DGIdb - CCND1 Gene Record

CCND1 595 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

595
CYCLIN D1
CCND1
BCL1
D11S287E
PRAD1
U21B31
168461
1582
ENSG00000110092
OTTHUMG00000167877
8
P24385
BCL-1
PRAD1 oncogene
BCL-1 oncogene
B-cell lymphoma 1 protein
G1/S-specific cyclin-D1
PA75
T12355

Gene Info:

Target Class	Miscellaneous
Target Subclass	Miscellaneous
Target Subclass	Cyclin
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Boutillier et al., 1999, Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway., Eur. J. Neurosci.
Absenger G et al., 2014, The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy., Pharmacogenomics J
Costea I et al., 2006, Folate cycle gene variants and chemotherapy toxicity in pediatric patients with acute lymphoblastic leukemia., Haematologica
Costea et al., 2003, The influence of cyclin D1 (CCND1) 870A>G polymorphism and CCND1-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia., Pharmacogenetics
Stendahl et al., 2004, Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients., Br. J. Cancer
Christov et al., 2003, Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors., Breast Cancer Res. Treat.
Han et al., Cyclin D1 expression and patient outcome after tamoxifen therapy in estrogen receptor positive metastatic breast cancer., Oncol. Rep.
Gadd et al., 2002, Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity., Toxicol. Sci.
Reddy MV et al., 2014, Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5)., J Med Chem
Sharma et al., 2004, Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes., J. Biol. Chem.
Saitoh et al., 2005, Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cells., Endocrinology
Van Poznak et al., 2001, Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial., Breast Cancer Res. Treat.
Lee HJ et al., 2018, A selective cyclin-dependent kinase 4, 6 dual inhibitor, Ribociclib (LEE011) inhibits cell proliferation and induces apoptosis in aggressive thyroid cancer., Cancer Lett
Ogawa et al., 2000, Aberrant expression of p27(Kip1) is associated with malignant transformation of the rat urinary bladder epithelium., Carcinogenesis
Galli et al., 2004, The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation., Arch. Biochem. Biophys.
Heathcote DA et al., 2010, A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration., J Med Chem
Dahan L et al., 2011, Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer., BMC Cancer
Graziano F et al., 2008, Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer., J Clin Oncol
Zhang W et al., 2006, Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab., Pharmacogenet Genomics
Ngo BT et al., 2010, Monitoring bortezomib therapy in multiple myeloma: screening of cyclin D1, D2, and D3 via reliable real-time polymerase chain reaction and association with clinico-pathological features and outcome., Leuk Lymphoma

BRICICLIB CCND1

Interaction Score: 6.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction G1/S-specific cyclin D1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
URACIL CCND1

Interaction Score: 1.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10607743

Sources:
NCI
RIBOCICLIB CCND1

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29306020

Sources:
ClearityFoundationBiomarkers CIViC
VITAMIN E CCND1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14871472

Sources:
NCI
SELICICLIB CCND1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21080703

Sources:
DTC
CETUXIMAB CCND1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22117530 18349392 16788380

Sources:
PharmGKB
TAMOXIFEN CCND1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15138475 12602925 12469160

Sources:
NCI CIViC
NAVITOCLAX CCND1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TROGLITAZONE CCND1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14764597

Sources:
NCI
ABEMACICLIB CCND1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers
PALBOCICLIB CCND1

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction CDK6/cyclin D1 inhibitor

Direct Interaction yes

PMIDs:
24417566

Sources:
DTC ChemblInteractions
ALVOCIDIB CCND1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACETAMINOPHEN CCND1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11896290

Sources:
NCI
GOSSYPOL CCND1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11510695

Sources:
NCI
NIFEDIPINE CCND1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10051745

Sources:
NCI
LAPATINIB CCND1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHOTREXATE CCND1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16870553 12972956

Sources:
NCI PharmGKB
PROGESTERONE CCND1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16123159

Sources:
NCI
BORTEZOMIB CCND1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20578819

Sources:
CIViC
FLUOROURACIL CCND1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23567490

Sources:
PharmGKB

Ensembl: ENSG00000110092
- Version: 101_38
Alternate Names:

CCND1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P24385
- Version: January-2014
Alternate Names:

