016, Atezolizumab: First Global Approval., Drugs
Hamid O et al., 2013, Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma., N Engl J Med
Faiena I et al., 2018, Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma., Drug Des Devel Ther
Lee HT et al., 2017, Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab., Sci Rep
Bellmunt J et al., 2017, A review on the evolution of PD-1/PD-L1 immunotherapy for bladder cancer: The future is now., Cancer Treat Rev
Garon et al., 2015, Pembrolizumab for the treatment of non-small-cell lung cancer., N. Engl. J. Med.
Reck et al., 2016, Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer., N. Engl. J. Med.

AVELUMAB CD274

Interaction Score: 23.19

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Programmed cell death 1 ligand 1 other

Direct Interaction yes

PMIDs:
28472902 26918451 23724846

Sources:
MyCancerGenome ChemblInteractions CIViC PharmGKB TTD FDA
ATEZOLIZUMAB CD274

Interaction Score: 10.3

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

PMIDs:
None found

Sources:
MyCancerGenome CancerCommons
DURVALUMAB CD274

Interaction Score: 7.73

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Programmed cell death 1 ligand 1 inhibitor

Direct Interaction yes

PMIDs:
28472902 29416316 28717238 28214651

Sources:
ChemblInteractions CIViC PharmGKB TTD FDA
LODAPOLIMAB CD274

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CX-072 CD274

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BMS-936559 CD274

Interaction Score: 5.15

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
ATEZOLIZUMAB CD274

Interaction Score: 5.15

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Programmed cell death 1 ligand 1 inhibitor

Direct Interaction yes

PMIDs:
24403232 24829850 28472902 26970723 26918451 26952546 27412122

Sources:
MyCancerGenome ChemblInteractions CIViC PharmGKB TTD FDA
ENVAFOLIMAB CD274

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PIDILIZUMAB CD274

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NIVOLUMAB CD274

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26086854 28472902 26918451

Sources:
CIViC PharmGKB FDA
PEMBROLIZUMAB CD274

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25891174 28472902 27718847 26918451 26086854

Sources:
CIViC PharmGKB FDA
M-7824 CD274

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000120217
- Version: 101_38
Alternate Names:

CD274 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
CancerCommons: CD274
- Version: 25-July-2013
Alternate Names:

29126 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Anti-PD-L1

Publications:

PharmGKB: CD274

Version: 18-August-2020

Alternate Names:

PA134915280 PharmGKB ID

Gene Info:

Publications:

Carbognin et al., 2015, Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers., PLoS ONE

CIViC: CD274

Version: 14-September-2020

Alternate Names:

29126 Entrez Gene ID

11335 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Skinner et al., 2017, Integrative Analysis Identifies a Novel AXL-PI3 Kinase-PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer., Clin. Cancer Res.

Passiglia et al., 2016, PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis., Oncotarget

Carbognin et al., 2015, Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers., PLoS ONE

TTD: Programmed cell death 1 ligand 1
- Version: 2020.06.01
Alternate Names:

PD-L1 TTD Gene Abbreviation

T99948 TTD Target ID

Gene Info:

Publications:

McDermott DF et al., 2013, PD-1 as a potential target in cancer therapy., Cancer Med

Vasekar M et al., 2014, Targeted immunotherapy for non-small cell lung cancer., World J Clin Oncol
HingoraniCasas: ENSG00000120217
- Version: 31-May-2017
Alternate Names:

ENSG00000120217 Gene Symbol

CD274 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: CD274
- Version: 20-Jun-2017
Alternate Names:

29126 Entrez Gene Id

CD274 MyCancerGenome Gene Symbol

PD-L1 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: B7H1
- Version: chembl_23
Alternate Names:

PDCD1L1 GENE_SYMBOL

PDCD1LG1 GENE_SYMBOL

PDL1 GENE_SYMBOL

Gene Info:

Publications:
GO: CD274
- Version: 01-February-2022
Alternate Names:

B7H1 GO Gene Synonym

PDCD1L1 GO Gene Synonym

PDCD1LG1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
Tempus: CD274
- Version: 11-November-2018
Alternate Names:

CD274 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
MskImpact: CD274
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: CD274
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: CD274
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FDA: CD274
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Programmed cell death 1 ligand 1 other
Direct Interaction	yes

Mechanism of Interaction	Programmed cell death 1 ligand 1 inhibitor
Direct Interaction	yes