CCND1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass Cyclin

Publications:

PharmGKB: CCND1

Version: 18-August-2020

Alternate Names:

PA75 PharmGKB ID

Gene Info:

Publications:

Absenger G et al., 2014, The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy., Pharmacogenomics J

Dahan L et al., 2011, Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer., BMC Cancer

Zhang W et al., 2006, Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab., Pharmacogenet Genomics

CIViC: CCND1

Version: 14-September-2020

Alternate Names:

595 Entrez Gene ID

8 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Lee HJ et al., 2018, A selective cyclin-dependent kinase 4, 6 dual inhibitor, Ribociclib (LEE011) inhibits cell proliferation and induces apoptosis in aggressive thyroid cancer., Cancer Lett

Stendahl et al., 2004, Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients., Br. J. Cancer

Ngo BT et al., 2010, Monitoring bortezomib therapy in multiple myeloma: screening of cyclin D1, D2, and D3 via reliable real-time polymerase chain reaction and association with clinico-pathological features and outcome., Leuk Lymphoma

NCI: CCND1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Boutillier et al., 1999, Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway., Eur. J. Neurosci.

Shinozaki et al., Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice., Anticancer Res.

Shen et al., 2006, p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1., Cancer Chemother. Pharmacol.

DTC: CCND1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Heathcote DA et al., 2010, A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration., J Med Chem

Reddy MV et al., 2014, Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5)., J Med Chem

HingoraniCasas: ENSG00000110092
- Version: 31-May-2017
Alternate Names:

ENSG00000110092 Gene Symbol

CCND1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: BCL1
- Version: chembl_23
Alternate Names:

PRAD1 GENE_SYMBOL

CCND1 GENE_SYMBOL

G1/S-specific cyclin-D1 UNIPROT

Gene Info:

Publications:
Tempus: CCND1
- Version: 11-November-2018
Alternate Names:

CCND1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: G1/S-specific cyclin-D1
- Version: 2020.06.01
Alternate Names:

CCND1 TTD Gene Abbreviation

T12355 TTD Target ID

Gene Info:

Publications:
Pharos: CCND1
- Version: 01-February-2022
Alternate Names:

G1/S-specific cyclin-D1 Gene Name

P24385 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
MskImpact: CCND1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationBiomarkers: CCND1
- Version: 26-July-2013
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: CCND1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: CCND1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: CCND1
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	G1/S-specific cyclin D1 inhibitor
Direct Interaction	yes

Mechanism of Interaction	CDK6/cyclin D1 inhibitor
Direct Interaction	yes

PRAD1	GENE_SYMBOL
CCND1	GENE_SYMBOL
G1/S-specific cyclin-D1	UNIPROT

CCND1 Gene Record

CCND1 595 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction G1/S-specific cyclin D1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10607743

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29306020

Sources: ClearityFoundationBiomarkers CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14871472

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21080703

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22117530 18349392 16788380

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15138475 12602925 12469160

Sources: NCI CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14764597

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationBiomarkers

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction CDK6/cyclin D1 inhibitor Direct Interaction yes

PMIDs: 24417566

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11896290

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11510695

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10051745

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16870553 12972956

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16123159

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction G1/S-specific cyclin D1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
10607743

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29306020

Sources:
ClearityFoundationBiomarkers CIViC

Interaction Types & Directionality:

n/a

PMIDs:
14871472

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21080703

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22117530 18349392 16788380

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15138475 12602925 12469160

Sources:
NCI CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
14764597

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction CDK6/cyclin D1 inhibitor

Direct Interaction yes

PMIDs:
24417566

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11896290

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11510695

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10051745

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16870553 12972956

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16123159

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20578819

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
23567490

Sources:
PharmGKB

Alternate Names:

CCND1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CCND1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass Cyclin

Alternate Names:

PA75 PharmGKB ID

Alternate Names:

595 Entrez Gene ID

8 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Alternate Names:

ENSG00000110092 Gene Symbol

CCND1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PRAD1 GENE_SYMBOL

CCND1 GENE_SYMBOL

G1/S-specific cyclin-D1 UNIPROT

Alternate Names:

CCND1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

CCND1 TTD Gene Abbreviation

T12355 TTD Target ID