29126	Entrez Gene Id
CD274	MyCancerGenome Gene Symbol
PD-L1	MyCancerGenome Reported Gene Name

B7H1	GO Gene Synonym
PDCD1L1	GO Gene Synonym
PDCD1LG1	GO Gene Synonym

antibody (inhibitory)
antagonist (inhibitory)

antibody (inhibitory)
inhibitor (inhibitory)

antibody (inhibitory)
inhibitor (inhibitory)

CD274 Gene Record

CD274 29126 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Programmed cell death 1 ligand 1 other Direct Interaction yes

PMIDs: 28472902 26918451 23724846

Sources: MyCancerGenome ChemblInteractions CIViC PharmGKB TTD FDA

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info: Reported Cancer Type Melanoma

PMIDs: None found

Sources: MyCancerGenome CancerCommons

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Programmed cell death 1 ligand 1 inhibitor Direct Interaction yes

PMIDs: 28472902 29416316 28717238 28214651

Sources: ChemblInteractions CIViC PharmGKB TTD FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Programmed cell death 1 ligand 1 inhibitor Direct Interaction yes

PMIDs: 24403232 24829850 28472902 26970723 26918451 26952546 27412122

Sources: MyCancerGenome ChemblInteractions CIViC PharmGKB TTD FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26086854 28472902 26918451

Sources: CIViC PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25891174 28472902 27718847 26918451 26086854

Sources: CIViC PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000120217

Alternate Names: CD274 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

CancerCommons: CD274

Alternate Names: 29126 Entrez Gene ID

Gene Info: CancerCommons Reported Gene Name Anti-PD-L1

Publications:

PharmGKB: CD274

Alternate Names: PA134915280 PharmGKB ID

Gene Info:

Publications: Carbognin et al., 2015, Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers., PLoS ONE

CIViC: CD274

Alternate Names: 29126 Entrez Gene ID 11335 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

TTD: Programmed cell death 1 ligand 1

Alternate Names: PD-L1 TTD Gene Abbreviation T99948 TTD Target ID

Gene Info:

Publications: McDermott DF et al., 2013, PD-1 as a potential target in cancer therapy., Cancer Med Vasekar M et al., 2014, Targeted immunotherapy for non-small cell lung cancer., World J Clin Oncol

HingoraniCasas: ENSG00000120217

Alternate Names: ENSG00000120217 Gene Symbol CD274 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

MyCancerGenome: CD274

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Programmed cell death 1 ligand 1 other

Direct Interaction yes

PMIDs:
28472902 26918451 23724846

Sources:
MyCancerGenome ChemblInteractions CIViC PharmGKB TTD FDA

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

PMIDs:
None found

Sources:
MyCancerGenome CancerCommons

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Programmed cell death 1 ligand 1 inhibitor

Direct Interaction yes

PMIDs:
28472902 29416316 28717238 28214651

Sources:
ChemblInteractions CIViC PharmGKB TTD FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antibody (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Programmed cell death 1 ligand 1 inhibitor

Direct Interaction yes

PMIDs:
24403232 24829850 28472902 26970723 26918451 26952546 27412122

Sources:
MyCancerGenome ChemblInteractions CIViC PharmGKB TTD FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
26086854 28472902 26918451

Sources:
CIViC PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
25891174 28472902 27718847 26918451 26086854

Sources:
CIViC PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

CD274 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

29126 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Anti-PD-L1

Alternate Names:

PA134915280 PharmGKB ID

Publications:

Carbognin et al., 2015, Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers., PLoS ONE

Alternate Names:

29126 Entrez Gene ID

11335 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Alternate Names:

PD-L1 TTD Gene Abbreviation

T99948 TTD Target ID

Publications:

McDermott DF et al., 2013, PD-1 as a potential target in cancer therapy., Cancer Med

Vasekar M et al., 2014, Targeted immunotherapy for non-small cell lung cancer., World J Clin Oncol

Alternate Names:

ENSG00000120217 Gene Symbol

CD274 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

29126 Entrez Gene Id

CD274 MyCancerGenome Gene Symbol

PD-L1 MyCancerGenome Reported Gene Name

Alternate Names:

PDCD1L1 GENE_SYMBOL

PDCD1LG1 GENE_SYMBOL

PDL1 GENE_SYMBOL

Alternate Names:

B7H1 GO Gene Synonym

PDCD1L1 GO Gene Synonym

PDCD1LG1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

CD274 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE